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"Omic" investigations of protozoa and worms for a deeper understanding of the human gut "parasitome".

Abstract：

:The human gut has been continuously exposed to a broad spectrum of intestinal organisms, including viruses, bacteria, fungi, and parasites (protozoa and worms), over millions of years of coevolution, and plays a central role in human health. The modern lifestyles of Western countries, such as the adoption of highly hygienic habits, the extensive use of antimicrobial drugs, and increasing globalisation, have dramatically altered the composition of the gut milieu, especially in terms of its eukaryotic "citizens." In the past few decades, numerous studies have highlighted the composition and role of human intestinal bacteria in physiological and pathological conditions, while few investigations exist on gut parasites and particularly on their coexistence and interaction with the intestinal microbiota. Studies of the gut "parasitome" through "omic" technologies, such as (meta)genomics, transcriptomics, proteomics, and metabolomics, are herein reviewed to better understand their role in the relationships between intestinal parasites, host, and resident prokaryotes, whether pathogens or commensals. Systems biology-based profiles of the gut "parasitome" under physiological and severe disease conditions can indeed contribute to the control of infectious diseases and offer a new perspective of omics-assisted tropical medicine.

journal_name

PLoS Negl Trop Dis

journal_title

PLoS neglected tropical diseases

authors

Marzano V,Mancinelli L,Bracaglia G,Del Chierico F,Vernocchi P,Di Girolamo F,Garrone S,Tchidjou Kuekou H,D'Argenio P,Dallapiccola B,Urbani A,Putignani L

doi

10.1371/journal.pntd.0005916

subject

Has Abstract

pub_date

2017-11-02 00:00:00

pages

e0005916

issue

11

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-17-00133

journal_volume

11

pub_type

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