Inward rectifier potassium (Kir) channels mediate salivary gland function and blood feeding in the lone star tick, Amblyomma americanum.

abstract：:Enterotoxigenic Escherichia coli (ETEC) is one of the most common diarrheal pathogens in the low- and middle-income regions of the world, however a systematic examination of the genomic content of isolates from Chile has not yet been undertaken. Whole genome sequencing and comparative analysis of a collection of 125 E...

journal_title：PLoS neglected tropical diseases

authors： Rasko DA,Del Canto F,Luo Q,Fleckenstein JM,Vidal R,Hazen TH

更新日期：2019-11-20 00:00:00

abstract：:In this communication, a case of black grain eumycetoma produced by the fungus C. atrobrunneum is reported. The patient was initially misdiagnosed with M. mycetomatis eumycetoma based on the grains' morphological and cytological features. However, further aerobic culture of the black grains generated a melanised fungu...

journal_title：PLoS neglected tropical diseases

authors： Mhmoud NA,Santona A,Fiamma M,Siddig EE,Deligios M,Bakhiet SM,Rubino S,Fahal AH

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:New strategies for collecting post-mortem tissue are necessary, particularly in areas with emerging infections. Minimally invasive autopsy (MIA) has been proposed as an alternative to conventional autopsy (CA), with promising results. Previous studies using MIA addressed the cause of death in adults and chil...

journal_title：PLoS neglected tropical diseases

authors： Duarte-Neto AN,Monteiro RAA,Johnsson J,Cunha MDP,Pour SZ,Saraiva AC,Ho YL,da Silva LFF,Mauad T,Zanotto PMA,Saldiva PHN,de Oliveira IRS,Dolhnikoff M

更新日期：2019-07-22 00:00:00

abstract：BACKGROUND:There is a pressing need for drug discovery against visceral leishmaniasis, a life-threatening protozoal infection, as the available chemotherapy is antiquated and not bereft of side effects. Plants as alternate drug resources has rewarded mankind in the past and aimed in this direction, we investigated the ...

journal_title：PLoS neglected tropical diseases

authors： Afrin F,Chouhan G,Islamuddin M,Want MY,Ozbak HA,Hemeg HA

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Mass azithromycin distribution reduces under-5 child mortality. Trachoma control programs currently treat infants aged 6 months and older. Here, we report findings from an infant adverse event survey in 1-5 month olds who received azithromycin as part of a large community-randomized trial in Niger. METHODS ...

journal_title：PLoS neglected tropical diseases

authors： Oldenburg CE,Arzika AM,Maliki R,Kane MS,Lebas E,Ray KJ,Cook C,Cotter SY,Zhou Z,West SK,Bailey R,Porco TC,Keenan JD,Lietman TM,MORDOR Study Group.

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:In 2007, a novel bunyavirus was found in Henan Province, China and named fever, thrombocytopenia and leukocytopenia syndrome virus (FTLSV); since then, FTLSV has been found in ticks and animals in many Chinese provinces. Human-to-human transmission has been documented, indicating that FTLSV should be conside...

journal_title：PLoS neglected tropical diseases

authors： Huang X,Liu L,Du Y,Wu W,Wang H,Su J,Tang X,Liu Q,Yang Y,Jiang Y,Chen W,Xu B

更新日期：2014-10-16 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hookworm infection is among the major causes of anaemia in poor communities, but its importance in causing maternal anaemia is poorly understood, and this has hampered effective lobbying for the inclusion of anthelmintic treatment in maternal health packages. We sought to review existing evide...

journal_title：PLoS neglected tropical diseases

authors： Brooker S,Hotez PJ,Bundy DA

更新日期：2008-09-17 00:00:00

abstract：BACKGROUND:In Latin America, there are 13 geographically isolated endemic foci distributed among Mexico, Guatemala, Colombia, Venezuela, Brazil and Ecuador. The communities of the three endemic foci found within Mexico have been receiving ivermectin treatment since 1989. In this study, we predicted the trend of occurre...

journal_title：PLoS neglected tropical diseases

authors： Lara-Ramírez EE,Rodríguez-Pérez MA,Pérez-Rodríguez MA,Adeleke MA,Orozco-Algarra ME,Arrendondo-Jiménez JI,Guo X

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Mass drug administration (MDA) using praziquantel is the WHO-recommended approach for control of schistosomiasis. However, few studies have compared the impact of different schedules of MDA on the resultant infection levels. We wished to evaluate whether annual MDA was more effective than less frequent treat...

journal_title：PLoS neglected tropical diseases

authors： Karanja DMS,Awino EK,Wiegand RE,Okoth E,Abudho BO,Mwinzi PNM,Montgomery SP,Secor WE

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Echinococcosis is a life-threatening parasitic disease caused by Echinococcus spp. tapeworms with over one million people affected globally at any time. The Echinococcus spp. tapeworms in the human body release DNA to the circulatory system, which can be a biomarker for echinococcosis. Cell-free DNA (cfDNA) ...

journal_title：PLoS neglected tropical diseases

authors： Ji J,Li B,Li J,Danzeng W,Li J,Zhao Y,Qiangba G,Zhang Q,Renzhen N,Basang Z,Jia C,Gongsang Q,Ma J,Wang Y,Chen F,Zhou H,Huasang,Yin J,Xie J,Pei N,Cai H,Jiang H,Yang H,Wang J,Asan,Han X,Li J,Chen W,Yan

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:Crimean-Congo hemorrhagic fever (CCHF) is a serious disease with a high fatality rate reported in many countries. The first case of CCHF in Oman was detected in 1995 and serosurveys have suggested widespread infection of humans and livestock throughout the country. METHODOLOGY:Cases of CCHF reported to the ...

journal_title：PLoS neglected tropical diseases

authors： Al-Abri SS,Hewson R,Al-Kindi H,Al-Abaidani I,Al-Jardani A,Al-Maani A,Almahrouqi S,Atkinson B,Al-Wahaibi A,Al-Rawahi B,Bawikar S,Beeching NJ

更新日期：2019-04-25 00:00:00

abstract：:Zika virus (ZIKV) is an arbovirus primarily transmitted by Aedes mosquitoes. Like most viral infections, ZIKV viremia varies over several orders of magnitude, with unknown consequences for transmission. To determine the effect of viral concentration on ZIKV transmission risk, we exposed field-derived Ae. aegypti mosqu...

journal_title：PLoS neglected tropical diseases

authors： Tesla B,Demakovsky LR,Packiam HS,Mordecai EA,Rodríguez AD,Bonds MH,Brindley MA,Murdock CC

更新日期：2018-08-22 00:00:00

abstract：:Rift Valley Fever is an acute zoonotic viral disease caused by Rift Valley Fever virus (RVFV) that affects ruminants and humans in Sub-Saharan Africa and the Arabian Peninsula. We used phylogenetic analyses to understand the demographic history of RVFV populations, using sequence data from the three minigenomic segmen...

journal_title：PLoS neglected tropical diseases

authors： Samy AM,Peterson AT,Hall M

更新日期：2017-01-09 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is an important flavivirus infection. Although ZIKV infection is rarely fatal, risk for severe disease in adults is not well described. Our objective was to describe the spectrum of illness in U.S. Veterans with ZIKV infection. METHODOLOGY:Case series study including patients with laborato...

journal_title：PLoS neglected tropical diseases

authors： Schirmer PL,Wendelboe A,Lucero-Obusan CA,Ryono RA,Winters MA,Oda G,Martinez M,Saavedra S,Holodniy M

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:The Norway rat (Rattus norvegicus) is the principal reservoir for leptospirosis in many urban settings. Few studies have identified markers for rat infestation in slum environments while none have evaluated the association between household rat infestation and Leptospira infection in humans or the use of inf...

journal_title：PLoS neglected tropical diseases

authors： Costa F,Ribeiro GS,Felzemburgh RD,Santos N,Reis RB,Santos AC,Fraga DB,Araujo WN,Santana C,Childs JE,Reis MG,Ko AI

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is highly prevalent in the Indian state of Bihar and, without proper diagnosis and treatment, is associated with high fatality. However, lack of efficient reporting mechanism had been an impediment in estimating the burden of mortality and its antecedents among symptomatic VL case...

journal_title：PLoS neglected tropical diseases

authors： Das A,Karthick M,Dwivedi S,Banerjee I,Mahapatra T,Srikantiah S,Chaudhuri I

更新日期：2016-11-21 00:00:00

abstract：:Cystic echinococcosis (CE) is distributed worldwide, extending from China to the Middle East and from Mediterranean countries to the sub-Saharan Africa and South America. According to WHO, one million people around the world are suffering from CE with an estimated burden of 183,573 DALYs. The annual monetary burden of...

journal_title：PLoS neglected tropical diseases

authors： Borhani M,Fathi S,Lahmar S,Ahmed H,Abdulhameed MF,Fasihi Harandi M

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Trachoma is a major cause of blindness in Southern Sudan. Its distribution has only been partially established and many communities in need of intervention have therefore not been identified or targeted. The present study aimed to develop a tool to improve targeting of survey and control activities. METHODS...

journal_title：PLoS neglected tropical diseases

authors： Clements AC,Kur LW,Gatpan G,Ngondi JM,Emerson PM,Lado M,Sabasio A,Kolaczinski JH

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2], a low mole...

journal_title：PLoS neglected tropical diseases

authors： Benítez D,Medeiros A,Fiestas L,Panozzo-Zenere EA,Maiwald F,Prousis KC,Roussaki M,Calogeropoulou T,Detsi A,Jaeger T,Šarlauskas J,Peterlin Mašič L,Kunick C,Labadie GR,Flohé L,Comini MA

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:The global burden of diarrhea is a leading cause of morbidity and mortality worldwide. In montane areas of South-East Asia such as northern Laos, recent changes in land use have induced increased runoff, soil erosion and in-stream suspended sediment loads, and potential pathogen dissemination. To our knowled...

journal_title：PLoS neglected tropical diseases

authors： Boithias L,Choisy M,Souliyaseng N,Jourdren M,Quet F,Buisson Y,Thammahacksa C,Silvera N,Latsachack K,Sengtaheuanghoung O,Pierret A,Rochelle-Newall E,Becerra S,Ribolzi O

更新日期：2016-12-09 00:00:00

abstract：:Digestive and cardiodigestive forms of Chagas' disease are observed in 2% to 27% of the patients, depending on their geographic location, Trypanosoma cruzi strain and immunopathological responses. The aim of this work was to evaluate the role of NOD2 innate immune receptor in the pathogenesis of the digestive system i...

journal_title：PLoS neglected tropical diseases

authors： Pereira NS,Queiroga TBD,da Silva DD,Nascimento MSL,Andrade CM,Souto JT,Ricci MF,Arantes RME,Zamboni DS,Chiari E,Câmara ACJD,Galvão LMDC,Guedes PMM

更新日期：2020-09-28 00:00:00

abstract：:Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness known as Zika fever. Since its recent emergence in 2014 in the American continent, ZIKV infection during pregnancy has been closely associated with a wide range of congenital abnormalities. To date, no vaccines or antivirals are publicl...

journal_title：PLoS neglected tropical diseases

authors： Salvo MA,Kingstad-Bakke B,Salas-Quinchucua C,Camacho E,Osorio JE

更新日期：2018-02-05 00:00:00

abstract：:Simian T-Leukemia Virus type 1 and Simian Foamy Virus infect non-human primates. While STLV-1, as HTLV-1, causes Adult T-cell Leukemia/lymphoma, SFV infection is asymptomatic. Both retroviruses can be transmitted from NHPs to humans through bites that allow contact between infected saliva and recipient blood. Because ...

journal_title：PLoS neglected tropical diseases

authors： Alais S,Pasquier A,Jegado B,Journo C,Rua R,Gessain A,Tobaly-Tapiero J,Lacoste R,Turpin J,Mahieux R

更新日期：2018-10-01 00:00:00

abstract：:Adenosine-5'-triphosphate (ATP) is an important phosphate metabolite abundantly found in Mycobacterium leprae bacilli. This pathogen does not derive ATP from its host but has its own mechanism for the generation of ATP. Interestingly, this molecule as well as several antigenic proteins act as bio-markers for the detec...

journal_title：PLoS neglected tropical diseases

authors： Nandi SK,Chakraborty A,Panda AK,Ray SS,Kar RK,Bhunia A,Biswas A

更新日期：2015-03-26 00:00:00

abstract：:Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from Chagas disease-endem...

journal_title：PLoS neglected tropical diseases

authors： Pinazo MJ,Posada Ede J,Izquierdo L,Tassies D,Marques AF,de Lazzari E,Aldasoro E,Muñoz J,Abras A,Tebar S,Gallego M,de Almeida IC,Reverter JC,Gascon J

更新日期：2016-01-04 00:00:00

abstract：:Zika virus (ZIKV) emerged as a global public health threat throughout the Americas since 2014. Phylogenetically, the virus is composed of three main lineages, an African, Asian, and American lineage. The recent emergence and spread of ZIKV has raised questions regarding the breadth and potency of human primary ZIKV im...

journal_title：PLoS neglected tropical diseases

authors： Nix CD,Salberg J,Coulter FJ,Kareko BW,Lyski ZL,Booty BL,Messer WB

更新日期：2020-04-13 00:00:00

abstract：:Recent years have seen the greatest ecological disturbances of our times, with global human expansion, species and habitat loss, climate change, and the emergence of new and previously-known infectious diseases. Biodiversity loss affects infectious disease risk by disrupting normal relationships between hosts and path...

journal_title：PLoS neglected tropical diseases

authors： Thongsripong P,Green A,Kittayapong P,Kapan D,Wilcox B,Bennett S

更新日期：2013-10-31 00:00:00

abstract：BACKGROUND:In 2012 the WHO formally recognised that infants and preschool children are at significant risk of schistosomiasis and qualify for treatment with praziquantel (PZQ). Targeted surveys determining both the performance and safety of this drug are now needed in endemic areas. We have formally assessed parasitolo...

journal_title：PLoS neglected tropical diseases

authors： Sousa-Figueiredo JC,Betson M,Atuhaire A,Arinaitwe M,Navaratnam AM,Kabatereine NB,Bickle Q,Stothard JR

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Of the three diseases targeted for eradication by WHO, two are so-called Neglected Tropical Diseases (NTDs)-guinea worm disease (GWD) and yaws. The Guinea Worm Eradication Programme (GWEP) is in its final stages, with only 25 reported in 2016. However, global eradication still requires certification by WHO o...

journal_title：PLoS neglected tropical diseases

authors： Fitzpatrick C,Sankara DP,Agua JF,Jonnalagedda L,Rumi F,Weiss A,Braden M,Ruiz-Tiben E,Kruse N,Braband K,Biswas G

更新日期：2017-10-05 00:00:00

abstract：:Drug combinations for the treatment of leishmaniasis represent a promising and challenging chemotherapeutic strategy that has recently been implemented in different endemic areas. However, the vast majority of studies undertaken to date have ignored the potential risk that Leishmania parasites could develop resistance...

journal_title：PLoS neglected tropical diseases

authors： García-Hernández R,Manzano JI,Castanys S,Gamarro F

更新日期：2012-01-01 00:00:00