Abstract:
:PTIP regulates gene transcription by controlling the methylation of histone H3, and also has important roles in cellular responses to DNA damage or to perturbed DNA replication. The available data suggest that the functions of PTIP in transcription and preserving genome stability might be independent and mediated by functionally distinct cellular pools of PTIP. Although considerable progress has been made in understanding how PTIP influences transcription, a coherent picture of how it protects cells from DNA damage at the molecular level has yet to emerge. Here, we describe recent progress made in understanding the cellular roles of PTIP and the relevance of PTIP-interacting proteins, as well as the questions that have yet to be answered.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Muñoz IM,Rouse Jdoi
10.1038/embor.2009.21subject
Has Abstractpub_date
2009-03-01 00:00:00pages
239-45issue
3eissn
1469-221Xissn
1469-3178pii
embor200921journal_volume
10pub_type
杂志文章,评审相关文献
EMBO REPORTS文献大全abstract::Understanding how cell fate decisions are regulated is a fundamental goal of developmental and stem cell biology. Most studies on the control of cell fate decisions address the contributions of changes in transcriptional programming, epigenetic modifications, and biochemical differentiation cues. However, recent studi...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.15252/embr.201744816
更新日期:2017-12-01 00:00:00
abstract::The Vav family of proteins are guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases, which regulate various cellular functions, including T-cell activation. They contain a catalytic Dbl homology (DH) domain that is invariably followed by a pleckstrin homology (PH) domain, which is often required fo...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.80
更新日期:2008-07-01 00:00:00
abstract::Growth plasticity is a key mechanism by which plants adapt to the ever-changing environmental conditions. Since growth is a high-energy-demanding and irreversible process, it is expected to be regulated by the integration of endogenous energy status as well as environmental conditions. Here, we show that trehalose-6-p...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201947828
更新日期:2019-10-04 00:00:00
abstract::The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal crypt progenitor cells were assessed by using a series of inducible gut-specific Notch mutant mice. We found that Notch1 and Notch2 receptors function redundantly in the gut, as only simultaneous loss of both receptors r...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.7
更新日期:2008-04-01 00:00:00
abstract::Potentially pathogenic bacteria, such as Escherichia coli and Vibrio cholerae, become non-culturable during stasis. The analysis of such cells has been hampered by difficulties in studying bacterial population heterogeneity. Using in situ detection of protein oxidation in single E. coli cells, and using a density-grad...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.embor799
更新日期:2003-04-01 00:00:00
abstract::Scrapie, bovine spongiform encephalopathy and chronic wasting disease are orally communicable, transmissible spongiform encephalopathies (TSEs). As zoonotic transmissions of TSE agents may pose a risk to human health, the identification of reservoirs for infectivity in animal tissues and their exclusion from human con...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.embor827
更新日期:2003-05-01 00:00:00
abstract::GlpF, the glycerol facilitator protein of Escherichia coli, is an archetypal member of the aquaporin superfamily. To assess its structure, recombinant histidine-tagged protein was overexpressed, solubilized in octylglucoside and purified to homogeneity. Negative stain electron microscopy of solubilized GlpF protein re...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1093/embo-reports/kvd022
更新日期:2000-08-01 00:00:00
abstract::The histone H3 N-terminal protein domain (N-tail) is regulated by multiple posttranslational modifications, including methylation, acetylation, phosphorylation, and by proteolytic cleavage. However, the mechanism underlying H3 N-tail proteolytic cleavage is largely elusive. Here, we report that JMJD5, a Jumonji C (Jmj...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201743892
更新日期:2017-12-01 00:00:00
abstract::Defects in protein folding and the proteasomal pathway have been linked with many neurodegenerative diseases. PLIC-1 (protein linking IAP to the cytoskeleton) is a ubiquitin-like protein that binds to the ubiquitin-interacting motif (UIM) of the proteasomal subunit S5a. Here, we show that PLIC-1 also binds to the UIM ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400823
更新日期:2006-12-01 00:00:00
abstract::Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent tra...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.97
更新日期:2009-08-01 00:00:00
abstract::Loss of the retinoblastoma protein, pRB, leads to apoptosis, and several results have suggested that this is dependent on the E2F transcription factors. However, so far, the ability of the different E2F family members to contribute to apoptosis is controversial. Here, we show that ectopic expression of E2F3 results in...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400452
更新日期:2005-07-01 00:00:00
abstract::LeuT serves as the model protein for understanding the relationships between structure, mechanism and pharmacology in neurotransmitter sodium symporters (NSSs). At the present time, however, there is a vigorous debate over whether there is a single high-affinity substrate site (S1) located at the original, crystallogr...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2012.110
更新日期:2012-09-01 00:00:00
abstract::Mutations in GRN, which encodes progranulin, are a common cause of familial frontotemporal dementia (FTD). FTD is a devastating disease characterised by neuronal loss in the frontal and temporal lobes that leads to changes in personality, behaviour and language. There are no effective treatments for this complex condi...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.202051668
更新日期:2020-10-05 00:00:00
abstract::The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhae...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2010.170
更新日期:2011-01-01 00:00:00
abstract::Sonic hedgehog (Shh), both as a mitogen and as a morphogen, plays an important role in cell proliferation and differentiation during early development. Here, we show that Shh inhibits glutamate transporter activities in neurons, rapidly enhances extracellular glutamate levels, and affects the development of epilepsy. ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201541569
更新日期:2016-05-01 00:00:00
abstract::DNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild-type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild-type p53 to a p53 response element in the promoter of Rad51 and the downregulati...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400587
更新日期:2006-02-01 00:00:00
abstract::MicroRNAs (miRNAs) regulate target mRNAs by silencing them. Reciprocally, however, target mRNAs can also modulate miRNA stability. Here, we uncover a remarkable efficacy of target RNA-directed miRNA degradation (TDMD) in rodent primary neurons. Coincident with degradation, and while still bound to Argonaute, targeted ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201540078
更新日期:2015-04-01 00:00:00
abstract::Adult tissue maintenance is often dependent on resident stem cells; however, the phenotypic and functional heterogeneity existing within this self-renewing population is poorly understood. Here, we define distinct subsets of undifferentiated spermatogonia (spermatogonial progenitor cells; SPCs) by differential respons...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201439379
更新日期:2015-04-01 00:00:00
abstract::Centromeric constitutive heterochromatin is marked by DNA methylation and dimethylated histone H3 Lys 9 (H3K9me2) in Arabidopsis. RNA-directed DNA methylation (RdDM) is a process that uses 24-nucleotide (nt) small interfering RNAs (siRNAs) to induce de novo methylation to its homologous DNA sequences. Despite the pres...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.152
更新日期:2009-09-01 00:00:00
abstract::Biasing the sex ratio of populations of different organisms, including plants, insects, crustacean, and fish, has been demonstrated by genetic and non-genetic approaches. However, biasing the sex ratio of mammalian populations has not been demonstrated genetically. Here, we provide a first proof of concept for such a ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201948269
更新日期:2019-08-01 00:00:00
abstract::Pair-rule genes in Drosophila integrate the positional information provided by the transcription factor gradients of gap genes and set the framework for the expression of the segment polarity genes. Pair-rule genes are also expressed during the segmentation of the short germ-band embryo of the flour beetle Tribolium, ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400148
更新日期:2004-06-01 00:00:00
abstract::Various aerolysin-like pore-forming proteins have been identified from bacteria to vertebrates. However, the mechanism of receptor recognition and/or pore formation of the eukaryotic members remains unknown. Here, we present the first crystal and electron microscopy structures of a vertebrate aerolysin-like protein fr...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201540851
更新日期:2016-02-01 00:00:00
abstract::The mitochondrial matrix protease CLPP plays a central role in the activation of the mitochondrial unfolded protein response (UPR(mt)) in Caenorhabditis elegans Far less is known about mammalian UPR(mt) signaling, although similar roles were assumed for central players, including CLPP To better understand the mammalia...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201642077
更新日期:2016-07-01 00:00:00
abstract::The COVID-19 crisis has further highlighted the challenges for open science and data sharing in biomedical research and the need for more traceability and transparency. ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.202051773
更新日期:2020-11-05 00:00:00
abstract::Cancer-associated p53 missense mutants confer gain of function (GOF) and promote tumorigenesis by regulating crucial signaling pathways. However, the role of GOF mutant p53 in regulating DNA replication, a commonly altered pathway in cancer, is less explored. Here, we show that enhanced Cdc7-dependent replication init...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201643347
更新日期:2017-11-01 00:00:00
abstract::In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.201947957
更新日期:2019-11-05 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in TMEM106B encoding the lysosomal type II transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) of GRN (progranulin gene) mutation carriers. Currently, it is unclear if progranulin (PGRN) and TMEM106B are synergistically linked and if a gain o...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.15252/embr.202050241
更新日期:2020-10-05 00:00:00
abstract::The bacterium Bacillus subtilis produces the DNA integrity scanning protein (DisA), a checkpoint protein that delays sporulation in response to DNA damage. DisA scans the chromosome and pauses at sites of DNA lesions. Structural analysis showed that DisA synthesizes the small molecule cyclic diadenosine monophosphate ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2011.77
更新日期:2011-06-01 00:00:00
abstract::The ubiquitin-like protein Urm1 can be covalently conjugated to other proteins, such as the yeast thioredoxin peroxidase protein Ahp1p, through a mechanism involving the ubiquitin E1-like enzyme Uba4. Recent findings have revealed a second function of Urm1 as a sulphur carrier in the thiolation of eukaryotic cytoplasm...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2008.209
更新日期:2008-12-01 00:00:00
abstract::A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and disc...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1093/embo-reports/kve231
更新日期:2001-11-01 00:00:00