Correction: Diagnosis of Bacterial Bloodstream Infections: A 16S Metagenomics Approach.

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination by the year 2020. As of 2017, 67 of the 72 endemic countries have implemented annual Mass Drug Administration (MDA) for interrupting LF transmission. Transmission Assessment Survey (TAS) is the recommended protocol to evaluate the impact of MDA and to dec...

journal_title：PLoS neglected tropical diseases

authors： Subramanian S,Jambulingam P,Krishnamoorthy K,Sivagnaname N,Sadanandane C,Vasuki V,Palaniswamy C,Vijayakumar B,Srividya A,Raju HKK

更新日期：2020-01-24 00:00:00

abstract：BACKGROUND:Efforts to control soil-transmitted helminth (STH) infections have intensified over the past decade. Field-survey data on STH prevalence, infection intensity and drug efficacy is necessary to guide the implementation of control programs and should be of the best possible quality. METHODOLOGY:During four cli...

journal_title：PLoS neglected tropical diseases

authors： Vlaminck J,Cools P,Albonico M,Ame S,Ayana M,Dana D,Keiser J,Matoso LF,Montresor A,Mekonnen Z,Corrêa-Oliveira R,Pinto SA,Sayasone S,Vercruysse J,Levecke B

更新日期：2020-09-21 00:00:00

abstract：:Tsetse are vectors of pathogenic trypanosomes, agents of human and animal trypanosomiasis in Africa. Components of tsetse saliva (sialome) are introduced into the mammalian host bite site during the blood feeding process and are important for tsetse's ability to feed efficiently, but can also influence disease transmi...

journal_title：PLoS neglected tropical diseases

authors： Zhao X,Alves e Silva TL,Cronin L,Savage AF,O'Neill M,Nerima B,Okedi LM,Aksoy S

更新日期：2015-08-27 00:00:00

abstract：BACKGROUND:Dengue is a serious vector-borne disease, and incidence rates have significantly increased during the past few years, particularly in 2014 in Guangzhou. The current situation is more complicated, due to various factors such as climate warming, urbanization, population increase, and human mobility. The purpos...

journal_title：PLoS neglected tropical diseases

authors： Zhu G,Liu J,Tan Q,Shi B

更新日期：2016-04-22 00:00:00

abstract：:To eliminate schistosomiasis, appropriate diagnostic tests are required to monitor its prevalence and transmission, especially in the settings with low endemicity resulting from the consecutive mass drug administration. Antibodies that react with either crude soluble schistosome egg antigens or soluble worm antigen pr...

journal_title：PLoS neglected tropical diseases

authors： Mohammed ES,Nakamura R,Kalenda YD,Deloer S,Moriyasu T,Tanaka M,Fujii Y,Kaneko S,Hirayama K,Ibrahim AI,El-Seify MA,Metwally AM,Hamano S

更新日期：2020-09-11 00:00:00

abstract：BACKGROUND:During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). APC has both an...

journal_title：PLoS neglected tropical diseases

authors： Kager LM,Wiersinga WJ,Roelofs JJ,de Boer OJ,Weiler H,van 't Veer C,van der Poll T

更新日期：2014-04-24 00:00:00

abstract：BACKGROUND:Vector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and vector control, however, much less is known about the burden of ...

journal_title：PLoS neglected tropical diseases

authors： Alroy KA,Huang C,Gilman RH,Quispe-Machaca VR,Marks MA,Ancca-Juarez J,Hillyard M,Verastegui M,Sanchez G,Cabrera L,Vidal E,Billig EM,Cama VA,Náquira C,Bern C,Levy MZ,Working Group on Chagas Disease in Peru.

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable. Cysteine leucine rich protein (CLrP), was recognized as one of the overexpressed...

journal_title：PLoS neglected tropical diseases

authors： Das S,Shah P,Tandon R,Yadav NK,Sahasrabuddhe AA,Sundar S,Siddiqi MI,Dube A

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND:Leprosy Type 1 (T1R) reactions are immune-mediated events leading to nerve damage and preventable disability affecting hands, feet and eyes. Type 1 Reactions are treated with oral corticosteroids. There is little evidence on alternative treatments for patients who do not respond to steroids or experience ste...

journal_title：PLoS neglected tropical diseases

authors： Lambert SM,Alembo DT,Nigusse SD,Yamuah LK,Walker SL,Lockwood DN

更新日期：2016-04-05 00:00:00

abstract：:Human excreta is a low cost source of nutrients vital to plant growth, but also a source of pathogens transmissible to people and animals. We investigated the cost-savings and infection risk of soil transmitted helminths (STHs) in four scenarios where farmers used either inorganic fertilizer or fresh/composted human e...

journal_title：PLoS neglected tropical diseases

authors： Tran-Thi N,Lowe RJ,Schurer JM,Vu-Van T,MacDonald LE,Pham-Duc P

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS:A seroepid...

journal_title：PLoS neglected tropical diseases

authors： Coral-Almeida M,Rodríguez-Hidalgo R,Celi-Erazo M,García HH,Rodríguez S,Devleesschauwer B,Benítez-Ortiz W,Dorny P,Praet N

更新日期：2014-05-22 00:00:00

abstract：BACKGROUND:Mass anthelmintic drug administration is recommended in developing countries to address infection by soil-transmitted helminthiases (STH). We quantified the public health benefit of treatment with mebendazole in eight million Vietnamese children aged 5-14 years from 2006 to 2011. This was compared to the env...

journal_title：PLoS neglected tropical diseases

authors： Debaveye S,Gonzalez Torres CV,De Smedt D,Heirman B,Kavanagh S,Dewulf J

更新日期：2018-11-12 00:00:00

abstract：:Japanese encephalitis virus (JEV) is a mosquito-borne, zoonotic flavivirus causing encephalitis in humans and reproductive disorder in pigs. JEV is present in large parts of Asia, where urbanization is high. Households within and outside Can Tho city, South Vietnam, were selected to monitor circulation of JEV. A neste...

journal_title：PLoS neglected tropical diseases

authors： Lindahl JF,Ståhl K,Chirico J,Boqvist S,Thu HT,Magnusson U

更新日期：2013-04-04 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is one of the most common diarrheal pathogens in the low- and middle-income regions of the world, however a systematic examination of the genomic content of isolates from Chile has not yet been undertaken. Whole genome sequencing and comparative analysis of a collection of 125 E...

journal_title：PLoS neglected tropical diseases

authors： Rasko DA,Del Canto F,Luo Q,Fleckenstein JM,Vidal R,Hazen TH

更新日期：2019-11-20 00:00:00

abstract：BACKGROUND:During blood feeding, sand flies inject Leishmania parasites in the presence of saliva. The types and functions of cells present at the first host-parasite contact are critical to the outcome on infection and sand fly saliva has been shown to play an important role in this setting. Herein, we investigated th...

journal_title：PLoS neglected tropical diseases

authors： de Moura TR,Oliveira F,Rodrigues GC,Carneiro MW,Fukutani KF,Novais FO,Miranda JC,Barral-Netto M,Brodskyn C,Barral A,de Oliveira CI

更新日期：2010-06-15 00:00:00

abstract：:Intracerebral microhemorrhages (CMHs) are small foci of hemorrhages in the cerebrum. Acute infections induced by some intracellular pathogens, including rickettsia, can result in CMHs. Annexin a2 (ANXA2) has been documented to play a functional role during intracellular bacterial adhesion. Here we report that ANXA2-kn...

journal_title：PLoS neglected tropical diseases

authors： Su Z,Chang Q,Drelich A,Shelite T,Judy B,Liu Y,Xiao J,Zhou C,He X,Jin Y,Saito T,Tang S,Soong L,Wakamiya M,Fang X,Bukreyev A,Ksiazek T,Russell WK,Gong B

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis has now emerged as an important opportunistic disease in patients coinfected with human immunodeficiency virus type-1 (HIV-1). Although the effectiveness of HIV-1 protease inhibitors, such as nelfinavir, in antiretroviral therapies is well documented, little is known of the impact of t...

journal_title：PLoS neglected tropical diseases

authors： Kumar P,Lodge R,Trudel N,Ouellet M,Ouellette M,Tremblay MJ

更新日期：2010-03-30 00:00:00

abstract：:This study focused on Oeosophagostomum sp., and more especially on O. bifurcum, as a parasite that can be lethal to humans and is widespread among humans and monkeys in endemic regions, but has not yet been documented in apes. Its epidemiology and the role played by non-human primates in its transmission are still poo...

journal_title：PLoS neglected tropical diseases

authors： Krief S,Vermeulen B,Lafosse S,Kasenene JM,Nieguitsila A,Berthelemy M,L'hostis M,Bain O,Guillot J

更新日期：2010-03-16 00:00:00

abstract：BACKGROUND:Protozoan parasites of the genus Leishmania cause a large spectrum of clinical manifestations known as Leishmaniases. These diseases are increasingly important public health problems in many countries both within and outside endemic regions. Thus, an accurate differential diagnosis is extremely relevant for ...

journal_title：PLoS neglected tropical diseases

authors： Zampieri RA,Laranjeira-Silva MF,Muxel SM,Stocco de Lima AC,Shaw JJ,Floeter-Winter LM

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the gamma-phospho of ATP to a hexose. Here we des...

journal_title：PLoS neglected tropical diseases

authors： Sharlow ER,Lyda TA,Dodson HC,Mustata G,Morris MT,Leimgruber SS,Lee KH,Kashiwada Y,Close D,Lazo JS,Morris JC

更新日期：2010-04-13 00:00:00

abstract：BACKGROUND:Aedes control interventions are considered the cornerstone of dengue control programmes, but there is scarce evidence on their effect on disease. We set-up a cluster randomized controlled trial in Santiago de Cuba to evaluate the entomological and epidemiological effectiveness of periodical intra- and peri-d...

journal_title：PLoS neglected tropical diseases

authors： Toledo ME,Vanlerberghe V,Rosales JP,Mirabal M,Cabrera P,Fonseca V,Gómez Padrón T,Pérez Menzies M,Montada D,Van der Stuyft P

更新日期：2017-11-08 00:00:00

abstract：BACKGROUND:Contacts of leprosy patients are at increased risk of developing leprosy and need to be targeted for early diagnosis. Seropositivity to the phenolic glycolipid I (PGL-I) antigen of Mycobacterium leprae has been used to identify contacts who have an increased risk of developing leprosy. In the present study, ...

journal_title：PLoS neglected tropical diseases

authors： Düppre NC,Camacho LA,Sales AM,Illarramendi X,Nery JA,Sampaio EP,Sarno EN,Bührer-Sékula S

更新日期：2012-01-01 00:00:00

abstract：:Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to mi...

journal_title：PLoS neglected tropical diseases

authors： Molina-Morant D,Sánchez-Montalvá A,Salvador F,Sao-Avilés A,Molina I

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:Predictive models can serve as early warning systems and can be used to forecast future risk of various infectious diseases. Conventionally, regression and time series models are used to forecast dengue incidence, using dengue surveillance (e.g., case counts) and weather data. However, these models may be li...

journal_title：PLoS neglected tropical diseases

authors： Benedum CM,Shea KM,Jenkins HE,Kim LY,Markuzon N

更新日期：2020-10-16 00:00:00

abstract：BACKGROUND:Aedes aegypti, the yellow fever mosquito, is an efficient vector of arboviruses and a convenient model system for laboratory research. Extensive linkage mapping of morphological and molecular markers localized a number of quantitative trait loci (QTLs) related to the mosquito's ability to transmit various pa...

journal_title：PLoS neglected tropical diseases

authors： Timoshevskiy VA,Severson DW,Debruyn BS,Black WC,Sharakhov IV,Sharakhova MV

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central role in dengue pathogenesis. Primary infections are typically associ...

journal_title：PLoS neglected tropical diseases

authors： Chaudhury S,Gromowski GD,Ripoll DR,Khavrutskii IV,Desai V,Wallqvist A

更新日期：2017-02-21 00:00:00

abstract：:Leishmaniasis is a neglected disease produced by the intracellular protozoan parasite Leishmania. In the present study, we show that LABCG2, a new ATP-binding cassette half-transporter (ABCG subfamily) from Leishmania, is involved in parasite virulence. Down-regulation of LABCG2 function upon expression of an inactive...

journal_title：PLoS neglected tropical diseases

authors： Campos-Salinas J,León-Guerrero D,González-Rey E,Delgado M,Castanys S,Pérez-Victoria JM,Gamarro F

更新日期：2013-04-25 00:00:00

abstract：:Greece was declared malaria-free in 1974 after a long antimalarial fight. In 2011-2012, an outbreak of P. vivax malaria was reported in Evrotas, an agricultural area in Southern Greece, where a large number of immigrants from endemic countries live and work. A total of 46 locally acquired and 38 imported malaria cases...

journal_title：PLoS neglected tropical diseases

authors： Tseroni M,Baka A,Kapizioni C,Snounou G,Tsiodras S,Charvalakou M,Georgitsou M,Panoutsakou M,Psinaki I,Tsoromokou M,Karakitsos G,Pervanidou D,Vakali A,Mouchtouri V,Georgakopoulou T,Mamuris Z,Papadopoulos N,Koliopoulos G,

更新日期：2015-11-19 00:00:00

abstract：:As the most widespread tick-borne arbovirus causing infections in numerous countries in Asia, Africa and Europe, Crimean-Congo Hemorrhagic Fever Virus (CCHFV, family Nairoviridae) was included in the WHO priority list of emerging pathogens needing urgent Research & Development attention. To ensure preparedness for pot...

journal_title：PLoS neglected tropical diseases

authors： Emmerich P,Mika A,von Possel R,Rackow A,Liu Y,Schmitz H,Günther S,Sherifi K,Halili B,Jakupi X,Berisha L,Ahmeti S,Deschermeier C

更新日期：2018-03-26 00:00:00

abstract：:Dengue virus transmission is endemic in Makassar, Indonesia, with the majority of cases reported soon after the start of the annual rainy season. Before 2006, larval source reduction, larvaciding, and reactive routine, outdoor, insecticide fogging campaigns did not result in a reduction in seasonal dengue incidence. B...

journal_title：PLoS neglected tropical diseases

authors： Wahid I,Ishak H,Hafid A,Fajri M,Sidjal S,Nurdin A,Azikin NT,Sudirman R,Hasan H,Yusuf M,Bachtiar I,Hawley WA,Rosenberg R,Lobo NF

更新日期：2019-08-05 00:00:00