当前位置： SCI文献检索 > PLoS Neglected Tropical Diseases期刊下所有文献 > Mycetoma in Uganda: A neglected tropical disease.

Mycetoma in Uganda: A neglected tropical disease.

Abstract：

:Mycetoma is considered a neglected tropical disease globally. However, data on its burden and the associated complications in Uganda are limited. Hence we aimed to estimate its burden in Uganda. Firstly, a systematic PubMed search for all studies of any design on mycetoma in Uganda without restriction to the year of publication was conducted. A retrospective review of all the biopsy reports at the Pathology Reference Laboratory, Department of Pathology, Makerere University, Kampala, Uganda from January 1950 to September 2019 was conducted to identify any reports on mycetoma histological diagnosis. During the 70-years study period, 30 cases were identified by the literature review, with 249 additional cases identified by review of biopsy reports (total of 279 cases). The average incidence was estimated at 0.32/100,000 persons and prevalence of 8.32/100,000 persons per decade. However, there was a general decline in the number of cases detected recently. Males and the age group of 21-30 years were the most affected by mycetoma in Uganda, and only 7% of the cases were children. The highest number of cases was recorded from Kampala (n = 30) and Jinja (n = 19) districts. The majority of the cases (68%) were referred from surgical units. The foot was the most affected part of the body (72%). Ten per cent of the cases had bone involvement of which 58% required amputation. Fungi were the most common causative agents (89%) followed by Nocardia species (5%) and Actinomycetes (4%). The index of clinical suspicion of mycetoma was low (45%) with a very large differential diagnosis. Mycetoma is a relatively rare disease in Uganda, mostly caused by fungi, and there is a big gap in data and epidemiological studies. More systematic studies are warranted to define the true burden of mycetoma in Uganda.

journal_name

PLoS Negl Trop Dis

journal_title

PLoS neglected tropical diseases

authors

Kwizera R,Bongomin F,Meya DB,Denning DW,Fahal AH,Lukande R

doi

10.1371/journal.pntd.0008240

subject

Has Abstract

pub_date

2020-04-29 00:00:00

pages

e0008240

issue

4

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-19-01892

journal_volume

14

pub_type

杂志文章

相关文献

PLoS Neglected Tropical Diseases文献大全
  • Rodent-borne diseases and their public health importance in Iran.

    abstract：BACKGROUND:Rodents are reservoirs and hosts for several zoonotic diseases such as plague, leptospirosis, and leishmaniasis. Rapid development of industry and agriculture, as well as climate change throughout the globe, has led to change or increase in occurrence of rodent-borne diseases. Considering the distribution of...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章,评审

    doi：10.1371/journal.pntd.0006256

    authors： Rabiee MH,Mahmoudi A,Siahsarvie R,Kryštufek B,Mostafavi E

    更新日期：2018-04-19 00:00:00

  • Diagnosis, treatment and risk factors of Strongyloides stercoralis in schoolchildren in Cambodia.

    abstract：BACKGROUND:Worldwide, an estimated 30 to 100 million people are infected with Strongyloides stercoralis, a soil-transmitted helminth. Information on the parasite is scarce in most settings. In semi-rural Cambodia, we determined infection rates and risk factors; compared two diagnostic methods (Koga agar plate [KAP] cul...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0002035

    authors： Khieu V,Schär F,Marti H,Sayasone S,Duong S,Muth S,Odermatt P

    更新日期：2013-01-01 00:00:00

  • Advanced case of PKDL due to delayed treatment: A rare case report.

    abstract：:Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Le...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0008052

    authors： Topno RK,Rabi Das VN,Kumar M,Madhukar M,Pandey K,Verma N,Agrawal K,Lal CS,Siddiqui NA,Bimal S,Das P

    更新日期：2020-03-23 00:00:00

  • Transcription Profiling of Malaria-Naïve and Semi-immune Colombian Volunteers in a Plasmodium vivax Sporozoite Challenge.

    abstract：BACKGROUND:Continued exposure to malaria-causing parasites in endemic regions of malaria induces significant levels of acquired immunity in adult individuals. A better understanding of the transcriptional basis for this acquired immunological response may provide insight into how the immune system can be boosted during...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0003978

    authors： Rojas-Peña ML,Vallejo A,Herrera S,Gibson G,Arévalo-Herrera M

    更新日期：2015-08-05 00:00:00

  • A clinical severity scoring system for visceral leishmaniasis in immunocompetent patients in South Sudan.

    abstract：BACKGROUND:South Sudan is one of the most endemic countries for visceral leishmaniasis (VL), and is frequently affected by large epidemics. In resource-limited settings, clinicians require a simple clinical tool to identify VL patients who are at increased risk of dying, and who need specialised treatment with liposoma...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0005921

    authors： Kämink SS,Collin SM,Harrison T,Gatluak F,Mullahzada AW,Ritmeijer K

    更新日期：2017-10-02 00:00:00

  • Hazara virus and Crimean-Congo Hemorrhagic Fever Virus show a different pattern of entry in fully-polarized Caco-2 cell line.

    abstract：:Crimean-Congo Hemorrhagic Fever Virus (CCHFV) and Hazara virus (HAZV) belong to the same viral serotype and family. HAZV has lately been used as a model system and surrogate to CCHFV. However, virus-host cell interaction and level of pathogenicity for these viruses are not well investigated nor compared. In this study...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0008863

    authors： Monteil V,Salata C,Appelberg S,Mirazimi A

    更新日期：2020-11-24 00:00:00

  • Pre-operative trichiatic eyelash pattern predicts post-operative trachomatous trichiasis.

    abstract：IMPORTANCE:Trichiasis surgery programs globally have faced high rates of poor surgical outcomes. Identifying correctable risk factors for improving long-term outcomes is essential for countries targeting elimination of trachoma as a public health problem. OBJECTIVE:To determine whether the location of trichiatic eyela...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章,随机对照试验

    doi：10.1371/journal.pntd.0007637

    authors： Gower EW,Munoz B,Rajak S,Habtamu E,West SK,Merbs SL,Harding JC,Alemayehu W,Callahan EK,Emerson PM,Gebre T,Burton MJ

    更新日期：2019-10-07 00:00:00

  • Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions.

    abstract：:Accumulating evidences have assigned a central role to parasite-derived proteins in immunomodulation. Here, we report on the proteomic identification and characterization of immunomodulatory excretory-secretory (ES) products from the metacestode larva (tetrathyridium) of the tapeworm Mesocestoides corti (syn. M. vogae...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0005061

    authors： Vendelova E,Camargo de Lima J,Lorenzatto KR,Monteiro KM,Mueller T,Veepaschit J,Grimm C,Brehm K,Hrčková G,Lutz MB,Ferreira HB,Nono JK

    更新日期：2016-10-13 00:00:00

  • Backpack PCR: A point-of-collection diagnostic platform for the rapid detection of Brugia parasites in mosquitoes.

    abstract：BACKGROUND:Currently, molecular xenomonitoring efforts for lymphatic filariasis rely on PCR or real-time PCR-based detection of Brugia malayi, Brugia timori and Wuchereria bancrofti in mosquito vectors. Most commonly, extraction of DNA from mosquitoes is performed using silica column-based technologies. However, such e...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0006962

    authors： Zaky WI,Tomaino FR,Pilotte N,Laney SJ,Williams SA

    更新日期：2018-11-21 00:00:00

  • Ecological processes underlying the emergence of novel enzootic cycles: Arboviruses in the neotropics as a case study.

    abstract：:Pathogens originating from wildlife (zoonoses) pose a significant public health burden, comprising the majority of emerging infectious diseases. Efforts to control and prevent zoonotic disease have traditionally focused on animal-to-human transmission, or "spillover." However, in the modern era, increasing internation...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章,评审

    doi：10.1371/journal.pntd.0008338

    authors： Guth S,Hanley KA,Althouse BM,Boots M

    更新日期：2020-08-13 00:00:00

  • Incidence of human Taenia solium larval Infections in an Ecuadorian endemic area: implications for disease burden assessment and control.

    abstract：BACKGROUND:Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS:A seroepid...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0002887

    authors： Coral-Almeida M,Rodríguez-Hidalgo R,Celi-Erazo M,García HH,Rodríguez S,Devleesschauwer B,Benítez-Ortiz W,Dorny P,Praet N

    更新日期：2014-05-22 00:00:00

  • Lymphatic Filariasis Elimination in American Samoa: Evaluation of Molecular Xenomonitoring as a Surveillance Tool in the Endgame.

    abstract：:The Global Programme to Eliminate Lymphatic Filariasis has made significant progress toward interrupting transmission of lymphatic filariasis (LF) through mass drug administration (MDA). Operational challenges in defining endpoints of elimination programs include the need to determine appropriate post-MDA surveillance...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0005108

    authors： Lau CL,Won KY,Lammie PJ,Graves PM

    更新日期：2016-11-01 00:00:00

  • Modeling the risk of transmission of schistosomiasis in Akure North Local Government Area of Ondo State, Nigeria using satellite derived environmental data.

    abstract：:Schistosomiasis is a parasitic disease and its distribution, in space and time, can be influenced by environmental factors such as rivers, elevation, slope, land surface temperature, land use/cover and rainfall. The aim of this study is to identify the areas with suitable conditions for schistosomiasis transmission on...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0005733

    authors： Ajakaye OG,Adedeji OI,Ajayi PO

    更新日期：2017-07-12 00:00:00

  • Trend analysis of leprosy in Morocco between 2000 and 2017: Evidence on the single dose rifampicin chemoprophylaxis.

    abstract：BACKGROUND:Morocco has achieved the goal of leprosy elimination as a public health problem several years ago (less than 1 case/ 10 000 habitant). The aim of this study was to analyze trends of leprosy detection during the last 17 years taking into consideration the implementation of single dose rifampicin chemoprophyla...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0006910

    authors： Khoudri I,Elyoussfi Z,Mourchid Y,Youbi M,Bennani Mechita N,Abouqal R,Maaroufi A

    更新日期：2018-12-20 00:00:00

  • The gut microbiota as a modulator of innate immunity during melioidosis.

    abstract：BACKGROUND:Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut microbiota supports local mucosal immunity and is increasingly recognized as a protective mediator in host defenses against systemic infection. Here, we aimed...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0005548

    authors： Lankelma JM,Birnie E,Weehuizen TAF,Scicluna BP,Belzer C,Houtkooper RH,Roelofs JJTH,de Vos AF,van der Poll T,Budding AE,Wiersinga WJ

    更新日期：2017-04-19 00:00:00

  • Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus.

    abstract：BACKGROUND:Aedes albopictus, the Asian tiger mosquito, is a vector of several arboviruses including dengue and chikungunya, and is also a significant nuisance mosquito. It is one of the most invasive of mosquitoes with a relentlessly increasing geographic distribution. Conventional control methods have so far failed to...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0001724

    authors： Labbé GM,Scaife S,Morgan SA,Curtis ZH,Alphey L

    更新日期：2012-01-01 00:00:00

  • Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.

    abstract：:Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manif...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章,评审

    doi：10.1371/journal.pntd.0002283

    authors： Mitjà O,Šmajs D,Bassat Q

    更新日期：2013-10-24 00:00:00

  • Characterization of schistosome tegumental alkaline phosphatase (SmAP).

    abstract：:Schistosomes are parasitic platyhelminths that currently infect over 200 million people globally. The parasites can live for years in a putatively hostile environment - the blood of vertebrates. We have hypothesized that the unusual schistosome tegument (outer-covering) plays a role in protecting parasites in the bloo...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0001011

    authors： Bhardwaj R,Skelly PJ

    更新日期：2011-04-05 00:00:00

  • Chaetomium atrobrunneum causing human eumycetoma: The first report.

    abstract：:In this communication, a case of black grain eumycetoma produced by the fungus C. atrobrunneum is reported. The patient was initially misdiagnosed with M. mycetomatis eumycetoma based on the grains' morphological and cytological features. However, further aerobic culture of the black grains generated a melanised fungu...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0007276

    authors： Mhmoud NA,Santona A,Fiamma M,Siddig EE,Deligios M,Bakhiet SM,Rubino S,Fahal AH

    更新日期：2019-05-30 00:00:00

  • Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.

    abstract：:Parasitic infections are a major source of human suffering, mortality, and economic loss, but drug development for these diseases has been stymied by the significant expense involved in bringing a drug though clinical trials and to market. Identification of single compounds active against multiple parasitic pathogens ...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0008150

    authors： Ehrenkaufer G,Li P,Stebbins EE,Kangussu-Marcolino MM,Debnath A,White CV,Moser MS,DeRisi J,Gisselberg J,Yeh E,Wang SC,Company AH,Monti L,Caffrey CR,Huston CD,Wang B,Singh U

    更新日期：2020-03-20 00:00:00

  • Historical Perspective and Risk of Multiple Neglected Tropical Diseases in Coastal Tanzania: Compositional and Contextual Determinants of Disease Risk.

    abstract：BACKGROUND:In the past decade, research on neglected tropical diseases (NTDs) has intensified in response to the need to enhance community participation in health delivery, establish monitoring and surveillance systems, and integrate existing disease-specific treatment programs to control overlapping NTD burdens and de...

    journal_title：PLoS neglected tropical diseases

    pub_type： 历史文章,杂志文章

    doi：10.1371/journal.pntd.0003939

    authors： Armah FA,Quansah R,Luginaah I,Chuenpagdee R,Hambati H,Campbell G

    更新日期：2015-08-04 00:00:00

  • Lipophosphoglycans from Leishmania amazonensis Strains Display Immunomodulatory Properties via TLR4 and Do Not Affect Sand Fly Infection.

    abstract：:The immunomodulatory properties of lipophosphoglycans (LPG) from New World species of Leishmania have been assessed in Leishmania infantum and Leishmania braziliensis, the causative agents of visceral and cutaneous leishmaniasis, respectively. This glycoconjugate is highly polymorphic among species with variation in s...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0004848

    authors： Nogueira PM,Assis RR,Torrecilhas AC,Saraiva EM,Pessoa NL,Campos MA,Marialva EF,Ríos-Velasquez CM,Pessoa FA,Secundino NF,Rugani JN,Nieves E,Turco SJ,Melo MN,Soares RP

    更新日期：2016-08-10 00:00:00

  • Refining the global spatial limits of dengue virus transmission by evidence-based consensus.

    abstract：BACKGROUND:Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distribution remains highly uncertain. Challenges in diagnosis and diagnostic methods as well as highly variable national health systems mean no single data source can reliably estimate the distribution o...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0001760

    authors： Brady OJ,Gething PW,Bhatt S,Messina JP,Brownstein JS,Hoen AG,Moyes CL,Farlow AW,Scott TW,Hay SI

    更新日期：2012-01-01 00:00:00

  • Correction: Brucellosis Seropositivity in Animals and Humans in Ethiopia: A Meta-analysis.

    abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0005006.]. ...

    journal_title：PLoS neglected tropical diseases

    pub_type： 已发布勘误

    doi：10.1371/journal.pntd.0005236

    authors： Tadesse G

    更新日期：2016-12-20 00:00:00

  • Socio-spatial heterogeneity in participation in mass dog rabies vaccination campaigns, Arequipa, Peru.

    abstract：:To control and prevent rabies in Latin America, mass dog vaccination campaigns (MDVC) are implemented mainly through fixed-location vaccination points: owners have to bring their dogs to the vaccination points where they receive the vaccination free of charge. Dog rabies is still endemic in some Latin-American countri...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0007600

    authors： Castillo-Neyra R,Toledo AM,Arevalo-Nieto C,MacDonald H,De la Puente-León M,Naquira-Velarde C,Paz-Soldan VA,Buttenheim AM,Levy MZ

    更新日期：2019-08-01 00:00:00

  • Increased risk for Entamoeba histolytica infection and invasive amebiasis in HIV seropositive men who have sex with men in Taiwan.

    abstract：BACKGROUND:Incidence of Entamoeba histolytica infection and clinical manifestations and treatment response of invasive amebiasis (IA) in HIV-infected patients have rarely been investigated before. METHODOLOGY/PRINCIPAL FINDINGS:At the National Taiwan University Hospital, medical records of HIV-infected patients who re...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0000175

    authors： Hung CC,Ji DD,Sun HY,Lee YT,Hsu SY,Chang SY,Wu CH,Chan YH,Hsiao CF,Liu WC,Colebunders R

    更新日期：2008-02-27 00:00:00

  • Potent inhibition of Junín virus infection by interferon in murine cells.

    abstract：:The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV. The mechanism underlying the mouse resistance to JUNV infection is largely unknown. We have reported that ...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0002933

    authors： Huang C,Walker AG,Grant AM,Kolokoltsova OA,Yun NE,Seregin AV,Paessler S

    更新日期：2014-06-05 00:00:00

  • Sero-Molecular Epidemiology of Japanese Encephalitis in Zhejiang, an Eastern Province of China.

    abstract：BACKGROUND:Sporadic Japanese encephalitis (JE) cases still have been reported in Zhejiang Province in recent years, and concerns about vaccine cross-protection and population-level immunity have been raised off and on within the public health sphere. Genotype I (GI) has replaced GIII as the dominant genotype in Asian c...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0004936

    authors： Pan JR,Yan JY,Zhou JY,Tang XW,He HQ,Xie RH,Mao HY,Zhang YJ,Xie SY

    更新日期：2016-08-25 00:00:00

  • Post-kala-azar dermal leishmaniasis in Nepal: a retrospective cohort study (2000-2010).

    abstract：INTRODUCTION:Post-kala-azar dermal leishmaniasis (PKDL) is a cutaneous complication appearing after treatment of visceral leishmaniasis, and PKDL patients are considered infectious to sand flies and may therefore play a role in the transmission of VL. We estimated the risk and risk factors of PKDL in patients with past...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章

    doi：10.1371/journal.pntd.0001433

    authors： Uranw S,Ostyn B,Rijal A,Devkota S,Khanal B,Menten J,Boelaert M,Rijal S

    更新日期：2011-12-01 00:00:00

  • Differential regional immune response in Chagas disease.

    abstract：:Following infection, lymphocytes expand exponentially and differentiate into effector cells to control infection and coordinate the multiple effector arms of the immune response. Soon after this expansion, the majority of antigen-specific lymphocytes die, thus keeping homeostasis, and a small pool of memory cells deve...

    journal_title：PLoS neglected tropical diseases

    pub_type： 杂志文章,评审

    doi：10.1371/journal.pntd.0000417

    authors： de Meis J,Morrot A,Farias-de-Oliveira DA,Villa-Verde DM,Savino W

    更新日期：2009-07-07 00:00:00