Coinjection with TLR2 agonist Pam3CSK4 reduces the pathology of leishmanization in mice.

abstract：:Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the...

journal_title：PLoS neglected tropical diseases

authors： de St Maurice A,Harmon J,Nyakarahuka L,Balinandi S,Tumusiime A,Kyondo J,Mulei S,Namutebi A,Knust B,Shoemaker T,Nichol ST,McElroy AK,Spiropoulou CF

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. METHODOLOGY:Cross-sectional interview data and stool s...

journal_title：PLoS neglected tropical diseases

authors： Riess H,Clowes P,Kroidl I,Kowuor DO,Nsojo A,Mangu C,Schüle SA,Mansmann U,Geldmacher C,Mhina S,Maboko L,Hoelscher M,Saathoff E

更新日期：2013-09-05 00:00:00

abstract：BACKGROUND:Measuring the impact of capacity strengthening support is a priority for the international development community. Several frameworks exist for monitoring and evaluating funding results and modalities. Based on its long history of support, we report on the impact of individual and institutional capacity stren...

journal_title：PLoS neglected tropical diseases

authors： Minja H,Nsanzabana C,Maure C,Hoffmann A,Rumisha S,Ogundahunsi O,Zicker F,Tanner M,Launois P

更新日期：2011-10-01 00:00:00

abstract：:The niche conservatism hypothesis states that related species diverge in niche characteristics at lower rates than expected, given their lineage divergence. Here we analyze whether niche conservatism is a common pattern among vector species (Hemiptera: Reduviidae: Triatominae) of Trypanosoma cruzi that inhabit North a...

journal_title：PLoS neglected tropical diseases

authors： Ibarra-Cerdeña CN,Zaldívar-Riverón A,Peterson AT,Sánchez-Cordero V,Ramsey JM

更新日期：2014-10-30 00:00:00

abstract：BACKGROUND:In South Asia, hundreds of millions of people are infected with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura). However, high-resolution risk profiles and the estimated number of people infected have yet to be determined. In turn, such information will assist control pro...

journal_title：PLoS neglected tropical diseases

authors： Lai YS,Biedermann P,Shrestha A,Chammartin F,À Porta N,Montresor A,Mistry NF,Utzinger J,Vounatsou P

更新日期：2019-08-09 00:00:00

abstract：:The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV. The mechanism underlying the mouse resistance to JUNV infection is largely unknown. We have reported that ...

journal_title：PLoS neglected tropical diseases

authors： Huang C,Walker AG,Grant AM,Kolokoltsova OA,Yun NE,Seregin AV,Paessler S

更新日期：2014-06-05 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination by the year 2020. As of 2017, 67 of the 72 endemic countries have implemented annual Mass Drug Administration (MDA) for interrupting LF transmission. Transmission Assessment Survey (TAS) is the recommended protocol to evaluate the impact of MDA and to dec...

journal_title：PLoS neglected tropical diseases

authors： Subramanian S,Jambulingam P,Krishnamoorthy K,Sivagnaname N,Sadanandane C,Vasuki V,Palaniswamy C,Vijayakumar B,Srividya A,Raju HKK

更新日期：2020-01-24 00:00:00

abstract：OBJECTIVE:We evaluated the profile of patients referred to the Fiocruz Outpatient Clinic, a reference center for the diagnosis and treatment of leprosy in Rio de Janeiro, RJ, and analyzed the origins and outcomes of these referrals. METHODS:This is an observational retrospective study based on information collected fr...

journal_title：PLoS neglected tropical diseases

authors： Barbieri RR,Sales AM,Hacker MA,Nery JA,Duppre NC,Machado AM,Moraes MO,Sarno EN

更新日期：2016-10-12 00:00:00

abstract：BACKGROUND:Cryptosporidium is a leading cause of moderate-to-severe diarrhea (MSD) in young children in Africa. We examined factors associated with Cryptosporidium infection in MSD cases enrolled at the rural western Kenya Global Enteric Multicenter Study (GEMS) site from 2008-2012. METHODOLOGY/PRINCIPAL FINDINGS:At h...

journal_title：PLoS neglected tropical diseases

authors： Delahoy MJ,Omore R,Ayers TL,Schilling KA,Blackstock AJ,Ochieng JB,Moke F,Jaron P,Awuor A,Okonji C,Juma J,Farag TH,Nasrin D,Panchalingam S,Nataro JP,Kotloff KL,Levine MM,Oundo J,Roellig DM,Xiao L,Parsons MB,Laser

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:Crimean-Congo hemorrhagic fever (CCHF) activity has recently been detected in the Kordufan region of Sudan. Since 2008, several sporadic cases and nosocomial outbreaks associated with high case-fatality have been reported in villages and rural hospitals in the region. PRINCIPAL FINDINGS:In the present study...

journal_title：PLoS neglected tropical diseases

authors： Aradaib IE,Erickson BR,Karsany MS,Khristova ML,Elageb RM,Mohamed ME,Nichol ST

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Trachoma prevalence surveys provide the evidence base for district and community-wide implementation of the SAFE strategy, and are used to evaluate the impact of trachoma control interventions. An economic analysis was performed to estimate the cost of trachoma prevalence surveys conducted between 2006 and 2...

journal_title：PLoS neglected tropical diseases

authors： Chen C,Cromwell EA,King JD,Mosher A,Harding-Esch EM,Ngondi JM,Emerson PM

更新日期：2011-03-08 00:00:00

abstract：BACKGROUND:Leishmaniasis is a complex disease in which clinical outcome depends on factors such as parasite species, host genetics and immunity and vector species. In Brazil, Leishmania (Viannia) braziliensis is a major etiological agent of cutaneous (CL) and mucosal leishmaniasis (MCL), a disfiguring form of the disea...

journal_title：PLoS neglected tropical diseases

authors： Alves-Ferreira EV,Toledo JS,De Oliveira AH,Ferreira TR,Ruy PC,Pinzan CF,Santos RF,Boaventura V,Rojo D,López-Gonzálvez Á,Rosa JC,Barbas C,Barral-Netto M,Barral A,Cruz AK

更新日期：2015-09-14 00:00:00

abstract：BACKGROUND:Paracoccidioidomycosis, a primary fungal infection restricted to Latin America, is acquired by inhalation of fungal particles. The immunoregulatory mechanisms that control the severe and mild forms of paracoccidioidomycosis are still unclear. Indoleamine 2,3-dioxygenase (IDO), an IFN-γ induced enzyme that ca...

journal_title：PLoS neglected tropical diseases

authors： Araújo EF,Loures FV,Bazan SB,Feriotti C,Pina A,Schanoski AS,Costa TA,Calich VL

更新日期：2014-11-20 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis is a neglected parasitic disease with no vaccine available and its pharmacological treatment is reduced to a limited number of unsafe drugs. The scarce readiness of new antileishmanial drugs is even more alarming when relapses appear or the occurrence of hard-to-treat resistant strains...

journal_title：PLoS neglected tropical diseases

authors： Álvarez-Velilla R,Gutiérrez-Corbo MDC,Punzón C,Pérez-Pertejo MY,Balaña-Fouce R,Fresno M,Reguera RM

更新日期：2019-02-14 00:00:00

abstract：INTRODUCTION:Little is known about hepatotoxicity in patients with schistosome and HIV co-infections. Several studies have reported increased liver enzymes and bilirubin levels associated with schistosome infection. We investigated whether HIV-infected adults on antiretroviral therapy who had S. mansoni co-infection ha...

journal_title：PLoS neglected tropical diseases

authors： Marti AI,Colombe S,Masikini PJ,Kalluvya SE,Smart LR,Wajanga BM,Jaka H,Peck RN,Downs JA

更新日期：2017-08-17 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0005370.]. ...

journal_title：PLoS neglected tropical diseases

authors： Loos JA,Dávila VA,Rodriguez Rodrigues C,Petrigh R,Zoppi JA,Crocenzi FA,Cumino AC

更新日期：2017-03-22 00:00:00

abstract：:Globally, early initiation of antiretroviral therapy for HIV led to a reduction in the estimated mortality from cryptococcal meningitis (CCM) from 624,700 in 2009 to 181,100 in 2014. However, CCM remains one of the leading causes of mortality among HIV infected patients especially in sub-Saharan Africa where 75% of th...

journal_title：PLoS neglected tropical diseases

authors： Kitonsa J,Nsubuga R,Mayanja Y,Kiwanuka J,Nikweri Y,Onyango M,Anywaine Z,Ggayi AB,Kibengo FM,Kaleebu P,Day J

更新日期：2020-11-30 00:00:00

abstract：:The N-linked glycosylation motif at amino acid position 154-156 of the envelope (E) protein of West Nile virus (WNV) is linked to enhanced murine neuroinvasiveness, avian pathogenicity and vector competence. Naturally occurring isolates with altered E protein glycosylation patterns have been observed in WNV isolates; ...

journal_title：PLoS neglected tropical diseases

authors： Maharaj PD,Langevin SA,Bolling BG,Andrade CC,Engle XA,Ramey WN,Bosco-Lauth A,Bowen RA,Sanders TA,Huang CY,Reisen WK,Brault AC

更新日期：2019-07-15 00:00:00

abstract：:Control of arbovirus transmission remains focused on vector control through application of insecticides directly to the environment. However, these insecticide applications are often reactive interventions that can be poorly-targeted, inadequate for localized control during outbreaks, and opposed due to environmental ...

journal_title：PLoS neglected tropical diseases

authors： Nguyen C,Gray M,Burton TA,Foy SL,Foster JR,Gendernalik AL,Rückert C,Alout H,Young MC,Boze B,Ebel GD,Clapsaddle B,Foy BD

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:In the late twentieth century, emergence of high rates of treatment failure with antimonial compounds (SSG) for visceral leishmaniasis (VL) caused a public health crisis in Bihar, India. We hypothesize that exposure to arsenic through drinking contaminated groundwater may be associated with SSG treatment fai...

journal_title：PLoS neglected tropical diseases

authors： Perry MR,Prajapati VK,Menten J,Raab A,Feldmann J,Chakraborti D,Sundar S,Fairlamb AH,Boelaert M,Picado A

更新日期：2015-03-02 00:00:00

abstract：BACKGROUND:Schistosome eggs must traverse tissues of the intestine or bladder to escape the human host and further the life cycle. Escape from host tissues is facilitated by secretion of immuno-reactive molecules by eggs and the formation of an intense strong granulomatous response by the host which acts to exclude the...

journal_title：PLoS neglected tropical diseases

authors： Jones MK,Bong SH,Green KM,Holmes P,Duke M,Loukas A,McManus DP

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appro...

journal_title：PLoS neglected tropical diseases

authors： Marks M,Kwakye-Maclean C,Doherty R,Adwere P,Aziz Abdulai A,Duah F,Ohene SA,Mitja O,Oguti B,Solomon AW,Mabey DCW,Adu-Sarkodie Y,Asiedu K,Ackumey MM

更新日期：2017-07-31 00:00:00

abstract：BACKGROUND:Transmission of dengue virus (DENV) from humans to mosquitoes represents a critical component of dengue epidemiology. Examinations of this process have generally been hampered by a lack of methods that adequately represent natural acquisition of DENV by mosquitoes from humans. In this study, we assessed arti...

journal_title：PLoS neglected tropical diseases

authors： Long KC,Sulca J,Bazan I,Astete H,Jaba HL,Siles C,Kocher C,Vilcarromero S,Schwarz J,Escobedo-Vargas KS,Castro-Llanos F,Angulo L,Flores G,Ramal-Asayag C,Halsey ES,Hontz RD,Paz-Soldan VA,Scott TW,Lambrechts L,Morrison

更新日期：2019-02-12 00:00:00

abstract：:Revealing the patterns and determinants of the spread of dengue virus (DENV) at local scales is central to understanding the epidemiology and evolution of this major human pathogen. We performed a phylogenetic analysis of the envelope (E) genes of DENV-1, -2, -3, and -4 isolates (involving 97, 23, 5, and 74 newly coll...

journal_title：PLoS neglected tropical diseases

authors： Rabaa MA,Klungthong C,Yoon IK,Holmes EC,Chinnawirotpisan P,Thaisomboonsuk B,Srikiatkhachorn A,Rothman AL,Tannitisupawong D,Aldstadt J,Nisalak A,Mammen MP,Gibbons RV,Endy TP,Fansiri T,Scott TW,Jarman RG

更新日期：2013-01-01 00:00:00

abstract：:Enzootic strains of Venezuelan equine encephalitis virus (VEEV) have been isolated from febrile patients in the Peruvian Amazon Basin at low but consistent levels since the early 1990s. Through a clinic-based febrile surveillance program, we detected an outbreak of VEEV infections in Iquitos, Peru, in the first half o...

journal_title：PLoS neglected tropical diseases

authors： Morrison AC,Forshey BM,Notyce D,Astete H,Lopez V,Rocha C,Carrion R,Carey C,Eza D,Montgomery JM,Kochel TJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Echinococcosis is a life-threatening parasitic disease caused by Echinococcus spp. tapeworms with over one million people affected globally at any time. The Echinococcus spp. tapeworms in the human body release DNA to the circulatory system, which can be a biomarker for echinococcosis. Cell-free DNA (cfDNA) ...

journal_title：PLoS neglected tropical diseases

authors： Ji J,Li B,Li J,Danzeng W,Li J,Zhao Y,Qiangba G,Zhang Q,Renzhen N,Basang Z,Jia C,Gongsang Q,Ma J,Wang Y,Chen F,Zhou H,Huasang,Yin J,Xie J,Pei N,Cai H,Jiang H,Yang H,Wang J,Asan,Han X,Li J,Chen W,Yan

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:There is conflicting evidence on the immunologic benefit of treating helminth co-infections ("deworming") in HIV-infected individuals. Several studies have documented reduced viral load and increased CD4 count in antiretroviral therapy (ART) naïve individuals after deworming. However, there are a lack of dat...

journal_title：PLoS neglected tropical diseases

authors： Lankowski AJ,Tsai AC,Kanyesigye M,Bwana M,Haberer JE,Wenger M,Martin JN,Bangsberg DR,Hunt PW,Siedner MJ

更新日期：2014-08-07 00:00:00

abstract：:Genomic data generated from clinical Vibrio cholerae O1 isolates collected over a five year period in an area of Kolkata, India with seasonal cholera outbreaks allowed a detailed genetic analysis of serotype switching that occurred from Ogawa to Inaba and back to Ogawa. The change from Ogawa to Inaba resulted from mut...

journal_title：PLoS neglected tropical diseases

authors： Karlsson SL,Thomson N,Mutreja A,Connor T,Sur D,Ali M,Clemens J,Dougan G,Holmgren J,Lebens M

更新日期：2016-10-05 00:00:00

abstract：BACKGROUND:Careful monitoring for recrudescence of Wuchereria bancrofti infection is necessary in communities where mass drug administration (MDA) for the elimination of lymphatic filariasis (LF) as a public health problem has been stopped. During the post-MDA period, transmission assessment surveys (TAS) are recommend...

journal_title：PLoS neglected tropical diseases

authors： Irish SR,Al-Amin HM,Paulin HN,Mahmood ASMS,Khan RK,Muraduzzaman AKM,Worrell CM,Flora MS,Karim MJ,Shirin T,Shamsuzzaman AKM,Tahmina S,Lenhart A,Dubray C

更新日期：2018-07-26 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is one of the most common diarrheal pathogens in the low- and middle-income regions of the world, however a systematic examination of the genomic content of isolates from Chile has not yet been undertaken. Whole genome sequencing and comparative analysis of a collection of 125 E...

journal_title：PLoS neglected tropical diseases

authors： Rasko DA,Del Canto F,Luo Q,Fleckenstein JM,Vidal R,Hazen TH

更新日期：2019-11-20 00:00:00