Trypanosomiasis-induced megacolon illustrates how myenteric neurons modulate the risk for colon cancer in rats and humans.

abstract：:The enteric protozoa Entamoeba histolytica is the causative agent of amebiasis, which is one of the most common parasitic diseases in developed and developing countries. Entamoeba nuttalli is the genetically closest species to E. histolytica in current phylogenetic analyses of Entamoeba species, and is prevalent in wi...

journal_title：PLoS neglected tropical diseases

authors： Tanaka M,Makiuchi T,Komiyama T,Shiina T,Osaki K,Tachibana H

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:The immune response in the skin of dogs infected with Leishmania infantum is poorly understood, and limited studies have described the immunopathological profile with regard to distinct levels of tissue parasitism and the clinical progression of canine visceral leishmaniasis (CVL). METHODOLOGY/PRINCIPAL FIN...

journal_title：PLoS neglected tropical diseases

authors： Menezes-Souza D,Guerra-Sá R,Carneiro CM,Vitoriano-Souza J,Giunchetti RC,Teixeira-Carvalho A,Silveira-Lemos D,Oliveira GC,Corrêa-Oliveira R,Reis AB

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Although leprosy is portrayed as a disappearing disease, leprosy affected persons in India are still suffering massively. Even further, nearly 60% of the world's newly detected cases are appearing from India alone. The problem has exacerbated due to the drastic decrease of global funding after India's offici...

journal_title：PLoS neglected tropical diseases

authors： Jung SH,Han HW,Koh H,Yu SY,Nawa N,Morita A,Ong KIC,Jimba M,Oh J

更新日期：2020-01-13 00:00:00

abstract：BACKGROUND:Mosquito salivary proteins (MSPs) modulate the host immune response, leading to enhancement of arboviral infections. Identification of proteins in saliva responsible for immunomodulation and counteracting their effects on host immune response is a potential strategy to protect against arboviral disease. We s...

journal_title：PLoS neglected tropical diseases

authors： Reagan KL,Machain-Williams C,Wang T,Blair CD

更新日期：2012-01-01 00:00:00

abstract：:In a cross sectional study, 19 French and 23 Colombian cases of confirmed active ocular toxoplasmosis (OT) were evaluated. The objective was to compare clinical, parasitological and immunological responses and relate them to the infecting strains. A complete ocular examination was performed in each patient. The infect...

journal_title：PLoS neglected tropical diseases

authors： de-la-Torre A,Sauer A,Pfaff AW,Bourcier T,Brunet J,Speeg-Schatz C,Ballonzoli L,Villard O,Ajzenberg D,Sundar N,Grigg ME,Gomez-Marin JE,Candolfi E

更新日期：2013-11-21 00:00:00

abstract：:Tsetse flies (Glossina spp.) transmit parasitic African trypanosomes (Trypanosoma spp.), including Trypanosoma congolense, which causes animal African trypanosomiasis (AAT). AAT detrimentally affects agricultural activities in sub-Saharan Africa and has negative impacts on the livelihood and nutrient availability for ...

journal_title：PLoS neglected tropical diseases

authors： Awuoche EO,Weiss BL,Vigneron A,Mireji PO,Aksoy E,Nyambega B,Attardo GM,Wu Y,O'Neill M,Murilla G,Aksoy S

更新日期：2017-11-20 00:00:00

abstract：BACKGROUND:Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. METHODOLOGY/PRINCIPAL FINDINGS:The TEN 11q/j isolate was characteriz...

journal_title：PLoS neglected tropical diseases

authors： Mikalová L,Strouhal M,Oppelt J,Grange PA,Janier M,Benhaddou N,Dupin N,Šmajs D

更新日期：2017-03-06 00:00:00

abstract：:Humoral immunity plays an important role in controlling dengue virus (DENV) infection. Antibodies (Abs) developed during primary infection protect against subsequent infection with the same dengue serotype, but can enhance disease following secondary infection with a heterologous serotype. A DENV virion has two surfac...

journal_title：PLoS neglected tropical diseases

authors： Rodenhuis-Zybert IA,da Silva Voorham JM,Torres S,van de Pol D,Smit JM

更新日期：2015-03-11 00:00:00

abstract：BACKGROUND:This paper presents the development of an agent-based model (ABM) to incorporate climatic drivers which affect tsetse fly (G. m. morsitans) population dynamics, and ultimately disease transmission. The model was used to gain a greater understanding of how tsetse populations fluctuate seasonally, and investig...

journal_title：PLoS neglected tropical diseases

authors： Alderton S,Macleod ET,Anderson NE,Palmer G,Machila N,Simuunza M,Welburn SC,Atkinson PM

更新日期：2018-02-09 00:00:00

abstract：:Schistosomiasis control and elimination has priority in public health agendas in several sub-Saharan countries. However, achieving these goals remains a substantial challenge. In order to assess progress of interventions and treatment efficacy it is pertinent to have accurate, feasible and affordable diagnostic tools....

journal_title：PLoS neglected tropical diseases

authors： Kildemoes AO,Vennervald BJ,Tukahebwa EM,Kabatereine NB,Magnussen P,de Dood CJ,Deelder AM,Wilson S,van Dam GJ

更新日期：2017-11-13 00:00:00

abstract：:The toxicity of available drugs for treatment of leishmaniasis, coupled with emerging drug resistance, make it urgent to find new therapies. Antimicrobial peptides (AMPs) have a strong broad-spectrum antimicrobial activity with distinctive modes of action and are considered as promising therapeutic agents. The defensi...

journal_title：PLoS neglected tropical diseases

authors： Dabirian S,Taslimi Y,Zahedifard F,Gholami E,Doustdari F,Motamedirad M,Khatami S,Azadmanesh K,Nylen S,Rafati S

更新日期：2013-10-17 00:00:00

abstract：BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4, promoting lethal, en...

journal_title：PLoS neglected tropical diseases

authors： De Jong HK,Achouiti A,Koh GC,Parry CM,Baker S,Faiz MA,van Dissel JT,Vollaard AM,van Leeuwen EM,Roelofs JJ,de Vos AF,Roth J,van der Poll T,Vogl T,Wiersinga WJ

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:The chikungunya virus (CHIKV) is a re-emerging alphavirus that can cause chronic and potentially incapacitating rheumatic musculoskeletal disorders known as chronic chikungunya arthritis (CCA). We conducted a prospective cohort study of CHIKV-infected subjects during the 2013 chikungunya outbreak in Martiniq...

journal_title：PLoS neglected tropical diseases

authors： Bertolotti A,Thioune M,Abel S,Belrose G,Calmont I,Césaire R,Cervantes M,Fagour L,Javelle É,Lebris C,Najioullah F,Pierre-François S,Rozé B,Vigan M,Laouénan C,Cabié A,Chronic Chikungunya working group of University Medical

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Trachomatous trichiasis (TT), inturned eyelashes from repeated infection with Chlamydia trachomatis, is the leading infectious cause of blindness in the world. Though surgery will correct entropion caused by trachoma, uptake of TT surgery remains low. In this case-control study, we identify barriers that pre...

journal_title：PLoS neglected tropical diseases

authors： Bickley RJ,Mkocha H,Munoz B,West S

更新日期：2017-01-04 00:00:00

abstract：:Malaria and schistosomiasis are major parasitic diseases causing morbidity and mortality in the tropics. Epidemiological surveys have revealed coinfection rates of up to 30% among children in Sub-Saharan Africa. To investigate the impact of coinfection of these two parasites on disease epidemiology and pathology, we c...

journal_title：PLoS neglected tropical diseases

authors： Moriyasu T,Nakamura R,Deloer S,Senba M,Kubo M,Inoue M,Culleton R,Hamano S

更新日期：2018-01-26 00:00:00

abstract：:Mycetoma, one of the badly neglected tropical diseases, it is a localised chronic granulomatous inflammatory disease characterised by painless subcutaneous mass and formation of multiple sinuses that produce purulent discharge and grains. If untreated early and appropriately, it usually spread to affect the deep struc...

journal_title：PLoS neglected tropical diseases

authors： Bakhiet SM,Fahal AH,Musa AM,Mohamed ESW,Omer RF,Ahmed ES,El Nour M,Mustafa ERM,Sheikh A Rahman ME,Suliman SH,El Mamoun MAG,El Amin HM

更新日期：2018-05-10 00:00:00

abstract：:Sand flies are the insects responsible for transmitting Leishmania parasites, the causative agents of leishmaniasis in humans. However, the effects of sand fly breeding sites on their biology and ecology remain poorly understood. Herein, we studied how larval nutrition associated with putative breeding sites of the sa...

journal_title：PLoS neglected tropical diseases

authors： Aguiar Martins K,Meirelles MHA,Mota TF,Abbasi I,de Queiroz ATL,Brodskyn CI,Veras PST,Mothé Fraga DB,Warburg A

更新日期：2021-01-21 00:00:00

abstract：:The application of the organophosphate larvicide temephos to water storage containers is one of the most commonly employed dengue vector control methods. This systematic literature review is to the knowledge of the authors the first that aims to assess the community-effectiveness of temephos in controlling both vector...

journal_title：PLoS neglected tropical diseases

authors： George L,Lenhart A,Toledo J,Lazaro A,Han WW,Velayudhan R,Runge Ranzinger S,Horstick O

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Uganda has reported five (5) Ebola virus disease outbreaks and three (3) Marburg virus disease outbreaks from 2000 to 2016. Peoples' knowledge and attitude towards Ebola and Marburg virus disease impact on control and prevention measures especially during outbreaks. We describe knowledge and attitude towards...

journal_title：PLoS neglected tropical diseases

authors： Nyakarahuka L,Skjerve E,Nabadda D,Sitali DC,Mumba C,Mwiine FN,Lutwama JJ,Balinandi S,Shoemaker T,Kankya C

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Currently, molecular xenomonitoring efforts for lymphatic filariasis rely on PCR or real-time PCR-based detection of Brugia malayi, Brugia timori and Wuchereria bancrofti in mosquito vectors. Most commonly, extraction of DNA from mosquitoes is performed using silica column-based technologies. However, such e...

journal_title：PLoS neglected tropical diseases

authors： Zaky WI,Tomaino FR,Pilotte N,Laney SJ,Williams SA

更新日期：2018-11-21 00:00:00

abstract：:Hand, foot and mouth disease (HFMD) continues to challenge Asia with pandemic potential. In Vietnam, there have been two major outbreaks occurring during 2011-2012 (>200,000 hospitalizations and >200 deaths) and more recently in 2018 (>130,000 hospitalizations and 17 deaths). Given the high burden and the complex epid...

journal_title：PLoS neglected tropical diseases

authors： Nhan LNT,Khanh TH,Hong NTT,Van HMT,Nhu LNT,Ny NTH,Nguyet LA,Thanh TT,Anh NT,Hang VTT,Qui PT,Viet HL,Tung TH,Ha DQ,Tuan HM,Thwaites G,Chau NVV,Thwaites L,Hung NT,van Doorn HR,Tan LV

更新日期：2020-08-17 00:00:00

abstract：BACKGROUND:Giardiasis is an intestinal infection correlated with poverty and poor drinking water quality, and treatment options are limited. According to the Center for Disease Control and Prevention, Giardia infections afflict nearly 33% of people in developing countries, and 2% of the adult population in the develope...

journal_title：PLoS neglected tropical diseases

authors： Kunz S,Balmer V,Sterk GJ,Pollastri MP,Leurs R,Müller N,Hemphill A,Spycher C

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:Real-Time PCR-High Resolution Melting (qPCR-HRM) analysis has been recently described for rapid drug susceptibility testing (DST) of Mycobacterium leprae. The purpose of the current study was to further evaluate the validity, reliability, and accuracy of this assay for M. leprae DST in clinical specimens. M...

journal_title：PLoS neglected tropical diseases

authors： Araujo S,Goulart LR,Truman RW,Goulart IMB,Vissa V,Li W,Matsuoka M,Suffys P,Fontes AB,Rosa PS,Scollard DM,Williams DL

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Population suppression through mass-release of Aedes aegypti males carrying dominant-lethal transgenes has been demonstrated in the field. Where population dynamics show negative density-dependence, suppression can be enhanced if lethality occurs after the density-dependent (i.e. larval) stage. Existing mole...

journal_title：PLoS neglected tropical diseases

authors： Haghighat-Khah RE,Harvey-Samuel T,Basu S,StJohn O,Scaife S,Verkuijl S,Lovett E,Alphey L

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Incidence of Entamoeba histolytica infection and clinical manifestations and treatment response of invasive amebiasis (IA) in HIV-infected patients have rarely been investigated before. METHODOLOGY/PRINCIPAL FINDINGS:At the National Taiwan University Hospital, medical records of HIV-infected patients who re...

journal_title：PLoS neglected tropical diseases

authors： Hung CC,Ji DD,Sun HY,Lee YT,Hsu SY,Chang SY,Wu CH,Chan YH,Hsiao CF,Liu WC,Colebunders R

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antibodies, though initially protective, decline during the first year of life to levels thought to be disease enhancing, before reaching undetectable levels. Infants have long been studied to understand the interaction betwee...

journal_title：PLoS neglected tropical diseases

authors： Clapham H,Cummings DA,Nisalak A,Kalayanarooj S,Thaisomboonsuk B,Klungthong C,Fernandez S,Srikiatkhachorn A,Macareo LR,Lessler J,Reiser J,Yoon IK

更新日期：2015-12-11 00:00:00

abstract：:Over 200,000 new cases of leprosy are detected each year, of which approximately 7% are associated with grade-2 disabilities (G2Ds). For achieving leprosy elimination, one of the main challenges will be targeting higher risk groups within endemic communities. Nevertheless, the socioeconomic risk markers of leprosy rem...

journal_title：PLoS neglected tropical diseases

authors： Pescarini JM,Strina A,Nery JS,Skalinski LM,Andrade KVF,Penna MLF,Brickley EB,Rodrigues LC,Barreto ML,Penna GO

更新日期：2018-07-09 00:00:00

abstract：:Leishmaniasis is a serious global health problem affecting many people worldwide. While patients with leishmaniasis can be treated with several agents, drug toxicicty and the emergence of resistant strains render available treatments ineffective in the long run. Inhibitors of the mammalian target of rapamycin (mTOR) h...

journal_title：PLoS neglected tropical diseases

authors： Khadir F,Shaler CR,Oryan A,Rudak PT,Mazzuca DM,Taheri T,Dikeakos JD,Haeryfar SMM,Rafati S

更新日期：2018-08-22 00:00:00

abstract：:Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Middle East, affecting both humans and ruminants. There are no licensed vaccines or antivirals available for humans, whereas research using RVF virus (RVFV) is strictly regulated in many countries with safety concerns. Nonpathogenic...

journal_title：PLoS neglected tropical diseases

authors： Hallam HJ,Lokugamage N,Ikegami T

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is an important flavivirus infection. Although ZIKV infection is rarely fatal, risk for severe disease in adults is not well described. Our objective was to describe the spectrum of illness in U.S. Veterans with ZIKV infection. METHODOLOGY:Case series study including patients with laborato...

journal_title：PLoS neglected tropical diseases

authors： Schirmer PL,Wendelboe A,Lucero-Obusan CA,Ryono RA,Winters MA,Oda G,Martinez M,Saavedra S,Holodniy M

更新日期：2018-05-24 00:00:00