Proteomic selection of immunodiagnostic antigens for Trypanosoma congolense.

abstract：:Rickettsia (R.) helvetica is the most prevalent rickettsia found in Ixodes ricinus ticks in Germany. Several studies reported antibodies against R. helvetica up to 12.5% in humans investigated, however, fulminant clinical cases are rare indicating a rather low pathogenicity compared to other rickettsiae. We investigat...

journal_title：PLoS neglected tropical diseases

authors： Speck S,Kern T,Aistleitner K,Dilcher M,Dobler G,Essbauer S

更新日期：2018-02-12 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is an infectious disease caused by various species of Leishmania and transmitted by several species of sand flies. CL is among the most neglected tropical diseases, and it has represented a major health threat over the past 20 years in Morocco. The main objectives of this study w...

journal_title：PLoS neglected tropical diseases

authors： Mhaidi I,El Kacem S,Ait Kbaich M,El Hamouchi A,Sarih M,Akarid K,Lemrani M

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:American visceral leishmaniasis (AVL) is an emerging disease in the state of São Paulo, Brazil. Its geographical expansion and the increase in the number of human cases has been linked to dispersion of Lutzomyia longipalpis into urban areas. To produce more accurate risk maps we investigated the geographic d...

journal_title：PLoS neglected tropical diseases

authors： Casanova C,Colla-Jacques FE,Hamilton JG,Brazil RP,Shaw JJ

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:Onchocerciasis in Yemen is one of the most neglected diseases, where baseline estimates of onchocerciasis and monitoring of the impact of ivermectin regularly administered to the affected individuals on its transmission are lacking. Therefore, this study aimed to determine the anti-Ov16 IgG4 seroprevalence a...

journal_title：PLoS neglected tropical diseases

authors： Mahdy MAK,Abdul-Ghani R,Abdulrahman TAA,Al-Eryani SMA,Al-Mekhlafi AM,Alhaidari SAA,Azazy AA

更新日期：2018-03-05 00:00:00

abstract：:Hantaviruses are endemic throughout the world and hosted by rodents and insectivores. Two human zoonoses, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), are caused by hantaviruses and case fatality rates have reached 12% for HFRS and 50% for HPS in some outbreaks. Symptomatic han...

journal_title：PLoS neglected tropical diseases

authors： Escadafal C,Avšič-Županc T,Vapalahti O,Niklasson B,Teichmann A,Niedrig M,Donoso-Mantke O

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Junín virus (JUNV), the etiologic agent of Argentine hemorrhagic fever (AHF), is classified by the NIAID and CDC as a Category A priority pathogen. Presently, antiviral therapy for AHF is limited to immune plasma, which is readily available only in the endemic regions of Argentina. T-705 (favipiravir) is a b...

journal_title：PLoS neglected tropical diseases

authors： Gowen BB,Juelich TL,Sefing EJ,Brasel T,Smith JK,Zhang L,Tigabu B,Hill TE,Yun T,Pietzsch C,Furuta Y,Freiberg AN

更新日期：2013-12-26 00:00:00

abstract：:Clinical manifestations in onchocerciasis range from generalized onchocerciasis (GEO) to the rare but severe hyperreactive (HO)/sowda form. Since disease pathogenesis is associated with host inflammatory reactions, we investigated whether Th17 responses could be related to aggravated pathology in HO. Using flow cytome...

journal_title：PLoS neglected tropical diseases

authors： Katawa G,Layland LE,Debrah AY,von Horn C,Batsa L,Kwarteng A,Arriens S,W Taylor D,Specht S,Hoerauf A,Adjobimey T

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Primary infection of Toxoplasma gondii during pregnancy can be transmitted to the unborn child and may have serious consequences, including retinochoroiditis, hydrocephaly, cerebral calcifications, encephalitis, splenomegaly, hearing loss, blindness, and death. Austria, a country with moderate seroprevalence...

journal_title：PLoS neglected tropical diseases

authors： Prusa AR,Kasper DC,Sawers L,Walter E,Hayde M,Stillwaggon E

更新日期：2017-07-10 00:00:00

abstract：:Schistosomes are parasitic platyhelminths that currently infect over 200 million people globally. The parasites can live for years in a putatively hostile environment - the blood of vertebrates. We have hypothesized that the unusual schistosome tegument (outer-covering) plays a role in protecting parasites in the bloo...

journal_title：PLoS neglected tropical diseases

authors： Bhardwaj R,Skelly PJ

更新日期：2011-04-05 00:00:00

abstract：:Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A. aegypti strain (SP) developed 1650-fold resistance to permethrin, which is one of the most widely used pyrethroid insecticides for mosquito control. SP larvae also developed 8790-fold resistance following sele...

journal_title：PLoS neglected tropical diseases

authors： Kasai S,Komagata O,Itokawa K,Shono T,Ng LC,Kobayashi M,Tomita T

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are responsible for a substantial health and economic burden, particularly to low-income societies. Quan...

journal_title：PLoS neglected tropical diseases

authors： Otero-Abad B,Torgerson PR

更新日期：2013-06-06 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hookworm infection is among the major causes of anaemia in poor communities, but its importance in causing maternal anaemia is poorly understood, and this has hampered effective lobbying for the inclusion of anthelmintic treatment in maternal health packages. We sought to review existing evide...

journal_title：PLoS neglected tropical diseases

authors： Brooker S,Hotez PJ,Bundy DA

更新日期：2008-09-17 00:00:00

abstract：:Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of Asia, where periodic outbreaks take hundreds of lives. Despite the catastrophes it causes, JE has remained a tropical disease uncom...

journal_title：PLoS neglected tropical diseases

authors： Ghosh D,Basu A

更新日期：2009-09-29 00:00:00

abstract：BACKGROUND:Usutu virus (USUV) is a member of the Japanese encephalitis virus (JEV) serocomplex in the Flaviviridae family. Emergence of USUV in Europe has led to disease burdens in birds and created increasing concern for the potential zoonotic transmission to humans. Whilst USUV has not been detected in the New World,...

journal_title：PLoS neglected tropical diseases

authors： Cook CL,Huang YS,Lyons AC,Alto BW,Unlu I,Higgs S,Vanlandingham DL

更新日期：2018-08-17 00:00:00

abstract：BACKGROUND:The success of the global strategy to eliminate lymphatic filariasis (LF) through mass drug administration (MDA) campaigns is dependent on meeting high coverage levels over long periods of time. Community engagement plays a critical role in driving coverage and involvement of local communities in MDA for LF....

journal_title：PLoS neglected tropical diseases

authors： Silumbwe A,Halwindi H,Zulu JM

更新日期：2019-11-27 00:00:00

abstract：:Canine rabies was endemic pre-urbanisation, yet little is known about how it persists in small populations of dogs typically seen in rural and remote regions. By simulating rabies outbreaks in such populations (50-90 dogs) using a network-based model, our objective was to determine if rabies-induced behavioural change...

journal_title：PLoS neglected tropical diseases

authors： Brookes VJ,Dürr S,Ward MP

更新日期：2019-09-23 00:00:00

abstract：BACKGROUND:Current WHO recommendations for lymphatic filariasis (LF) surveillance advise programs to implement activities to monitor for new foci of transmission after stopping mass drug administration (MDA). A current need in the global effort to eliminate LF is to standardize diagnostic tools and surveillance activit...

journal_title：PLoS neglected tropical diseases

authors： Won KY,Robinson K,Hamlin KL,Tufa J,Seespesara M,Wiegand RE,Gass K,Kubofcik J,Nutman TB,Lammie PJ,Fuimaono S

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Rodents are major reservoirs of pathogens responsible for numerous zoonotic diseases in humans and livestock. Assessing their microbial diversity at both the individual and population level is crucial for monitoring endemic infections and revealing microbial association patterns within reservoirs. Recently, ...

journal_title：PLoS neglected tropical diseases

authors： Razzauti M,Galan M,Bernard M,Maman S,Klopp C,Charbonnel N,Vayssier-Taussat M,Eloit M,Cosson JF

更新日期：2015-08-18 00:00:00

abstract：BACKGROUND:Trypanosomiasis induces a remarkable myenteric neuronal degeneration leading to megacolon. Very little is known about the risk for colon cancer in chagasic megacolon patients. To clarify whether chagasic megacolon impacts on colon carcinogenesis, we investigated the risk for colon cancer in Trypanosoma cruzi...

journal_title：PLoS neglected tropical diseases

authors： Kannen V,de Oliveira EC,Motta BZ,Chaguri AJ,Brunaldi MO,Garcia SB

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:Opisthorchis felineus, O. viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose a serious threat to humans in some countries and cause opisthorchiasis/clonorchiasis. Chronic disease may lead to a risk of carcinogenesis in the biliary ducts. MicroRNAs (miRNAs) are small...

journal_title：PLoS neglected tropical diseases

authors： Ovchinnikov VY,Afonnikov DA,Vasiliev GV,Kashina EV,Sripa B,Mordvinov VA,Katokhin AV

更新日期：2015-04-21 00:00:00

abstract：BACKGROUND:Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS:A seroepid...

journal_title：PLoS neglected tropical diseases

authors： Coral-Almeida M,Rodríguez-Hidalgo R,Celi-Erazo M,García HH,Rodríguez S,Devleesschauwer B,Benítez-Ortiz W,Dorny P,Praet N

更新日期：2014-05-22 00:00:00

abstract：BACKGROUND:Epilepsy is one of the most common signs of Neurocysticercosis (NCC). In this study, spatial and temporal variations in the incidence of hospitalized cases (IHC) of epilepsy and NCC in Ecuadorian municipalities were analyzed. Additionally, potential socio-economic and landscape indicators were evaluated in o...

journal_title：PLoS neglected tropical diseases

authors： Ron-Garrido L,Coral-Almeida M,Gabriël S,Benitez-Ortiz W,Saegerman C,Dorny P,Berkvens D,Abatih EN

更新日期：2015-11-18 00:00:00

abstract：BACKGROUND:The protozoan parasite Giardia intestinalis and the pathogenic bacterium Helicobacter pylori are well known for their high prevalences in human hosts worldwide. The prevalence of both organisms is known to peak in densely populated, low resource settings and children are infected early in life. Different Gia...

journal_title：PLoS neglected tropical diseases

authors： Ankarklev J,Hestvik E,Lebbad M,Lindh J,Kaddu-Mulindwa DH,Andersson JO,Tylleskär T,Tumwine JK,Svärd SG

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Dengue is the most prevalent arboviral disease transmitted by Aedes aegypti worldwide, whose chemical control is difficult, expensive, and of inconsistent efficacy. Releases of Metarhizium anisopliae--exposed Ae. aegypti males to disseminate conidia among female mosquitoes by mating represents a promising bi...

journal_title：PLoS neglected tropical diseases

authors： Garza-Hernández JA,Reyes-Villanueva F,Russell TL,Braks MA,Garcia-Munguia AM,Rodríguez-Pérez MA

更新日期：2015-10-16 00:00:00

abstract：:Rift Valley fever (RVF), a mosquito-borne zoonosis, is a major public health and veterinary problem in sub-Saharan Africa. Surveillance to monitor mosquito populations during the inter-epidemic period (IEP) and viral activity in these vectors is critical to informing public health decisions for early warning and contr...

journal_title：PLoS neglected tropical diseases

authors： Tchouassi DP,Sang R,Sole CL,Bastos AD,Teal PE,Borgemeister C,Torto B

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is a re-emerging arbovirus associated with febrile illness often accompanied by rash and arthralgia that may persist for several years. Outbreaks are associated with high morbidity and create a public health challenge for countries affected. Recent outbreaks have occurred in both Eu...

journal_title：PLoS neglected tropical diseases

authors： Weger-Lucarelli J,Chu H,Aliota MT,Partidos CD,Osorio JE

更新日期：2014-07-24 00:00:00

abstract：:The proportion of Plasmodium vivax malaria among all malarias is increasing worldwide. Treatment with 8-aminoquinolines remain the only radical cure. However, 8-aminoquinolines can cause severe hemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. The population of the multi-ethnic Chittagong Hill ...

journal_title：PLoS neglected tropical diseases

authors： Ley B,Kibria MG,Khan WA,Auburn S,Phru CS,Jahan N,Johora FT,Thriemer K,Ami JQ,Hossain MS,Price RN,Koepfli C,Alam MS

更新日期：2020-09-14 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0007140.]. ...

journal_title：PLoS neglected tropical diseases

authors： PLOS Neglected Tropical Diseases Staff.

更新日期：2019-06-28 00:00:00

abstract：:Two recombinant Fasciola hepatica antigens, saposin-like protein-2 (recSAP2) and cathepsin L-1 (recCL1), were assessed individually and in combination in enzyme-linked immunosorbent assays (ELISA) for the specific serodiagnosis of human fasciolosis in areas of low endemicity as encountered in Central Europe. Antibody ...

journal_title：PLoS neglected tropical diseases

authors： Gottstein B,Schneeberger M,Boubaker G,Merkle B,Huber C,Spiliotis M,Müller N,Garate T,Doherr MG

更新日期：2014-06-12 00:00:00

abstract：:Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness known as Zika fever. Since its recent emergence in 2014 in the American continent, ZIKV infection during pregnancy has been closely associated with a wide range of congenital abnormalities. To date, no vaccines or antivirals are publicl...

journal_title：PLoS neglected tropical diseases

authors： Salvo MA,Kingstad-Bakke B,Salas-Quinchucua C,Camacho E,Osorio JE

更新日期：2018-02-05 00:00:00