当前位置： SCI文献检索 > PLoS Neglected Tropical Diseases期刊下所有文献 > Severe South American ocular toxoplasmosis is associated with decreased Ifn-γ/Il-17a and increased Il-6/Il-13 intraocular levels.

Severe South American ocular toxoplasmosis is associated with decreased Ifn-γ/Il-17a and increased Il-6/Il-13 intraocular levels.

Abstract：

:In a cross sectional study, 19 French and 23 Colombian cases of confirmed active ocular toxoplasmosis (OT) were evaluated. The objective was to compare clinical, parasitological and immunological responses and relate them to the infecting strains. A complete ocular examination was performed in each patient. The infecting strain was characterized by genotyping when intraocular Toxoplasma DNA was detectable, as well as by peptide-specific serotyping for each patient. To characterize the immune response, we assessed Toxoplasma protein recognition patterns by intraocular antibodies and the intraocular profile of cytokines, chemokines and growth factors. Significant differences were found for size of active lesions, unilateral macular involvement, unilateral visual impairment, vitreous inflammation, synechiae, and vasculitis, with higher values observed throughout for Colombian patients. Multilocus PCR-DNA sequence genotyping was only successful in three Colombian patients revealing one type I and two atypical strains. The Colombian OT patients possessed heterogeneous atypical serotypes whereas the French were uniformly reactive to type II strain peptides. The protein patterns recognized by intraocular antibodies and the cytokine patterns were strikingly different between the two populations. Intraocular IFN-γ and IL-17 expression was lower, while higher levels of IL-13 and IL-6 were detected in aqueous humor of Colombian patients. Our results are consistent with the hypothesis that South American strains may cause more severe OT due to an inhibition of the protective effect of IFN-γ.

journal_name

PLoS Negl Trop Dis

journal_title

PLoS neglected tropical diseases

authors

de-la-Torre A,Sauer A,Pfaff AW,Bourcier T,Brunet J,Speeg-Schatz C,Ballonzoli L,Villard O,Ajzenberg D,Sundar N,Grigg ME,Gomez-Marin JE,Candolfi E

doi

10.1371/journal.pntd.0002541

subject

Has Abstract

pub_date

2013-11-21 00:00:00

pages

e2541

issue

11

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-13-00633

journal_volume

7

pub_type

杂志文章

相关文献

PLoS Neglected Tropical Diseases文献大全
  • Levofloxacin cures experimental pneumonic plague in African green monkeys.

    abstract：BACKGROUND:Yersinia pestis, the agent of plague, is considered a potential bioweapon due to rapid lethality when delivered as an aerosol. Levofloxacin was tested for primary pneumonic plague treatment in a nonhuman primate model mimicking human disease. METHODS AND RESULTS:Twenty-four African Green monkeys (AGMs, Chlo...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0000959

    authors： Layton RC,Mega W,McDonald JD,Brasel TL,Barr EB,Gigliotti AP,Koster F

    更新日期：2011-02-08 00:00:00

  • Regulatory T cells enhance susceptibility to experimental Trypanosoma congolense infection independent of mouse genetic background.

    abstract：BACKGROUND:BALB/c mice are highly susceptible while C57BL/6 are relatively resistant to experimental Trypanosoma congolense infection. Although regulatory T cells (Tregs) have been shown to regulate the pathogenesis of experimental T. congolense infection, their exact role remains controversial. We wished to determine ...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0001761

    authors： Okwor I,Onyilagha C,Kuriakose S,Mou Z,Jia P,Uzonna JE

    更新日期：2012-01-01 00:00:00

  • Evidence that lipopolisaccharide may contribute to the cytokine storm and cellular activation in patients with visceral leishmaniasis.

    abstract：BACKGROUND:Visceral leishmaniasis (VL) is characterized by parasite-specific immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide (LPS) has been implicated in the immune activation of T-cell deficient diseases such as HIV/AIDS and idiopathic lymphocytopenia. The source of LPS is gram-negat...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0001198

    authors： Santos-Oliveira JR,Regis EG,Leal CR,Cunha RV,Bozza PT,Da-Cruz AM

    更新日期：2011-07-01 00:00:00

  • Sensitive and specific detection of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)-Specific IgM and IgG antibodies in human sera using recombinant CCHFV nucleoprotein as antigen in μ-capture and IgG immune complex (IC) ELISA tests.

    abstract：:As the most widespread tick-borne arbovirus causing infections in numerous countries in Asia, Africa and Europe, Crimean-Congo Hemorrhagic Fever Virus (CCHFV, family Nairoviridae) was included in the WHO priority list of emerging pathogens needing urgent Research & Development attention. To ensure preparedness for pot...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0006366

    authors： Emmerich P,Mika A,von Possel R,Rackow A,Liu Y,Schmitz H,Günther S,Sherifi K,Halili B,Jakupi X,Berisha L,Ahmeti S,Deschermeier C

    更新日期：2018-03-26 00:00:00

  • A meta-analysis of infection rates of Schistosoma japonicum in sentinel mice associated with infectious waters in mainland China over last 40 years.

    abstract：BACKGROUND:Schistosomiasis japonica is a zoonotic parasitic disease. After nearly 70 years of control efforts in China, Schistosomiasis transmission has been reduced to a much lower level. The absence or near absence of infections in humans or livestock, based on traditional fecal and serological tests, has made the ta...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章,meta分析

    doi：10.1371/journal.pntd.0007475

    authors： Qiu C,Zou HY,Deng Y,Liang YS,Lu DB

    更新日期：2019-06-07 00:00:00

  • Backpack PCR: A point-of-collection diagnostic platform for the rapid detection of Brugia parasites in mosquitoes.

    abstract：BACKGROUND:Currently, molecular xenomonitoring efforts for lymphatic filariasis rely on PCR or real-time PCR-based detection of Brugia malayi, Brugia timori and Wuchereria bancrofti in mosquito vectors. Most commonly, extraction of DNA from mosquitoes is performed using silica column-based technologies. However, such e...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0006962

    authors： Zaky WI,Tomaino FR,Pilotte N,Laney SJ,Williams SA

    更新日期：2018-11-21 00:00:00

  • Spatiotemporal patterns of Japanese encephalitis in China, 2002-2010.

    abstract：OBJECTIVE:The aim of the study is to examine the spatiotemporal pattern of Japanese Encephalitis (JE) in mainland China during 2002-2010. Specific objectives of the study were to quantify the temporal variation in incidence of JE cases, to determine if clustering of JE cases exists, to detect high risk spatiotemporal c...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0002285

    authors： Wang LY,Zhang WY,Ding F,Hu WB,Soares Magalhaes RJ,Sun HL,Li YX,Zou W,Wang Y,Liu QY,Li SL,Yin WW,Huang LY,Clements AC,Bi P,Li CY

    更新日期：2013-06-20 00:00:00

  • Comparative gene expression analysis throughout the life cycle of Leishmania braziliensis: diversity of expression profiles among clinical isolates.

    abstract：BACKGROUND:Most of the Leishmania genome is reported to be constitutively expressed during the life cycle of the parasite, with a few regulated genes. Inter-species comparative transcriptomics evidenced a low number of species-specific differences related to differentially distributed genes or the differential regulati...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0001021

    authors： Adaui V,Castillo D,Zimic M,Gutierrez A,Decuypere S,Vanaerschot M,De Doncker S,Schnorbusch K,Maes I,Van der Auwera G,Maes L,Llanos-Cuentas A,Arevalo J,Dujardin JC

    更新日期：2011-05-10 00:00:00

  • A systematic review of the epidemiology of echinococcosis in domestic and wild animals.

    abstract：BACKGROUND:Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are responsible for a substantial health and economic burden, particularly to low-income societies. Quan...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章,评审

    doi：10.1371/journal.pntd.0002249

    authors： Otero-Abad B,Torgerson PR

    更新日期：2013-06-06 00:00:00

  • Point-of-care testing for Toxoplasma gondii IgG/IgM using Toxoplasma ICT IgG-IgM test with sera from the United States and implications for developing countries.

    abstract：BACKGROUND:Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection and treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed and treated and outcomes can be improved. METHODS:We tested 180 sera with the Toxoplasma ICT Ig...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0005670

    authors： Begeman IJ,Lykins J,Zhou Y,Lai BS,Levigne P,El Bissati K,Boyer K,Withers S,Clouser F,Noble AG,Rabiah P,Swisher CN,Heydemann PT,Contopoulos-Ioannidis DG,Montoya JG,Maldonado Y,Ramirez R,Press C,Stillwaggon E,Peyron F

    更新日期：2017-06-26 00:00:00

  • Functional genomics in sand fly-derived Leishmania promastigotes.

    abstract：BACKGROUND:Leishmania development in the sand fly gut leads to highly infective forms called metacyclic promastigotes. This process can be routinely mimicked in culture. Gene expression-profiling studies by transcriptome analysis have been performed with the aim of studying promastigote forms in the sand fly gut, as we...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章,评审

    doi：10.1371/journal.pntd.0007288

    authors： Alcolea PJ,Alonso A,Molina R,Jiménez M,Myler PJ,Larraga V

    更新日期：2019-05-09 00:00:00

  • Comparative Ability of Oropsylla montana and Xenopsylla cheopis Fleas to Transmit Yersinia pestis by Two Different Mechanisms.

    abstract：BACKGROUND:Transmission of Yersinia pestis by flea bite can occur by two mechanisms. After taking a blood meal from a bacteremic mammal, fleas have the potential to transmit the very next time they feed. This early-phase transmission resembles mechanical transmission in some respects, but the mechanism is unknown. Ther...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0005276

    authors： Hinnebusch BJ,Bland DM,Bosio CF,Jarrett CO

    更新日期：2017-01-12 00:00:00

  • An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia.

    abstract：BACKGROUND:Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited. METHODOLOGY/PRINCIPAL FINDINGS:Four hundred and seventy nine acutely febrile...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0008934

    authors： Stubbs SCB,Johar E,Yudhaputri FA,Yohan B,Santoso MS,Hayati RF,Denis D,Blacklaws BA,Powers AM,Sasmono RT,Myint KSA,Frost SDW

    更新日期：2020-12-21 00:00:00

  • A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

    abstract：BACKGROUND:During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). APC has both an...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0002819

    authors： Kager LM,Wiersinga WJ,Roelofs JJ,de Boer OJ,Weiler H,van 't Veer C,van der Poll T

    更新日期：2014-04-24 00:00:00

  • Recombinant modified vaccinia virus Ankara expressing glycoprotein E2 of Chikungunya virus protects AG129 mice against lethal challenge.

    abstract：:Chikungunya virus (CHIKV) infection is characterized by rash, acute high fever, chills, headache, nausea, photophobia, vomiting, and severe polyarthralgia. There is evidence that arthralgia can persist for years and result in long-term discomfort. Neurologic disease with fatal outcome has been documented, although at ...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0003101

    authors： van den Doel P,Volz A,Roose JM,Sewbalaksing VD,Pijlman GP,van Middelkoop I,Duiverman V,van de Wetering E,Sutter G,Osterhaus AD,Martina BE

    更新日期：2014-09-04 00:00:00

  • Molecular and epidemiological analysis of a Burkholderia cepacia sepsis outbreak from a tertiary care hospital in Bangladesh.

    abstract：BACKGROUND:Burkholderia cepacia complex (Bcc) is a group of serious pathogens in cystic fibrosis patients and causes life threatening infections in immunocompromised patients. Species within the Bcc are widely distributed within the environment, can survive in the presence of disinfectants and antiseptics, and are inhe...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0008200

    authors： Farzana R,Jones LS,Rahman MA,Sands K,Portal E,Boostrom I,Kalam MA,Hasan B,Khan A,Walsh TR

    更新日期：2020-04-09 00:00:00

  • Inward rectifier potassium (Kir) channels mediate salivary gland function and blood feeding in the lone star tick, Amblyomma americanum.

    abstract：BACKGROUND:Tick feeding causes extreme morbidity and mortality to humans through transmission of pathogens and causes severe economic losses to the agricultural industry by reducing livestock yield. Salivary gland secretions are essential for tick feeding and thus, reducing or preventing saliva secretions into the vert...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0007153

    authors： Li Z,Macaluso KR,Foil LD,Swale DR

    更新日期：2019-02-07 00:00:00

  • High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.

    abstract：BACKGROUND:Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active protein kinase complex with Leishmania cyclins CYCA and C...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0001033

    authors： Walker RG,Thomson G,Malone K,Nowicki MW,Brown E,Blake DG,Turner NJ,Walkinshaw MD,Grant KM,Mottram JC

    更新日期：2011-04-05 00:00:00

  • Risk profiling of soil-transmitted helminth infection and estimated number of infected people in South Asia: A systematic review and Bayesian geostatistical Analysis.

    abstract：BACKGROUND:In South Asia, hundreds of millions of people are infected with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura). However, high-resolution risk profiles and the estimated number of people infected have yet to be determined. In turn, such information will assist control pro...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0007580

    authors： Lai YS,Biedermann P,Shrestha A,Chammartin F,À Porta N,Montresor A,Mistry NF,Utzinger J,Vounatsou P

    更新日期：2019-08-09 00:00:00

  • Baseline patterns of infection in regions of Benin, Malawi and India seeking to interrupt transmission of soil transmitted helminths (STH) in the DeWorm3 trial.

    abstract：:Global efforts to control morbidity associated with soil-transmitted helminth infections (STH) have focused largely on the targeted treatment of high-risk groups, including children and pregnant women. However, it is not clear when such programs can be discontinued and there are concerns about the sustainability of cu...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0008771

    authors： DeWorm3 Trials Team.

    更新日期：2020-11-02 00:00:00

  • Second external quality assurance study for the serological diagnosis of hantaviruses in Europe.

    abstract：:Hantaviruses are endemic throughout the world and hosted by rodents and insectivores. Two human zoonoses, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), are caused by hantaviruses and case fatality rates have reached 12% for HFRS and 50% for HPS in some outbreaks. Symptomatic han...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0001607

    authors： Escadafal C,Avšič-Županc T,Vapalahti O,Niklasson B,Teichmann A,Niedrig M,Donoso-Mantke O

    更新日期：2012-01-01 00:00:00

  • Schistosoma mansoni Infections in young children: when are schistosome antigens in urine, eggs in stool and antibodies to eggs first detectable?

    abstract：BACKGROUND:in uganda, control of intestinal schistosomiasis with preventive chemotherapy is typically focused towards treatment of school-aged children; the needs of younger children are presently being investigated as in lakeshore communities very young children can be infected. In the context of future epidemiologica...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0000938

    authors： Stothard JR,Sousa-Figueiredo JC,Betson M,Adriko M,Arinaitwe M,Rowell C,Besiyge F,Kabatereine NB

    更新日期：2011-01-04 00:00:00

  • Misconceptions and paradoxes in soil-transmitted helminthiases control as a public health problem.

    abstract：:Soil-transmitted helminthiases (STHs) constitute a public health problem that requires immediate action to resolve the morbidity of those harboring the parasites in their guts, to prevent infection in all those at risk, and to interrupt the vicious circle of poverty and disease in the affected communities, structural ...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0006672

    authors： Krolewiecki AJ

    更新日期：2018-09-13 00:00:00

  • Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients.

    abstract：BACKGROUND:Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear. METHODOL...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0007312

    authors： Shaw T,Tellapragada C,Kamath A,Kalwaje Eshwara V,Mukhopadhyay C

    更新日期：2019-05-15 00:00:00

  • Hospital-based surveillance for viral hemorrhagic fevers and hepatitides in Ghana.

    abstract：BACKGROUND:Viral hemorrhagic fevers (VHF) are acute diseases associated with bleeding, organ failure, and shock. VHF may hardly be distinguished clinically from other diseases in the African hospital, including viral hepatitis. This study was conducted to determine if VHF and viral hepatitis contribute to hospital morb...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0002435

    authors： Bonney JH,Osei-Kwasi M,Adiku TK,Barnor JS,Amesiya R,Kubio C,Ahadzie L,Olschläger S,Lelke M,Becker-Ziaja B,Pahlmann M,Günther S

    更新日期：2013-09-19 00:00:00

  • Ticks as potential vectors of Mycobacterium leprae: Use of tick cell lines to culture the bacilli and generate transgenic strains.

    abstract：:Leprosy is an infectious disease caused by Mycobacterium leprae and frequently resulting in irreversible deformities and disabilities. Ticks play an important role in infectious disease transmission due to their low host specificity, worldwide distribution, and the biological ability to support transovarial transmissi...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0007001

    authors： Ferreira JDS,Souza Oliveira DA,Santos JP,Ribeiro CCDU,Baêta BA,Teixeira RC,Neumann ADS,Rosa PS,Pessolani MCV,Moraes MO,Bechara GH,de Oliveira PL,Sorgine MHF,Suffys PN,Fontes ANB,Bell-Sakyi L,Fonseca AH,Lara FA

    更新日期：2018-12-19 00:00:00

  • The natural history of acute Ebola Virus Disease among patients managed in five Ebola treatment units in West Africa: A retrospective cohort study.

    abstract：INTRODUCTION:Previous studies of Ebola Virus Disease (EVD) have focused on clinical symptoms and Ebola virus (EBOV) cycle threshold (CT) values recorded at patient triage. Our study explores EVD symptoms and EBOV CT values from onset of illness to recovery or death in a diverse population of patients. METHODOLOGY/PRIN...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0005700

    authors： Skrable K,Roshania R,Mallow M,Wolfman V,Siakor M,Levine AC

    更新日期：2017-07-19 00:00:00

  • Killing of diverse eye pathogens (Acanthamoeba spp., Fusarium solani, and Chlamydia trachomatis) with alcohols.

    abstract：BACKGROUND:Blindness is caused by eye pathogens that include a free-living protist (Acanthamoeba castellanii, A. byersi, and/or other Acanthamoeba spp.), a fungus (Fusarium solani), and a bacterium (Chlamydia trachomatis). Hand-eye contact is likely a contributor to the spread of these pathogens, and so hand washing wi...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0005382

    authors： Aqeel Y,Rodriguez R,Chatterjee A,Ingalls RR,Samuelson J

    更新日期：2017-02-09 00:00:00

  • Evaluation of a novel microfluidic immuno-magnetic agglutination assay method for detection of dengue virus NS1 antigen.

    abstract：BACKGROUND:Dengue virus (DENV) is the most important arbovirus worldwide, causing infections in endemic countries and returning travellers from these areas. Rapid diagnostic tests are needed to improve patient management and monitor local transmission. The detection of DENV non-structural protein 1 (NS1) is a useful to...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0008082

    authors： Alejo-Cancho I,Navero-Castillejos J,Peiró-Mestres A,Albarracín R,Barrachina J,Navarro A,Gonzalo V,Pastor V,Muñoz J,Martínez MJ

    更新日期：2020-02-18 00:00:00

  • Phylogeny and niche conservatism in North and Central American triatomine bugs (Hemiptera: Reduviidae: Triatominae), vectors of Chagas' disease.

    abstract：:The niche conservatism hypothesis states that related species diverge in niche characteristics at lower rates than expected, given their lineage divergence. Here we analyze whether niche conservatism is a common pattern among vector species (Hemiptera: Reduviidae: Triatominae) of Trypanosoma cruzi that inhabit North a...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0003266

    authors： Ibarra-Cerdeña CN,Zaldívar-Riverón A,Peterson AT,Sánchez-Cordero V,Ramsey JM

    更新日期：2014-10-30 00:00:00