A CATT negative result after treatment for human African trypanosomiasis is no indication for cure.

abstract：BACKGROUND:Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology has rapidly emerged as a very effective tool for gene editing. Although great advances on gene editing in the medical entomology field have arisen, no attempts of gene editing have been reported in sand flies, the vectors of L...

journal_title：PLoS neglected tropical diseases

authors： Martin-Martin I,Aryan A,Meneses C,Adelman ZN,Calvo E

更新日期：2018-09-04 00:00:00

abstract：BACKGROUND:Praziquantel-based mass treatment is the main approach to controlling schistosomiasis mansoni in endemic areas. Interventions such as provision and use of safe water, minimising contact with infested water, disposal of stool in latrines and snail control provide key avenues to break the transmission cycle an...

journal_title：PLoS neglected tropical diseases

authors： Sanya RE,Tumwesige E,Elliott AM,Seeley J

更新日期：2017-10-02 00:00:00

abstract：BACKGROUND:Dengue virus infection (DVI) among children is a leading cause of hospitalization in endemic areas. Hospitalized patients are at risk of receiving unnecessary antibiotics. METHODS:A retrospective medical review analysis study was conducted to evaluate the prevalence, indication, and choice of antibiotics gi...

journal_title：PLoS neglected tropical diseases

authors： Adrizain R,Setiabudi D,Chairulfatah A

更新日期：2019-06-21 00:00:00

abstract：:Vector control is still our primary intervention for both prevention and mitigation of epidemics of many vector-borne diseases. Efficiently targeting control measures is important since control can involve substantial economic costs. Targeting is not always straightforward, as transmission of vector-borne diseases is ...

journal_title：PLoS neglected tropical diseases

authors： Stone CM,Schwab SR,Fonseca DM,Fefferman NH

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:Between 20 and 30 bacteriologically confirmed cases of leprosy are diagnosed each year at the French National Reference Center for mycobacteria. Patients are mainly immigrants from various endemic countries or living in French overseas territories. We aimed at expanding data regarding the geographical distri...

journal_title：PLoS neglected tropical diseases

authors： Reibel F,Chauffour A,Brossier F,Jarlier V,Cambau E,Aubry A

更新日期：2015-10-06 00:00:00

abstract：:Control of arbovirus transmission remains focused on vector control through application of insecticides directly to the environment. However, these insecticide applications are often reactive interventions that can be poorly-targeted, inadequate for localized control during outbreaks, and opposed due to environmental ...

journal_title：PLoS neglected tropical diseases

authors： Nguyen C,Gray M,Burton TA,Foy SL,Foster JR,Gendernalik AL,Rückert C,Alout H,Young MC,Boze B,Ebel GD,Clapsaddle B,Foy BD

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. Pharmacological...

journal_title：PLoS neglected tropical diseases

authors： Tzertzinis G,Egaña AL,Palli SR,Robinson-Rechavi M,Gissendanner CR,Liu C,Unnasch TR,Maina CV

更新日期：2010-03-09 00:00:00

abstract：BACKGROUND:Ecological determinants of most emerging vector-borne diseases are understudied, particularly for neglected tropical disease. Moreover, although socioeconomic impacts can have significant downstream effects on human risks to vector-borne diseases via a change in land cover, particularly facilitating the inva...

journal_title：PLoS neglected tropical diseases

authors： Wei CY,Wang JK,Shih HC,Wang HC,Kuo CC

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Dengue is the most prevalent arthropod-borne viral illness in humans with half of the world's population at risk. During early infancy, severe dengue can develop after a primary dengue virus infection. There has been a clinical observation that severe dengue during the first year of life is seen only in chub...

journal_title：PLoS neglected tropical diseases

authors： Libraty DH,Wang P,Guo Z,Bigcas V,Brion JD,Capeding RZ

更新日期：2015-12-04 00:00:00

abstract：BACKGROUND:The aetiological diagnostic of fevers in Laos remains difficult due to limited laboratory diagnostic facilities. However, it has recently become apparent that both scrub and murine typhus are common causes of previous undiagnosed fever. Epidemiological data suggests that scrub typhus would be more common in ...

journal_title：PLoS neglected tropical diseases

authors： Vallée J,Thaojaikong T,Moore CE,Phetsouvanh R,Richards AL,Souris M,Fournet F,Salem G,Gonzalez JP,Newton PN

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Leprosy is a Neglected Tropical Diseases (NTDs) known to cause stigma and discrimination in low-and middle-income countries. It often results in visible impairments, thus pre-disposing to poor mental health. Aim of the study was to estimate the prevalence of depression and anxiety among people affected by Le...

journal_title：PLoS neglected tropical diseases

authors： Govindasamy K,Jacob I,Solomon RM,Darlong J

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Schistosomiasis remains a significant health burden in many areas of the world. Morbidity control, focused on limiting infection intensity through periodic delivery of anti-schistosomal medicines, is the thrust of current World Health Organization guidelines (2006) for reduction of Schistosoma-related diseas...

journal_title：PLoS neglected tropical diseases

authors： Wang X,Gurarie D,Mungai PL,Muchiri EM,Kitron U,King CH

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Dengue virus (DENV) is the most important arbovirus worldwide, causing infections in endemic countries and returning travellers from these areas. Rapid diagnostic tests are needed to improve patient management and monitor local transmission. The detection of DENV non-structural protein 1 (NS1) is a useful to...

journal_title：PLoS neglected tropical diseases

authors： Alejo-Cancho I,Navero-Castillejos J,Peiró-Mestres A,Albarracín R,Barrachina J,Navarro A,Gonzalo V,Pastor V,Muñoz J,Martínez MJ

更新日期：2020-02-18 00:00:00

abstract：:Rabies is a fatal neurologic disease caused by lyssavirus infection. Bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. The epidemiology and pathogenesis of rabies in bats are poorly understood, making it difficult to prevent zoonotic transmission. To further our unde...

journal_title：PLoS neglected tropical diseases

authors： Begeman L,Suu-Ire R,Banyard AC,Drosten C,Eggerbauer E,Freuling CM,Gibson L,Goharriz H,Horton DL,Jennings D,Marston DA,Ntiamoa-Baidu Y,Riesle Sbarbaro S,Selden D,Wise EL,Kuiken T,Fooks AR,Müller T,Wood JLN,Cunningham

更新日期：2020-12-15 00:00:00

abstract：:Rift Valley fever (RVF) is endemic in most parts of Africa and has also been reported to occur in the Arabian Peninsula. It is responsible for significant morbidity and mortality, particularly in livestock, but also in humans. During the last two decades several outbreaks of RVF have been reported in countries in Sout...

journal_title：PLoS neglected tropical diseases

authors： Fafetine J,Neves L,Thompson PN,Paweska JT,Rutten VP,Coetzer JA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents. Intense local pain is the major symptom reported after bites of P. nigriventer, although the mechanisms involved are sti...

journal_title：PLoS neglected tropical diseases

authors： Gewehr C,Oliveira SM,Rossato MF,Trevisan G,Dalmolin GD,Rigo FK,de Castro Júnior CJ,Cordeiro MN,Ferreira J,Gomez MV

更新日期：2013-04-25 00:00:00

abstract：BACKGROUND:The range of the Asian tiger mosquito Aedes albopictus is expanding globally, raising the threat of emerging and re-emerging arbovirus transmission risks including dengue and chikungunya. Its detection in Papua New Guinea's (PNG) southern Fly River coastal region in 1988 and 1992 placed it 150 km from mainla...

journal_title：PLoS neglected tropical diseases

authors： Beebe NW,Ambrose L,Hill LA,Davis JB,Hapgood G,Cooper RD,Russell RC,Ritchie SA,Reimer LJ,Lobo NF,Syafruddin D,van den Hurk AF

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:Soil-transmitted helminth (STH) infections are among the most prevalent neglected tropical diseases (NTD) worldwide. Since the publication of the WHO road map to combat NTD in 2012, there has been a renewed commitment to control STH. In this study, we analysed the geographical distribution and effect of comm...

journal_title：PLoS neglected tropical diseases

authors： Silver ZA,Kaliappan SP,Samuel P,Venugopal S,Kang G,Sarkar R,Ajjampur SSR

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:BALB/c mice are highly susceptible while C57BL/6 are relatively resistant to experimental Trypanosoma congolense infection. Although regulatory T cells (Tregs) have been shown to regulate the pathogenesis of experimental T. congolense infection, their exact role remains controversial. We wished to determine ...

journal_title：PLoS neglected tropical diseases

authors： Okwor I,Onyilagha C,Kuriakose S,Mou Z,Jia P,Uzonna JE

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although cross-sectional studies are essential to detect people exposed to rickettsiae, they are not sui...

journal_title：PLoS neglected tropical diseases

authors： Quintero Vélez JC,Aguirre-Acevedo DC,Rodas JD,Arboleda M,Troyo A,Vega Aguilar F,Osorio Quintero L,Rojas Arbeláez C

更新日期：2018-10-31 00:00:00

abstract：BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4, promoting lethal, en...

journal_title：PLoS neglected tropical diseases

authors： De Jong HK,Achouiti A,Koh GC,Parry CM,Baker S,Faiz MA,van Dissel JT,Vollaard AM,van Leeuwen EM,Roelofs JJ,de Vos AF,Roth J,van der Poll T,Vogl T,Wiersinga WJ

更新日期：2015-04-10 00:00:00

abstract：:Two recombinant Fasciola hepatica antigens, saposin-like protein-2 (recSAP2) and cathepsin L-1 (recCL1), were assessed individually and in combination in enzyme-linked immunosorbent assays (ELISA) for the specific serodiagnosis of human fasciolosis in areas of low endemicity as encountered in Central Europe. Antibody ...

journal_title：PLoS neglected tropical diseases

authors： Gottstein B,Schneeberger M,Boubaker G,Merkle B,Huber C,Spiliotis M,Müller N,Garate T,Doherr MG

更新日期：2014-06-12 00:00:00

abstract：:Visceral leishmaniasis is hypoendemic in Mediterranean countries, where it is caused by the flagellate protozoan Leishmania infantum. VL cases in this area account for 5%-6% of the global burden. Cases of Leishmania/HIV coinfection have been reported in the Mediterranean region, mainly in France, Italy, Portugal, and ...

journal_title：PLoS neglected tropical diseases

authors： Monge-Maillo B,Norman FF,Cruz I,Alvar J,López-Vélez R

更新日期：2014-08-21 00:00:00

abstract：:Non-typhoidal Salmonella (NTS) is a major global health concern that often causes bloodstream infections in areas of the world affected by malnutrition and comorbidities such as HIV and malaria. Developing a strategy to control the emergence and spread of highly invasive and antimicrobial resistant NTS isolates requir...

journal_title：PLoS neglected tropical diseases

authors： Kubicek-Sutherland JZ,Xie G,Shakya M,Dighe PK,Jacobs LL,Daligault H,Davenport K,Stromberg LR,Stromberg ZR,Cheng Q,Kempaiah P,Ong'echa JM,Otieno V,Raballah E,Anyona S,Ouma C,Chain PSG,Perkins DJ,Mukundan H,McMahon BH

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei, a Tier 1 Select Agent and the cause of melioidosis, is a Gram-negative bacillus present in the environment in many tropical countries. Defining the global pattern of B. pseudomallei distribution underpins efforts to prevent infection, and is dependent upon robust environmental samp...

journal_title：PLoS neglected tropical diseases

authors： Limmathurotsakul D,Dance DA,Wuthiekanun V,Kaestli M,Mayo M,Warner J,Wagner DM,Tuanyok A,Wertheim H,Yoke Cheng T,Mukhopadhyay C,Puthucheary S,Day NP,Steinmetz I,Currie BJ,Peacock SJ

更新日期：2013-01-01 00:00:00

abstract：:The enteric protozoa Entamoeba histolytica is the causative agent of amebiasis, which is one of the most common parasitic diseases in developed and developing countries. Entamoeba nuttalli is the genetically closest species to E. histolytica in current phylogenetic analyses of Entamoeba species, and is prevalent in wi...

journal_title：PLoS neglected tropical diseases

authors： Tanaka M,Makiuchi T,Komiyama T,Shiina T,Osaki K,Tachibana H

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is highly prevalent in the Indian state of Bihar and, without proper diagnosis and treatment, is associated with high fatality. However, lack of efficient reporting mechanism had been an impediment in estimating the burden of mortality and its antecedents among symptomatic VL case...

journal_title：PLoS neglected tropical diseases

authors： Das A,Karthick M,Dwivedi S,Banerjee I,Mahapatra T,Srikantiah S,Chaudhuri I

更新日期：2016-11-21 00:00:00

abstract：:The spread of Aedes aegypti in California and other regions of the U.S. has increased the need to understand the potential for local chains of Ae. aegypti-borne virus transmission, particularly in arid regions where the ecology of these mosquitoes is less understood. For public health and vector control programs, it i...

journal_title：PLoS neglected tropical diseases

authors： Donnelly MAP,Kluh S,Snyder RE,Barker CM

更新日期：2020-07-21 00:00:00

abstract：:Soil-transmitted helminths (STH) are a major cause of morbidity in tropical developing countries with a global infection prevalence of more than one billion people and disease burden of around 3.4 million disability adjusted life years. Infection prevalence directly correlates to inadequate sanitation, impoverished co...

journal_title：PLoS neglected tropical diseases

authors： Stracke K,Clarke N,Awburn CV,Vaz Nery S,Khieu V,Traub RJ,Jex AR

更新日期：2019-06-17 00:00:00

abstract：:Zika virus (ZIKV) is a Flavivirus (Flaviviridae) transmitted to humans mainly by the bite of an infected Aedes mosquitoes. Aedes aegypti is the primary epidemic vector of ZIKV and Ae. albopictus, the secondary one. However, the epidemiological role of both Aedes species in Central Africa where Ae. albopictus was recen...

journal_title：PLoS neglected tropical diseases

authors： Kamgang B,Vazeille M,Tedjou A,Yougang AP,Wilson-Bahun TA,Mousson L,Wondji CS,Failloux AB

更新日期：2020-03-23 00:00:00