Zika virus like particles elicit protective antibodies in mice.

abstract：BACKGROUND:Echinococcosis is a life-threatening parasitic disease caused by Echinococcus spp. tapeworms with over one million people affected globally at any time. The Echinococcus spp. tapeworms in the human body release DNA to the circulatory system, which can be a biomarker for echinococcosis. Cell-free DNA (cfDNA) ...

journal_title：PLoS neglected tropical diseases

authors： Ji J,Li B,Li J,Danzeng W,Li J,Zhao Y,Qiangba G,Zhang Q,Renzhen N,Basang Z,Jia C,Gongsang Q,Ma J,Wang Y,Chen F,Zhou H,Huasang,Yin J,Xie J,Pei N,Cai H,Jiang H,Yang H,Wang J,Asan,Han X,Li J,Chen W,Yan

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:Rhinoentomophthoromycosis, or rhino-facial conidiobolomycosis, is a rare, grossly disfiguring disease due to an infection with entomophthoralean fungi. We report a case of rhinoentomophthoromycosis from Gabon and suggest a staging system, which provides information on the prognosis and duration of antifungal...

journal_title：PLoS neglected tropical diseases

authors： Blumentrath CG,Grobusch MP,Matsiégui PB,Pahlke F,Zoleko-Manego R,Nzenze-Aféne S,Mabicka B,Sanguinetti M,Kremsner PG,Schaumburg F

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Melioidosis, a fatal infectious disease caused by Burkholderia pseudomallei, is increasingly diagnosed in tropical regions. However, data on risk factors and the geographic epidemiology of the disease are still limited. Previous studies have also largely been based on the analysis of case series data. Here, ...

journal_title：PLoS neglected tropical diseases

authors： Abu Hassan MR,Aziz N,Ismail N,Shafie Z,Mayala B,Donohue RE,Pani SP,Michael E

更新日期：2019-03-18 00:00:00

abstract：:Mosquito-borne diseases continue to remain major threats to human and animal health and impediments to socioeconomic development. Increasing mosquito resistance to chemical insecticides is a great public health concern, and new strategies/technologies are necessary to develop the next-generation of vector control tool...

journal_title：PLoS neglected tropical diseases

authors： Phanse Y,Dunphy BM,Perry JL,Airs PM,Paquette CC,Carlson JO,Xu J,Luft JC,DeSimone JM,Beaty BJ,Bartholomay LC

更新日期：2015-05-21 00:00:00

abstract：:In Tunisia, cases of zoonotic cutaneous leishmaniasis caused by Leishmania major are increasing and spreading from the south-west to new areas in the center. To improve the current knowledge on L. major evolution and population dynamics, we performed multi-locus microsatellite typing of human isolates from Tunisian go...

journal_title：PLoS neglected tropical diseases

authors： Harrabi M,Bettaieb J,Ghawar W,Toumi A,Zaâtour A,Yazidi R,Chaâbane S,Chalghaf B,Hide M,Bañuls AL,Ben Salah A

更新日期：2015-08-24 00:00:00

abstract：BACKGROUND:Schistosomiasis (or bilharzia), a major parasitic disease, affects more than 260 million people worldwide. In chronic cases of intestinal schistosomiasis caused by trematodes of the Schistosoma genus, hepatic fibrosis develops as a host immune response to the helminth eggs, followed by potentially lethal por...

journal_title：PLoS neglected tropical diseases

authors： Masi B,Perles-Barbacaru TA,Laprie C,Dessein H,Bernard M,Dessein A,Viola A

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Mass drug administration (MDA) using praziquantel is the WHO-recommended approach for control of schistosomiasis. However, few studies have compared the impact of different schedules of MDA on the resultant infection levels. We wished to evaluate whether annual MDA was more effective than less frequent treat...

journal_title：PLoS neglected tropical diseases

authors： Karanja DMS,Awino EK,Wiegand RE,Okoth E,Abudho BO,Mwinzi PNM,Montgomery SP,Secor WE

更新日期：2017-10-23 00:00:00

abstract：:Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by Leishmania parasites. By performing experiments with primary human cells in vitro, we demonstrate that the expression of IL-32 isoforms is dependent on the time exposed ...

journal_title：PLoS neglected tropical diseases

authors： Dos Santos JC,Leite Quixabeira VB,Teodoro Silva MV,Damen MSMA,Schraa K,Jaeger M,Oosting M,Keating ST,Dorta ML,Alves Pinto S,Bugalho Duarte F,de Araújo Pereira LI,Netea MG,Ribeiro-Dias F,Joosten LAB

更新日期：2020-02-05 00:00:00

abstract：:Approximately 300,000 persons in the United States (US) are infected with Trypanosoma cruzi, the protozoan that causes Chagas disease, but less than 1% are estimated to have received antiparasitic treatment. Benznidazole was approved by the US Food and Drug Administration (FDA) for treatment of T. cruzi infection in 2...

journal_title：PLoS neglected tropical diseases

authors： Yoshioka K,Manne-Goehler J,Maguire JH,Reich MR

更新日期：2020-06-22 00:00:00

abstract：:Wolbachia bacteria are now being introduced into Aedes aegypti mosquito populations for dengue control. When Wolbachia infections are at a high frequency, they influence the local transmission of dengue by direct virus blocking as well as deleterious effects on vector mosquito populations. However, the effectiveness o...

journal_title：PLoS neglected tropical diseases

authors： Ross PA,Ritchie SA,Axford JK,Hoffmann AA

更新日期：2019-04-19 00:00:00

abstract：BACKGROUND:Cutaneous dirofilariosis is a canine mosquito-borne zoonosis that can cause larva migrans disease in humans. Dirofilaria repens is considered an emerging pathogen occurring with high prevalence in Mediterranean areas and many parts of tropical Asia. In Hong Kong, a second species, Candidatus Dirofilaria hong...

journal_title：PLoS neglected tropical diseases

authors： Yilmaz E,Fritzenwanker M,Pantchev N,Lendner M,Wongkamchai S,Otranto D,Kroidl I,Dennebaum M,Le TH,Anh Le T,Ramünke S,Schaper R,von Samson-Himmelstjerna G,Poppert S,Krücken J

更新日期：2016-10-11 00:00:00

abstract：BACKGROUND:Trachoma programs rely on guidelines made in large part using expert opinion of what will happen with and without intervention. Large community-randomized trials offer an opportunity to actually compare forecasting methods in a masked fashion. METHODS:The Program for the Rapid Elimination of Trachoma trials...

journal_title：PLoS neglected tropical diseases

authors： Liu F,Porco TC,Amza A,Kadri B,Nassirou B,West SK,Bailey RL,Keenan JD,Solomon AW,Emerson PM,Gambhir M,Lietman TM

更新日期：2015-08-24 00:00:00

abstract：:We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysacchari...

journal_title：PLoS neglected tropical diseases

authors： Im J,Islam MT,Kim DR,Ahmmed F,Chon Y,Zaman K,Khan AI,Ali M,Sur D,Kanungo S,Dutta S,Bhattacharya SK,Dougan G,Holt KE,Marks F,Kim JH,Qadri F,Clemens JD

更新日期：2020-08-17 00:00:00

abstract：:Leishmaniasis is a serious global health problem affecting many people worldwide. While patients with leishmaniasis can be treated with several agents, drug toxicicty and the emergence of resistant strains render available treatments ineffective in the long run. Inhibitors of the mammalian target of rapamycin (mTOR) h...

journal_title：PLoS neglected tropical diseases

authors： Khadir F,Shaler CR,Oryan A,Rudak PT,Mazzuca DM,Taheri T,Dikeakos JD,Haeryfar SMM,Rafati S

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:Crimean-Congo hemorrhagic fever (CCHF) is a serious disease with a high fatality rate reported in many countries. The first case of CCHF in Oman was detected in 1995 and serosurveys have suggested widespread infection of humans and livestock throughout the country. METHODOLOGY:Cases of CCHF reported to the ...

journal_title：PLoS neglected tropical diseases

authors： Al-Abri SS,Hewson R,Al-Kindi H,Al-Abaidani I,Al-Jardani A,Al-Maani A,Almahrouqi S,Atkinson B,Al-Wahaibi A,Al-Rawahi B,Bawikar S,Beeching NJ

更新日期：2019-04-25 00:00:00

abstract：BACKGROUND:Patients with Chagas disease have migrated to cities, where obesity, hypertension and other cardiac risk factors are common. METHODOLOGY/PRINCIPAL FINDINGS:The study included adult patients evaluated by the cardiology service in a public hospital in Santa Cruz, Bolivia. Data included risk factors for T. cru...

journal_title：PLoS neglected tropical diseases

authors： Hidron AI,Gilman RH,Justiniano J,Blackstock AJ,Lafuente C,Selum W,Calderon M,Verastegui M,Ferrufino L,Valencia E,Tornheim JA,O'Neal S,Comer R,Galdos-Cardenas G,Bern C,Chagas Disease Working Group in Peru and Bolivia.

更新日期：2010-05-18 00:00:00

abstract：BACKGROUND:Although leprosy is portrayed as a disappearing disease, leprosy affected persons in India are still suffering massively. Even further, nearly 60% of the world's newly detected cases are appearing from India alone. The problem has exacerbated due to the drastic decrease of global funding after India's offici...

journal_title：PLoS neglected tropical diseases

authors： Jung SH,Han HW,Koh H,Yu SY,Nawa N,Morita A,Ong KIC,Jimba M,Oh J

更新日期：2020-01-13 00:00:00

abstract：BACKGROUND:Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable. Cysteine leucine rich protein (CLrP), was recognized as one of the overexpressed...

journal_title：PLoS neglected tropical diseases

authors： Das S,Shah P,Tandon R,Yadav NK,Sahasrabuddhe AA,Sundar S,Siddiqi MI,Dube A

更新日期：2015-08-21 00:00:00

abstract：:Novel strategies are required to control mosquitoes and the pathogens they transmit. One attractive approach involves maternally inherited endosymbiotic Wolbachia bacteria. After artificial infection with Wolbachia, many mosquitoes become refractory to infection and transmission of diverse pathogens. We evaluated the ...

journal_title：PLoS neglected tropical diseases

authors： Dodson BL,Hughes GL,Paul O,Matacchiero AC,Kramer LD,Rasgon JL

更新日期：2014-07-10 00:00:00

abstract：BACKGROUND:Ofloxacin is a fluoroquinolone (FQ) used for the treatment of leprosy. FQs are known to interact with both A and B subunits of DNA gyrase and inhibit supercoiling activity of this enzyme. Mutations conferring FQ resistance have been reported to be found only in the gene encoding A subunit of this enzyme (gyr...

journal_title：PLoS neglected tropical diseases

authors： Yokoyama K,Kim H,Mukai T,Matsuoka M,Nakajima C,Suzuki Y

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susceptibility in vivo. ...

journal_title：PLoS neglected tropical diseases

authors： Carneiro MW,Fukutani KF,Andrade BB,Curvelo RP,Cristal JR,Carvalho AM,Barral A,Van Weyenbergh J,Barral-Netto M,de Oliveira CI

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management. Here, we quantify heterogeneities in Leishmania infantum parasite numbers in reservoir and non-reservoir host populations, and relate this ...

journal_title：PLoS neglected tropical diseases

authors： Courtenay O,Carson C,Calvo-Bado L,Garcez LM,Quinnell RJ

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are responsible for a substantial health and economic burden, particularly to low-income societies. Quan...

journal_title：PLoS neglected tropical diseases

authors： Otero-Abad B,Torgerson PR

更新日期：2013-06-06 00:00:00

abstract：BACKGROUND:In 2012 the WHO formally recognised that infants and preschool children are at significant risk of schistosomiasis and qualify for treatment with praziquantel (PZQ). Targeted surveys determining both the performance and safety of this drug are now needed in endemic areas. We have formally assessed parasitolo...

journal_title：PLoS neglected tropical diseases

authors： Sousa-Figueiredo JC,Betson M,Atuhaire A,Arinaitwe M,Navaratnam AM,Kabatereine NB,Bickle Q,Stothard JR

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The Asian tiger mosquito, Aedes albopictus, is an important vector of dengue, chikungunya and Zika viruses and is a highly invasive and aggressive biter. Established populations of this species were first recognised in Australia in 2005 when they were discovered on islands in the Torres Strait, between mainl...

journal_title：PLoS neglected tropical diseases

authors： Muzari MO,Devine G,Davis J,Crunkhorn B,van den Hurk A,Whelan P,Russell R,Walker J,Horne P,Ehlers G,Ritchie S

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:Diagnosis of urogenital schistosomiasis in chronically infected adults is challenging but important, especially because long term infection of the bladder and urinary tract can have dire consequences. We evaluated three tests for viable infection: detection of parasite specific DNA Dra1 fragments, haematuria...

journal_title：PLoS neglected tropical diseases

authors： Ibironke O,Koukounari A,Asaolu S,Moustaki I,Shiff C

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Increased vascular permeability is a hallmark feature in severe dengue virus (DV) infection, and dysfunction of endothelial cells has been speculated to contribute in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Rho-family GTPase Rac1 is a significant element of endothelial b...

journal_title：PLoS neglected tropical diseases

authors： Wang JL,Zhang JL,Chen W,Xu XF,Gao N,Fan DY,An J

更新日期：2010-08-31 00:00:00

abstract：BACKGROUND:Cryptosporidium infection causes gastrointestinal disease and has a worldwide distribution. The highest burden is in developing countries. OBJECTIVES:We sought to conduct a systematic review and meta-analysis to identify Cryptosporidium risk factors in Low and Middle Income countries (LMICs). METHODS:Medli...

journal_title：PLoS neglected tropical diseases

authors： Bouzid M,Kintz E,Hunter PR

更新日期：2018-06-07 00:00:00

abstract：OBJECTIVE:The aim of the study is to examine the spatiotemporal pattern of Japanese Encephalitis (JE) in mainland China during 2002-2010. Specific objectives of the study were to quantify the temporal variation in incidence of JE cases, to determine if clustering of JE cases exists, to detect high risk spatiotemporal c...

journal_title：PLoS neglected tropical diseases

authors： Wang LY,Zhang WY,Ding F,Hu WB,Soares Magalhaes RJ,Sun HL,Li YX,Zou W,Wang Y,Liu QY,Li SL,Yin WW,Huang LY,Clements AC,Bi P,Li CY

更新日期：2013-06-20 00:00:00

abstract：:Yellow fever virus (YFV) is a mosquito-borne flavivirus that is a major public health problem in tropical areas of Africa and South America. There have been detailed studies on YFV ecology in West Africa and South America, but current understanding of YFV circulation on the African continent is incomplete. This inadeq...

journal_title：PLoS neglected tropical diseases

authors： Beck A,Guzman H,Li L,Ellis B,Tesh RB,Barrett AD

更新日期：2013-01-01 00:00:00