Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection.

Abstract:

:Aedes aegypti is the primary vector of several medically relevant arboviruses including dengue virus (DENV) types 1-4. Ae. aegypti transmits DENV by inoculating virus-infected saliva into host skin during probing and feeding. Ae. aegypti saliva contains over one hundred unique proteins and these proteins have diverse functions, including facilitating blood feeding. Previously, we showed that Ae. aegypti salivary gland extracts (SGEs) enhanced dissemination of DENV to draining lymph nodes. In contrast, HPLC-fractionation revealed that some SGE components inhibited infection. Here, we show that D7 proteins are enriched in HPLC fractions that are inhibitory to DENV infection, and that recombinant D7 protein can inhibit DENV infection in vitro and in vivo. Further, binding assays indicate that D7 protein can directly interact with DENV virions and recombinant DENV envelope protein. These data reveal a novel role for D7 proteins, which inhibits arbovirus transmission to vertebrates through a direct interaction with virions.

journal_name

PLoS Negl Trop Dis

authors

Conway MJ,Londono-Renteria B,Troupin A,Watson AM,Klimstra WB,Fikrig E,Colpitts TM

doi

10.1371/journal.pntd.0004941

subject

Has Abstract

pub_date

2016-09-15 00:00:00

pages

e0004941

issue

9

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-16-00987

journal_volume

10

pub_type

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