Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.

abstract：:Most statistical and mechanistic models used to predict mosquito-borne disease transmission incorporate climate drivers of disease transmission by utilizing environmental data collected at geographic scales that are potentially coarser than what mosquito populations may actually experience. Temperature and relative hu...

journal_title：PLoS neglected tropical diseases

authors： Murdock CC,Evans MV,McClanahan TD,Miazgowicz KL,Tesla B

更新日期：2017-05-30 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0004470.]. ...

journal_title：PLoS neglected tropical diseases

authors： Decuypere S,Meehan CJ,Van Puyvelde S,De Block T,Maltha J,Palpouguini L,Tahita M,Tinto H,Jacobs J,Deborggraeve S

更新日期：2017-07-28 00:00:00

abstract：:Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of Asia, where periodic outbreaks take hundreds of lives. Despite the catastrophes it causes, JE has remained a tropical disease uncom...

journal_title：PLoS neglected tropical diseases

authors： Ghosh D,Basu A

更新日期：2009-09-29 00:00:00

abstract：BACKGROUND:The control of neglected tropical diseases (NTDs) has primarily focused on preventive chemotherapy and case management. Less attention has been placed on the role of ensuring access to adequate water, sanitation, and hygiene and personal preventive measures in reducing exposure to infection. Our aim was to a...

journal_title：PLoS neglected tropical diseases

authors： Tomczyk S,Deribe K,Brooker SJ,Clark H,Rafique K,Knopp S,Utzinger J,Davey G

更新日期：2014-11-13 00:00:00

abstract：:Response to Zika virus (ZIKV) invasion in Brazil lagged a year from its estimated February 2014 introduction, and was triggered by the occurrence of severe congenital malformations. Dengue (DENV) and chikungunya (CHIKV) invasions tend to show similar response lags. We analyzed geo-coded symptomatic case reports from t...

journal_title：PLoS neglected tropical diseases

authors： Bisanzio D,Dzul-Manzanilla F,Gomez-Dantés H,Pavia-Ruz N,Hladish TJ,Lenhart A,Palacio-Vargas J,González Roldan JF,Correa-Morales F,Sánchez-Tejeda G,Kuri Morales P,Manrique-Saide P,Longini IM,Halloran ME,Vazquez-Prokopec GM

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Hookworm infections are an important cause of (severe) anemia and iron deficiency in children in the tropics. Type of hookworm species (Ancylostoma duodenale or Necator americanus) and infection load are considered associated with disease burden, although these parameters are rarely assessed due to limitatio...

journal_title：PLoS neglected tropical diseases

authors： Jonker FA,Calis JC,Phiri K,Brienen EA,Khoffi H,Brabin BJ,Verweij JJ,van Hensbroek MB,van Lieshout L

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Chagas disease is a vector-borne disease of major importance in the Americas. Disease prevention is mostly limited to vector control. Integrated interventions targeting ecological, biological and social determinants of vector-borne diseases are increasingly used for improved control. METHODOLOGY/PRINCIPAL F...

journal_title：PLoS neglected tropical diseases

authors： Dumonteil E,Nouvellet P,Rosecrans K,Ramirez-Sierra MJ,Gamboa-León R,Cruz-Chan V,Rosado-Vallado M,Gourbière S

更新日期：2013-09-26 00:00:00

abstract：OBJECTIVE:We conducted a systematic literature review with indirect comparison of studies evaluating therapeutic efficacy and toxicity associated to visceral leishmaniasis (VL) therapy among HIV infected individuals. MAIN OUTCOME MEASUREMENTS:The outcomes of interest were clinical and parasitological cure, mortality, ...

journal_title：PLoS neglected tropical diseases

authors： Cota GF,de Sousa MR,Fereguetti TO,Rabello A

更新日期：2013-05-02 00:00:00

abstract：BACKGROUND:The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susceptibility in vivo. ...

journal_title：PLoS neglected tropical diseases

authors： Carneiro MW,Fukutani KF,Andrade BB,Curvelo RP,Cristal JR,Carvalho AM,Barral A,Van Weyenbergh J,Barral-Netto M,de Oliveira CI

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS:A seroepid...

journal_title：PLoS neglected tropical diseases

authors： Coral-Almeida M,Rodríguez-Hidalgo R,Celi-Erazo M,García HH,Rodríguez S,Devleesschauwer B,Benítez-Ortiz W,Dorny P,Praet N

更新日期：2014-05-22 00:00:00

abstract：:Rift Valley fever (RVF) is endemic in most parts of Africa and has also been reported to occur in the Arabian Peninsula. It is responsible for significant morbidity and mortality, particularly in livestock, but also in humans. During the last two decades several outbreaks of RVF have been reported in countries in Sout...

journal_title：PLoS neglected tropical diseases

authors： Fafetine J,Neves L,Thompson PN,Paweska JT,Rutten VP,Coetzer JA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Diagnosis of Trypanosoma cruzi infection by direct pathogen detection is complicated by the low parasite burden in subjects persistently infected with this agent of human Chagas disease. Determination of infection status by serological analysis has also been faulty, largely due to the lack of well-characteri...

journal_title：PLoS neglected tropical diseases

authors： Cooley G,Etheridge RD,Boehlke C,Bundy B,Weatherly DB,Minning T,Haney M,Postan M,Laucella S,Tarleton RL

更新日期：2008-10-08 00:00:00

abstract：BACKGROUND:Blindness is caused by eye pathogens that include a free-living protist (Acanthamoeba castellanii, A. byersi, and/or other Acanthamoeba spp.), a fungus (Fusarium solani), and a bacterium (Chlamydia trachomatis). Hand-eye contact is likely a contributor to the spread of these pathogens, and so hand washing wi...

journal_title：PLoS neglected tropical diseases

authors： Aqeel Y,Rodriguez R,Chatterjee A,Ingalls RR,Samuelson J

更新日期：2017-02-09 00:00:00

abstract：BACKGROUND:Rodents are major reservoirs of pathogens responsible for numerous zoonotic diseases in humans and livestock. Assessing their microbial diversity at both the individual and population level is crucial for monitoring endemic infections and revealing microbial association patterns within reservoirs. Recently, ...

journal_title：PLoS neglected tropical diseases

authors： Razzauti M,Galan M,Bernard M,Maman S,Klopp C,Charbonnel N,Vayssier-Taussat M,Eloit M,Cosson JF

更新日期：2015-08-18 00:00:00

abstract：:In French Guiana, from 1984 to 2011, 14 animal rabies cases and 1 human rabies case (2008) were diagnosed. In January 2011, vampire-bat attacks occurred in 2 isolated villages. In mid-January, a medical team from the Cayenne Centre for Anti-Rabies Treatment visited the sites to manage individuals potentially exposed t...

journal_title：PLoS neglected tropical diseases

authors： Berger F,Desplanches N,Baillargeaux S,Joubert M,Miller M,Ribadeau-Dumas F,Spiegel A,Bourhy H

更新日期：2013-06-27 00:00:00

abstract：BACKGROUND:Culex tritaeniorhynchus is the primary vector of Japanese encephalitis virus (JEV), a leading cause of encephalitis in Asia. JEV is transmitted in an enzootic cycle involving large wading birds as the reservoirs and swine as amplifying hosts. The development of a JEV vaccine reduced the number of JE cases in...

journal_title：PLoS neglected tropical diseases

authors： Miller RH,Masuoka P,Klein TA,Kim HC,Somer T,Grieco J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) in human immunodeficiency virus (HIV) co-infected patients requires special case management. AmBisome monotherapy at 40 mg/kg is recommended by the World Health Organization. The objective of the study was to assess if a combination of a lower dose of AmBisome with miltefosine wou...

journal_title：PLoS neglected tropical diseases

authors： Diro E,Blesson S,Edwards T,Ritmeijer K,Fikre H,Admassu H,Kibret A,Ellis SJ,Bardonneau C,Zijlstra EE,Soipei P,Mutinda B,Omollo R,Kimutai R,Omwalo G,Wasunna M,Tadesse F,Alves F,Strub-Wourgaft N,Hailu A,Alexander N,

更新日期：2019-01-17 00:00:00

abstract：BACKGROUND:Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi (T. cruzi) that affects more than 6 million people, mainly in Latin America. Benznidazole is still the drug of choice in many countries to treat it in spite of its dosage regimen and adverse side effects such as such ...

journal_title：PLoS neglected tropical diseases

authors： Rial MS,Scalise ML,Arrúa EC,Esteva MI,Salomon CJ,Fichera LE

更新日期：2017-12-21 00:00:00

abstract：:A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja ...

journal_title：PLoS neglected tropical diseases

authors： Dellagi K,Salez N,Maquart M,Larrieu S,Yssouf A,Silaï R,Leparc-Goffart I,Tortosa P,de Lamballerie X

更新日期：2016-12-15 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease possess extensive genetic diversity. This has led to the development of a plethora of molecular typing methods for the identification of both the known major genetic lineages and for more fine scale characterization of different multilocus genotypes within th...

journal_title：PLoS neglected tropical diseases

authors： Diosque P,Tomasini N,Lauthier JJ,Messenger LA,Monje Rumi MM,Ragone PG,Alberti-D'Amato AM,Pérez Brandán C,Barnabé C,Tibayrenc M,Lewis MD,Llewellyn MS,Miles MA,Yeo M

更新日期：2014-08-28 00:00:00

abstract：:Global efforts to address schistosomiasis and soil-transmitted helminthiases (STH) include deworming programs for school-aged children that are made possible by large-scale drug donations. Decisions on these mass drug administration (MDA) programs currently rely on microscopic examination of clinical specimens to dete...

journal_title：PLoS neglected tropical diseases

authors： Hawkins KR,Cantera JL,Storey HL,Leader BT,de Los Santos T

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:The success of the global strategy to eliminate lymphatic filariasis (LF) through mass drug administration (MDA) campaigns is dependent on meeting high coverage levels over long periods of time. Community engagement plays a critical role in driving coverage and involvement of local communities in MDA for LF....

journal_title：PLoS neglected tropical diseases

authors： Silumbwe A,Halwindi H,Zulu JM

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:Antibody-detecting rapid diagnostic tests (RDTs) against rK39 are available to aid in the diagnosis of visceral leishmaniasis (VL). Although these rK39 RDTs have been developed, validated and approved for use with serum, they are universally performed using whole blood. It was therefore necessary to determin...

journal_title：PLoS neglected tropical diseases

authors： Matlashewski G,Das VN,Pandey K,Singh D,Das S,Ghosh AK,Pandey RN,Das P

更新日期：2013-05-23 00:00:00

abstract：OBJECTIVES:Burkholderia pseudomallei, the causative agent for melioidosis, has become a public health problem in India and across the world. Melioidosis can be difficult to diagnose because of the inconsistent clinical presentations of the disease. This study aims to determine the genetic diversity among the clinical i...

journal_title：PLoS neglected tropical diseases

authors： Balaji V,Perumalla S,Perumal R,Inbanathan FY,Rajamani Sekar SK,Paul MM,Sahni RD,Prakash JAJ,Iyadurai R

更新日期：2018-06-27 00:00:00

abstract：:To obtain further insight into geographic distribution of Leishmania species in Peru, a countrywide survey, including central to southern rainforest areas where information on causative parasite species is limited, was performed based on cytochrome b (cyt b) and mannose phosphate isomerase (mpi) gene analyses. A total...

journal_title：PLoS neglected tropical diseases

authors： Kato H,Cáceres AG,Seki C,Silupu García CR,Holguín Mauricci C,Castro Martínez SC,Moreno Paico D,Castro Muniz JL,Troyes Rivera LD,Villegas Briones ZI,Guerrero Quincho S,Sulca Jayo GL,Tineo Villafuerte E,Manrique de Lara Estrada C

更新日期：2019-06-20 00:00:00

abstract：:The human gut has been continuously exposed to a broad spectrum of intestinal organisms, including viruses, bacteria, fungi, and parasites (protozoa and worms), over millions of years of coevolution, and plays a central role in human health. The modern lifestyles of Western countries, such as the adoption of highly hy...

journal_title：PLoS neglected tropical diseases

authors： Marzano V,Mancinelli L,Bracaglia G,Del Chierico F,Vernocchi P,Di Girolamo F,Garrone S,Tchidjou Kuekou H,D'Argenio P,Dallapiccola B,Urbani A,Putignani L

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") st...

journal_title：PLoS neglected tropical diseases

authors： Bisoffi Z,Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Gobbo M,Bonafini S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:Few studies have assessed the burden of Chagas disease in non-endemic countries and most of them are based on prevalence estimates from Latin American (LA) countries that likely differ from the prevalence in migrants living in Europe. The aim of this study was to systematically review the existing data infor...

journal_title：PLoS neglected tropical diseases

authors： Requena-Méndez A,Aldasoro E,de Lazzari E,Sicuri E,Brown M,Moore DA,Gascon J,Muñoz J

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Appropriate health and nutrition interventions to prevent long-term adverse effects in children are necessary before two years of age. One such intervention may include population-based deworming, recommended as of 12 months of age by the World Health Organization in soil-transmitted helminth (STH)-endemic a...

journal_title：PLoS neglected tropical diseases

authors： Joseph SA,Casapía M,Montresor A,Rahme E,Ward BJ,Marquis GS,Pezo L,Blouin B,Maheu-Giroux M,Gyorkos TW

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Buruli ulcer (BU) is a subcutaneous skin disease listed among the neglected tropical diseases by the World Health Organization (WHO). Early case detection and management is very important to reduce morbidity and the accompanied characteristic disfiguring nature of BU. Since diagnosis based on clinical eviden...

journal_title：PLoS neglected tropical diseases

authors： Sakyi SA,Aboagye SY,Otchere ID,Liao AM,Caltagirone TG,Yeboah-Manu D

更新日期：2016-10-24 00:00:00