Circulation of Japanese encephalitis virus in pigs and mosquito vectors within Can Tho city, Vietnam.

abstract：BACKGROUND:Miltefosine (MF) is the only oral drug available for treatment of visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL). Although the drug is effective and well tolerated in treatment of VL, the efficacy and safety of MF for longer treatment durations (>28 days) in PKDL remains unclear. ...

journal_title：PLoS neglected tropical diseases

authors： Pijpers J,den Boer ML,Essink DR,Ritmeijer K

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Dengue is endemic in the Western Pacific and Oceania and the region reports more than 200,000 cases annually. Outbreaks of dengue and severe dengue occur regularly and movement of virus throughout the region has been reported. Disease surveillance systems, however, in many areas are not fully established and...

journal_title：PLoS neglected tropical diseases

authors： Luang-Suarkia D,Mitja O,Ernst T,Bennett S,Tay A,Hays R,Smith DW,Imrie A

更新日期：2018-03-01 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease possess extensive genetic diversity. This has led to the development of a plethora of molecular typing methods for the identification of both the known major genetic lineages and for more fine scale characterization of different multilocus genotypes within th...

journal_title：PLoS neglected tropical diseases

authors： Diosque P,Tomasini N,Lauthier JJ,Messenger LA,Monje Rumi MM,Ragone PG,Alberti-D'Amato AM,Pérez Brandán C,Barnabé C,Tibayrenc M,Lewis MD,Llewellyn MS,Miles MA,Yeo M

更新日期：2014-08-28 00:00:00

abstract：:Digestive and cardiodigestive forms of Chagas' disease are observed in 2% to 27% of the patients, depending on their geographic location, Trypanosoma cruzi strain and immunopathological responses. The aim of this work was to evaluate the role of NOD2 innate immune receptor in the pathogenesis of the digestive system i...

journal_title：PLoS neglected tropical diseases

authors： Pereira NS,Queiroga TBD,da Silva DD,Nascimento MSL,Andrade CM,Souto JT,Ricci MF,Arantes RME,Zamboni DS,Chiari E,Câmara ACJD,Galvão LMDC,Guedes PMM

更新日期：2020-09-28 00:00:00

abstract：:Soil-transmitted helminthiases (STHs) constitute a public health problem that requires immediate action to resolve the morbidity of those harboring the parasites in their guts, to prevent infection in all those at risk, and to interrupt the vicious circle of poverty and disease in the affected communities, structural ...

journal_title：PLoS neglected tropical diseases

authors： Krolewiecki AJ

更新日期：2018-09-13 00:00:00

abstract：:The niche conservatism hypothesis states that related species diverge in niche characteristics at lower rates than expected, given their lineage divergence. Here we analyze whether niche conservatism is a common pattern among vector species (Hemiptera: Reduviidae: Triatominae) of Trypanosoma cruzi that inhabit North a...

journal_title：PLoS neglected tropical diseases

authors： Ibarra-Cerdeña CN,Zaldívar-Riverón A,Peterson AT,Sánchez-Cordero V,Ramsey JM

更新日期：2014-10-30 00:00:00

abstract：:All of our current knowledge of African trypanosome metabolism is based on results from trypanosomes grown in culture or in rodents. Drugs against sleeping sickness must however treat trypanosomes in humans. We here compare the transcriptomes of Trypanosoma brucei rhodesiense from the blood and cerebrospinal fluid of ...

journal_title：PLoS neglected tropical diseases

authors： Mulindwa J,Leiss K,Ibberson D,Kamanyi Marucha K,Helbig C,Melo do Nascimento L,Silvester E,Matthews K,Matovu E,Enyaru J,Clayton C

更新日期：2018-02-23 00:00:00

abstract：BACKGROUND:Travelers who acquire dengue infection are often routes for virus transmission to other regions. Nevertheless, the interplay between infected travelers, climate, vectors, and indigenous dengue incidence remains unclear. The role of foreign-origin cases on local dengue epidemics thus has been largely neglecte...

journal_title：PLoS neglected tropical diseases

authors： Shang CS,Fang CT,Liu CM,Wen TH,Tsai KH,King CC

更新日期：2010-08-03 00:00:00

abstract：:A comprehensive analysis was done to evaluate the potential use of anti-parasitic macrocyclic lactones (including avermectins and milbemycins) for Buruli ulcer (BU) therapy. A panel containing nearly all macrocyclic lactones used in human or in veterinary medicine was analyzed for activity in vitro against clinical is...

journal_title：PLoS neglected tropical diseases

authors： Scherr N,Pluschke G,Thompson CJ,Ramón-García S

更新日期：2015-08-13 00:00:00

abstract：BACKGROUND:Rift Valley fever (RVF) is a zoonotic arbovirosis for which the primary hosts are domestic livestock (cattle, sheep and goats). RVF was first described in South Africa in 1950-1951. Mechanisms for short and long distance transmission have been hypothesised, but there is little supporting evidence. Here we de...

journal_title：PLoS neglected tropical diseases

authors： Métras R,Porphyre T,Pfeiffer DU,Kemp A,Thompson PN,Collins LM,White RG

更新日期：2012-01-01 00:00:00

abstract：:The potential use of clinically approved beta-lactams for Buruli ulcer (BU) treatment was investigated with representative classes analyzed in vitro for activity against Mycobacterium ulcerans. Beta-lactams tested were effective alone and displayed a strong synergistic profile in combination with antibiotics currently...

journal_title：PLoS neglected tropical diseases

authors： Arenaz-Callao MP,González Del Río R,Lucía Quintana A,Thompson CJ,Mendoza-Losana A,Ramón-García S

更新日期：2019-01-28 00:00:00

abstract：:Crimean-Congo Hemorrhagic Fever Virus (CCHFV) and Hazara virus (HAZV) belong to the same viral serotype and family. HAZV has lately been used as a model system and surrogate to CCHFV. However, virus-host cell interaction and level of pathogenicity for these viruses are not well investigated nor compared. In this study...

journal_title：PLoS neglected tropical diseases

authors： Monteil V,Salata C,Appelberg S,Mirazimi A

更新日期：2020-11-24 00:00:00

abstract：:Isothermal microcalorimetry is an established tool to measure heat flow of physical, chemical or biological processes. The metabolism of viable cells produces heat, and if sufficient cells are present, their heat production can be assessed by this method. In this study, we investigated the heat flow of two medically i...

journal_title：PLoS neglected tropical diseases

authors： Wenzler T,Steinhuber A,Wittlin S,Scheurer C,Brun R,Trampuz A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents carry L. interrogans asymptomatically in their kidneys and excrete bacteria in the urine, contaminating the environment. Humans get infected through skin contact and develop a mild or severe leptospirosis that m...

journal_title：PLoS neglected tropical diseases

authors： Fanton d'Andon M,Quellard N,Fernandez B,Ratet G,Lacroix-Lamandé S,Vandewalle A,Boneca IG,Goujon JM,Werts C

更新日期：2014-01-30 00:00:00

abstract：BACKGROUND:Leptospirosis occurs worldwide, but the global incidence of human disease and its mortality are not well understood. Many patients are undiagnosed and untreated due to its non-specific symptoms and a lack of access to diagnostics. This study systematically reviews the literature to clarify the mortality from...

journal_title：PLoS neglected tropical diseases

authors： Taylor AJ,Paris DH,Newton PN

更新日期：2015-06-25 00:00:00

abstract：BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. Pharmacological...

journal_title：PLoS neglected tropical diseases

authors： Tzertzinis G,Egaña AL,Palli SR,Robinson-Rechavi M,Gissendanner CR,Liu C,Unnasch TR,Maina CV

更新日期：2010-03-09 00:00:00

abstract：BACKGROUND:This year, Brazil will host about 600,000 foreign visitors during the 2014 FIFA World Cup. The concern of possible dengue transmission during this event has been raised given the high transmission rates reported in the past by this country. METHODOLOGY/PRINCIPAL FINDINGS:We used dengue incidence rates repor...

journal_title：PLoS neglected tropical diseases

authors： van Panhuis WG,Hyun S,Blaney K,Marques ET Jr,Coelho GE,Siqueira JB Jr,Tibshirani R,da Silva JB Jr,Rosenfeld R

更新日期：2014-07-31 00:00:00

abstract：BACKGROUND:Bithynia siamensis goniomphalos is the snail intermediate host of the liver fluke, Opisthorchis viverrini, the leading cause of cholangiocarcinoma (CCA) in the Greater Mekong sub-region of Thailand. Despite the severe public health impact of Opisthorchis-induced CCA, knowledge of the molecular interactions o...

journal_title：PLoS neglected tropical diseases

authors： Prasopdee S,Sotillo J,Tesana S,Laha T,Kulsantiwong J,Nolan MJ,Loukas A,Cantacessi C

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:Schistosomiasis in one of the most prevalent parasitic diseases, affecting millions of people and animals in developing countries. Amongst the human-infective species S. haematobium is one of the most widespread causing urogenital schistosomiasis, a major human health problem across Africa, however in terms ...

journal_title：PLoS neglected tropical diseases

authors： Webster BL,Emery AM,Webster JP,Gouvras A,Garba A,Diaw O,Seye MM,Tchuente LA,Simoonga C,Mwanga J,Lange C,Kariuki C,Mohammed KA,Stothard JR,Rollinson D

更新日期：2012-01-01 00:00:00

abstract：:The increasing burden of dengue, and the relative failure of traditional vector control programs highlight the need to develop new control methods. SIT using self-limiting genetic technology is one such promising method. A self-limiting strain of Aedes aegypti, OX513A, has already reached the stage of field evaluation...

journal_title：PLoS neglected tropical diseases

authors： Carvalho DO,McKemey AR,Garziera L,Lacroix R,Donnelly CA,Alphey L,Malavasi A,Capurro ML

更新日期：2015-07-02 00:00:00

abstract：:Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to mi...

journal_title：PLoS neglected tropical diseases

authors： Molina-Morant D,Sánchez-Montalvá A,Salvador F,Sao-Avilés A,Molina I

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:Hosts repeatedly bitten by sand flies develop antibodies against sand fly saliva and screening of these immunoglobulins can be employed to estimate the risk of Leishmania transmission, to indicate the feeding preferences of sand flies, or to evaluate the effectiveness of vector control campaigns. Previously,...

journal_title：PLoS neglected tropical diseases

authors： Sima M,Ferencova B,Bhattacharyya T,Miles MA,Litvinov SV,Hailu A,Baneth G,Volf P

更新日期：2019-01-24 00:00:00

abstract：:Our knowledge and control of the pathogenesis induced by the filariae remain limited due to experimental obstacles presented by parasitic nematode biology and the lack of selective prophylactic or curative drugs. Here we thought to investigate the role of neutrophils in the host innate immune response to the infection...

journal_title：PLoS neglected tropical diseases

authors： Pionnier N,Brotin E,Karadjian G,Hemon P,Gaudin-Nomé F,Vallarino-Lhermitte N,Nieguitsila A,Fercoq F,Aknin ML,Marin-Esteban V,Chollet-Martin S,Schlecht-Louf G,Bachelerie F,Martin C

更新日期：2016-04-25 00:00:00

abstract：:To eliminate schistosomiasis, appropriate diagnostic tests are required to monitor its prevalence and transmission, especially in the settings with low endemicity resulting from the consecutive mass drug administration. Antibodies that react with either crude soluble schistosome egg antigens or soluble worm antigen pr...

journal_title：PLoS neglected tropical diseases

authors： Mohammed ES,Nakamura R,Kalenda YD,Deloer S,Moriyasu T,Tanaka M,Fujii Y,Kaneko S,Hirayama K,Ibrahim AI,El-Seify MA,Metwally AM,Hamano S

更新日期：2020-09-11 00:00:00

abstract：BACKGROUND:In the past decade, research on neglected tropical diseases (NTDs) has intensified in response to the need to enhance community participation in health delivery, establish monitoring and surveillance systems, and integrate existing disease-specific treatment programs to control overlapping NTD burdens and de...

journal_title：PLoS neglected tropical diseases

authors： Armah FA,Quansah R,Luginaah I,Chuenpagdee R,Hambati H,Campbell G

更新日期：2015-08-04 00:00:00

abstract：BACKGROUND:Leptospirosis is an emerging zoonosis that is often under-recognized in children and commonly confused with dengue in tropical settings. An enhanced ability to distinguish leptospirosis from dengue in children would guide clinicians and public health personnel in the appropriate use of limited healthcare res...

journal_title：PLoS neglected tropical diseases

authors： Libraty DH,Myint KS,Murray CK,Gibbons RV,Mammen MP,Endy TP,Li W,Vaughn DW,Nisalak A,Kalayanarooj S,Hospenthal DR,Green S,Rothman AL,Ennis FA

更新日期：2007-12-26 00:00:00

abstract：INTRODUCTION:Chikungunya is an emerging public health problem in tropical and subtropical regions, due to ongoing transmission and its incapacitating acute disease phase, and chronic sequelae. The disease is responsible for a major impact on Health Related Quality of Life (HRQoL), which may last several years. To our k...

journal_title：PLoS neglected tropical diseases

authors： Elsinga J,Grobusch MP,Tami A,Gerstenbluth I,Bailey A

更新日期：2017-10-09 00:00:00

abstract：:Tsetse are vectors of pathogenic trypanosomes, agents of human and animal trypanosomiasis in Africa. Components of tsetse saliva (sialome) are introduced into the mammalian host bite site during the blood feeding process and are important for tsetse's ability to feed efficiently, but can also influence disease transmi...

journal_title：PLoS neglected tropical diseases

authors： Zhao X,Alves e Silva TL,Cronin L,Savage AF,O'Neill M,Nerima B,Okedi LM,Aksoy S

更新日期：2015-08-27 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0006803.]. ...

journal_title：PLoS neglected tropical diseases

authors： PLOS Neglected Tropical Diseases Staff.

更新日期：2019-02-26 00:00:00

abstract：:Rift Valley fever (RVF), a re-emerging mosquito-borne disease of ruminants and man, was endemic in Africa but spread to Saudi Arabia and Yemen, meaning it could spread even further. Little is known about innate and cell-mediated immunity to RVF virus (RVFV) in ruminants, which is knowledge required for adequate vaccin...

journal_title：PLoS neglected tropical diseases

authors： Nfon CK,Marszal P,Zhang S,Weingartl HM

更新日期：2012-01-01 00:00:00