Abstract:
:The components and pathways that regulate and execute developmental cell death programmes in plants remain largely unknown. We have found that the PROMOTION OF CELL SURVIVAL 1 (PCS1) gene in Arabidopsis, which encodes an aspartic protease, has an important role in determining the fate of cells in embryonic development and in reproduction processes. The loss-of-function mutation of PCS1 causes degeneration of both male and female gametophytes and excessive cell death of developing embryos. Conversely, ectopic expression of PCS1 causes the septum and stomium cells that normally die in the anther wall to survive instead, leading to a failure in anther dehiscence and male sterility. PCS1 provides a new avenue for understanding the mechanisms of the programmed cell death processes that are associated with developmental pathways in plants and makes available a useful tool for engineering the male sterility trait for hybrid seed production.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Ge X,Dietrich C,Matsuno M,Li G,Berg H,Xia Ydoi
10.1038/sj.embor.7400357keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
282-8issue
3eissn
1469-221Xissn
1469-3178pii
7400357journal_volume
6pub_type
杂志文章相关文献
EMBO REPORTS文献大全abstract::Ligand-dependent transcriptional activation of retinoic acid receptors (RARs) is a multistep process culminating in the formation of a multimeric co-activator complex on regulated promoters. Several co-activator complexes harbor an acetyl transferase activity, which is required for retinoid-induced transcription of re...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1093/embo-reports/kvf066
更新日期:2002-04-01 00:00:00
abstract::Although iron is required for cell proliferation, iron-dependent programmed cell death serves as a critical barrier to tumor growth and metastasis. Emerging evidence suggests that iron-mediated lipid oxidation also facilitates immune eradication of cancer. However, the regulatory mechanisms of iron metabolism in cance...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.202051162
更新日期:2021-01-04 00:00:00
abstract::Cohesin cofactors regulate the loading, maintenance, and release of cohesin complexes from chromosomes during mitosis but little is known on their role during vertebrate meiosis. One such cofactor is PDS5, which exists as two paralogs in somatic and germline cells, PDS5A and PDS5B, with unclear functions. Here, we hav...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201949273
更新日期:2020-06-04 00:00:00
abstract::Global climate change and the increasing human population require crop varieties with higher yield and draught resistance. But meeting both goals is not an easy task for breeders and plant science. ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.202051598
更新日期:2020-11-29 00:00:00
abstract::Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field s...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2012.215
更新日期:2013-02-01 00:00:00
abstract::Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent tra...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.97
更新日期:2009-08-01 00:00:00
abstract::Retinoic acid (RA) signalling ensures that vertebrate mesoderm segmentation is bilaterally synchronized, and corrects transient interferences from asymmetric left-right (L-R) signals involved in organ lateralization. Snail genes participate in both these processes and, although they are expressed symmetrically in the ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400867
更新日期:2007-01-01 00:00:00
abstract::In an attempt to further increase transgene expression levels in plants over and above the enhancement obtained with a 5' untranslated leader intron, three different maize introns were inserted at three different positions within the coding sequence of the luciferase reporter gene. Constructs were transformed into mai...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1093/embo-reports/kve090
更新日期:2001-05-01 00:00:00
abstract::Codon bias has been implicated as one of the major factors contributing to mRNA stability in several model organisms. However, the molecular mechanisms of codon bias on mRNA stability remain unclear in humans. Here, we show that human cells possess a mechanism to modulate RNA stability through a unique codon bias. Bio...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201948220
更新日期:2019-11-05 00:00:00
abstract::Several studies have shown that ribosomal proteins (RPs) are important mediators of p53 activation in response to nucleolar disruption; however, the pathways that control this signalling function of RPs are currently unknown. We have recently shown that RPs are targets for the ubiquitin-like molecule NEDD8, and that N...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.178
更新日期:2009-10-01 00:00:00
abstract::The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal crypt progenitor cells were assessed by using a series of inducible gut-specific Notch mutant mice. We found that Notch1 and Notch2 receptors function redundantly in the gut, as only simultaneous loss of both receptors r...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.7
更新日期:2008-04-01 00:00:00
abstract::The primary cilium, critical for morphogenic and growth factor signaling, is assembled upon cell cycle exit, but the links between ciliogenesis and cell cycle progression are unclear. KV10.1 is a voltage-gated potassium channel frequently overexpressed in tumors. We have previously reported that expression of KV10.1 i...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201541082
更新日期:2016-05-01 00:00:00
abstract::The ubiquitin ligase Highwire restrains synaptic growth and promotes evoked neurotransmission at NMJ synapses in Drosophila Highwire regulates synaptic morphology by downregulating the MAP3K Wallenda, but excess Wallenda signaling does not account for the decreased presynaptic release observed in highwire mutants. Hen...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201846975
更新日期:2019-03-01 00:00:00
abstract::Sirtuins (SIRTs) are a class of lysine deacylases that regulate cellular metabolism and energy homeostasis. Although sirtuins have been proposed to function in nutrient sensing and signaling, the underlying mechanism remains elusive. SIRT7, a histone H3K18-specific deacetylase, epigenetically controls mitochondria bio...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201846377
更新日期:2018-12-01 00:00:00
abstract::Short interfering RNAs (siRNAs) are short (21-23 nt) double-stranded RNAs that direct the sequence-specific degradation of corresponding mRNAs, resulting in suppression of gene activity. siRNAs are powerful tools for gene functional analysis in mammals. Chemically synthesized siRNAs permit transient gene repression bu...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400064
更新日期:2004-02-01 00:00:00
abstract::Despite its limited resources, Portugal has gained a prominent position in research on malaria. Several historical and personal factors have contributed to this achievement. ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.202051692
更新日期:2021-01-10 00:00:00
abstract::Various aerolysin-like pore-forming proteins have been identified from bacteria to vertebrates. However, the mechanism of receptor recognition and/or pore formation of the eukaryotic members remains unknown. Here, we present the first crystal and electron microscopy structures of a vertebrate aerolysin-like protein fr...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201540851
更新日期:2016-02-01 00:00:00
abstract::Activation of the elongation factor 2 kinase (eEF2K) leads to the phosphorylation and inhibition of the elongation factor eEF2, reducing mRNA translation rates. Emerging evidence indicates that the regulation of factors involved in protein synthesis may be critical for controlling diverse biological processes includin...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201642194
更新日期:2016-10-01 00:00:00
abstract::Although many signal transduction pathways have been implicated in the development of human disease, the identification of pathway targets and the biological processes that mediate disease progression remains challenging. One such disease-related pathway is the Janus kinase (JAK)/signal transducer and activator of tra...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2010.1
更新日期:2010-03-01 00:00:00
abstract::Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surfa...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1093/embo-reports/kvf242
更新日期:2002-12-01 00:00:00
abstract::Brinker is a nuclear protein that antagonizes Dpp signalling in Drosophila. Its expression is negatively regulated by Dpp. Here, we show that Brinker represses Ultrabithorax (Ubx) in the embryonic midgut, a HOX gene that activates, and responds to, the localized expression of Dpp during endoderm induction. We find tha...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1093/embo-reports/kve068
更新日期:2001-04-01 00:00:00
abstract::Mammalian artificial chromosomes (MACs) provide a new tool for the improvement of our knowledge of chromosome structure and function. Moreover, they constitute an alternative and potentially powerful tool for gene delivery both in cultured cells and for the production of transgenic animals. In the present work we desc...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1093/embo-reports/kve018
更新日期:2001-02-01 00:00:00
abstract::Post-translational protein arginylation is essential for cardiovascular development and angiogenesis in mice and is mediated by arginyl-transfer RNA-protein transferases Ate1-a functionally conserved but poorly understood class of enzymes. Here, we used sequence analysis to detect the evolutionary relationship between...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400747
更新日期:2006-08-01 00:00:00
abstract::Plexins are receptors for the axonal guidance molecules known as semaphorins, and the semaphorin 4D (Sema4D) receptor plexin-B1 induces repulsive responses by functioning as an R-Ras GTPase-activating protein (GAP). Here we characterized the downstream signalling of plexin-B1-mediated R-Ras GAP activity, inducing grow...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400737
更新日期:2006-07-01 00:00:00
abstract::Processive motor proteins are stochastic steppers that perform actual mechanical steps for only a minor fraction of the time they are bound to the filament track. Motors usually work in teams and therefore the question arises whether the stochasticity of stepping can cause mutual interference when motors are mechanica...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.169
更新日期:2008-11-01 00:00:00
abstract::Regulated intramembrane proteolysis of the amyloid precursor-protein (APP) produces both a characterstic amyloid-β peptide that contributes to neuritic plaque formation and neurodegeneration in Alzheimer disease and a small APP intracellular domain (AICD) that transcriptionally activates genes implicated in Alzheimer ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2010.210
更新日期:2011-03-01 00:00:00
abstract::Oncogenic signals contribute to enhanced glycolysis and mTORC1 activity, leading to rapid cell proliferation in cancer. Regulation of glycolysis and mTORC1 by PI3K/Akt signaling is well established, but how KRAS-induced MEK signaling regulates these pathways remains poorly understood. Here, we report a role for MEK-dr...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201847451
更新日期:2019-06-01 00:00:00
abstract::In Drosophila, a cascade of maternal, gap, pair-rule and segment polarity genes subdivides the antero/posterior axis of the embryo into repeating segmental stripes. This review summarizes what happens next, i.e. how an intrasegmental pattern is generated and controls the differentiation of specific cell types in the e...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1093/embo-reports/kve255
更新日期:2001-12-01 00:00:00
abstract::A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and disc...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1093/embo-reports/kve231
更新日期:2001-11-01 00:00:00
abstract::The structure of the DNA-binding NAC domain of Arabidopsis ANAC (abscisic-acid-responsive NAC) has been determined by X-ray crystallography to 1.9A resolution (Protein Data Bank codes 1UT4 and 1UT7). This is the first structure determined for a member of the NAC family of plant-specific transcriptional regulators. NAC...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400093
更新日期:2004-03-01 00:00:00