Abstract：
BACKGROUND:Dengue is a serious vector-borne disease, and incidence rates have significantly increased during the past few years, particularly in 2014 in Guangzhou. The current situation is more complicated, due to various factors such as climate warming, urbanization, population increase, and human mobility. The purpose of this study is to detect dengue transmission patterns and identify the disease dispersion dynamics in Guangzhou, China. METHODOLOGY:We conducted surveys in 12 districts of Guangzhou, and collected daily data of Breteau index (BI) and reported cases between September and November 2014 from the public health authority reports. Based on the available data and the Ross-Macdonald theory, we propose a dengue transmission model that systematically integrates entomologic, demographic, and environmental information. In this model, we use (1) BI data and geographic variables to evaluate the spatial heterogeneities of Aedes mosquitoes, (2) a radiation model to simulate the daily mobility of humans, and (3) a Markov chain Monte Carlo (MCMC) method to estimate the model parameters. RESULTS/CONCLUSIONS:By implementing our proposed model, we can (1) estimate the incidence rates of dengue, and trace the infection time and locations, (2) assess risk factors and evaluate the infection threat in a city, and (3) evaluate the primary diffusion process in different districts. From the results, we can see that dengue infections exhibited a spatial and temporal variation during 2014 in Guangzhou. We find that urbanization, vector activities, and human behavior play significant roles in shaping the dengue outbreak and the patterns of its spread. This study offers useful information on dengue dynamics, which can help policy makers improve control and prevention measures.
journal_name
PLoS Negl Trop Disjournal_title
PLoS neglected tropical diseasesauthors
Zhu G,Liu J,Tan Q,Shi Bdoi
10.1371/journal.pntd.0004633subject
Has Abstractpub_date
2016-04-22 00:00:00pages
e0004633issue
4eissn
1935-2727issn
1935-2735pii
PNTD-D-15-01193journal_volume
10pub_type
杂志文章abstract：:Trypanosoma cruzi has been subdivided into seven Discrete Typing Units (DTUs), TcI-TcVI and Tcbat. Two major evolutionary models have been proposed to explain the origin of hybrid lineages, but while it is widely accepted that TcV and TcVI are the result of genetic exchange between TcII and TcIII strains, the origin o...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0006139
更新日期：2017-12-18 00:00:00
abstract：BACKGROUND:Chagas disease is one of the most important neglected tropical diseases in the Americas. Vectorborne transmission of Chagas disease has been historically rare in urban settings. However, in marginal communities near the city of Arequipa, Peru, urban transmission cycles have become established. We examined th...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0000567
更新日期：2009-12-15 00:00:00
abstract：:One of the most important clinical signs of dengue virus infection is the reduction of white blood cells and platelets in human peripheral blood (leukopenia and thrombocytopenia, respectively), which may significantly impair the clearance of dengue virus by the immune system. The cause of thrombocytopenia and leukopen...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0007837
更新日期：2019-11-25 00:00:00
abstract：:Nipah virus (NiV) is a paramyxovirus (genus Henipavirus) that emerged in the late 1990s in Malaysia and has since been identified as the cause of sporadic outbreaks of severe febrile disease in Bangladesh and India. NiV infection is frequently associated with severe respiratory or neurological disease in infected huma...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0005532
更新日期：2017-04-07 00:00:00
abstract：BACKGROUND:Health promotion is essential to the SAFE strategy for trachoma elimination. Schools are a valuable venue for health promotion. However, there is little literature about the impact of health education and water infrastructure in schools on facial cleanliness and trachoma in the community. Our study aimed to ...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0009119
更新日期：2021-02-01 00:00:00
abstract：:Novel strategies are required to control mosquitoes and the pathogens they transmit. One attractive approach involves maternally inherited endosymbiotic Wolbachia bacteria. After artificial infection with Wolbachia, many mosquitoes become refractory to infection and transmission of diverse pathogens. We evaluated the ...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0002965
更新日期：2014-07-10 00:00:00
abstract：:Schistosomiasis control and elimination has priority in public health agendas in several sub-Saharan countries. However, achieving these goals remains a substantial challenge. In order to assess progress of interventions and treatment efficacy it is pertinent to have accurate, feasible and affordable diagnostic tools....
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,随机对照试验
doi：10.1371/journal.pntd.0006054
更新日期：2017-11-13 00:00:00
abstract：:Revealing the dispersal of dengue viruses (DENV) in time and space is central to understanding their epidemiology. However, the processes that shape DENV transmission patterns at the scale of local populations are not well understood, particularly the impact of such factors as human population movement and urbanizatio...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0000766
更新日期：2010-07-27 00:00:00
abstract：:Between March 2014 and July 2015 at least 10,500 Ebola cases including more than 4,800 deaths occurred in Liberia, the majority in Monrovia. However, official numbers may have underestimated the size of the outbreak. Closure of health facilities and mistrust in existing structures may have additionally impacted on all...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0004899
更新日期：2016-08-23 00:00:00
abstract：BACKGROUND:There is a worldwide upscale in mass drug administration (MDA) programs to control the morbidity caused by soil-transmitted helminths (STHs): Ascaris lumbricoides, Trichuris trichiura and hookworm. Although anthelminthic drugs which are used for MDA are supplied by two pharmaceutical companies through donati...
journal_title：PLoS neglected tropical diseases
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1371/journal.pntd.0004057
更新日期：2015-09-25 00:00:00
abstract：OBJECTIVE:Where human African trypanosomiasis (HAT) patients are seen, failure to microscopically diagnose infections by Trypanosoma brucei gambiense in blood smears and/or cerebrospinal fluid (CSF) in the critical early stages of the disease is the single most important factor in treatment failure, a result of delayed...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0007631
更新日期：2019-08-19 00:00:00
abstract：BACKGROUND:Mycobacterium tuberculosis causes the majority of tuberculosis (TB) cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M. bovis is considered a zoonosis; transmission is mainly through consumption of unpasteurized dairy products, ...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0004124
更新日期：2015-09-30 00:00:00
abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0006803.]. ...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,已发布勘误
doi：10.1371/journal.pntd.0007150
更新日期：2019-02-26 00:00:00
abstract：INTRODUCTION:A high proportion of grade 2 disability (visible deformity) is indicative of delay in detection of leprosy and leprosy is one of the major causes of preventable disability. We conducted this study to determine the risk factors associated with disability (G2D and G1D) among adult new leprosy cases and to me...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,多中心研究
doi：10.1371/journal.pntd.0007495
更新日期：2019-06-27 00:00:00
abstract：:The spread of dengue (DEN) worldwide combined with an increased severity of the DEN-associated clinical outcomes have made this mosquito-borne virus of great global public health importance. Progress in understanding DEN pathogenesis and in developing effective treatments has been hampered by the lack of a suitable sm...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0000672
更新日期：2010-04-27 00:00:00
abstract：BACKGROUND:The options for treating the fatal disease human African trypanosomiasis are limited to a few drugs that are toxic or facing increasing resistance. New drugs that kill the causative agents, subspecies of Trypanosoma brucei, are therefore urgently needed. Little is known about the cellular mechanisms that lea...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0000678
更新日期：2010-05-04 00:00:00
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journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0008739
更新日期：2020-10-23 00:00:00
abstract：BACKGROUND:On the Zanzibar islands, United Republic of Tanzania, elimination of urogenital schistosomiasis is strived for in the coming years. This qualitative study aimed to better understand community knowledge, perceptions, and practices associated with schistosomiasis among school-aged children on Unguja and Pemba ...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0004814
更新日期：2016-07-11 00:00:00
abstract：:Morbidity burden of lymphatic filariasis (LF) relies on the information from the Mass Drug Administration (MDA) programme where Community Health Volunteers (CHVs) passively report cases identified. Consequently, the exact prevalence of morbidity cases is not always accurate. The use of mobile phone technology to repor...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0008839
更新日期：2020-11-12 00:00:00
abstract：BACKGROUND:The objectives of this study were to 1) evaluate the influence of treatment with praziquantel on the inflammatory milieu in maternal, placental, and cord blood, 2) assess the extent to which proinflammatory signatures in placental and cord blood impacts birth outcomes, and 3) evaluate the impact of other hel...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,随机对照试验
doi：10.1371/journal.pntd.0007371
更新日期：2019-06-12 00:00:00
abstract：BACKGROUND:Mycobacterium tuberculosis complex (MTBC), the causative agent of tuberculosis (TB), is composed of eight subspecies. TB in West Africa, in contrast to other geographical regions, is caused by Mycobacterium africanum (MAF) in addition to M. tuberculosis (MTB), with both infections presenting similar symptoms...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0008230
更新日期：2020-05-13 00:00:00
abstract：BACKGROUND:Continued exposure to malaria-causing parasites in endemic regions of malaria induces significant levels of acquired immunity in adult individuals. A better understanding of the transcriptional basis for this acquired immunological response may provide insight into how the immune system can be boosted during...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0003978
更新日期：2015-08-05 00:00:00
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journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,meta分析,评审
doi：10.1371/journal.pntd.0006088
更新日期：2017-11-27 00:00:00
abstract：BACKGROUND:Cutaneous leishmaniasis is caused by several Leishmania species that are associated with variable outcomes before and after therapy. Optimal treatment decision is based on an accurate identification of the infecting species but current methods to type Leishmania isolates are relatively complex and/or slow. T...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0002841
更新日期：2014-06-05 00:00:00
abstract：BACKGROUND:The global burden of cholera is largely unknown because the majority of cases are not reported. The low reporting can be attributed to limited capacity of epidemiological surveillance and laboratories, as well as social, political, and economic disincentives for reporting. We previously estimated 2.8 million...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0003832
更新日期：2015-06-04 00:00:00
abstract：:Disseminated disease from non-typhoidal Salmonella enterica strains results in >20% mortality globally. Barriers to effective treatment include emerging multidrug resistance, antibiotic treatment failure, and risk factors such as malnutrition and related micronutrient deficiencies. Individuals in sub-Saharan Africa ar...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0008737
更新日期：2020-10-02 00:00:00
abstract：BACKGROUND:Leptospirosis occurs worldwide, but the global incidence of human disease and its mortality are not well understood. Many patients are undiagnosed and untreated due to its non-specific symptoms and a lack of access to diagnostics. This study systematically reviews the literature to clarify the mortality from...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,评审
doi：10.1371/journal.pntd.0003866
更新日期：2015-06-25 00:00:00
abstract：INTRODUCTION:Chikungunya is an emerging public health problem in tropical and subtropical regions, due to ongoing transmission and its incapacitating acute disease phase, and chronic sequelae. The disease is responsible for a major impact on Health Related Quality of Life (HRQoL), which may last several years. To our k...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0005987
更新日期：2017-10-09 00:00:00
abstract：BACKGROUND:Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are responsible for a substantial health and economic burden, particularly to low-income societies. Quan...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,评审
doi：10.1371/journal.pntd.0002249
更新日期：2013-06-06 00:00:00
abstract：BACKGROUND:Many small studies have been done in Honduras estimating soil-transmitted helminthiasis (STH) prevalence but a country-wide study was last done in 2005. The country has the highest burden of malaria among all Central American countries. The present study was done to estimate country-wide STH prevalence and i...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0003248
更新日期：2014-10-16 00:00:00
