SARS-CoV-2 infection in China-Before the pandemic.

Abstract:

:In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, the epidemiological trend in China and impact of interventional measures, and some lessons learned. We concluded that the epidemic is containable with traditional nonpharmacological interventions, mainly through social distancing and finding and isolating suspected patients and close contacts. Nonpharmacological interventions are the only effective measures currently accessible and have suppressed some 90% of the infections in China. Close contacts are the major mechanism of transmission, which makes it possible to control this epidemic through nonpharmacological methods. Nucleic-acid testing alone may miss some 50% of infected patients, and other methods such as chest computerized tomography (CT) or serology should be considered to supplement molecular testing. The development of vaccines and drugs is important, but hesitation to make use of nonpharmacological interventions may mean missing golden opportunities for effective actions.

journal_name

PLoS Negl Trop Dis

authors

Liang H,Zheng L,Xia H,Tang J

doi

10.1371/journal.pntd.0008472

subject

Has Abstract

pub_date

2020-08-06 00:00:00

pages

e0008472

issue

8

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-20-00636

journal_volume

14

pub_type

杂志文章,评审
  • Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection.

    abstract:BACKGROUND:Increased vascular permeability is a hallmark feature in severe dengue virus (DV) infection, and dysfunction of endothelial cells has been speculated to contribute in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Rho-family GTPase Rac1 is a significant element of endothelial b...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0000809

    authors: Wang JL,Zhang JL,Chen W,Xu XF,Gao N,Fan DY,An J

    更新日期:2010-08-31 00:00:00

  • Geospatial analysis of tegumentary leishmaniasis in Rio de Janeiro state, Brazil from 2000 to 2015: Species typing and flow of travelers and migrants with leishmaniasis.

    abstract:BACKGROUND:We identified the species of Leishmania isolated from traveling and migrant patients attended in a reference center from 2000 to 2015, we performed the georeferencing of these species in Rio de Janeiro (RJ) state and we had knowledge about the human flows between the likely location of infection (LLI) and pl...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0007748

    authors: Miranda LFC,Pacheco RDS,Pimentel MIF,Salgueiro MM,da Silva AF,de Mello CX,Barros JHDS,Valete-Rosalino CM,Madeira MF,Xavier SCDC,Schubach AO

    更新日期:2019-11-15 00:00:00

  • An agent-based model of tsetse fly response to seasonal climatic drivers: Assessing the impact on sleeping sickness transmission rates.

    abstract:BACKGROUND:This paper presents the development of an agent-based model (ABM) to incorporate climatic drivers which affect tsetse fly (G. m. morsitans) population dynamics, and ultimately disease transmission. The model was used to gain a greater understanding of how tsetse populations fluctuate seasonally, and investig...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006188

    authors: Alderton S,Macleod ET,Anderson NE,Palmer G,Machila N,Simuunza M,Welburn SC,Atkinson PM

    更新日期:2018-02-09 00:00:00

  • Optimization of sand fly embryo microinjection for gene editing by CRISPR/Cas9.

    abstract:BACKGROUND:Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology has rapidly emerged as a very effective tool for gene editing. Although great advances on gene editing in the medical entomology field have arisen, no attempts of gene editing have been reported in sand flies, the vectors of L...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006769

    authors: Martin-Martin I,Aryan A,Meneses C,Adelman ZN,Calvo E

    更新日期:2018-09-04 00:00:00

  • Hookworm infection and environmental factors in mbeya region, Tanzania: a cross-sectional, population-based study.

    abstract:BACKGROUND:Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. METHODOLOGY:Cross-sectional interview data and stool s...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0002408

    authors: Riess H,Clowes P,Kroidl I,Kowuor DO,Nsojo A,Mangu C,Schüle SA,Mansmann U,Geldmacher C,Mhina S,Maboko L,Hoelscher M,Saathoff E

    更新日期:2013-09-05 00:00:00

  • Trypanosoma cruzi I and IV stocks from Brazilian Amazon are divergent in terms of biological and medical properties in mice.

    abstract:BACKGROUND:In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0002069

    authors: Monteiro WM,Margioto Teston AP,Gruendling AP,dos Reis D,Gomes ML,de Araújo SM,Bahia MT,Magalhães LK,de Oliveira Guerra JA,Silveira H,Toledo MJ,Vale Barbosa Md

    更新日期:2013-01-01 00:00:00

  • Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin.

    abstract::Leishmaniasis is a serious global health problem affecting many people worldwide. While patients with leishmaniasis can be treated with several agents, drug toxicicty and the emergence of resistant strains render available treatments ineffective in the long run. Inhibitors of the mammalian target of rapamycin (mTOR) h...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006701

    authors: Khadir F,Shaler CR,Oryan A,Rudak PT,Mazzuca DM,Taheri T,Dikeakos JD,Haeryfar SMM,Rafati S

    更新日期:2018-08-22 00:00:00

  • Source tracking Mycobacterium ulcerans infections in the Ashanti region, Ghana.

    abstract::Although several studies have associated Mycobacterium ulcerans (MU) infection, Buruli ulcer (BU), with slow moving water bodies, there is still no definite mode of transmission. Ecological and transmission studies suggest Variable Number Tandem Repeat (VNTR) typing as a useful tool to differentiate MU strains from ot...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0003437

    authors: Narh CA,Mosi L,Quaye C,Dassi C,Konan DO,Tay SC,de Souza DK,Boakye DA,Bonfoh B

    更新日期:2015-01-22 00:00:00

  • Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis.

    abstract::The metacestode (larval) stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), a very severe and in many cases incurable disease. To date, benzimidazoles such as albendazole and mebendazole are the only approved chemotherapeutical treatment options. Benzimidazoles inhibit metacestode p...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0004535

    authors: Stadelmann B,Rufener R,Aeschbacher D,Spiliotis M,Gottstein B,Hemphill A

    更新日期:2016-03-11 00:00:00

  • Syndromic Approach to Arboviral Diagnostics for Global Travelers as a Basis for Infectious Disease Surveillance.

    abstract:BACKGROUND:Arboviruses have overlapping geographical distributions and can cause symptoms that coincide with more common infections. Therefore, arbovirus infections are often neglected by travel diagnostics. Here, we assessed the potential of syndrome-based approaches for diagnosis and surveillance of neglected arbovir...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0004073

    authors: Cleton NB,Reusken CB,Wagenaar JF,van der Vaart EE,Reimerink J,van der Eijk AA,Koopmans MP

    更新日期:2015-09-15 00:00:00

  • Mycetoma in Uganda: A neglected tropical disease.

    abstract::Mycetoma is considered a neglected tropical disease globally. However, data on its burden and the associated complications in Uganda are limited. Hence we aimed to estimate its burden in Uganda. Firstly, a systematic PubMed search for all studies of any design on mycetoma in Uganda without restriction to the year of p...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0008240

    authors: Kwizera R,Bongomin F,Meya DB,Denning DW,Fahal AH,Lukande R

    更新日期:2020-04-29 00:00:00

  • Vaccination with a chikungunya virus-like particle vaccine exacerbates disease in aged mice.

    abstract:INTRODUCTION:Chikungunya virus (CHIKV) is a re-emerging pathogen responsible for causing outbreaks of febrile disease accompanied with debilitating joint pain. Symptoms typically persist for two weeks, but more severe and chronic chikungunya illnesses have been reported, especially in the elderly. Currently, there are ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0007316

    authors: Arévalo MT,Huang Y,Jones CA,Ross TM

    更新日期:2019-04-26 00:00:00

  • Zebra skin odor repels the savannah tsetse fly, Glossina pallidipes (Diptera: Glossinidae).

    abstract:BACKGROUND:African trypanosomosis, primarily transmitted by tsetse flies, remains a serious public health and economic challenge in sub-Saharan Africa. Interventions employing natural repellents from non-preferred hosts of tsetse flies represent a promising management approach. Although zebras have been identified as n...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0007460

    authors: Olaide OY,Tchouassi DP,Yusuf AA,Pirk CWW,Masiga DK,Saini RK,Torto B

    更新日期:2019-06-10 00:00:00

  • Loss in lung volume and changes in the immune response demonstrate disease progression in African green monkeys infected by small-particle aerosol and intratracheal exposure to Nipah virus.

    abstract::Nipah virus (NiV) is a paramyxovirus (genus Henipavirus) that emerged in the late 1990s in Malaysia and has since been identified as the cause of sporadic outbreaks of severe febrile disease in Bangladesh and India. NiV infection is frequently associated with severe respiratory or neurological disease in infected huma...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0005532

    authors: Cong Y,Lentz MR,Lara A,Alexander I,Bartos C,Bohannon JK,Hammoud D,Huzella L,Jahrling PB,Janosko K,Jett C,Kollins E,Lackemeyer M,Mollura D,Ragland D,Rojas O,Solomon J,Xu Z,Munster V,Holbrook MR

    更新日期:2017-04-07 00:00:00

  • The public health benefit and burden of mass drug administration programs in Vietnamese schoolchildren: Impact of mebendazole.

    abstract:BACKGROUND:Mass anthelmintic drug administration is recommended in developing countries to address infection by soil-transmitted helminthiases (STH). We quantified the public health benefit of treatment with mebendazole in eight million Vietnamese children aged 5-14 years from 2006 to 2011. This was compared to the env...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006954

    authors: Debaveye S,Gonzalez Torres CV,De Smedt D,Heirman B,Kavanagh S,Dewulf J

    更新日期:2018-11-12 00:00:00

  • Comprehensive Transcriptome Analysis of Sex-Biased Expressed Genes Reveals Discrete Biological and Physiological Features of Male and Female Schistosoma japonicum.

    abstract::Schistosomiasis is a chronic and debilitating disease caused by blood flukes (digenetic trematodes) of the genus Schistosoma. Schistosomes are sexually dimorphic and exhibit dramatic morphological changes during a complex lifecycle which requires subtle gene regulatory mechanisms to fulfil these complex biological pro...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0004684

    authors: Cai P,Liu S,Piao X,Hou N,Gobert GN,McManus DP,Chen Q

    更新日期:2016-04-29 00:00:00

  • Fulminant Amebic Colitis after Corticosteroid Therapy: A Systematic Review.

    abstract:BACKGROUND:Amebic colitis, caused by intestinal infection with the parasite, Entamoeba histolytica, is a common cause of diarrhea worldwide. Fulminant amebic colitis is the most devastating complication of this infection, associated with both high mortality and morbidity. We conducted a review of the English literature...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,评审

    doi:10.1371/journal.pntd.0004879

    authors: Shirley DA,Moonah S

    更新日期:2016-07-28 00:00:00

  • A novel animal model of Borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice.

    abstract::Louse-borne relapsing fever (LBRF) borreliosis is caused by Borrelia recurrentis, and it is a deadly although treatable disease that is endemic in the Horn of Africa but has epidemic potential. Research on LBRF has been severely hampered because successful infection with B. recurrentis has been achieved only in primat...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0000522

    authors: Larsson C,Lundqvist J,van Rooijen N,Bergström S

    更新日期:2009-09-29 00:00:00

  • Blockade of dengue virus transmission from viremic blood to Aedes aegypti mosquitoes using human monoclonal antibodies.

    abstract:BACKGROUND:Dengue is the most prevalent arboviral disease of humans. Virus neutralizing antibodies are likely to be critical for clinical immunity after vaccination or natural infection. A number of human monoclonal antibodies (mAbs) have previously been characterized as able to neutralize the infectivity of dengue vir...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0007142

    authors: Tuan Vu T,Clapham H,Huynh VTT,Vo Thi L,Le Thi D,Vu NT,Nguyen GT,Huynh TTX,Duong KTH,Tran VT,Huynh HLA,Le Huynh DT,Huynh TLP,Nguyen TTV,Nguyen NM,Luong TTH,Phong NT,Nguyen CVV,Gough G,Wills B,Carrington LB,Simmon

    更新日期:2019-11-01 00:00:00

  • Environmental methods for dengue vector control - A systematic review and meta-analysis.

    abstract:BACKGROUND:Vector control remains the primary method to prevent dengue infections. Environmental interventions represent sustainable and safe methods as there are limited risks of environmental contamination and toxicity. The objective of this study is to perform a systematic review and meta-analysis of the effectivene...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,meta分析

    doi:10.1371/journal.pntd.0007420

    authors: Buhler C,Winkler V,Runge-Ranzinger S,Boyce R,Horstick O

    更新日期:2019-07-11 00:00:00

  • Hydrological Regime and Water Shortage as Drivers of the Seasonal Incidence of Diarrheal Diseases in a Tropical Montane Environment.

    abstract:BACKGROUND:The global burden of diarrhea is a leading cause of morbidity and mortality worldwide. In montane areas of South-East Asia such as northern Laos, recent changes in land use have induced increased runoff, soil erosion and in-stream suspended sediment loads, and potential pathogen dissemination. To our knowled...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0005195

    authors: Boithias L,Choisy M,Souliyaseng N,Jourdren M,Quet F,Buisson Y,Thammahacksa C,Silvera N,Latsachack K,Sengtaheuanghoung O,Pierret A,Rochelle-Newall E,Becerra S,Ribolzi O

    更新日期:2016-12-09 00:00:00

  • Sero-Molecular Epidemiology of Japanese Encephalitis in Zhejiang, an Eastern Province of China.

    abstract:BACKGROUND:Sporadic Japanese encephalitis (JE) cases still have been reported in Zhejiang Province in recent years, and concerns about vaccine cross-protection and population-level immunity have been raised off and on within the public health sphere. Genotype I (GI) has replaced GIII as the dominant genotype in Asian c...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0004936

    authors: Pan JR,Yan JY,Zhou JY,Tang XW,He HQ,Xie RH,Mao HY,Zhang YJ,Xie SY

    更新日期:2016-08-25 00:00:00

  • Correlative and dynamic imaging of the hatching biology of Schistosoma japonicum from eggs prepared by high pressure freezing.

    abstract:BACKGROUND:Schistosome eggs must traverse tissues of the intestine or bladder to escape the human host and further the life cycle. Escape from host tissues is facilitated by secretion of immuno-reactive molecules by eggs and the formation of an intense strong granulomatous response by the host which acts to exclude the...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0000334

    authors: Jones MK,Bong SH,Green KM,Holmes P,Duke M,Loukas A,McManus DP

    更新日期:2008-01-01 00:00:00

  • Incremental cost of conducting population-based prevalence surveys for a neglected tropical disease: the example of trachoma in 8 national programs.

    abstract:BACKGROUND:Trachoma prevalence surveys provide the evidence base for district and community-wide implementation of the SAFE strategy, and are used to evaluate the impact of trachoma control interventions. An economic analysis was performed to estimate the cost of trachoma prevalence surveys conducted between 2006 and 2...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0000979

    authors: Chen C,Cromwell EA,King JD,Mosher A,Harding-Esch EM,Ngondi JM,Emerson PM

    更新日期:2011-03-08 00:00:00

  • Interaction of ATP with a small heat shock protein from Mycobacterium leprae: effect on its structure and function.

    abstract::Adenosine-5'-triphosphate (ATP) is an important phosphate metabolite abundantly found in Mycobacterium leprae bacilli. This pathogen does not derive ATP from its host but has its own mechanism for the generation of ATP. Interestingly, this molecule as well as several antigenic proteins act as bio-markers for the detec...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0003661

    authors: Nandi SK,Chakraborty A,Panda AK,Ray SS,Kar RK,Bhunia A,Biswas A

    更新日期:2015-03-26 00:00:00

  • Molecular identification and antifungal susceptibility profiles of clinical strains of Fonsecaea spp. isolated from patients with chromoblastomycosis in Rio de Janeiro, Brazil.

    abstract:BACKGROUND:Chromoblastomycosis (CBM) is a difficult-to-treat chronic subcutaneous mycosis. In Brazil, the main agent of this disease is Fonsecaea pedrosoi, which is phenotypically very similar to other Fonsecaea species, differing only genetically. The correct species identification is relevant since different species ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006675

    authors: Coelho RA,Brito-Santos F,Figueiredo-Carvalho MHG,Silva JVDS,Gutierrez-Galhardo MC,do Valle ACF,Zancopé-Oliveira RM,Trilles L,Meyer W,Freitas DFS,Almeida-Paes R

    更新日期:2018-07-26 00:00:00

  • Copulation Activity, Sperm Production and Conidia Transfer in Aedes aegypti Males Contaminated by Metarhizium anisopliae: A Biological Control Prospect.

    abstract:BACKGROUND:Dengue is the most prevalent arboviral disease transmitted by Aedes aegypti worldwide, whose chemical control is difficult, expensive, and of inconsistent efficacy. Releases of Metarhizium anisopliae--exposed Ae. aegypti males to disseminate conidia among female mosquitoes by mating represents a promising bi...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0004144

    authors: Garza-Hernández JA,Reyes-Villanueva F,Russell TL,Braks MA,Garcia-Munguia AM,Rodríguez-Pérez MA

    更新日期:2015-10-16 00:00:00

  • Costs of Three Wolbachia Infections on the Survival of Aedes aegypti Larvae under Starvation Conditions.

    abstract::The mosquito Aedes aegypti, the principal vector of dengue virus, has recently been infected experimentally with Wolbachia: intracellular bacteria that possess potential as dengue biological control agents. Wolbachia depend on their hosts for nutrients they are unable to synthesize themselves. Consequently, competitio...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0004320

    authors: Ross PA,Endersby NM,Hoffmann AA

    更新日期:2016-01-08 00:00:00

  • Ruling out early trimester pregnancy when implementing community-based deworming programs.

    abstract:BACKGROUND:Large-scale deworming programs have, to date, mostly targeted preschool- and school-age children. As community-based deworming programs become more common, deworming will be offered to women of reproductive age. The World Health Organization recommends preventive chemotherapy be administered to pregnant wome...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0007901

    authors: St-Denis K,Blouin B,Rahme E,Casapia M,Montresor A,Mupfasoni D,Mbabazi PS,Gyorkos TW

    更新日期:2020-01-30 00:00:00

  • Comparison of antigen and antibody responses in repeat lymphatic filariasis transmission assessment surveys in American Samoa.

    abstract:BACKGROUND:Current WHO recommendations for lymphatic filariasis (LF) surveillance advise programs to implement activities to monitor for new foci of transmission after stopping mass drug administration (MDA). A current need in the global effort to eliminate LF is to standardize diagnostic tools and surveillance activit...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006347

    authors: Won KY,Robinson K,Hamlin KL,Tufa J,Seespesara M,Wiegand RE,Gass K,Kubofcik J,Nutman TB,Lammie PJ,Fuimaono S

    更新日期:2018-03-09 00:00:00