Stress susceptibility in Trypanosoma brucei lacking the RNA-binding protein ZC3H30.

abstract：BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. Pharmacological...

journal_title：PLoS neglected tropical diseases

authors： Tzertzinis G,Egaña AL,Palli SR,Robinson-Rechavi M,Gissendanner CR,Liu C,Unnasch TR,Maina CV

更新日期：2010-03-09 00:00:00

abstract：:Helminth parasites are an assemblage of two major phyla of nematodes (also known as roundworms) and platyhelminths (also called flatworms). These parasites are a major human health burden, and infections caused by helminths are considered under neglected tropical diseases (NTDs). These infections are typified by limit...

journal_title：PLoS neglected tropical diseases

authors： Sharma A,Sharma M,Yogavel M,Sharma A

更新日期：2016-11-02 00:00:00

abstract：INTRODUCTION:The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species. This study aims to evaluate associations between Paracoccidioides phylogenetic species and corresponding clinical data. METHODS:Paracoccidioides strains from INI/Fioc...

journal_title：PLoS neglected tropical diseases

authors： de Macedo PM,Teixeira MM,Barker BM,Zancopé-Oliveira RM,Almeida-Paes R,Francesconi do Valle AC

更新日期：2019-04-15 00:00:00

abstract：:Cysticercosis is caused by Taenia solium, a parasitic disease that affects humans and rurally bred pigs in developing countries. The cysticercus may localize in the central nervous system of the human, causing neurocysticercosis, the most severe and frequent form of the disease. There appears to be an association betw...

journal_title：PLoS neglected tropical diseases

authors： Morales J,Martínez JJ,Rosetti M,Fleury A,Maza V,Hernandez M,Villalobos N,Fragoso G,de Aluja AS,Larralde C,Sciutto E

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Hookworm infections are an important cause of (severe) anemia and iron deficiency in children in the tropics. Type of hookworm species (Ancylostoma duodenale or Necator americanus) and infection load are considered associated with disease burden, although these parameters are rarely assessed due to limitatio...

journal_title：PLoS neglected tropical diseases

authors： Jonker FA,Calis JC,Phiri K,Brienen EA,Khoffi H,Brabin BJ,Verweij JJ,van Hensbroek MB,van Lieshout L

更新日期：2012-01-01 00:00:00

abstract：:Leprosy is an infectious disease caused by Mycobacterium leprae and frequently resulting in irreversible deformities and disabilities. Ticks play an important role in infectious disease transmission due to their low host specificity, worldwide distribution, and the biological ability to support transovarial transmissi...

journal_title：PLoS neglected tropical diseases

authors： Ferreira JDS,Souza Oliveira DA,Santos JP,Ribeiro CCDU,Baêta BA,Teixeira RC,Neumann ADS,Rosa PS,Pessolani MCV,Moraes MO,Bechara GH,de Oliveira PL,Sorgine MHF,Suffys PN,Fontes ANB,Bell-Sakyi L,Fonseca AH,Lara FA

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:Area-wide integrated pest management strategies that include a sterile insect technique component have been successfully used to eradicate tsetse fly populations in the past. To ensure the success of the sterile insect technique, the released males must be adequately sterile and be able to compete with their...

journal_title：PLoS neglected tropical diseases

authors： de Beer CJ,Moyaba P,Boikanyo SN,Majatladi D,Yamada H,Venter GJ,Vreysen MJ

更新日期：2017-03-17 00:00:00

abstract：BACKGROUND:Incidence of Entamoeba histolytica infection and clinical manifestations and treatment response of invasive amebiasis (IA) in HIV-infected patients have rarely been investigated before. METHODOLOGY/PRINCIPAL FINDINGS:At the National Taiwan University Hospital, medical records of HIV-infected patients who re...

journal_title：PLoS neglected tropical diseases

authors： Hung CC,Ji DD,Sun HY,Lee YT,Hsu SY,Chang SY,Wu CH,Chan YH,Hsiao CF,Liu WC,Colebunders R

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable in blood by the Card...

journal_title：PLoS neglected tropical diseases

authors： Lejon V,Ngoyi DM,Boelaert M,Büscher P

更新日期：2010-01-26 00:00:00

abstract：:As the most widespread tick-borne arbovirus causing infections in numerous countries in Asia, Africa and Europe, Crimean-Congo Hemorrhagic Fever Virus (CCHFV, family Nairoviridae) was included in the WHO priority list of emerging pathogens needing urgent Research & Development attention. To ensure preparedness for pot...

journal_title：PLoS neglected tropical diseases

authors： Emmerich P,Mika A,von Possel R,Rackow A,Liu Y,Schmitz H,Günther S,Sherifi K,Halili B,Jakupi X,Berisha L,Ahmeti S,Deschermeier C

更新日期：2018-03-26 00:00:00

abstract：BACKGROUND:Since its beginning in 1999, the Schistosomiasis Control Program within the Unified Health System (PCE-SUS) has registered a cumulative coverage of just 20% of the population from the Rainforest Zone of Pernambuco (ZMP), northeast Brazil. This jeopardizes the accomplishment of the minimum goal of the Fifty-F...

journal_title：PLoS neglected tropical diseases

authors： Favre TC,Pereira AP,Galvão AF,Zani LC,Barbosa CS,Pieri OS

更新日期：2009-01-01 00:00:00

abstract：:The Qinghai-Tibet plateau is a natural plague focus and is the largest such focus in China. In this area, while Marmota himalayana is the primary host, a total of 18 human plague outbreaks associated with Tibetan sheep (78 cases with 47 deaths) have been reported on the Qinghai-Tibet plateau since 1956. All of the ind...

journal_title：PLoS neglected tropical diseases

authors： Dai R,Wei B,Xiong H,Yang X,Peng Y,He J,Jin J,Wang Y,Zha X,Zhang Z,Liang Y,Zhang Q,Xu J,Wang Z,Li W

更新日期：2018-08-16 00:00:00

abstract：:Nucleoside hydrolases (NHs) show homology among parasite protozoa, fungi and bacteria. They are vital protagonists in the establishment of early infection and, therefore, are excellent candidates for the pathogen recognition by adaptive immune responses. Immune protection against NHs would prevent disease at the early...

journal_title：PLoS neglected tropical diseases

authors： Nico D,Claser C,Borja-Cabrera GP,Travassos LR,Palatnik M,Soares IS,Rodrigues MM,Palatnik-de-Sousa CB

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. METHODOLOGY/PRINCIPAL FINDINGS:The TEN 11q/j isolate was characteriz...

journal_title：PLoS neglected tropical diseases

authors： Mikalová L,Strouhal M,Oppelt J,Grange PA,Janier M,Benhaddou N,Dupin N,Šmajs D

更新日期：2017-03-06 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0004470.]. ...

journal_title：PLoS neglected tropical diseases

authors： Decuypere S,Meehan CJ,Van Puyvelde S,De Block T,Maltha J,Palpouguini L,Tahita M,Tinto H,Jacobs J,Deborggraeve S

更新日期：2017-07-28 00:00:00

abstract：:The yellow fever vaccines (YF-17D-204 and 17DD) are considered to be among the safest vaccines and the presence of neutralizing antibodies is correlated with protection, although other immune effector mechanisms are known to be involved. T-cell responses are known to play an important role modulating antibody producti...

journal_title：PLoS neglected tropical diseases

authors： de Melo AB,Nascimento EJ,Braga-Neto U,Dhalia R,Silva AM,Oelke M,Schneck JP,Sidney J,Sette A,Montenegro SM,Marques ET

更新日期：2013-01-01 00:00:00

abstract：:Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Par...

journal_title：PLoS neglected tropical diseases

authors： de Léséleuc L,Orlova M,Cobat A,Girard M,Huong NT,Ba NN,Thuc NV,Truman R,Spencer JS,Adams L,Thai VH,Alcais A,Schurr E

更新日期：2013-01-01 00:00:00

abstract：:The application of the organophosphate larvicide temephos to water storage containers is one of the most commonly employed dengue vector control methods. This systematic literature review is to the knowledge of the authors the first that aims to assess the community-effectiveness of temephos in controlling both vector...

journal_title：PLoS neglected tropical diseases

authors： George L,Lenhart A,Toledo J,Lazaro A,Han WW,Velayudhan R,Runge Ranzinger S,Horstick O

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Morbidity due to Schistosoma haematobium and hookworm infections is marked in those with intense co-infections by these parasites. The development of a spatial predictive decision-support tool is crucial for targeting the delivery of integrated mass drug administration (MDA) to those most in need. We investi...

journal_title：PLoS neglected tropical diseases

authors： Soares Magalhães RJ,Biritwum NK,Gyapong JO,Brooker S,Zhang Y,Blair L,Fenwick A,Clements AC

更新日期：2011-06-01 00:00:00

abstract：:Rabies virus kills tens of thousands of people globally each year, especially in resource-limited countries. Yet, there are genetically- and antigenically-related lyssaviruses, all capable of causing the disease rabies, circulating globally among bats without causing conspicuous disease outbreaks. The species richness...

journal_title：PLoS neglected tropical diseases

authors： Hayman DT,Fooks AR,Marston DA,Garcia-R JC

更新日期：2016-12-30 00:00:00

abstract：:Genomic data generated from clinical Vibrio cholerae O1 isolates collected over a five year period in an area of Kolkata, India with seasonal cholera outbreaks allowed a detailed genetic analysis of serotype switching that occurred from Ogawa to Inaba and back to Ogawa. The change from Ogawa to Inaba resulted from mut...

journal_title：PLoS neglected tropical diseases

authors： Karlsson SL,Thomson N,Mutreja A,Connor T,Sur D,Ali M,Clemens J,Dougan G,Holmgren J,Lebens M

更新日期：2016-10-05 00:00:00

abstract：INTRODUCTION:Individuals exposed to malaria infections for a long time develop immune responses capable of blocking Plasmodium transmission to mosquito vectors, potentially limiting parasite spreading in nature. Development of a malaria TB vaccine requires a better understanding of the mechanisms and main effectors res...

journal_title：PLoS neglected tropical diseases

authors： Vallejo AF,Rubiano K,Amado A,Krystosik AR,Herrera S,Arévalo-Herrera M

更新日期：2016-06-29 00:00:00

abstract：:The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts. What is less clear are the factors influencing the distribution of virus-specific lineages. Japanese encephalitis virus (JEV) is the most important eti...

journal_title：PLoS neglected tropical diseases

authors： Schuh AJ,Ward MJ,Brown AJ,Barrett AD

更新日期：2013-08-29 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination in Sierra Leone. Epidemiological coverage of mass drug administration (MDA) with ivermectin and albendazole had been reported >65% in all 12 districts annually. Eight districts qualified to implement transmission assessment survey (TAS) in 2013 but were d...

journal_title：PLoS neglected tropical diseases

authors： Bah YM,Paye J,Bah MS,Conteh A,Redwood-Sawyerr V,Sonnie M,Veinoglou A,Koroma JB,Hodges MH,Zhang Y

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited. METHODOLOGY/PRINCIPAL FINDINGS:Four hundred and seventy nine acutely febrile...

journal_title：PLoS neglected tropical diseases

authors： Stubbs SCB,Johar E,Yudhaputri FA,Yohan B,Santoso MS,Hayati RF,Denis D,Blacklaws BA,Powers AM,Sasmono RT,Myint KSA,Frost SDW

更新日期：2020-12-21 00:00:00

abstract：BACKGROUND:During blood feeding, sand flies inject Leishmania parasites in the presence of saliva. The types and functions of cells present at the first host-parasite contact are critical to the outcome on infection and sand fly saliva has been shown to play an important role in this setting. Herein, we investigated th...

journal_title：PLoS neglected tropical diseases

authors： de Moura TR,Oliveira F,Rodrigues GC,Carneiro MW,Fukutani KF,Novais FO,Miranda JC,Barral-Netto M,Brodskyn C,Barral A,de Oliveira CI

更新日期：2010-06-15 00:00:00

abstract：:The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characteristics make 8-oxoG a g...

journal_title：PLoS neglected tropical diseases

authors： Aguiar PH,Furtado C,Repolês BM,Ribeiro GA,Mendes IC,Peloso EF,Gadelha FR,Macedo AM,Franco GR,Pena SD,Teixeira SM,Vieira LQ,Guarneri AA,Andrade LO,Machado CR

更新日期：2013-06-13 00:00:00

abstract：:Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant maca...

journal_title：PLoS neglected tropical diseases

authors： Bidokhti MRM,Dutta D,Madduri LSV,Woollard SM,Norgren R Jr,Giavedoni L,Byrareddy SN

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:The diagnosis of canine echinococcosis can be a challenge in surveillance studies because there is no perfect gold standard that can be used routinely. However, unknown test specificities and sensitivities can be overcome using latent-class analysis with appropriate data. METHODOLOGY:We utilised a set of fa...

journal_title：PLoS neglected tropical diseases

authors： Hartnack S,Budke CM,Craig PS,Jiamin Q,Boufana B,Campos-Ponce M,Torgerson PR

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Vector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and vector control, however, much less is known about the burden of ...

journal_title：PLoS neglected tropical diseases

authors： Alroy KA,Huang C,Gilman RH,Quispe-Machaca VR,Marks MA,Ancca-Juarez J,Hillyard M,Verastegui M,Sanchez G,Cabrera L,Vidal E,Billig EM,Cama VA,Náquira C,Bern C,Levy MZ,Working Group on Chagas Disease in Peru.

更新日期：2015-05-22 00:00:00