Decision support for evidence-based integration of disease control: A proof of concept for malaria and schistosomiasis.

abstract：BACKGROUND:Scrub typhus is a neglected tropical disease that causes acute febrile illness. Diagnosis is made based upon serology, or detection of the causative agent-Orientia tsutsugamushi-using PCR or in vitro isolation. The enzyme-linked immunosorbent assay (ELISA) is an objective and reproducible means of detecting ...

journal_title：PLoS neglected tropical diseases

authors： Saraswati K,Phanichkrivalkosil M,Day NPJ,Blacksell SD

更新日期：2019-02-04 00:00:00

abstract：BACKGROUND:The neglected tropical disease Buruli ulcer (BU) caused by Mycobacterium ulcerans is an infection of the subcutaneous tissue leading to chronic ulcerative skin lesions. Histopathological features are progressive tissue necrosis, extracellular clusters of acid fast bacilli (AFB) and poor inflammatory response...

journal_title：PLoS neglected tropical diseases

authors： Ruf MT,Chauty A,Adeye A,Ardant MF,Koussemou H,Johnson RC,Pluschke G

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The genus Trichuris includes parasites of major relevance in veterinary and human medicine. Despite serious economic losses and enormous impact on public health, treatment options against whipworms are very limited. Additionally, there is an obvious lack of appropriately characterized experimental infection ...

journal_title：PLoS neglected tropical diseases

authors： Kulke D,Krücken J,Harder A,von Samson-Himmelstjerna G

更新日期：2014-02-20 00:00:00

abstract：BACKGROUND:Diagnosis of human African trypanosomiasis (HAT) remains a challenge both for active screening, which is critical in control of the disease, and in the point-of-care scenario where early and accurate diagnosis is essential. Recently, the first field deployment of a lateral flow rapid diagnostic test (RDT) fo...

journal_title：PLoS neglected tropical diseases

authors： Sternberg JM,Gierliński M,Biéler S,Ferguson MA,Ndung'u JM

更新日期：2014-12-18 00:00:00

abstract：:In this communication, a case of black grain eumycetoma produced by the fungus C. atrobrunneum is reported. The patient was initially misdiagnosed with M. mycetomatis eumycetoma based on the grains' morphological and cytological features. However, further aerobic culture of the black grains generated a melanised fungu...

journal_title：PLoS neglected tropical diseases

authors： Mhmoud NA,Santona A,Fiamma M,Siddig EE,Deligios M,Bakhiet SM,Rubino S,Fahal AH

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:treatment of Mycobacterium ulcerans disease, or Buruli ulcer (BU), has shifted from surgery to treatment with streptomycin(STR)+rifampin(RIF) since 2004 based on studies in a mouse model and clinical trials. We tested two entirely oral regimens for BU treatment, rifampin(RIF)+clarithromycin(CLR) and rifapent...

journal_title：PLoS neglected tropical diseases

authors： Almeida D,Converse PJ,Ahmad Z,Dooley KE,Nuermberger EL,Grosset JH

更新日期：2011-01-04 00:00:00

abstract：:Dengue virus transmission is endemic in Makassar, Indonesia, with the majority of cases reported soon after the start of the annual rainy season. Before 2006, larval source reduction, larvaciding, and reactive routine, outdoor, insecticide fogging campaigns did not result in a reduction in seasonal dengue incidence. B...

journal_title：PLoS neglected tropical diseases

authors： Wahid I,Ishak H,Hafid A,Fajri M,Sidjal S,Nurdin A,Azikin NT,Sudirman R,Hasan H,Yusuf M,Bachtiar I,Hawley WA,Rosenberg R,Lobo NF

更新日期：2019-08-05 00:00:00

abstract：:Dengue, a vector-borne disease spread by Aedes mosquitoes, is a global threat. In the absence of an efficacious dengue vaccine, vector control is the key intervention tool in Singapore. A good understanding of vector habitats is essential to formulate operational strategies. We examined the distribution, long-term tre...

journal_title：PLoS neglected tropical diseases

authors： Rajarethinam J,Ong J,Neo ZW,Ng LC,Aik J

更新日期：2020-04-20 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is a soil saprophytic bacterium that causes melioidosis. The infection occurs through cutaneous inoculation, inhalation or ingestion. Bacteriophages (phages) in the same ecosystem may significantly impact the biology of this bacterium in the environment, and in their culturability i...

journal_title：PLoS neglected tropical diseases

authors： Withatanung P,Chantratita N,Muangsombut V,Saiprom N,Lertmemongkolchai G,Klumpp J,Clokie MR,Galyov EE,Korbsrisate S

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is a life-threatening disease caused by protozoan parasites of the Leishmania donovani complex. Early case detection followed by adequate treatment is essential to the control of VL. However, the available diagnostic tests are either invasive and require considerable expertise (pa...

journal_title：PLoS neglected tropical diseases

authors： Gao CH,Yang YT,Shi F,Wang JY,Steverding D,Wang X

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:Schistosomiasis remains a global public health challenge, with 93% of the ~237 million infections occurring in sub-Saharan Africa. Though rarely fatal, its recurring nature makes it a lifetime disorder with significant chronic health burdens. Much of its negative health impact is due to non-specific conditio...

journal_title：PLoS neglected tropical diseases

authors： Terer CC,Bustinduy AL,Magtanong RV,Muhoho N,Mungai PL,Muchiri EM,Kitron U,King CH,Mutuku FM

更新日期：2013-01-01 00:00:00

abstract：:Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manif...

journal_title：PLoS neglected tropical diseases

authors： Mitjà O,Šmajs D,Bassat Q

更新日期：2013-10-24 00:00:00

abstract：INTRODUCTION:Plasmodium knowlesi is now recognised as a leading cause of malaria in Malaysia. As humans come into increasing contact with the reservoir host (long-tailed macaques) as a consequence of deforestation, assessing the potential for a shift from zoonotic to sustained P. knowlesi transmission between humans is...

journal_title：PLoS neglected tropical diseases

authors： Imai N,White MT,Ghani AC,Drakeley CJ

更新日期：2014-07-24 00:00:00

abstract：:Entamoeba histolytica infection may have various clinical manifestations. Nine out of ten E. histolytica infections remain asymptomatic, while the remainder become invasive and cause disease. The most common form of invasive infection is amebic diarrhea and colitis, whereas the most common extra-intestinal disease is ...

journal_title：PLoS neglected tropical diseases

authors： Ali IK,Solaymani-Mohammadi S,Akhter J,Roy S,Gorrini C,Calderaro A,Parker SK,Haque R,Petri WA Jr,Clark CG

更新日期：2008-04-09 00:00:00

abstract：:Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After ...

journal_title：PLoS neglected tropical diseases

authors： El Baidouri F,Diancourt L,Berry V,Chevenet F,Pratlong F,Marty P,Ravel C

更新日期：2013-06-13 00:00:00

abstract：:Most studies evaluating epidemiologic relationships between helminths and HIV have been conducted in the pre-ART era, and evidence of the impact of helminth infections on HIV disease progression remains conflicting. Less is known about helminth infection and clinical outcomes in HIV-infected adults receiving antiretro...

journal_title：PLoS neglected tropical diseases

authors： Morawski BM,Yunus M,Kerukadho E,Turyasingura G,Barbra L,Ojok AM,DiNardo AR,Sowinski S,Boulware DR,Mejia R

更新日期：2017-05-25 00:00:00

abstract：BACKGROUND:Opisthorchis felineus, O. viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose a serious threat to humans in some countries and cause opisthorchiasis/clonorchiasis. Chronic disease may lead to a risk of carcinogenesis in the biliary ducts. MicroRNAs (miRNAs) are small...

journal_title：PLoS neglected tropical diseases

authors： Ovchinnikov VY,Afonnikov DA,Vasiliev GV,Kashina EV,Sripa B,Mordvinov VA,Katokhin AV

更新日期：2015-04-21 00:00:00

abstract：BACKGROUND:Schistosomiasis in one of the most prevalent parasitic diseases, affecting millions of people and animals in developing countries. Amongst the human-infective species S. haematobium is one of the most widespread causing urogenital schistosomiasis, a major human health problem across Africa, however in terms ...

journal_title：PLoS neglected tropical diseases

authors： Webster BL,Emery AM,Webster JP,Gouvras A,Garba A,Diaw O,Seye MM,Tchuente LA,Simoonga C,Mwanga J,Lange C,Kariuki C,Mohammed KA,Stothard JR,Rollinson D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hookworm infections are an important cause of (severe) anemia and iron deficiency in children in the tropics. Type of hookworm species (Ancylostoma duodenale or Necator americanus) and infection load are considered associated with disease burden, although these parameters are rarely assessed due to limitatio...

journal_title：PLoS neglected tropical diseases

authors： Jonker FA,Calis JC,Phiri K,Brienen EA,Khoffi H,Brabin BJ,Verweij JJ,van Hensbroek MB,van Lieshout L

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The immune response in the skin of dogs infected with Leishmania infantum is poorly understood, and limited studies have described the immunopathological profile with regard to distinct levels of tissue parasitism and the clinical progression of canine visceral leishmaniasis (CVL). METHODOLOGY/PRINCIPAL FIN...

journal_title：PLoS neglected tropical diseases

authors： Menezes-Souza D,Guerra-Sá R,Carneiro CM,Vitoriano-Souza J,Giunchetti RC,Teixeira-Carvalho A,Silveira-Lemos D,Oliveira GC,Corrêa-Oliveira R,Reis AB

更新日期：2012-01-01 00:00:00

abstract：:The interaction between Plasmodium vivax Duffy binding protein (PvDBP) and Duffy antigen receptor for chemokines (DARC) has been described as critical for the invasion of human reticulocytes, although increasing reports of P. vivax infections in Duffy-negative individuals questions its unique role. To investigate the ...

journal_title：PLoS neglected tropical diseases

authors： Roesch C,Popovici J,Bin S,Run V,Kim S,Ramboarina S,Rakotomalala E,Rakotoarison RL,Rasoloharimanana T,Andriamanantena Z,Kumar A,Guillotte-Blisnick M,Huon C,Serre D,Chitnis CE,Vigan-Womas I,Menard D

更新日期：2018-10-22 00:00:00

abstract：:ELISA-based methods of detecting Fasciola cathepsins in feces are powerful techniques for diagnosing infections by F. hepatica and F. gigantica. In the last decade, the in-house MM3-COPRO ELISA and its commercial version BIO K 201 (BIO X Diagnostics, Belgium) have been recognized as useful tools for detecting early in...

journal_title：PLoS neglected tropical diseases

authors： Martínez-Sernández V,Orbegozo-Medina RA,González-Warleta M,Mezo M,Ubeira FM

更新日期：2016-07-20 00:00:00

abstract：:In a cross sectional study, 19 French and 23 Colombian cases of confirmed active ocular toxoplasmosis (OT) were evaluated. The objective was to compare clinical, parasitological and immunological responses and relate them to the infecting strains. A complete ocular examination was performed in each patient. The infect...

journal_title：PLoS neglected tropical diseases

authors： de-la-Torre A,Sauer A,Pfaff AW,Bourcier T,Brunet J,Speeg-Schatz C,Ballonzoli L,Villard O,Ajzenberg D,Sundar N,Grigg ME,Gomez-Marin JE,Candolfi E

更新日期：2013-11-21 00:00:00

abstract：:Vector control is still our primary intervention for both prevention and mitigation of epidemics of many vector-borne diseases. Efficiently targeting control measures is important since control can involve substantial economic costs. Targeting is not always straightforward, as transmission of vector-borne diseases is ...

journal_title：PLoS neglected tropical diseases

authors： Stone CM,Schwab SR,Fonseca DM,Fefferman NH

更新日期：2019-07-03 00:00:00

abstract：:For scientists working on gonochoric organisms, determining sex can be crucial for many biological questions and experimental studies, such as crossbreeding, but it can also be a challenging task, particularly when no sexual dimorphism is visible or cannot be directly observed. In metazoan parasites of the genus Schis...

journal_title：PLoS neglected tropical diseases

authors： Kincaid-Smith J,Boissier J,Allienne JF,Oleaga A,Djuikwo-Teukeng F,Toulza E

更新日期：2016-11-18 00:00:00

abstract：BACKGROUND:The mosquito resistance to the insecticides threatens malaria control efforts, potentially becoming a major public health issue. Alternative methods like ivermectin (IVM) administration to humans has been suggested as a possible vector control to reduce Plasmodium transmission. Anopheles aquasalis and Anophe...

journal_title：PLoS neglected tropical diseases

authors： Pinilla YT,C P Lopes S,S Sampaio V,Andrade FS,Melo GC,Orfanó AS,Secundino NFC,Guerra MGVB,Lacerda MVG,Kobylinski KC,Escobedo-Vargas KS,López-Sifuentes VM,Stoops CA,Baldeviano GC,Tarning J,Vasquez GM,Pimenta PFP,Monteiro

更新日期：2018-02-14 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL or kala azar) is the most serious form of human leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal leishmaniasis (PKDL) is a stigmatizing skin condition that often occurs in patients after successful treatment for VL. Lack of effective or appropri...

journal_title：PLoS neglected tropical diseases

authors： Osman M,Mistry A,Keding A,Gabe R,Cook E,Forrester S,Wiggins R,Di Marco S,Colloca S,Siani L,Cortese R,Smith DF,Aebischer T,Kaye PM,Lacey CJ

更新日期：2017-05-12 00:00:00

abstract：BACKGROUND:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") st...

journal_title：PLoS neglected tropical diseases

authors： Bisoffi Z,Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Gobbo M,Bonafini S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:Patients with Chagas disease have migrated to cities, where obesity, hypertension and other cardiac risk factors are common. METHODOLOGY/PRINCIPAL FINDINGS:The study included adult patients evaluated by the cardiology service in a public hospital in Santa Cruz, Bolivia. Data included risk factors for T. cru...

journal_title：PLoS neglected tropical diseases

authors： Hidron AI,Gilman RH,Justiniano J,Blackstock AJ,Lafuente C,Selum W,Calderon M,Verastegui M,Ferrufino L,Valencia E,Tornheim JA,O'Neal S,Comer R,Galdos-Cardenas G,Bern C,Chagas Disease Working Group in Peru and Bolivia.

更新日期：2010-05-18 00:00:00

abstract：BACKGROUND:Phlebotomus tobbi is a vector of Leishmania infantum, and P. sergenti is a vector of Leishmania tropica. Le. infantum and Le. tropica typically cause visceral or cutaneous leishmaniasis, respectively, but Le. infantum strains transmitted by P. tobbi can cause cutaneous disease. To better understand the compo...

journal_title：PLoS neglected tropical diseases

authors： Rohoušová I,Subrahmanyam S,Volfová V,Mu J,Volf P,Valenzuela JG,Jochim RC

更新日期：2012-01-01 00:00:00