Development and validation of a multiplexed-tandem qPCR tool for diagnostics of human soil-transmitted helminth infections.

abstract：BACKGROUND:African trypanosomosis, primarily transmitted by tsetse flies, remains a serious public health and economic challenge in sub-Saharan Africa. Interventions employing natural repellents from non-preferred hosts of tsetse flies represent a promising management approach. Although zebras have been identified as n...

journal_title：PLoS neglected tropical diseases

authors： Olaide OY,Tchouassi DP,Yusuf AA,Pirk CWW,Masiga DK,Saini RK,Torto B

更新日期：2019-06-10 00:00:00

abstract：:The major arboviral diseases in mainland China include Japanese encephalitis, dengue fever, Crimean-Congo hemorrhagic fever (also known as Xinjiang hemorrhagic fever), and tick-borne encephalitis. These and other newly found arbovirus infections due to Banna virus and Tahyna virus contribute to a large and relatively ...

journal_title：PLoS neglected tropical diseases

authors： Gao X,Nasci R,Liang G

更新日期：2010-04-27 00:00:00

abstract：:We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse ...

journal_title：PLoS neglected tropical diseases

authors： Morizot G,Jouffroy R,Faye A,Chabert P,Belhouari K,Calin R,Charlier C,Miailhes P,Siriez JY,Mouri O,Yera H,Gilquin J,Tubiana R,Lanternier F,Mamzer MF,Legendre C,Peyramond D,Caumes E,Lortholary O,Buffet P

更新日期：2016-01-06 00:00:00

abstract：:Trypanosoma cruzi has been subdivided into seven Discrete Typing Units (DTUs), TcI-TcVI and Tcbat. Two major evolutionary models have been proposed to explain the origin of hybrid lineages, but while it is widely accepted that TcV and TcVI are the result of genetic exchange between TcII and TcIII strains, the origin o...

journal_title：PLoS neglected tropical diseases

authors： Ramírez JC,Torres C,Curto MLA,Schijman AG

更新日期：2017-12-18 00:00:00

abstract：:Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to...

journal_title：PLoS neglected tropical diseases

authors： Nunes MR,Palacios G,Faria NR,Sousa EC Jr,Pantoja JA,Rodrigues SG,Carvalho VL,Medeiros DB,Savji N,Baele G,Suchard MA,Lemey P,Vasconcelos PF,Lipkin WI

更新日期：2014-04-17 00:00:00

abstract：BACKGROUND:In the Old World, sandfly species of the genus Phlebotomus are known vectors of Leishmania, Bartonella and several viruses. Recent sandfly catches and autochthonous cases of leishmaniasis hint on spreading tendencies of the vectors towards Central Europe. However, studies addressing potential future distribu...

journal_title：PLoS neglected tropical diseases

authors： Fischer D,Moeller P,Thomas SM,Naucke TJ,Beierkuhnlein C

更新日期：2011-11-01 00:00:00

abstract：:Schistosomiasis control and elimination has priority in public health agendas in several sub-Saharan countries. However, achieving these goals remains a substantial challenge. In order to assess progress of interventions and treatment efficacy it is pertinent to have accurate, feasible and affordable diagnostic tools....

journal_title：PLoS neglected tropical diseases

authors： Kildemoes AO,Vennervald BJ,Tukahebwa EM,Kabatereine NB,Magnussen P,de Dood CJ,Deelder AM,Wilson S,van Dam GJ

更新日期：2017-11-13 00:00:00

abstract：:In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, the epidemiological trend in Chin...

journal_title：PLoS neglected tropical diseases

authors： Liang H,Zheng L,Xia H,Tang J

更新日期：2020-08-06 00:00:00

abstract：:Approximately 300,000 persons in the United States (US) are infected with Trypanosoma cruzi, the protozoan that causes Chagas disease, but less than 1% are estimated to have received antiparasitic treatment. Benznidazole was approved by the US Food and Drug Administration (FDA) for treatment of T. cruzi infection in 2...

journal_title：PLoS neglected tropical diseases

authors： Yoshioka K,Manne-Goehler J,Maguire JH,Reich MR

更新日期：2020-06-22 00:00:00

abstract：:Snakebite is a neglected tropical disease with significant morbidity and mortality. Thrombotic microangiopathy (TMA) is an important but poorly understood complication of snakebite associated with acute kidney injury (AKI). Numerous treatments have been attempted based on limited evidence. We conducted a systematic re...

journal_title：PLoS neglected tropical diseases

authors： Noutsos T,Currie BJ,Lek RA,Isbister GK

更新日期：2020-12-08 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries. Efficient delivery of these toxins requires ETEC to engage target host enterocytes. This engagement is accomplished using a va...

journal_title：PLoS neglected tropical diseases

authors： Sheikh A,Rashu R,Begum YA,Kuhlman FM,Ciorba MA,Hultgren SJ,Qadri F,Fleckenstein JM

更新日期：2017-05-22 00:00:00

abstract：INTRODUCTION:While we lack a complete understanding of the molecular mechanisms by which parasites establish and achieve protection from host immune responses, it is accepted that many of these processes are mediated by products, primarily proteins, released from the parasite. Parasitic nematodes occur in different lif...

journal_title：PLoS neglected tropical diseases

authors： Moreno Y,Geary TG

更新日期：2008-01-01 00:00:00

abstract：:Human excreta is a low cost source of nutrients vital to plant growth, but also a source of pathogens transmissible to people and animals. We investigated the cost-savings and infection risk of soil transmitted helminths (STHs) in four scenarios where farmers used either inorganic fertilizer or fresh/composted human e...

journal_title：PLoS neglected tropical diseases

authors： Tran-Thi N,Lowe RJ,Schurer JM,Vu-Van T,MacDonald LE,Pham-Duc P

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:Human alveolar echinococcosis (AE) is known to be common in certain rural communities in China whilst it is generally rare and sporadic elsewhere. The objective of this study was to provide a first estimate of the global incidence of this disease by country. The second objective was to estimate the global di...

journal_title：PLoS neglected tropical diseases

authors： Torgerson PR,Keller K,Magnotta M,Ragland N

更新日期：2010-06-22 00:00:00

abstract：:Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. East Africa and t...

journal_title：PLoS neglected tropical diseases

authors： Akuffo H,Costa C,van Griensven J,Burza S,Moreno J,Herrero M

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:Chagas disease is one of the most important neglected tropical diseases in the Americas. Vectorborne transmission of Chagas disease has been historically rare in urban settings. However, in marginal communities near the city of Arequipa, Peru, urban transmission cycles have become established. We examined th...

journal_title：PLoS neglected tropical diseases

authors： Bayer AM,Hunter GC,Gilman RH,Cornejo Del Carpio JG,Naquira C,Bern C,Levy MZ

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Rabies is a fatal encephalitis caused by viruses belonging to the genus Lyssavirus of the family Rhabdoviridae. It is a viral disease primarily affecting mammals, though all warm blooded animals are susceptible. Experimental rabies virus infection in birds has been reported, but naturally occurring infection...

journal_title：PLoS neglected tropical diseases

authors： Baby J,Mani RS,Abraham SS,Thankappan AT,Pillai PM,Anand AM,Madhusudana SN,Ramachandran J,Sreekumar S

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Dengue is the most prevalent arthropod-borne viral illness in humans with half of the world's population at risk. During early infancy, severe dengue can develop after a primary dengue virus infection. There has been a clinical observation that severe dengue during the first year of life is seen only in chub...

journal_title：PLoS neglected tropical diseases

authors： Libraty DH,Wang P,Guo Z,Bigcas V,Brion JD,Capeding RZ

更新日期：2015-12-04 00:00:00

abstract：BACKGROUND:Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distribution remains highly uncertain. Challenges in diagnosis and diagnostic methods as well as highly variable national health systems mean no single data source can reliably estimate the distribution o...

journal_title：PLoS neglected tropical diseases

authors： Brady OJ,Gething PW,Bhatt S,Messina JP,Brownstein JS,Hoen AG,Moyes CL,Farlow AW,Scott TW,Hay SI

更新日期：2012-01-01 00:00:00

abstract：:Nipah virus (NiV) is a paramyxovirus (genus Henipavirus) that emerged in the late 1990s in Malaysia and has since been identified as the cause of sporadic outbreaks of severe febrile disease in Bangladesh and India. NiV infection is frequently associated with severe respiratory or neurological disease in infected huma...

journal_title：PLoS neglected tropical diseases

authors： Cong Y,Lentz MR,Lara A,Alexander I,Bartos C,Bohannon JK,Hammoud D,Huzella L,Jahrling PB,Janosko K,Jett C,Kollins E,Lackemeyer M,Mollura D,Ragland D,Rojas O,Solomon J,Xu Z,Munster V,Holbrook MR

更新日期：2017-04-07 00:00:00

abstract：BACKGROUND:Molecular diagnostics has become essential in the identification of many infectious and neglected diseases, and the detection of nucleic acids often serves as the gold standard technique for most infectious agents. However, established techniques like polymerase chain reaction (PCR) are time-consuming labora...

journal_title：PLoS neglected tropical diseases

authors： Müller K,Daßen S,Holowachuk S,Zwirglmaier K,Stehr J,Buersgens F,Ullerich L,Stoecker K

更新日期：2021-01-29 00:00:00

abstract：:Strongyloidiasis is a much-neglected but sometimes fatal soil born helminthiasis. The causing agent, the small intestinal parasitic nematode Strongyloides stercoralis can reproduce sexually through the indirect/heterogonic life cycle, or asexually through the auto-infective or the direct/homogonic life cycles. Usually...

journal_title：PLoS neglected tropical diseases

authors： Zhou S,Fu X,Pei P,Kucka M,Liu J,Tang L,Zhan T,He S,Chan YF,Rödelsperger C,Liu D,Streit A

更新日期：2019-05-06 00:00:00

abstract：:One of the stated goals of the London Declaration on Neglected Tropical Diseases is the interruption of domiciliary transmissions of Chagas disease in the region of the Americas. We used a game-theoretic approach to assess the voluntary use of insecticide treated nets (ITNs) in the prevention of the spread of infectio...

journal_title：PLoS neglected tropical diseases

authors： Han CY,Issa H,Rychtář J,Taylor D,Umana N

更新日期：2020-11-03 00:00:00

abstract：:Clinical manifestations in onchocerciasis range from generalized onchocerciasis (GEO) to the rare but severe hyperreactive (HO)/sowda form. Since disease pathogenesis is associated with host inflammatory reactions, we investigated whether Th17 responses could be related to aggravated pathology in HO. Using flow cytome...

journal_title：PLoS neglected tropical diseases

authors： Katawa G,Layland LE,Debrah AY,von Horn C,Batsa L,Kwarteng A,Arriens S,W Taylor D,Specht S,Hoerauf A,Adjobimey T

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Anti-leishmanial drug regimens that include a single dose AmBisome could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the appropriate single dose is unknown. METHODOLOGY:A multi-centre, open-label, non-inferiority, randomized controlled trial with an adaptive des...

journal_title：PLoS neglected tropical diseases

authors： Khalil EA,Weldegebreal T,Younis BM,Omollo R,Musa AM,Hailu W,Abuzaid AA,Dorlo TP,Hurissa Z,Yifru S,Haleke W,Smith PG,Ellis S,Balasegaram M,EL-Hassan AM,Schoone GJ,Wasunna M,Kimutai R,Edwards T,Hailu A

更新日期：2014-01-16 00:00:00

abstract：BACKGROUND:Many small studies have been done in Honduras estimating soil-transmitted helminthiasis (STH) prevalence but a country-wide study was last done in 2005. The country has the highest burden of malaria among all Central American countries. The present study was done to estimate country-wide STH prevalence and i...

journal_title：PLoS neglected tropical diseases

authors： Mejia Torres RE,Franco Garcia DN,Fontecha Sandoval GA,Hernandez Santana A,Singh P,Mancero Bucheli ST,Saboya M,Paz MY

更新日期：2014-10-16 00:00:00

abstract：AUTHOR SUMMARY:Designing and implementing effective programs for infectious disease control requires complex decision-making, informed by an understanding of the diseases, the types of disease interventions and control measures available, and the disease-relevant characteristics of the local community. Though disease m...

journal_title：PLoS neglected tropical diseases

authors： Standley CJ,Graeden E,Kerr J,Sorrell EM,Katz R

更新日期：2018-04-12 00:00:00

abstract：BACKGROUND:Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is comp...

journal_title：PLoS neglected tropical diseases

authors： Lestinova T,Rohousova I,Sima M,de Oliveira CI,Volf P

更新日期：2017-07-13 00:00:00

abstract：BACKGROUND:Although infection with Trypanosoma cruzi is thought to be lifelong, less than half of those infected develop cardiomyopathy, suggesting greater parasite control or even clearance. Antibody levels appear to correlate with T. cruzi (antigen) load. We test the association between a downwards antibody trajector...

journal_title：PLoS neglected tropical diseases

authors： Buss LF,Campos de Oliveira-da Silva L,Moreira CHV,Manuli ER,Sales FC,Morales I,Di Germanio C,de Almeida-Neto C,Bakkour S,Constable P,Pinto-Filho MM,Ribeiro AL,Busch M,Sabino EC

更新日期：2020-10-27 00:00:00

abstract：:Dengue appears to be endemic in Africa with a number of reported outbreaks. In February 2013, several individuals with dengue-like illnesses and negative malaria blood smears were identified in Mombasa, Kenya. Dengue was laboratory confirmed and an investigation was conducted to estimate the magnitude of local transmi...

journal_title：PLoS neglected tropical diseases

authors： Ellis EM,Neatherlin JC,Delorey M,Ochieng M,Mohamed AH,Mogeni DO,Hunsperger E,Patta S,Gikunju S,Waiboic L,Fields B,Ofula V,Konongoi SL,Torres-Velasquez B,Marano N,Sang R,Margolis HS,Montgomery JM,Tomashek KM

更新日期：2015-04-29 00:00:00