QTL mapping of genome regions controlling temephos resistance in larvae of the mosquito Aedes aegypti.

abstract：:In Latin America and the Caribbean, around 195 million people live in poverty, a situation that increases the burden of some infectious diseases. Neglected diseases, in particular, are often restricted to poor, marginalized sections of the population. Tools exist to combat these diseases, making it imperative to work ...

journal_title：PLoS neglected tropical diseases

authors： Schneider MC,Aguilera XP,Barbosa da Silva Junior J,Ault SK,Najera P,Martinez J,Requejo R,Nicholls RS,Yadon Z,Silva JC,Leanes LF,Periago MR

更新日期：2011-02-15 00:00:00

abstract：:Insecticide resistance poses a significant threat to the control of arthropods that transmit disease agents. Nanoparticle carriers offer exciting opportunities to expand the armamentarium of insecticides available for public health and other pests. Most chemical insecticides are delivered by contact or feeding, and fr...

journal_title：PLoS neglected tropical diseases

authors： Norris EJ,Mullis AS,Phanse Y,Narasimhan B,Coats JR,Bartholomay LC

更新日期：2020-09-08 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0005125.]. ...

journal_title：PLoS neglected tropical diseases

authors： PLOS Neglected Tropical Diseases Staff.

更新日期：2017-01-31 00:00:00

abstract：BACKGROUND:Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homolo...

journal_title：PLoS neglected tropical diseases

authors： Woo PC,Lau SK,Lau CC,Tung ET,Chong KT,Yang F,Zhang H,Lo RK,Cai JP,Au-Yeung RK,Ng WF,Tse H,Wong SS,Xu S,Lam WH,Tse MK,Sze KH,Kao RY,Reiner NE,Hao Q,Yuen KY

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:The success of the global strategy to eliminate lymphatic filariasis (LF) through mass drug administration (MDA) campaigns is dependent on meeting high coverage levels over long periods of time. Community engagement plays a critical role in driving coverage and involvement of local communities in MDA for LF....

journal_title：PLoS neglected tropical diseases

authors： Silumbwe A,Halwindi H,Zulu JM

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:Wolbachia inherited intracellular bacteria can manipulate the reproduction of their insect hosts through cytoplasmic incompatibility (CI), and certain strains have also been shown to inhibit the replication or dissemination of viruses. Wolbachia strains also vary in their relative fitness effects on their ho...

journal_title：PLoS neglected tropical diseases

authors： Blagrove MS,Arias-Goeta C,Di Genua C,Failloux AB,Sinkins SP

更新日期：2013-01-01 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease possess extensive genetic diversity. This has led to the development of a plethora of molecular typing methods for the identification of both the known major genetic lineages and for more fine scale characterization of different multilocus genotypes within th...

journal_title：PLoS neglected tropical diseases

authors： Diosque P,Tomasini N,Lauthier JJ,Messenger LA,Monje Rumi MM,Ragone PG,Alberti-D'Amato AM,Pérez Brandán C,Barnabé C,Tibayrenc M,Lewis MD,Llewellyn MS,Miles MA,Yeo M

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:In 2007, a novel bunyavirus was found in Henan Province, China and named fever, thrombocytopenia and leukocytopenia syndrome virus (FTLSV); since then, FTLSV has been found in ticks and animals in many Chinese provinces. Human-to-human transmission has been documented, indicating that FTLSV should be conside...

journal_title：PLoS neglected tropical diseases

authors： Huang X,Liu L,Du Y,Wu W,Wang H,Su J,Tang X,Liu Q,Yang Y,Jiang Y,Chen W,Xu B

更新日期：2014-10-16 00:00:00

abstract：BACKGROUND:Traditional faecal-based methods have poor sensitivity for the detection of S. stercoralis, therefore are inadequate for post-treatment evaluation of infected patients who should be carefully monitored to exclude the persistence of the infection. In a previous study, we demonstrated high accuracy of five ser...

journal_title：PLoS neglected tropical diseases

authors： Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Degani M,Tais S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB,Bisoffi Z

更新日期：2015-02-10 00:00:00

abstract：BACKGROUND:Epidemics of meningococcal meningitis (MM) recurrently strike the African Meningitis Belt. This study aimed at investigating factors, still poorly understood, that influence annual incidence of MM serogroup A, the main etiologic agent over 2004-2010, at a fine spatial scale in Niger. METHODOLOGY/PRINCIPAL F...

journal_title：PLoS neglected tropical diseases

authors： Paireau J,Maïnassara HB,Jusot JF,Collard JM,Idi I,Moulia-Pelat JP,Mueller JE,Fontanet A

更新日期：2014-05-22 00:00:00

abstract：BACKGROUND:The mosquito resistance to the insecticides threatens malaria control efforts, potentially becoming a major public health issue. Alternative methods like ivermectin (IVM) administration to humans has been suggested as a possible vector control to reduce Plasmodium transmission. Anopheles aquasalis and Anophe...

journal_title：PLoS neglected tropical diseases

authors： Pinilla YT,C P Lopes S,S Sampaio V,Andrade FS,Melo GC,Orfanó AS,Secundino NFC,Guerra MGVB,Lacerda MVG,Kobylinski KC,Escobedo-Vargas KS,López-Sifuentes VM,Stoops CA,Baldeviano GC,Tarning J,Vasquez GM,Pimenta PFP,Monteiro

更新日期：2018-02-14 00:00:00

abstract：:A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja ...

journal_title：PLoS neglected tropical diseases

authors： Dellagi K,Salez N,Maquart M,Larrieu S,Yssouf A,Silaï R,Leparc-Goffart I,Tortosa P,de Lamballerie X

更新日期：2016-12-15 00:00:00

abstract：BACKGROUND:Although antibody responses to dengue virus (DENV) in naturally infected individuals have been extensively studied, the functionality of DENV specific memory T cell responses in relation to clinical disease severity is incompletely understood. METHODOLOGY/PRINCIPAL FINDINGS:Using ex vivo IFNγ ELISpot assays...

journal_title：PLoS neglected tropical diseases

authors： Jeewandara C,Adikari TN,Gomes L,Fernando S,Fernando RH,Perera MK,Ariyaratne D,Kamaladasa A,Salimi M,Prathapan S,Ogg GS,Malavige GN

更新日期：2015-04-13 00:00:00

abstract：BACKGROUND:Yersinia pestis, the agent of plague, is considered a potential bioweapon due to rapid lethality when delivered as an aerosol. Levofloxacin was tested for primary pneumonic plague treatment in a nonhuman primate model mimicking human disease. METHODS AND RESULTS:Twenty-four African Green monkeys (AGMs, Chlo...

journal_title：PLoS neglected tropical diseases

authors： Layton RC,Mega W,McDonald JD,Brasel TL,Barr EB,Gigliotti AP,Koster F

更新日期：2011-02-08 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0007140.]. ...

journal_title：PLoS neglected tropical diseases

authors： PLOS Neglected Tropical Diseases Staff.

更新日期：2019-06-28 00:00:00

abstract：:Burkholderia pseudomallei, the bacterial agent of melioidosis, causes disease through inhalation of infectious particles, and is classified as a Tier 1 Select Agent. Optical diagnostic imaging has demonstrated that murine respiratory disease models are subject to significant upper respiratory tract (URT) colonization....

journal_title：PLoS neglected tropical diseases

authors： Gutierrez MG,Pfeffer TL,Warawa JM

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Ofloxacin is a fluoroquinolone (FQ) used for the treatment of leprosy. FQs are known to interact with both A and B subunits of DNA gyrase and inhibit supercoiling activity of this enzyme. Mutations conferring FQ resistance have been reported to be found only in the gene encoding A subunit of this enzyme (gyr...

journal_title：PLoS neglected tropical diseases

authors： Yokoyama K,Kim H,Mukai T,Matsuoka M,Nakajima C,Suzuki Y

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Optimal management of eumycetoma, a severely debilitating chronic progressive fungal infection of skin, disseminating to bone and viscera, remains challenging. Especially, optimal antifungal treatment and duration are ill defined. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a monocentric retrospective study...

journal_title：PLoS neglected tropical diseases

authors： Crabol Y,Poiree S,Bougnoux ME,Maunoury C,Barete S,Zeller V,Arvieux C,Pineau S,Amazzough K,Lecuit M,Lanternier F,Lortholary O,French Mycosis Study Group.

更新日期：2014-10-09 00:00:00

abstract：BACKGROUND:The Asian bush mosquito Aedes japonicus is invading Europe and was first discovered in Lelystad, the Netherlands in 2013, where it has established a permanent population. In this study, we investigated the vector competence of Ae. japonicus from the Netherlands for the emerging Zika virus (ZIKV) and zoonotic...

journal_title：PLoS neglected tropical diseases

authors： Abbo SR,Visser TM,Wang H,Göertz GP,Fros JJ,Abma-Henkens MHC,Geertsema C,Vogels CBF,Koopmans MPG,Reusken CBEM,Hall-Mendelin S,Hall RA,van Oers MM,Koenraadt CJM,Pijlman GP

更新日期：2020-04-13 00:00:00

abstract：INTRODUCTION:Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although cross-sectional studies are essential to detect people exposed to rickettsiae, they are not sui...

journal_title：PLoS neglected tropical diseases

authors： Quintero Vélez JC,Aguirre-Acevedo DC,Rodas JD,Arboleda M,Troyo A,Vega Aguilar F,Osorio Quintero L,Rojas Arbeláez C

更新日期：2018-10-31 00:00:00

abstract：BACKGROUND:Trypanosomiasis induces a remarkable myenteric neuronal degeneration leading to megacolon. Very little is known about the risk for colon cancer in chagasic megacolon patients. To clarify whether chagasic megacolon impacts on colon carcinogenesis, we investigated the risk for colon cancer in Trypanosoma cruzi...

journal_title：PLoS neglected tropical diseases

authors： Kannen V,de Oliveira EC,Motta BZ,Chaguri AJ,Brunaldi MO,Garcia SB

更新日期：2015-04-17 00:00:00

abstract：:Cystic echinococcosis is still a major concern in South America. While some regions show advances in the control of the disease, others have among the highest incidence in the world. To reverse this situation the Pan American Health Organization (PAHO) has launched a regional project on cystic echinococcosis control a...

journal_title：PLoS neglected tropical diseases

authors： Morel N,Lassabe G,Elola S,Bondad M,Herrera S,Marí C,Last JA,Jensen O,Gonzalez-Sapienza G

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Intestinal schistosomiasis and soil-transmitted helminth (STH) infections constitute major public health problems in many parts of sub-Saharan Africa. In this study we examined the functional significance of such polyparasite infections in anemia and undernutrition in Rwandan individuals. METHODS:Three poly...

journal_title：PLoS neglected tropical diseases

authors： Mupfasoni D,Karibushi B,Koukounari A,Ruberanziza E,Kaberuka T,Kramer MH,Mukabayire O,Kabera M,Nizeyimana V,Deville MA,Ruxin J,Webster JP,Fenwick A

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination by the year 2020. As of 2017, 67 of the 72 endemic countries have implemented annual Mass Drug Administration (MDA) for interrupting LF transmission. Transmission Assessment Survey (TAS) is the recommended protocol to evaluate the impact of MDA and to dec...

journal_title：PLoS neglected tropical diseases

authors： Subramanian S,Jambulingam P,Krishnamoorthy K,Sivagnaname N,Sadanandane C,Vasuki V,Palaniswamy C,Vijayakumar B,Srividya A,Raju HKK

更新日期：2020-01-24 00:00:00

abstract：:A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and twelve variations respectively at the P1, P2 and P3 positions. A Ki ...

journal_title：PLoS neglected tropical diseases

authors： Avelar LA,Camilo CD,de Albuquerque S,Fernandes WB,Gonçalez C,Kenny PW,Leitão A,McKerrow JH,Montanari CA,Orozco EV,Ribeiro JF,Rocha JR,Rosini F,Saidel ME

更新日期：2015-07-14 00:00:00

abstract：:Nipah virus (NiV) is a paramyxovirus (genus Henipavirus) that emerged in the late 1990s in Malaysia and has since been identified as the cause of sporadic outbreaks of severe febrile disease in Bangladesh and India. NiV infection is frequently associated with severe respiratory or neurological disease in infected huma...

journal_title：PLoS neglected tropical diseases

authors： Cong Y,Lentz MR,Lara A,Alexander I,Bartos C,Bohannon JK,Hammoud D,Huzella L,Jahrling PB,Janosko K,Jett C,Kollins E,Lackemeyer M,Mollura D,Ragland D,Rojas O,Solomon J,Xu Z,Munster V,Holbrook MR

更新日期：2017-04-07 00:00:00

abstract：BACKGROUND:Efforts to control soil-transmitted helminth (STH) infections have intensified over the past decade. Field-survey data on STH prevalence, infection intensity and drug efficacy is necessary to guide the implementation of control programs and should be of the best possible quality. METHODOLOGY:During four cli...

journal_title：PLoS neglected tropical diseases

authors： Vlaminck J,Cools P,Albonico M,Ame S,Ayana M,Dana D,Keiser J,Matoso LF,Montresor A,Mekonnen Z,Corrêa-Oliveira R,Pinto SA,Sayasone S,Vercruysse J,Levecke B

更新日期：2020-09-21 00:00:00

abstract：BACKGROUND:Mycobacterium tuberculosis complex (MTBC), the causative agent of tuberculosis (TB), is composed of eight subspecies. TB in West Africa, in contrast to other geographical regions, is caused by Mycobacterium africanum (MAF) in addition to M. tuberculosis (MTB), with both infections presenting similar symptoms...

journal_title：PLoS neglected tropical diseases

authors： Namasivayam S,Diarra B,Diabate S,Sarro YDS,Kone A,Kone B,Tolofoudie M,Baya B,Diakite MT,Kodio O,Cohen K,Holl J,Achenbach CJ,Chatterjee S,Murphy RL,Bishai W,Diallo S,Sher A,Maiga M

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:Scrub typhus is a neglected tropical disease that causes acute febrile illness. Diagnosis is made based upon serology, or detection of the causative agent-Orientia tsutsugamushi-using PCR or in vitro isolation. The enzyme-linked immunosorbent assay (ELISA) is an objective and reproducible means of detecting ...

journal_title：PLoS neglected tropical diseases

authors： Saraswati K,Phanichkrivalkosil M,Day NPJ,Blacksell SD

更新日期：2019-02-04 00:00:00

abstract：BACKGROUND:Dengue is the most prevalent arboviral disease of humans. Virus neutralizing antibodies are likely to be critical for clinical immunity after vaccination or natural infection. A number of human monoclonal antibodies (mAbs) have previously been characterized as able to neutralize the infectivity of dengue vir...

journal_title：PLoS neglected tropical diseases

authors： Tuan Vu T,Clapham H,Huynh VTT,Vo Thi L,Le Thi D,Vu NT,Nguyen GT,Huynh TTX,Duong KTH,Tran VT,Huynh HLA,Le Huynh DT,Huynh TLP,Nguyen TTV,Nguyen NM,Luong TTH,Phong NT,Nguyen CVV,Gough G,Wills B,Carrington LB,Simmon

更新日期：2019-11-01 00:00:00