Phylogeography of Rift Valley Fever Virus in Africa and the Arabian Peninsula.

abstract：BACKGROUND:Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. METHODOLOGY:Cross-sectional interview data and stool s...

journal_title：PLoS neglected tropical diseases

authors： Riess H,Clowes P,Kroidl I,Kowuor DO,Nsojo A,Mangu C,Schüle SA,Mansmann U,Geldmacher C,Mhina S,Maboko L,Hoelscher M,Saathoff E

更新日期：2013-09-05 00:00:00

abstract：BACKGROUND:The transitional period between the oncosphere and the cysticercus of Taenia solium is the postoncospheral (PO) form, which has not yet been completely characterized. The aim of this work was to standardize a method to obtain T. solium PO forms by in vitro cultivation. We studied the morphology of the PO for...

journal_title：PLoS neglected tropical diseases

authors： Chile N,Clark T,Arana Y,Ortega YR,Palma S,Mejia A,Angulo N,Kosek JC,Kosek M,Gomez-Puerta LA,Garcia HH,Gavidia CM,Gilman RH,Verastegui M,Cysticercosis Working Group in Peru.

更新日期：2016-02-10 00:00:00

abstract：:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious blinding disease worldwide. Chronic conjunctival inflammation develops in childhood and leads to eyelid scarring and blindness in adulthood. The immune response to Ct provides only partial protection against re-infection, which can be frequent. ...

journal_title：PLoS neglected tropical diseases

authors： Hu VH,Holland MJ,Burton MJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Hosts repeatedly bitten by sand flies develop antibodies against sand fly saliva and screening of these immunoglobulins can be employed to estimate the risk of Leishmania transmission, to indicate the feeding preferences of sand flies, or to evaluate the effectiveness of vector control campaigns. Previously,...

journal_title：PLoS neglected tropical diseases

authors： Sima M,Ferencova B,Bhattacharyya T,Miles MA,Litvinov SV,Hailu A,Baneth G,Volf P

更新日期：2019-01-24 00:00:00

abstract：:Mycetoma is a unique neglected tropical disease which is endemic in what is known as the "mycetoma belt". The disease has many devastating impacts on patients and communities in endemic area and is characterised by massive deformity, destruction and disability. Mycetoma is commonly seen in the foot and hand and less f...

journal_title：PLoS neglected tropical diseases

authors： Fahal A,Mahgoub el S,El Hassan AM,Jacoub AO,Hassan D

更新日期：2015-03-13 00:00:00

abstract：:Schistosomes are amongst the most important and neglected pathogens in the world, and schistosomiasis control relies almost exclusively on a single drug. The neuromuscular system of schistosomes is fertile ground for therapeutic intervention, yet the details of physiological events involved in neuromuscular function r...

journal_title：PLoS neglected tropical diseases

authors： Novozhilova E,Kimber MJ,Qian H,McVeigh P,Robertson AP,Zamanian M,Maule AG,Day TA

更新日期：2010-08-10 00:00:00

abstract：BACKGROUND:Taenia solium cysticercosis affects millions of impoverished people worldwide and can cause neurocysticercosis, an infection of the central nervous system which is potentially fatal. Children may represent an especially vulnerable population to neurocysticercosis, due to the risk of cognitive impairment duri...

journal_title：PLoS neglected tropical diseases

authors： Openshaw JJ,Medina A,Felt SA,Li T,Huan Z,Rozelle S,Luby SP

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Although leprosy is portrayed as a disappearing disease, leprosy affected persons in India are still suffering massively. Even further, nearly 60% of the world's newly detected cases are appearing from India alone. The problem has exacerbated due to the drastic decrease of global funding after India's offici...

journal_title：PLoS neglected tropical diseases

authors： Jung SH,Han HW,Koh H,Yu SY,Nawa N,Morita A,Ong KIC,Jimba M,Oh J

更新日期：2020-01-13 00:00:00

abstract：BACKGROUND:Schistosome eggs must traverse tissues of the intestine or bladder to escape the human host and further the life cycle. Escape from host tissues is facilitated by secretion of immuno-reactive molecules by eggs and the formation of an intense strong granulomatous response by the host which acts to exclude the...

journal_title：PLoS neglected tropical diseases

authors： Jones MK,Bong SH,Green KM,Holmes P,Duke M,Loukas A,McManus DP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Leptospirosis is often difficult to diagnose because of its nonspecific symptoms. The drawbacks of direct isolation and serological tests have led to the increased development of nucleic acid-based assays, which are more rapid and accurate. A meta-analysis was performed to evaluate the diagnostic accuracy of...

journal_title：PLoS neglected tropical diseases

authors： Lam JY,Low GK,Chee HY

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:The two front-line drugs for chronic Trypanosoma cruzi infections are limited by adverse side-effects and declining efficacy. One potential new target for Chagas' disease chemotherapy is sterol 14alpha-demethylase (CYP51), a cytochrome P450 enzyme involved in biosynthesis of membrane sterols. METHODOLOGY/PR...

journal_title：PLoS neglected tropical diseases

authors： Chen CK,Doyle PS,Yermalitskaya LV,Mackey ZB,Ang KK,McKerrow JH,Podust LM

更新日期：2009-01-01 00:00:00

abstract：:Plasmodium vivax, one of the five species of Plasmodium parasites that cause human malaria, is responsible for 25-40% of malaria cases worldwide. Malaria global elimination efforts will benefit from accurate and effective genotyping tools that will provide insight into the population genetics and diversity of this par...

journal_title：PLoS neglected tropical diseases

authors： Baniecki ML,Faust AL,Schaffner SF,Park DJ,Galinsky K,Daniels RF,Hamilton E,Ferreira MU,Karunaweera ND,Serre D,Zimmerman PA,Sá JM,Wellems TE,Musset L,Legrand E,Melnikov A,Neafsey DE,Volkman SK,Wirth DF,Sabeti PC

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:Dengue diagnosis is complex and until recently only specialized laboratories were able to definitively confirm dengue infection. Rapid tests are now available commercially making biological diagnosis possible in the field. The aim of this study was to evaluate a combined dengue rapid test for the detection o...

journal_title：PLoS neglected tropical diseases

authors： Andries AC,Duong V,Ngan C,Ong S,Huy R,Sroin KK,Te V,Y B,Try PL,Buchy P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hospitalization of patients during outbreaks of chikungunya virus has been reported to be uncommon (0.5-8.7%), but more frequent among infants and the elderly. CHIKV was first detected in Puerto Rico in May 2014. We enrolled patients with acute febrile illness (AFI) presenting to two hospital emergency depar...

journal_title：PLoS neglected tropical diseases

authors： Hsu CH,Cruz-Lopez F,Vargas Torres D,Perez-Padilla J,Lorenzi OD,Rivera A,Staples JE,Lugo E,Munoz-Jordan J,Fischer M,Garcia Gubern C,Rivera Garcia B,Alvarado L,Sharp TM

更新日期：2019-01-14 00:00:00

abstract：:Diarrheagenic Escherichia coli (DEC) cause acute and persistent diarrhoea worldwide, but little is known about their epidemiology in Mexico. We determined the prevalence of bacterial enteropathogens in 831 children with acute diarrhoea over a four-year period in Yucatan, Mexico. Six DEC supplementary virulence genes (...

journal_title：PLoS neglected tropical diseases

authors： Patzi-Vargas S,Zaidi MB,Perez-Martinez I,León-Cen M,Michel-Ayala A,Chaussabel D,Estrada-Garcia T

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:Schistosome cercariae are the human-infectious stage of the Schistosoma parasite. They are shed by snail intermediate hosts living in freshwater, and penetrate the skin of the human host to develop into schistosomes, resulting in schistosomiasis infection. Water treatment (e.g. filtration or chlorination) is...

journal_title：PLoS neglected tropical diseases

authors： Braun L,Hazell L,Webb AJ,Allan F,Emery AM,Templeton MR

更新日期：2020-03-26 00:00:00

abstract：:Morbidity burden of lymphatic filariasis (LF) relies on the information from the Mass Drug Administration (MDA) programme where Community Health Volunteers (CHVs) passively report cases identified. Consequently, the exact prevalence of morbidity cases is not always accurate. The use of mobile phone technology to repor...

journal_title：PLoS neglected tropical diseases

authors： Debrah LB,Mohammed A,Osei-Mensah J,Mubarik Y,Agbenyega O,Ayisi-Boateng NK,Pfarr K,Kuehlwein JM,Klarmann-Schulz U,Hoerauf A,Debrah AY

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Leptospirosis, a spirochaetal zoonotic disease, is the cause of epidemics associated with high mortality in urban slum communities. Infection with pathogenic Leptospira occurs during environmental exposures and is traditionally associated with occupational risk activities. However, slum inhabitants reside in...

journal_title：PLoS neglected tropical diseases

authors： Maciel EA,de Carvalho AL,Nascimento SF,de Matos RB,Gouveia EL,Reis MG,Ko AI

更新日期：2008-01-30 00:00:00

abstract：:Community drug distributors (CDDs) who are volunteers have the responsibility of awareness creation, household census, drug distribution and record-keeping and are thus key stakeholders in the campaign for Lymphatic Filariasis (LF) elimination. Taking into account their experiences and perceptions is important for a s...

journal_title：PLoS neglected tropical diseases

authors： Njomo DW,Kimani BW,Kibe LW,Okoyo C,Omondi WP,Sultani HM

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:Global deworming programs aim to reach 75% of at-risk preschool-age children (pre-SAC) by 2020. The 2013 global pre-SAC deworming coverage initially published by the World Health Organization (WHO) was 23.9%, but this estimate inadequately captured deworming delivered through Child Health Day (CHD) platforms...

journal_title：PLoS neglected tropical diseases

authors： Kumapley RS,Kupka R,Dalmiya N

更新日期：2015-11-06 00:00:00

abstract：:Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) that recently caused outbreaks in the Americas. Over the past 60 years, this virus has been observed circulating among African, Asian, and Pacific Island populations, but little attention has been paid by the scientific community until the discovery that large-...

journal_title：PLoS neglected tropical diseases

authors： Epelboin Y,Talaga S,Epelboin L,Dusfour I

更新日期：2017-11-16 00:00:00

abstract：:Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic members of the genus Leptospira. Infection can lead to illness ranging from mild and non-specific to severe, with jaundice, kidney and liver dysfunction, and widespread endothelial damage. The adhesion of pathogenic Leptospira sp...

journal_title：PLoS neglected tropical diseases

authors： Evangelista KV,Hahn B,Wunder EA Jr,Ko AI,Haake DA,Coburn J

更新日期：2014-10-02 00:00:00

abstract：:Dengue and chikungunya are viral diseases transmitted to humans by infected Aedes spp. mosquitoes. With an estimated 390 million infected people per year dengue virus (DENV) currently causes the most prevalent arboviral disease. During the last decade chikungunya virus (CHIKV) has caused large outbreaks and has expand...

journal_title：PLoS neglected tropical diseases

authors： Ruiz Silva M,Aguilar Briseño JA,Upasani V,van der Ende-Metselaar H,Smit JM,Rodenhuis-Zybert IA

更新日期：2017-06-23 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi, the etiologic agent of Chagas Disease, is a major vector borne health problem in Latin America and an emerging infectious disease in the United States. METHODS:We tested the efficacy of a multi-component DNA-prime/DNA-boost vaccine (TcVac1) against experimental T. cruzi infection in a can...

journal_title：PLoS neglected tropical diseases

authors： Aparicio-Burgos JE,Ochoa-García L,Zepeda-Escobar JA,Gupta S,Dhiman M,Martínez JS,de Oca-Jiménez RM,Val Arreola M,Barbabosa-Pliego A,Vázquez-Chagoyán JC,Garg NJ

更新日期：2011-01-01 00:00:00

abstract：:Filoviruses such as Ebola virus (EBOV) cause outbreaks of viral hemorrhagic fevers for which no FDA-approved vaccines or drugs are available. The 2014-2016 EBOV outbreak in West Africa infected approximately 30,000 people, killing more than 11,000 and affecting thousands more in areas still suffering from the effects ...

journal_title：PLoS neglected tropical diseases

authors： Haun BK,Kamara V,Dweh AS,Garalde-Machida K,Forkay SSE,Takaaze M,Namekar M,Wong TAS,Bell-Gam Woto AER,Humphreys P,Weeks OI,Fallah MP,Berestecky JM,Nerurkar VR,Lehrer AT

更新日期：2019-07-22 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets is essential for the development of more efficient therapeutic alternatives. Inhibition of sirtuins ...

journal_title：PLoS neglected tropical diseases

authors： Ritagliati C,Alonso VL,Manarin R,Cribb P,Serra EC

更新日期：2015-04-15 00:00:00

abstract：:Infected Ixodes scapularis (black-legged tick) transmit a host of serious pathogens via their bites, including Borrelia burgdorferi, Babesia microti, and tick-borne flaviviruses (TBFVs), such as Powassan virus (POWV). Although the role of female I. scapularis ticks in disease transmission is well characterized, the ro...

journal_title：PLoS neglected tropical diseases

authors： Kendall BL,Grabowski JM,Rosenke R,Pulliam M,Long DR,Scott DP,Offerdahl DK,Bloom ME

更新日期：2020-10-05 00:00:00

abstract：BACKGROUND:In the late twentieth century, emergence of high rates of treatment failure with antimonial compounds (SSG) for visceral leishmaniasis (VL) caused a public health crisis in Bihar, India. We hypothesize that exposure to arsenic through drinking contaminated groundwater may be associated with SSG treatment fai...

journal_title：PLoS neglected tropical diseases

authors： Perry MR,Prajapati VK,Menten J,Raab A,Feldmann J,Chakraborti D,Sundar S,Fairlamb AH,Boelaert M,Picado A

更新日期：2015-03-02 00:00:00

abstract：:Most statistical and mechanistic models used to predict mosquito-borne disease transmission incorporate climate drivers of disease transmission by utilizing environmental data collected at geographic scales that are potentially coarser than what mosquito populations may actually experience. Temperature and relative hu...

journal_title：PLoS neglected tropical diseases

authors： Murdock CC,Evans MV,McClanahan TD,Miazgowicz KL,Tesla B

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:Hantaan virus (HTNV) causes a severe lethal haemorrhagic fever with renal syndrome (HFRS) in humans. Despite a limited understanding of the pathogenesis of HFRS, the importance of the abundant production of pro-inflammatory cytokines has been widely recognized. Interleukin 33 (IL-33) has been demonstrated to...

journal_title：PLoS neglected tropical diseases

authors： Zhang Y,Zhang C,Zhuang R,Ma Y,Zhang Y,Yi J,Yang A,Jin B

更新日期：2015-02-06 00:00:00