Estimating the effects of variation in viremia on mosquito susceptibility, infectiousness, and R0 of Zika in Aedes aegypti.

abstract：BACKGROUND:Careful monitoring for recrudescence of Wuchereria bancrofti infection is necessary in communities where mass drug administration (MDA) for the elimination of lymphatic filariasis (LF) as a public health problem has been stopped. During the post-MDA period, transmission assessment surveys (TAS) are recommend...

journal_title：PLoS neglected tropical diseases

authors： Irish SR,Al-Amin HM,Paulin HN,Mahmood ASMS,Khan RK,Muraduzzaman AKM,Worrell CM,Flora MS,Karim MJ,Shirin T,Shamsuzzaman AKM,Tahmina S,Lenhart A,Dubray C

更新日期：2018-07-26 00:00:00

abstract：:Several studies suggest that HTLV-1 infection may be associated with a wider spectrum of neurologic manifestations that do not meet diagnostic criteria for HAM/TSP. These conditions may later progress to HAM/TSP or constitute an intermediate clinical form, between asymptomatic HTLV-1 carriers and those with full myelo...

journal_title：PLoS neglected tropical diseases

authors： Haziot ME,Gascon MR,Assone T,Fonseca LAM,Luiz ODC,Smid J,Paiva AM,Marcusso RMDN,de Oliveira ACP,Casseb J

更新日期：2019-05-01 00:00:00

abstract：:Helminth parasites are an assemblage of two major phyla of nematodes (also known as roundworms) and platyhelminths (also called flatworms). These parasites are a major human health burden, and infections caused by helminths are considered under neglected tropical diseases (NTDs). These infections are typified by limit...

journal_title：PLoS neglected tropical diseases

authors： Sharma A,Sharma M,Yogavel M,Sharma A

更新日期：2016-11-02 00:00:00

abstract：BACKGROUND:French Guiana is a territory that has a decades-long history of dengue outbreaks and more recently, in 2014, a chikungunya outbreak. Zika virus (ZIKV) emerged in late 2015 and subsequently led to an important outbreak. METHODOLOGY/PRINCIPAL FINDINGS:A cross-sectional phone survey was conducted among the gen...

journal_title：PLoS neglected tropical diseases

authors： Fritzell C,Raude J,Kazanji M,Flamand C

更新日期：2018-01-25 00:00:00

abstract：:Zika virus (ZIKV) is a Flavivirus (Flaviviridae) transmitted to humans mainly by the bite of an infected Aedes mosquitoes. Aedes aegypti is the primary epidemic vector of ZIKV and Ae. albopictus, the secondary one. However, the epidemiological role of both Aedes species in Central Africa where Ae. albopictus was recen...

journal_title：PLoS neglected tropical diseases

authors： Kamgang B,Vazeille M,Tedjou A,Yougang AP,Wilson-Bahun TA,Mousson L,Wondji CS,Failloux AB

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:The World Health Organization now recommends semiannual mass drug administration (MDA) of albendazole with integrated vector management as an option for eliminating lymphatic filariasis (LF) in areas of loiasis-endemic countries where it may not be safe to use diethylcarbamazine or ivermectin in MDA programs...

journal_title：PLoS neglected tropical diseases

authors： Pion SDS,Chesnais CB,Awaca-Uvon NP,Vlaminck J,Abdou A,Kunyu-Shako B,Kuyangisa Simuna G,Tambwe JP,Weil GJ,Boussinesq M

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Optimal management of eumycetoma, a severely debilitating chronic progressive fungal infection of skin, disseminating to bone and viscera, remains challenging. Especially, optimal antifungal treatment and duration are ill defined. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a monocentric retrospective study...

journal_title：PLoS neglected tropical diseases

authors： Crabol Y,Poiree S,Bougnoux ME,Maunoury C,Barete S,Zeller V,Arvieux C,Pineau S,Amazzough K,Lecuit M,Lanternier F,Lortholary O,French Mycosis Study Group.

更新日期：2014-10-09 00:00:00

abstract：BACKGROUND:Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antive...

journal_title：PLoS neglected tropical diseases

authors： Silva A,Johnston C,Kuruppu S,Kneisz D,Maduwage K,Kleifeld O,Smith AI,Siribaddana S,Buckley NA,Hodgson WC,Isbister GK

更新日期：2016-12-02 00:00:00

abstract：:Globally, early initiation of antiretroviral therapy for HIV led to a reduction in the estimated mortality from cryptococcal meningitis (CCM) from 624,700 in 2009 to 181,100 in 2014. However, CCM remains one of the leading causes of mortality among HIV infected patients especially in sub-Saharan Africa where 75% of th...

journal_title：PLoS neglected tropical diseases

authors： Kitonsa J,Nsubuga R,Mayanja Y,Kiwanuka J,Nikweri Y,Onyango M,Anywaine Z,Ggayi AB,Kibengo FM,Kaleebu P,Day J

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:Phlebotomus tobbi is a vector of Leishmania infantum, and P. sergenti is a vector of Leishmania tropica. Le. infantum and Le. tropica typically cause visceral or cutaneous leishmaniasis, respectively, but Le. infantum strains transmitted by P. tobbi can cause cutaneous disease. To better understand the compo...

journal_title：PLoS neglected tropical diseases

authors： Rohoušová I,Subrahmanyam S,Volfová V,Mu J,Volf P,Valenzuela JG,Jochim RC

更新日期：2012-01-01 00:00:00

abstract：:Hansen's disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70-75% worldwide. About 10-50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5%...

journal_title：PLoS neglected tropical diseases

authors： Pavezzi PD,do Prado RB,Boin Filho PÂ,Gon ADS,Tuma B,Fornazieri MA,Scalone FM,Alves LRM,Montero RH,Casella AMB

更新日期：2020-09-21 00:00:00

abstract：BACKGROUND:Trichinellosis is a serious zoonositc parasitosis worldwide. Because its clinical manifestations aren't specific, the diagnosis of trichinellosis is not easy to be made. Trichinella spiralis muscle larva (ML) excretory-secretory (ES) antigens are the most widely applied diagnostic antigens for human trichine...

journal_title：PLoS neglected tropical diseases

authors： Sun GG,Song YY,Jiang P,Ren HN,Yan SW,Han Y,Liu RD,Zhang X,Wang ZQ,Cui J

更新日期：2018-05-14 00:00:00

abstract：BACKGROUND:Sensitive diagnostic tools are required for an accurate assessment of prevalence and intensity of helminth infections in areas undergoing regular deworming, and for monitoring anthelmintic drug efficacy. We compared the diagnostic accuracy of the Kato-Katz and FLOTAC techniques in the frame of a drug efficac...

journal_title：PLoS neglected tropical diseases

authors： Knopp S,Speich B,Hattendorf J,Rinaldi L,Mohammed KA,Khamis IS,Mohammed AS,Albonico M,Rollinson D,Marti H,Cringoli G,Utzinger J

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:Dengue is a re-emerging infectious disease of humans, rapidly growing from endemic areas to dengue-free regions due to favorable conditions. In recent decades, Guangzhou has again suffered from several big outbreaks of dengue; as have its neighboring cities. This study aims to examine the impact of dengue ep...

journal_title：PLoS neglected tropical diseases

authors： Zhang Y,Wang T,Liu K,Xia Y,Lu Y,Jing Q,Yang Z,Hu W,Lu J

更新日期：2016-02-19 00:00:00

abstract：INTRODUCTION:Previous studies of Ebola Virus Disease (EVD) have focused on clinical symptoms and Ebola virus (EBOV) cycle threshold (CT) values recorded at patient triage. Our study explores EVD symptoms and EBOV CT values from onset of illness to recovery or death in a diverse population of patients. METHODOLOGY/PRIN...

journal_title：PLoS neglected tropical diseases

authors： Skrable K,Roshania R,Mallow M,Wolfman V,Siakor M,Levine AC

更新日期：2017-07-19 00:00:00

abstract：:Revealing the patterns and determinants of the spread of dengue virus (DENV) at local scales is central to understanding the epidemiology and evolution of this major human pathogen. We performed a phylogenetic analysis of the envelope (E) genes of DENV-1, -2, -3, and -4 isolates (involving 97, 23, 5, and 74 newly coll...

journal_title：PLoS neglected tropical diseases

authors： Rabaa MA,Klungthong C,Yoon IK,Holmes EC,Chinnawirotpisan P,Thaisomboonsuk B,Srikiatkhachorn A,Rothman AL,Tannitisupawong D,Aldstadt J,Nisalak A,Mammen MP,Gibbons RV,Endy TP,Fansiri T,Scott TW,Jarman RG

更新日期：2013-01-01 00:00:00

abstract：:Leprosy is a curable neglected disease of humans caused by Mycobacterium leprae that affects the skin and peripheral nerves and manifests clinically in various forms ranging from self-resolving, tuberculoid leprosy to lepromatous leprosy having significant pathology with ensuing disfiguration disability and social sti...

journal_title：PLoS neglected tropical diseases

authors： Wheat WH,Casali AL,Thomas V,Spencer JS,Lahiri R,Williams DL,McDonnell GE,Gonzalez-Juarrero M,Brennan PJ,Jackson M

更新日期：2014-12-18 00:00:00

abstract：:Mycobacterium africanum is a member of the Mycobacterium tuberculosis complex (MTBC) and an important cause of human tuberculosis in West Africa that is rarely observed elsewhere. Here we genotyped 613 MTBC clinical isolates from Ghana, and searched for associations between the different phylogenetic lineages of MTBC ...

journal_title：PLoS neglected tropical diseases

authors： Asante-Poku A,Yeboah-Manu D,Otchere ID,Aboagye SY,Stucki D,Hattendorf J,Borrell S,Feldmann J,Danso E,Gagneux S

更新日期：2015-01-08 00:00:00

abstract：:Dengue and chikungunya are viral diseases transmitted to humans by infected Aedes spp. mosquitoes. With an estimated 390 million infected people per year dengue virus (DENV) currently causes the most prevalent arboviral disease. During the last decade chikungunya virus (CHIKV) has caused large outbreaks and has expand...

journal_title：PLoS neglected tropical diseases

authors： Ruiz Silva M,Aguilar Briseño JA,Upasani V,van der Ende-Metselaar H,Smit JM,Rodenhuis-Zybert IA

更新日期：2017-06-23 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis is a neglected parasitic disease with no vaccine available and its pharmacological treatment is reduced to a limited number of unsafe drugs. The scarce readiness of new antileishmanial drugs is even more alarming when relapses appear or the occurrence of hard-to-treat resistant strains...

journal_title：PLoS neglected tropical diseases

authors： Álvarez-Velilla R,Gutiérrez-Corbo MDC,Punzón C,Pérez-Pertejo MY,Balaña-Fouce R,Fresno M,Reguera RM

更新日期：2019-02-14 00:00:00

abstract：:Dengue fever (DEN) is the most common arboviral disease in the world and dengue virus (DENV) causes 390 million annual infections around the world, of which 240 million are inapparent and 96 million are symptomatic. During the past decade a changing epidemiological pattern has been observed in Africa, with DEN outbrea...

journal_title：PLoS neglected tropical diseases

authors： Gaye A,Wang E,Vasilakis N,Guzman H,Diallo D,Talla C,Ba Y,Dia I,Weaver SC,Diallo M

更新日期：2019-02-13 00:00:00

abstract：:Tsetse flies (Glossina spp.) transmit parasitic African trypanosomes (Trypanosoma spp.), including Trypanosoma congolense, which causes animal African trypanosomiasis (AAT). AAT detrimentally affects agricultural activities in sub-Saharan Africa and has negative impacts on the livelihood and nutrient availability for ...

journal_title：PLoS neglected tropical diseases

authors： Awuoche EO,Weiss BL,Vigneron A,Mireji PO,Aksoy E,Nyambega B,Attardo GM,Wu Y,O'Neill M,Murilla G,Aksoy S

更新日期：2017-11-20 00:00:00

abstract：:In Tunisia, cases of zoonotic cutaneous leishmaniasis caused by Leishmania major are increasing and spreading from the south-west to new areas in the center. To improve the current knowledge on L. major evolution and population dynamics, we performed multi-locus microsatellite typing of human isolates from Tunisian go...

journal_title：PLoS neglected tropical diseases

authors： Harrabi M,Bettaieb J,Ghawar W,Toumi A,Zaâtour A,Yazidi R,Chaâbane S,Chalghaf B,Hide M,Bañuls AL,Ben Salah A

更新日期：2015-08-24 00:00:00

abstract：BACKGROUND:Increased vascular permeability is a hallmark feature in severe dengue virus (DV) infection, and dysfunction of endothelial cells has been speculated to contribute in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Rho-family GTPase Rac1 is a significant element of endothelial b...

journal_title：PLoS neglected tropical diseases

authors： Wang JL,Zhang JL,Chen W,Xu XF,Gao N,Fan DY,An J

更新日期：2010-08-31 00:00:00

abstract：BACKGROUND:Rabies is a fatal encephalitis caused by viruses belonging to the genus Lyssavirus of the family Rhabdoviridae. It is a viral disease primarily affecting mammals, though all warm blooded animals are susceptible. Experimental rabies virus infection in birds has been reported, but naturally occurring infection...

journal_title：PLoS neglected tropical diseases

authors： Baby J,Mani RS,Abraham SS,Thankappan AT,Pillai PM,Anand AM,Madhusudana SN,Ramachandran J,Sreekumar S

更新日期：2015-07-22 00:00:00

abstract：:Trypanosomes rely on post-transcriptional mechanisms and mRNA-binding proteins for control of gene expression. Trypanosoma brucei ZC3H30 is an mRNA-binding protein that is expressed in both the bloodstream form (which grows in mammals) and the procyclic form (which grows in the tsetse fly midgut). Attachment of ZC3H30...

journal_title：PLoS neglected tropical diseases

authors： Chakraborty C,Clayton C

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited. METHODOLOGY/PRINCIPAL FINDINGS:Four hundred and seventy nine acutely febrile...

journal_title：PLoS neglected tropical diseases

authors： Stubbs SCB,Johar E,Yudhaputri FA,Yohan B,Santoso MS,Hayati RF,Denis D,Blacklaws BA,Powers AM,Sasmono RT,Myint KSA,Frost SDW

更新日期：2020-12-21 00:00:00

abstract：BACKGROUND:Mapping of lymphatic filariasis (LF) is essential for the delineation of endemic implementation units and determining the population at risk that will be targeted for mass drug administration (MDA). Prior to the current study, only 116 of the 832 woredas (districts) in Ethiopia had been mapped for LF. The ai...

journal_title：PLoS neglected tropical diseases

authors： Rebollo MP,Sime H,Assefa A,Cano J,Deribe K,Gonzalez-Escalada A,Shafi O,Davey G,Brooker SJ,Kebede A,Bockarie MJ

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is a mosquito-borne flavivirus distributed throughout much of Africa and Asia. Infection with the virus may cause acute febrile illness that clinically resembles dengue fever. A recent study indicated the existence of three geographically distinct viral lineages; however this analysis utili...

journal_title：PLoS neglected tropical diseases

authors： Haddow AD,Schuh AJ,Yasuda CY,Kasper MR,Heang V,Huy R,Guzman H,Tesh RB,Weaver SC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:There is a pressing need for drug discovery against visceral leishmaniasis, a life-threatening protozoal infection, as the available chemotherapy is antiquated and not bereft of side effects. Plants as alternate drug resources has rewarded mankind in the past and aimed in this direction, we investigated the ...

journal_title：PLoS neglected tropical diseases

authors： Afrin F,Chouhan G,Islamuddin M,Want MY,Ozbak HA,Hemeg HA

更新日期：2019-05-09 00:00:00