Emerging trends of Zika apprehension in an epidemic setting.

abstract：:Global distribution patterns of Cladophialophora carrionii, agent of human chromoblastomycosis in arid climates of Africa, Asia, Australia, Central-and South-America, were compared with similar data of the vicarious Fonsecaea spp., agents of the disease in tropical rain forests. Population diversities among 73 C. carr...

journal_title：PLoS neglected tropical diseases

authors： Deng S,Tsui CK,Gerrits van den Ende AH,Yang L,Najafzadeh MJ,Badali H,Li R,Hagen F,Meis JF,Sun J,Dolatabadi S,Papierok B,Pan W,de Hoog GS,Liao W

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Dengue diagnosis is complex and until recently only specialized laboratories were able to definitively confirm dengue infection. Rapid tests are now available commercially making biological diagnosis possible in the field. The aim of this study was to evaluate a combined dengue rapid test for the detection o...

journal_title：PLoS neglected tropical diseases

authors： Andries AC,Duong V,Ngan C,Ong S,Huy R,Sroin KK,Te V,Y B,Try PL,Buchy P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2], a low mole...

journal_title：PLoS neglected tropical diseases

authors： Benítez D,Medeiros A,Fiestas L,Panozzo-Zenere EA,Maiwald F,Prousis KC,Roussaki M,Calogeropoulou T,Detsi A,Jaeger T,Šarlauskas J,Peterlin Mašič L,Kunick C,Labadie GR,Flohé L,Comini MA

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic shock is the most serious ...

journal_title：PLoS neglected tropical diseases

authors： Lam PK,Ngoc TV,Thu Thuy TT,Hong Van NT,Nhu Thuy TT,Hoai Tam DT,Dung NM,Hanh Tien NT,Thanh Kieu NT,Simmons C,Wills B,Wolbers M

更新日期：2017-04-27 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID) intake. METHODS/PRINCIPAL FINDINGS:We conducted a hospital-based case-control study covering 215 UGIB ...

journal_title：PLoS neglected tropical diseases

authors： Ubeira FM,Anadón AM,Salgado A,Carvajal A,Ortega S,Aguirre C,López-Goikoetxea MJ,Ibanez L,Figueiras A

更新日期：2011-06-01 00:00:00

abstract：:Insecticide resistance poses a significant threat to the control of arthropods that transmit disease agents. Nanoparticle carriers offer exciting opportunities to expand the armamentarium of insecticides available for public health and other pests. Most chemical insecticides are delivered by contact or feeding, and fr...

journal_title：PLoS neglected tropical diseases

authors： Norris EJ,Mullis AS,Phanse Y,Narasimhan B,Coats JR,Bartholomay LC

更新日期：2020-09-08 00:00:00

abstract：:The disease burden of Wuchereria bancrofti and Plasmodium falciparum malaria is high, particularly in Africa, and co-infection is common. However, the effects of filarial infection on the risk of severe malaria are unknown. We used the remaining serum samples from a large cohort study in Muheza, Tanzania to describe v...

journal_title：PLoS neglected tropical diseases

authors： Kwan JL,Seitz AE,Fried M,Lee KL,Metenou S,Morrison R,Kabyemela E,Nutman TB,Prevots DR,Duffy PE

更新日期：2018-03-26 00:00:00

abstract：BACKGROUND:Oncomelania hupensis is the unique intermediate host of Schistosoma japonicum, which causes schistosomiasis endemic in the Far East, and especially in mainland China. O. hupensis largely determines the parasite's geographical range. How O. hupensis's genetic diversity is distributed geographically in mainlan...

journal_title：PLoS neglected tropical diseases

authors： Zhao QP,Jiang MS,Littlewood DT,Nie P

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:Imported strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported strongyloidiasis in Spain. METHODOLOGY:This is an observational retrospective study that included ...

journal_title：PLoS neglected tropical diseases

authors： Salvador F,Treviño B,Chamorro-Tojeiro S,Sánchez-Montalvá A,Herrero-Martínez JM,Rodríguez-Guardado A,Serre-Delcor N,Torrús D,Goikoetxea J,Zubero Z,Velasco M,Sulleiro E,Molina I,López-Vélez R,Pérez-Molina JA,on behalf the +RE

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:The neglected human diseases caused by trypanosomatids are currently treated with toxic therapy with limited efficacy. In search for novel anti-trypanosomatid agents, we showed previously that the Crotalus viridis viridis (Cvv) snake venom was active against infective forms of Trypanosoma cruzi. Here, we des...

journal_title：PLoS neglected tropical diseases

authors： Adade CM,Carvalho AL,Tomaz MA,Costa TF,Godinho JL,Melo PA,Lima AP,Rodrigues JC,Zingali RB,Souto-Padrón T

更新日期：2014-10-16 00:00:00

abstract：BACKGROUND:Appropriate health and nutrition interventions to prevent long-term adverse effects in children are necessary before two years of age. One such intervention may include population-based deworming, recommended as of 12 months of age by the World Health Organization in soil-transmitted helminth (STH)-endemic a...

journal_title：PLoS neglected tropical diseases

authors： Joseph SA,Casapía M,Montresor A,Rahme E,Ward BJ,Marquis GS,Pezo L,Blouin B,Maheu-Giroux M,Gyorkos TW

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Most available drugs against visceral leishmaniasis are toxic, and growing limitations in available chemotherapeutic strategies due to emerging resistant strains and lack of an effective vaccine against visceral leishmaniasis deepens the crisis. Antineoplastic drugs like miltefosine have in the past been eff...

journal_title：PLoS neglected tropical diseases

authors： Sharma M,Sehgal R,Kaur S

更新日期：2012-01-01 00:00:00

abstract：:Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant maca...

journal_title：PLoS neglected tropical diseases

authors： Bidokhti MRM,Dutta D,Madduri LSV,Woollard SM,Norgren R Jr,Giavedoni L,Byrareddy SN

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:The range of the Asian tiger mosquito Aedes albopictus is expanding globally, raising the threat of emerging and re-emerging arbovirus transmission risks including dengue and chikungunya. Its detection in Papua New Guinea's (PNG) southern Fly River coastal region in 1988 and 1992 placed it 150 km from mainla...

journal_title：PLoS neglected tropical diseases

authors： Beebe NW,Ambrose L,Hill LA,Davis JB,Hapgood G,Cooper RD,Russell RC,Ritchie SA,Reimer LJ,Lobo NF,Syafruddin D,van den Hurk AF

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:Intestinal parasitic infections remain among the most common infectious diseases worldwide. This study aimed to estimate their prevalence and provide a detailed analysis of geographical distribution of intestinal parasites in the metropolitan region of Rio de Janeiro, considering demographic, socio-economic,...

journal_title：PLoS neglected tropical diseases

authors： Faria CP,Zanini GM,Dias GS,da Silva S,de Freitas MB,Almendra R,Santana P,Sousa MD

更新日期：2017-03-08 00:00:00

abstract：BACKGROUND:The main objective of the study was to determine the degree of sensitization to Anisakis spp. antigens in healthy coastal population of Dalmatia given the high thermally unprocessed fish intake rate present in this area, suggested as a significant risk factor for anisakiasis. We performed a monocenter, cross...

journal_title：PLoS neglected tropical diseases

authors： Mladineo I,Poljak V,Martínez-Sernández V,Ubeira FM

更新日期：2014-02-06 00:00:00

abstract：:Cystic echinococcosis (CE) is distributed worldwide, extending from China to the Middle East and from Mediterranean countries to the sub-Saharan Africa and South America. According to WHO, one million people around the world are suffering from CE with an estimated burden of 183,573 DALYs. The annual monetary burden of...

journal_title：PLoS neglected tropical diseases

authors： Borhani M,Fathi S,Lahmar S,Ahmed H,Abdulhameed MF,Fasihi Harandi M

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:For decades La Réunion has experienced a number of epidemics that have resulted in efforts to control the density of Aedes species on this Island. This study was conducted to assess household-level expenditure on protective measures against mosquito nuisance on the Island of La Réunion in 2012. METHODOLOGY/...

journal_title：PLoS neglected tropical diseases

authors： Thuilliez J,Bellia C,Dehecq JS,Reilhes O

更新日期：2014-01-02 00:00:00

abstract：:The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV. The mechanism underlying the mouse resistance to JUNV infection is largely unknown. We have reported that ...

journal_title：PLoS neglected tropical diseases

authors： Huang C,Walker AG,Grant AM,Kolokoltsova OA,Yun NE,Seregin AV,Paessler S

更新日期：2014-06-05 00:00:00

abstract：:Globally, early initiation of antiretroviral therapy for HIV led to a reduction in the estimated mortality from cryptococcal meningitis (CCM) from 624,700 in 2009 to 181,100 in 2014. However, CCM remains one of the leading causes of mortality among HIV infected patients especially in sub-Saharan Africa where 75% of th...

journal_title：PLoS neglected tropical diseases

authors： Kitonsa J,Nsubuga R,Mayanja Y,Kiwanuka J,Nikweri Y,Onyango M,Anywaine Z,Ggayi AB,Kibengo FM,Kaleebu P,Day J

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low...

journal_title：PLoS neglected tropical diseases

authors： Chu BK,Deming M,Biritwum NK,Bougma WR,Dorkenoo AM,El-Setouhy M,Fischer PU,Gass K,Gonzalez de Peña M,Mercado-Hernandez L,Kyelem D,Lammie PJ,Flueckiger RM,Mwingira UJ,Noordin R,Offei Owusu I,Ottesen EA,Pavluck A,Pilotte

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Visceral Leishmaniasis in humans presents with fever, anemia, and splenomegaly and can be lethal if not treated. Nevertheless, the majority of Leishmania infantum-infected individuals does not manifest symptoms and remain so provided they are not immunosuppressed. In this work, the performance of different t...

journal_title：PLoS neglected tropical diseases

authors： Porcino GN,Carvalho KSS,Braz DC,Costa Silva V,Costa CHN,de Miranda Santos IKF

更新日期：2019-07-01 00:00:00

abstract：:Soil-transmitted helminths (STH) are endemic and widespread across Sub-Saharan Africa. A community wide soil-transmitted helminth (STH) prevalence survey was performed on the island of Bubaque in Guinea-Bissau using both Kato-katz microscopy and qPCR methodology. Predictors of infection and morbidity indicators were i...

journal_title：PLoS neglected tropical diseases

authors： Farrant O,Marlais T,Houghton J,Goncalves A,Teixeira da Silva Cassama E,Cabral MG,Nakutum J,Manjuba C,Rodrigues A,Mabey D,Bailey R,Last A

更新日期：2020-12-16 00:00:00

abstract：:The mosquito Aedes aegypti, the principal vector of dengue virus, has recently been infected experimentally with Wolbachia: intracellular bacteria that possess potential as dengue biological control agents. Wolbachia depend on their hosts for nutrients they are unable to synthesize themselves. Consequently, competitio...

journal_title：PLoS neglected tropical diseases

authors： Ross PA,Endersby NM,Hoffmann AA

更新日期：2016-01-08 00:00:00

abstract：:Leishmaniasis is a serious global health problem affecting many people worldwide. While patients with leishmaniasis can be treated with several agents, drug toxicicty and the emergence of resistant strains render available treatments ineffective in the long run. Inhibitors of the mammalian target of rapamycin (mTOR) h...

journal_title：PLoS neglected tropical diseases

authors： Khadir F,Shaler CR,Oryan A,Rudak PT,Mazzuca DM,Taheri T,Dikeakos JD,Haeryfar SMM,Rafati S

更新日期：2018-08-22 00:00:00

abstract：INTRODUCTION:In addition to the commonly accepted importance of the vampire bat in the maintenance and transmission of the rabies virus (RABV) in South America, RABV infection of other species is widely evidenced, challenging their role in the viral cycle. METHODOLOGY / PRINCIPLES FINDINGS:To identify the bioecologica...

journal_title：PLoS neglected tropical diseases

authors： de Thoisy B,Bourhy H,Delaval M,Pontier D,Dacheux L,Darcissac E,Donato D,Guidez A,Larrous F,Lavenir R,Salmier A,Lacoste V,Lavergne A

更新日期：2016-01-25 00:00:00

abstract：:The human mutilating disease chromoblastomycosis is caused by melanized members of the order Chaetothyriales. To assess population diversity among 123 clinical strains of agents of the disease in Brazil we applied sequencing of the rDNA internal transcribed spacer region, and partial cell division cycle and β-tubulin ...

journal_title：PLoS neglected tropical diseases

authors： Gomes RR,Vicente VA,Azevedo CM,Salgado CG,da Silva MB,Queiroz-Telles F,Marques SG,Santos DW,de Andrade TS,Takagi EH,Cruz KS,Fornari G,Hahn RC,Scroferneker ML,Caligine RB,Ramirez-Castrillon M,de Araújo DP,Heidrich D,Co

更新日期：2016-11-28 00:00:00

abstract：BACKGROUND:Despite the known burden of neglected tropical diseases (NTDs) on child health, there is limited information on current efforts to increase pediatric therapeutic options. Our objective was to quantify and characterize research activity and treatment availability for NTDs in children in order to inform the pr...

journal_title：PLoS neglected tropical diseases

authors： Rees CA,Hotez PJ,Monuteaux MC,Niescierenko M,Bourgeois FT

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:The World Health Organization now recommends semiannual mass drug administration (MDA) of albendazole with integrated vector management as an option for eliminating lymphatic filariasis (LF) in areas of loiasis-endemic countries where it may not be safe to use diethylcarbamazine or ivermectin in MDA programs...

journal_title：PLoS neglected tropical diseases

authors： Pion SDS,Chesnais CB,Awaca-Uvon NP,Vlaminck J,Abdou A,Kunyu-Shako B,Kuyangisa Simuna G,Tambwe JP,Weil GJ,Boussinesq M

更新日期：2020-06-23 00:00:00

abstract：:Despite Nipah virus outbreaks having high mortality rates (>70% in Southeast Asia), there are no licensed drugs against it. In this study, we have considered all 9 Nipah proteins as potential therapeutic targets and computationally identified 4 putative peptide inhibitors (against G, F and M proteins) and 146 small mo...

journal_title：PLoS neglected tropical diseases

authors： Sen N,Kanitkar TR,Roy AA,Soni N,Amritkar K,Supekar S,Nair S,Singh G,Madhusudhan MS

更新日期：2019-12-12 00:00:00