Selamectin Is the Avermectin with the Best Potential for Buruli Ulcer Treatment.

abstract：BACKGROUND:Emerging information technologies present new opportunities to reduce the burden of malaria, dengue and other infectious diseases. For example, use of a data management system software package can help disease control programs to better manage and analyze their data, and thus enhances their ability to carry ...

journal_title：PLoS neglected tropical diseases

authors： Eisen L,Coleman M,Lozano-Fuentes S,McEachen N,Orlans M,Coleman M

更新日期：2011-03-29 00:00:00

abstract：:Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of Asia, where periodic outbreaks take hundreds of lives. Despite the catastrophes it causes, JE has remained a tropical disease uncom...

journal_title：PLoS neglected tropical diseases

authors： Ghosh D,Basu A

更新日期：2009-09-29 00:00:00

abstract：:Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance. The pathogenesis of several of the most prevalent infections, including cholera and enteroxigenic Escherichia coli, is dom...

journal_title：PLoS neglected tropical diseases

authors： Das S,Angsantikul P,Le C,Bao D,Miyamoto Y,Gao W,Zhang L,Eckmann L

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hookworm infection is among the major causes of anaemia in poor communities, but its importance in causing maternal anaemia is poorly understood, and this has hampered effective lobbying for the inclusion of anthelmintic treatment in maternal health packages. We sought to review existing evide...

journal_title：PLoS neglected tropical diseases

authors： Brooker S,Hotez PJ,Bundy DA

更新日期：2008-09-17 00:00:00

abstract：:Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circu...

journal_title：PLoS neglected tropical diseases

authors： Angulo J,Martínez-Valdebenito C,Marco C,Galeno H,Villagra E,Vera L,Lagos N,Becerra N,Mora J,Bermúdez A,Díaz J,Ferrés M,López-Lastra M

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Aedes aegypti, the "yellow fever mosquito", is the primary vector to humans of the four serotypes of dengue viruses (DENV1-4) and yellow fever virus (YFV) and is a known vector of Chikungunya virus. There are two recognized subspecies of Ae. aegypti sensu latu (s.l.): the presumed ancestral form, Ae. aegypti...

journal_title：PLoS neglected tropical diseases

authors： Sylla M,Bosio C,Urdaneta-Marquez L,Ndiaye M,Black WC 4th

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Usutu virus (USUV) is a member of the Japanese encephalitis virus (JEV) serocomplex in the Flaviviridae family. Emergence of USUV in Europe has led to disease burdens in birds and created increasing concern for the potential zoonotic transmission to humans. Whilst USUV has not been detected in the New World,...

journal_title：PLoS neglected tropical diseases

authors： Cook CL,Huang YS,Lyons AC,Alto BW,Unlu I,Higgs S,Vanlandingham DL

更新日期：2018-08-17 00:00:00

abstract：:Dengue fever, a mosquito-borne viral disease in humans, has been endemic in many Southeast Asian countries. Since its first outbreak in 1978 in Foshan, Guangdong province, China, dengue has been continually epidemic in recent years in Guangdong, which raised the concern whether dengue infection is endemic in Guangdong...

journal_title：PLoS neglected tropical diseases

authors： Sun B,Zhang X,Zhang H,Liu H,Sun L,Tan Q,Liang M,Wu,Liu D

更新日期：2020-03-03 00:00:00

abstract：:Burkholderia pseudomallei, the bacterial agent of melioidosis, causes disease through inhalation of infectious particles, and is classified as a Tier 1 Select Agent. Optical diagnostic imaging has demonstrated that murine respiratory disease models are subject to significant upper respiratory tract (URT) colonization....

journal_title：PLoS neglected tropical diseases

authors： Gutierrez MG,Pfeffer TL,Warawa JM

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Control of onchocerciasis as a public health problem in Africa relies on annual mass ivermectin distribution. New tools are needed to achieve elimination of infection. This study determined in a small number of Onchocerca volvulus infected individuals whether moxidectin, a veterinary anthelminthic, is safe e...

journal_title：PLoS neglected tropical diseases

authors： Awadzi K,Opoku NO,Attah SK,Lazdins-Helds J,Kuesel AC

更新日期：2014-06-26 00:00:00

abstract：:Canine rabies was endemic pre-urbanisation, yet little is known about how it persists in small populations of dogs typically seen in rural and remote regions. By simulating rabies outbreaks in such populations (50-90 dogs) using a network-based model, our objective was to determine if rabies-induced behavioural change...

journal_title：PLoS neglected tropical diseases

authors： Brookes VJ,Dürr S,Ward MP

更新日期：2019-09-23 00:00:00

abstract：BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central role in dengue pathogenesis. Primary infections are typically associ...

journal_title：PLoS neglected tropical diseases

authors： Chaudhury S,Gromowski GD,Ripoll DR,Khavrutskii IV,Desai V,Wallqvist A

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Hantaan virus (HTNV; family Hantaviridae, order Bunyavirales) causes hemorrhagic fever with renal syndrome (HFRS), which has raised serious concerns in Eurasia, especially in China, Russia, and South Korea. Previous studies reported genetic diversity and phylogenetic features of HTNV in different parts of Ch...

journal_title：PLoS neglected tropical diseases

authors： Li N,Li A,Liu Y,Wu W,Li C,Yu D,Zhu Y,Li J,Li D,Wang S,Liang M

更新日期：2020-08-20 00:00:00

abstract：:Schistosomiasis control and elimination has priority in public health agendas in several sub-Saharan countries. However, achieving these goals remains a substantial challenge. In order to assess progress of interventions and treatment efficacy it is pertinent to have accurate, feasible and affordable diagnostic tools....

journal_title：PLoS neglected tropical diseases

authors： Kildemoes AO,Vennervald BJ,Tukahebwa EM,Kabatereine NB,Magnussen P,de Dood CJ,Deelder AM,Wilson S,van Dam GJ

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is a life-threatening disease caused by protozoan parasites of the Leishmania donovani complex. Early case detection followed by adequate treatment is essential to the control of VL. However, the available diagnostic tests are either invasive and require considerable expertise (pa...

journal_title：PLoS neglected tropical diseases

authors： Gao CH,Yang YT,Shi F,Wang JY,Steverding D,Wang X

更新日期：2015-06-30 00:00:00

abstract：:The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determined the minimum nu...

journal_title：PLoS neglected tropical diseases

authors： Coutinho ML,Choy HA,Kelley MM,Matsunaga J,Babbitt JT,Lewis MS,Aleixo JA,Haake DA

更新日期：2011-12-01 00:00:00

abstract：:Strongyloidiasis is a much-neglected but sometimes fatal soil born helminthiasis. The causing agent, the small intestinal parasitic nematode Strongyloides stercoralis can reproduce sexually through the indirect/heterogonic life cycle, or asexually through the auto-infective or the direct/homogonic life cycles. Usually...

journal_title：PLoS neglected tropical diseases

authors： Zhou S,Fu X,Pei P,Kucka M,Liu J,Tang L,Zhan T,He S,Chan YF,Rödelsperger C,Liu D,Streit A

更新日期：2019-05-06 00:00:00

abstract：:Rhinoscleroma is a chronic granulomatous infection of the upper airways caused by the bacterium Klebsiella pneumoniae subsp. rhinoscleromatis. The disease is endemic in tropical and subtropical areas, but its diagnosis remains difficult. As a consequence, and despite available antibiotherapy, some patients evolve adva...

journal_title：PLoS neglected tropical diseases

authors： Fevre C,Passet V,Deletoile A,Barbe V,Frangeul L,Almeida AS,Sansonetti P,Tournebize R,Brisse S

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Sensitization to Anisakis spp. can produce allergic reactions after eating raw or undercooked parasitized fish. Specific IgE is detected long after the onset of symptoms, but the changes in specific IgE levels over a long follow-up period are unknown; furthermore, the influence of Anisakis spp. allergen expo...

journal_title：PLoS neglected tropical diseases

authors： Carballeda-Sangiao N,Rodríguez-Mahillo AI,Careche M,Navas A,Moneo I,González-Muñoz M

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:Vector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and vector control, however, much less is known about the burden of ...

journal_title：PLoS neglected tropical diseases

authors： Alroy KA,Huang C,Gilman RH,Quispe-Machaca VR,Marks MA,Ancca-Juarez J,Hillyard M,Verastegui M,Sanchez G,Cabrera L,Vidal E,Billig EM,Cama VA,Náquira C,Bern C,Levy MZ,Working Group on Chagas Disease in Peru.

更新日期：2015-05-22 00:00:00

abstract：:The infectious form of many parasitic nematodes, which afflict over one billion people globally, is a developmentally arrested third-stage larva (L3i). The parasitic nematode Strongyloides stercoralis differs from other nematode species that infect humans, in that its life cycle includes both parasitic and free-living...

journal_title：PLoS neglected tropical diseases

authors： Stoltzfus JD,Minot S,Berriman M,Nolan TJ,Lok JB

更新日期：2012-01-01 00:00:00

abstract：:The human mutilating disease chromoblastomycosis is caused by melanized members of the order Chaetothyriales. To assess population diversity among 123 clinical strains of agents of the disease in Brazil we applied sequencing of the rDNA internal transcribed spacer region, and partial cell division cycle and β-tubulin ...

journal_title：PLoS neglected tropical diseases

authors： Gomes RR,Vicente VA,Azevedo CM,Salgado CG,da Silva MB,Queiroz-Telles F,Marques SG,Santos DW,de Andrade TS,Takagi EH,Cruz KS,Fornari G,Hahn RC,Scroferneker ML,Caligine RB,Ramirez-Castrillon M,de Araújo DP,Heidrich D,Co

更新日期：2016-11-28 00:00:00

abstract：:Schistosomes are amongst the most important and neglected pathogens in the world, and schistosomiasis control relies almost exclusively on a single drug. The neuromuscular system of schistosomes is fertile ground for therapeutic intervention, yet the details of physiological events involved in neuromuscular function r...

journal_title：PLoS neglected tropical diseases

authors： Novozhilova E,Kimber MJ,Qian H,McVeigh P,Robertson AP,Zamanian M,Maule AG,Day TA

更新日期：2010-08-10 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0007140.]. ...

journal_title：PLoS neglected tropical diseases

authors： PLOS Neglected Tropical Diseases Staff.

更新日期：2019-06-28 00:00:00

abstract：:Revealing the patterns and determinants of the spread of dengue virus (DENV) at local scales is central to understanding the epidemiology and evolution of this major human pathogen. We performed a phylogenetic analysis of the envelope (E) genes of DENV-1, -2, -3, and -4 isolates (involving 97, 23, 5, and 74 newly coll...

journal_title：PLoS neglected tropical diseases

authors： Rabaa MA,Klungthong C,Yoon IK,Holmes EC,Chinnawirotpisan P,Thaisomboonsuk B,Srikiatkhachorn A,Rothman AL,Tannitisupawong D,Aldstadt J,Nisalak A,Mammen MP,Gibbons RV,Endy TP,Fansiri T,Scott TW,Jarman RG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Cryptosporidium infection causes gastrointestinal disease and has a worldwide distribution. The highest burden is in developing countries. OBJECTIVES:We sought to conduct a systematic review and meta-analysis to identify Cryptosporidium risk factors in Low and Middle Income countries (LMICs). METHODS:Medli...

journal_title：PLoS neglected tropical diseases

authors： Bouzid M,Kintz E,Hunter PR

更新日期：2018-06-07 00:00:00

abstract：:Humoral immunity plays an important role in controlling dengue virus (DENV) infection. Antibodies (Abs) developed during primary infection protect against subsequent infection with the same dengue serotype, but can enhance disease following secondary infection with a heterologous serotype. A DENV virion has two surfac...

journal_title：PLoS neglected tropical diseases

authors： Rodenhuis-Zybert IA,da Silva Voorham JM,Torres S,van de Pol D,Smit JM

更新日期：2015-03-11 00:00:00

abstract：:Global efforts to address schistosomiasis and soil-transmitted helminthiases (STH) include deworming programs for school-aged children that are made possible by large-scale drug donations. Decisions on these mass drug administration (MDA) programs currently rely on microscopic examination of clinical specimens to dete...

journal_title：PLoS neglected tropical diseases

authors： Hawkins KR,Cantera JL,Storey HL,Leader BT,de Los Santos T

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:Rodents are major reservoirs of pathogens responsible for numerous zoonotic diseases in humans and livestock. Assessing their microbial diversity at both the individual and population level is crucial for monitoring endemic infections and revealing microbial association patterns within reservoirs. Recently, ...

journal_title：PLoS neglected tropical diseases

authors： Razzauti M,Galan M,Bernard M,Maman S,Klopp C,Charbonnel N,Vayssier-Taussat M,Eloit M,Cosson JF

更新日期：2015-08-18 00:00:00

abstract：INTRODUCTION:Plasmodium knowlesi is now recognised as a leading cause of malaria in Malaysia. As humans come into increasing contact with the reservoir host (long-tailed macaques) as a consequence of deforestation, assessing the potential for a shift from zoonotic to sustained P. knowlesi transmission between humans is...

journal_title：PLoS neglected tropical diseases

authors： Imai N,White MT,Ghani AC,Drakeley CJ

更新日期：2014-07-24 00:00:00