Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening.

Abstract:

:The potential use of clinically approved beta-lactams for Buruli ulcer (BU) treatment was investigated with representative classes analyzed in vitro for activity against Mycobacterium ulcerans. Beta-lactams tested were effective alone and displayed a strong synergistic profile in combination with antibiotics currently used to treat BU, i.e. rifampicin and clarithromycin; this activity was further potentiated in the presence of the beta-lactamase inhibitor clavulanate. In addition, quadruple combinations of rifampicin, clarithromycin, clavulanate and beta-lactams resulted in multiplicative reductions in their minimal inhibitory concentration (MIC) values. The MIC of amoxicillin against a panel of clinical isolates decreased more than 200-fold within this quadruple combination. Amoxicillin/clavulanate formulations are readily available with clinical pedigree, low toxicity, and orally and pediatric available; thus, supporting its potential inclusion as a new anti-BU drug in current combination therapies.

journal_name

PLoS Negl Trop Dis

authors

Arenaz-Callao MP,González Del Río R,Lucía Quintana A,Thompson CJ,Mendoza-Losana A,Ramón-García S

doi

10.1371/journal.pntd.0007126

subject

Has Abstract

pub_date

2019-01-28 00:00:00

pages

e0007126

issue

1

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-18-01585

journal_volume

13

pub_type

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