Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening.


:The potential use of clinically approved beta-lactams for Buruli ulcer (BU) treatment was investigated with representative classes analyzed in vitro for activity against Mycobacterium ulcerans. Beta-lactams tested were effective alone and displayed a strong synergistic profile in combination with antibiotics currently used to treat BU, i.e. rifampicin and clarithromycin; this activity was further potentiated in the presence of the beta-lactamase inhibitor clavulanate. In addition, quadruple combinations of rifampicin, clarithromycin, clavulanate and beta-lactams resulted in multiplicative reductions in their minimal inhibitory concentration (MIC) values. The MIC of amoxicillin against a panel of clinical isolates decreased more than 200-fold within this quadruple combination. Amoxicillin/clavulanate formulations are readily available with clinical pedigree, low toxicity, and orally and pediatric available; thus, supporting its potential inclusion as a new anti-BU drug in current combination therapies.


PLoS Negl Trop Dis


Arenaz-Callao MP,González Del Río R,Lucía Quintana A,Thompson CJ,Mendoza-Losana A,Ramón-García S




Has Abstract


2019-01-28 00:00:00














  • Changes over Time in IgE Sensitization to Allergens of the Fish Parasite Anisakis spp.

    abstract:BACKGROUND:Sensitization to Anisakis spp. can produce allergic reactions after eating raw or undercooked parasitized fish. Specific IgE is detected long after the onset of symptoms, but the changes in specific IgE levels over a long follow-up period are unknown; furthermore, the influence of Anisakis spp. allergen expo...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Carballeda-Sangiao N,Rodríguez-Mahillo AI,Careche M,Navas A,Moneo I,González-Muñoz M

    更新日期:2016-07-22 00:00:00

  • Serological evidence of Rift Valley fever virus circulation in sheep and goats in Zambézia Province, Mozambique.

    abstract::Rift Valley fever (RVF) is endemic in most parts of Africa and has also been reported to occur in the Arabian Peninsula. It is responsible for significant morbidity and mortality, particularly in livestock, but also in humans. During the last two decades several outbreaks of RVF have been reported in countries in Sout...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Fafetine J,Neves L,Thompson PN,Paweska JT,Rutten VP,Coetzer JA

    更新日期:2013-01-01 00:00:00

  • Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress.

    abstract:BACKGROUND:Miltefosine (MIL) is an oral antileishmanial drug used for treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Recent reports indicate a significant decline in its efficacy with a high rate of relapse in VL as well as post kala-azar dermal leishmaniasis (PKDL). We investigated the parasitic ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Deep DK,Singh R,Bhandari V,Verma A,Sharma V,Wajid S,Sundar S,Ramesh V,Dujardin JC,Salotra P

    更新日期:2017-06-02 00:00:00

  • Source tracking Mycobacterium ulcerans infections in the Ashanti region, Ghana.

    abstract::Although several studies have associated Mycobacterium ulcerans (MU) infection, Buruli ulcer (BU), with slow moving water bodies, there is still no definite mode of transmission. Ecological and transmission studies suggest Variable Number Tandem Repeat (VNTR) typing as a useful tool to differentiate MU strains from ot...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Narh CA,Mosi L,Quaye C,Dassi C,Konan DO,Tay SC,de Souza DK,Boakye DA,Bonfoh B

    更新日期:2015-01-22 00:00:00

  • LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania.

    abstract::Leishmaniasis is a neglected disease produced by the intracellular protozoan parasite Leishmania. In the present study, we show that LABCG2, a new ATP-binding cassette half-transporter (ABCG subfamily) from Leishmania, is involved in parasite virulence. Down-regulation of LABCG2 function upon expression of an inactive...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Campos-Salinas J,León-Guerrero D,González-Rey E,Delgado M,Castanys S,Pérez-Victoria JM,Gamarro F

    更新日期:2013-04-25 00:00:00

  • Neutral polymorphisms in putative housekeeping genes and tandem repeats unravels the population genetics and evolutionary history of Plasmodium vivax in India.

    abstract::The evolutionary history and age of Plasmodium vivax has been inferred as both recent and ancient by several studies, mainly using mitochondrial genome diversity. Here we address the age of P. vivax on the Indian subcontinent using selectively neutral housekeeping genes and tandem repeat loci. Analysis of ten housekee...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Prajapati SK,Joshi H,Carlton JM,Rizvi MA

    更新日期:2013-09-19 00:00:00

  • A Comparison between Transcriptome Sequencing and 16S Metagenomics for Detection of Bacterial Pathogens in Wildlife.

    abstract:BACKGROUND:Rodents are major reservoirs of pathogens responsible for numerous zoonotic diseases in humans and livestock. Assessing their microbial diversity at both the individual and population level is crucial for monitoring endemic infections and revealing microbial association patterns within reservoirs. Recently, ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Razzauti M,Galan M,Bernard M,Maman S,Klopp C,Charbonnel N,Vayssier-Taussat M,Eloit M,Cosson JF

    更新日期:2015-08-18 00:00:00

  • Viral etiology of encephalitis in children in southern Vietnam: results of a one-year prospective descriptive study.

    abstract:BACKGROUND:Acute encephalitis is an important and severe disease in children in Vietnam. However, little is known about the etiology while such knowledge is essential for optimal prevention and treatment. To identify viral causes of encephalitis, in 2004 we conducted a one-year descriptive study at Children's Hospital ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Le VT,Phan TQ,Do QH,Nguyen BH,Lam QB,Bach V,Truong H,Tran TH,Nguyen V,Tran T,Vo M,Tran VT,Schultsz C,Farrar J,van Doorn HR,de Jong MD

    更新日期:2010-10-26 00:00:00

  • RNA-Seq reveals infection-induced gene expression changes in the snail intermediate host of the carcinogenic liver fluke, Opisthorchis viverrini.

    abstract:BACKGROUND:Bithynia siamensis goniomphalos is the snail intermediate host of the liver fluke, Opisthorchis viverrini, the leading cause of cholangiocarcinoma (CCA) in the Greater Mekong sub-region of Thailand. Despite the severe public health impact of Opisthorchis-induced CCA, knowledge of the molecular interactions o...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Prasopdee S,Sotillo J,Tesana S,Laha T,Kulsantiwong J,Nolan MJ,Loukas A,Cantacessi C

    更新日期:2014-03-27 00:00:00

  • The Mbam drainage system and onchocerciasis transmission post ivermectin mass drug administration (MDA) campaign, Cameroon.

    abstract:BACKGROUND:The impact of large scale Mass Drug Adminstration (MDA) of ivermectin on active onchocerciasis transmission by Simulium damnosum, which transmits the parasite O. volvulus is of great importance for onchocerciasis control programmes. We investigated in the Mbam river system area, the impact of MDA of ivermect...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Abong RA,Amambo GN,Hamid AA,Enow BA,Beng AA,Nietcho FN,Nji TM,Njouendou AJ,Ritter M,Esum ME,Deribe K,Cho JF,Fombad FF,Enyong PI,Poole C,Pfarr K,Hoerauf A,Carlow C,Wanji S

    更新日期:2021-01-19 00:00:00

  • Imported endemic mycoses in Spain: Evolution of hospitalized cases, clinical characteristics and correlation with migratory movements, 1997-2014.

    abstract::Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to mi...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Molina-Morant D,Sánchez-Montalvá A,Salvador F,Sao-Avilés A,Molina I

    更新日期:2018-02-15 00:00:00

  • High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.

    abstract:BACKGROUND:Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active protein kinase complex with Leishmania cyclins CYCA and C...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Walker RG,Thomson G,Malone K,Nowicki MW,Brown E,Blake DG,Turner NJ,Walkinshaw MD,Grant KM,Mottram JC

    更新日期:2011-04-05 00:00:00

  • Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana.

    abstract:INTRODUCTION:Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appro...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Marks M,Kwakye-Maclean C,Doherty R,Adwere P,Aziz Abdulai A,Duah F,Ohene SA,Mitja O,Oguti B,Solomon AW,Mabey DCW,Adu-Sarkodie Y,Asiedu K,Ackumey MM

    更新日期:2017-07-31 00:00:00

  • Evaluation of ocular involvement in patients with Hansen's disease.

    abstract::Hansen's disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70-75% worldwide. About 10-50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5%...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Pavezzi PD,do Prado RB,Boin Filho PÂ,Gon ADS,Tuma B,Fornazieri MA,Scalone FM,Alves LRM,Montero RH,Casella AMB

    更新日期:2020-09-21 00:00:00

  • Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment.

    abstract:BACKGROUND:Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is a paucity of data on ILC2s in the context of human parasitic infections and in particula...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Nausch N,Appleby LJ,Sparks AM,Midzi N,Mduluza T,Mutapi F

    更新日期:2015-03-23 00:00:00

  • A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital.

    abstract:BACKGROUND:Salmonella serovars Typhi (S. Typhi) and Paratyphi A (S. Paratyphi A), the causative agents of enteric fever, have been routinely isolated organisms from the blood of febrile patients in the Kathmandu Valley since the early 1990s. Susceptibility against commonly used antimicrobials for treating enteric fever...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Zellweger RM,Basnyat B,Shrestha P,Prajapati KG,Dongol S,Sharma PK,Koirala S,Darton TC,Dolecek C,Thompson CN,Thwaites GE,Baker SG,Karkey A

    更新日期:2017-11-27 00:00:00

  • Empiric deworming and CD4 count recovery in HIV-infected Ugandans initiating antiretroviral therapy.

    abstract:BACKGROUND:There is conflicting evidence on the immunologic benefit of treating helminth co-infections ("deworming") in HIV-infected individuals. Several studies have documented reduced viral load and increased CD4 count in antiretroviral therapy (ART) naïve individuals after deworming. However, there are a lack of dat...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Lankowski AJ,Tsai AC,Kanyesigye M,Bwana M,Haberer JE,Wenger M,Martin JN,Bangsberg DR,Hunt PW,Siedner MJ

    更新日期:2014-08-07 00:00:00

  • Determinants of two-year mortality among HIV positive patients with Cryptococcal meningitis initiating standard antifungal treatment with or without adjunctive dexamethasone in Uganda.

    abstract::Globally, early initiation of antiretroviral therapy for HIV led to a reduction in the estimated mortality from cryptococcal meningitis (CCM) from 624,700 in 2009 to 181,100 in 2014. However, CCM remains one of the leading causes of mortality among HIV infected patients especially in sub-Saharan Africa where 75% of th...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Kitonsa J,Nsubuga R,Mayanja Y,Kiwanuka J,Nikweri Y,Onyango M,Anywaine Z,Ggayi AB,Kibengo FM,Kaleebu P,Day J

    更新日期:2020-11-30 00:00:00

  • Identification of French Guiana sand flies using MALDI-TOF mass spectrometry with a new mass spectra library.

    abstract::Phlebotomine sand flies are insects that are highly relevant in medicine, particularly as the sole proven vectors of leishmaniasis. Accurate identification of sand fly species is an essential prerequisite for eco-epidemiological studies aiming to better understand the disease. Traditional morphological identification ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Chavy A,Nabet C,Normand AC,Kocher A,Ginouves M,Prévot G,Vasconcelos Dos Santos T,Demar M,Piarroux R,de Thoisy B

    更新日期:2019-02-01 00:00:00

  • The concentrations of ambient Burkholderia pseudomallei during typhoon season in endemic area of melioidosis in Taiwan.

    abstract:BACKGROUND:Melioidosis is a severe bacterial infection caused by Burkholderia pseudomallei with a high case-fatality rate. Epidemiological and animal studies show the possibility of inhalation transmission. However, no B. pseudomallei concentrations in ambient air have been researched. Here, we developed a method to qu...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Chen YL,Yen YC,Yang CY,Lee MS,Ho CK,Mena KD,Wang PY,Chen PS

    更新日期:2014-05-29 00:00:00

  • Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us.

    abstract::Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: El Baidouri F,Diancourt L,Berry V,Chevenet F,Pratlong F,Marty P,Ravel C

    更新日期:2013-06-13 00:00:00

  • Innate immune response to Rift Valley fever virus in goats.

    abstract::Rift Valley fever (RVF), a re-emerging mosquito-borne disease of ruminants and man, was endemic in Africa but spread to Saudi Arabia and Yemen, meaning it could spread even further. Little is known about innate and cell-mediated immunity to RVF virus (RVFV) in ruminants, which is knowledge required for adequate vaccin...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Nfon CK,Marszal P,Zhang S,Weingartl HM

    更新日期:2012-01-01 00:00:00

  • Identification of microRNA genes in three opisthorchiids.

    abstract:BACKGROUND:Opisthorchis felineus, O. viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose a serious threat to humans in some countries and cause opisthorchiasis/clonorchiasis. Chronic disease may lead to a risk of carcinogenesis in the biliary ducts. MicroRNAs (miRNAs) are small...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Ovchinnikov VY,Afonnikov DA,Vasiliev GV,Kashina EV,Sripa B,Mordvinov VA,Katokhin AV

    更新日期:2015-04-21 00:00:00

  • Directed evaluation of enterotoxigenic Escherichia coli autotransporter proteins as putative vaccine candidates.

    abstract:BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) is a major diarrheal pathogen in developing countries, where it accounts for millions of infections and hundreds of thousands of deaths annually. While vaccine development to prevent diarrheal illness due to ETEC is feasible, extensive effort is needed to identify cons...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Harris JA,Roy K,Woo-Rasberry V,Hamilton DJ,Kansal R,Qadri F,Fleckenstein JM

    更新日期:2011-12-01 00:00:00

  • The invasive Asian bush mosquito Aedes japonicus found in the Netherlands can experimentally transmit Zika virus and Usutu virus.

    abstract:BACKGROUND:The Asian bush mosquito Aedes japonicus is invading Europe and was first discovered in Lelystad, the Netherlands in 2013, where it has established a permanent population. In this study, we investigated the vector competence of Ae. japonicus from the Netherlands for the emerging Zika virus (ZIKV) and zoonotic...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Abbo SR,Visser TM,Wang H,Göertz GP,Fros JJ,Abma-Henkens MHC,Geertsema C,Vogels CBF,Koopmans MPG,Reusken CBEM,Hall-Mendelin S,Hall RA,van Oers MM,Koenraadt CJM,Pijlman GP

    更新日期:2020-04-13 00:00:00

  • Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.

    abstract::We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Morizot G,Jouffroy R,Faye A,Chabert P,Belhouari K,Calin R,Charlier C,Miailhes P,Siriez JY,Mouri O,Yera H,Gilquin J,Tubiana R,Lanternier F,Mamzer MF,Legendre C,Peyramond D,Caumes E,Lortholary O,Buffet P

    更新日期:2016-01-06 00:00:00

  • Associations between selective attention and soil-transmitted helminth infections, socioeconomic status, and physical fitness in disadvantaged children in Port Elizabeth, South Africa: An observational study.

    abstract:BACKGROUND:Socioeconomically deprived children are at increased risk of ill-health associated with sedentary behavior, malnutrition, and helminth infection. The resulting reduced physical fitness, growth retardation, and impaired cognitive abilities may impede children's capacity to pay attention. The present study exa...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Gall S,Müller I,Walter C,Seelig H,Steenkamp L,Pühse U,du Randt R,Smith D,Adams L,Nqweniso S,Yap P,Ludyga S,Steinmann P,Utzinger J,Gerber M

    更新日期:2017-05-08 00:00:00

  • Molecular Epidemiology of Amoebiasis: A Cross-Sectional Study among North East Indian Population.

    abstract:BACKGROUND:Epidemiological studies carried out using culture or microscopy in most of the amoebiasis endemic developing countries, yielded confusing results since none of these could differentiate the pathogenic Entamoeba histolytica from the non-pathogenic Entamoeba dispar and Entamoeba moshkovskii. The Northeastern p...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Nath J,Ghosh SK,Singha B,Paul J

    更新日期:2015-12-03 00:00:00

  • Seroepidemiology of helminths and the association with severe malaria among infants and young children in Tanzania.

    abstract::The disease burden of Wuchereria bancrofti and Plasmodium falciparum malaria is high, particularly in Africa, and co-infection is common. However, the effects of filarial infection on the risk of severe malaria are unknown. We used the remaining serum samples from a large cohort study in Muheza, Tanzania to describe v...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Kwan JL,Seitz AE,Fried M,Lee KL,Metenou S,Morrison R,Kabyemela E,Nutman TB,Prevots DR,Duffy PE

    更新日期:2018-03-26 00:00:00

  • Assessing Lymphatic Filariasis Data Quality in Endemic Communities in Ghana, Using the Neglected Tropical Diseases Data Quality Assessment Tool for Preventive Chemotherapy.

    abstract:BACKGROUND:The activities of the Global Programme for the Elimination of Lymphatic Filariasis have been in operation since the year 2000, with Mass Drug Administration (MDA) undertaken yearly in disease endemic communities. Information collected during MDA-such as population demographics, age, sex, drugs used and remai...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: de Souza DK,Yirenkyi E,Otchere J,Biritwum NK,Ameme DK,Sackey S,Ahorlu C,Wilson MD

    更新日期:2016-03-30 00:00:00