Transmission and control of Plasmodium knowlesi: a mathematical modelling study.

abstract：:Despite Nipah virus outbreaks having high mortality rates (>70% in Southeast Asia), there are no licensed drugs against it. In this study, we have considered all 9 Nipah proteins as potential therapeutic targets and computationally identified 4 putative peptide inhibitors (against G, F and M proteins) and 146 small mo...

journal_title：PLoS neglected tropical diseases

authors： Sen N,Kanitkar TR,Roy AA,Soni N,Amritkar K,Supekar S,Nair S,Singh G,Madhusudhan MS

更新日期：2019-12-12 00:00:00

abstract：:Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant maca...

journal_title：PLoS neglected tropical diseases

authors： Bidokhti MRM,Dutta D,Madduri LSV,Woollard SM,Norgren R Jr,Giavedoni L,Byrareddy SN

更新日期：2018-10-25 00:00:00

abstract：:Accumulating evidences have assigned a central role to parasite-derived proteins in immunomodulation. Here, we report on the proteomic identification and characterization of immunomodulatory excretory-secretory (ES) products from the metacestode larva (tetrathyridium) of the tapeworm Mesocestoides corti (syn. M. vogae...

journal_title：PLoS neglected tropical diseases

authors： Vendelova E,Camargo de Lima J,Lorenzatto KR,Monteiro KM,Mueller T,Veepaschit J,Grimm C,Brehm K,Hrčková G,Lutz MB,Ferreira HB,Nono JK

更新日期：2016-10-13 00:00:00

abstract：:Mycetoma, one of the badly neglected tropical diseases, it is a localised chronic granulomatous inflammatory disease characterised by painless subcutaneous mass and formation of multiple sinuses that produce purulent discharge and grains. If untreated early and appropriately, it usually spread to affect the deep struc...

journal_title：PLoS neglected tropical diseases

authors： Bakhiet SM,Fahal AH,Musa AM,Mohamed ESW,Omer RF,Ahmed ES,El Nour M,Mustafa ERM,Sheikh A Rahman ME,Suliman SH,El Mamoun MAG,El Amin HM

更新日期：2018-05-10 00:00:00

abstract：:The proportion of Plasmodium vivax malaria among all malarias is increasing worldwide. Treatment with 8-aminoquinolines remain the only radical cure. However, 8-aminoquinolines can cause severe hemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. The population of the multi-ethnic Chittagong Hill ...

journal_title：PLoS neglected tropical diseases

authors： Ley B,Kibria MG,Khan WA,Auburn S,Phru CS,Jahan N,Johora FT,Thriemer K,Ami JQ,Hossain MS,Price RN,Koepfli C,Alam MS

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Dengue is a mosquito-borne viral disease caused by the four dengue viruses (DENV-1 to 4) that can also be transmitted by blood transfusion and organ transplantation. The distribution of DENV in the components of blood from infected donors is poorly understood. METHODS:We used an in-house TaqMan qRT-PCR assa...

journal_title：PLoS neglected tropical diseases

authors： Añez G,Heisey DA,Chancey C,Fares RC,Espina LM,Souza KP,Teixeira-Carvalho A,Krysztof DE,Foster GA,Stramer SL,Rios M

更新日期：2016-02-12 00:00:00

abstract：BACKGROUND:The genus Trichuris includes parasites of major relevance in veterinary and human medicine. Despite serious economic losses and enormous impact on public health, treatment options against whipworms are very limited. Additionally, there is an obvious lack of appropriately characterized experimental infection ...

journal_title：PLoS neglected tropical diseases

authors： Kulke D,Krücken J,Harder A,von Samson-Himmelstjerna G

更新日期：2014-02-20 00:00:00

abstract：:Mosquito-borne diseases continue to remain major threats to human and animal health and impediments to socioeconomic development. Increasing mosquito resistance to chemical insecticides is a great public health concern, and new strategies/technologies are necessary to develop the next-generation of vector control tool...

journal_title：PLoS neglected tropical diseases

authors： Phanse Y,Dunphy BM,Perry JL,Airs PM,Paquette CC,Carlson JO,Xu J,Luft JC,DeSimone JM,Beaty BJ,Bartholomay LC

更新日期：2015-05-21 00:00:00

abstract：:Globally, early initiation of antiretroviral therapy for HIV led to a reduction in the estimated mortality from cryptococcal meningitis (CCM) from 624,700 in 2009 to 181,100 in 2014. However, CCM remains one of the leading causes of mortality among HIV infected patients especially in sub-Saharan Africa where 75% of th...

journal_title：PLoS neglected tropical diseases

authors： Kitonsa J,Nsubuga R,Mayanja Y,Kiwanuka J,Nikweri Y,Onyango M,Anywaine Z,Ggayi AB,Kibengo FM,Kaleebu P,Day J

更新日期：2020-11-30 00:00:00

abstract：:Between March 2014 and July 2015 at least 10,500 Ebola cases including more than 4,800 deaths occurred in Liberia, the majority in Monrovia. However, official numbers may have underestimated the size of the outbreak. Closure of health facilities and mistrust in existing structures may have additionally impacted on all...

journal_title：PLoS neglected tropical diseases

authors： Kuehne A,Lynch E,Marshall E,Tiffany A,Alley I,Bawo L,Massaquoi M,Lodesani C,Le Vaillant P,Porten K,Gignoux E

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon...

journal_title：PLoS neglected tropical diseases

authors： Monteiro WM,Margioto Teston AP,Gruendling AP,dos Reis D,Gomes ML,de Araújo SM,Bahia MT,Magalhães LK,de Oliveira Guerra JA,Silveira H,Toledo MJ,Vale Barbosa Md

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The success of the global strategy to eliminate lymphatic filariasis (LF) through mass drug administration (MDA) campaigns is dependent on meeting high coverage levels over long periods of time. Community engagement plays a critical role in driving coverage and involvement of local communities in MDA for LF....

journal_title：PLoS neglected tropical diseases

authors： Silumbwe A,Halwindi H,Zulu JM

更新日期：2019-11-27 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) and helminth infections elicit antagonistic immune effector functions and are co-endemic in several regions of the world. We therefore hypothesized that helminth infection may influence Mtb-specific T-cell immune responses. We evaluated the cytokine profile of Mtb-specific T cells in 7...

journal_title：PLoS neglected tropical diseases

authors： Amelio P,Portevin D,Reither K,Mhimbira F,Mpina M,Tumbo A,Nickel B,Marti H,Knopp S,Ding S,Penn-Nicholson A,Darboe F,Ohmiti K,Scriba TJ,Pantaleo G,Daubenberger C,Perreau M

更新日期：2017-07-31 00:00:00

abstract：BACKGROUND:The main objective of the study was to determine the degree of sensitization to Anisakis spp. antigens in healthy coastal population of Dalmatia given the high thermally unprocessed fish intake rate present in this area, suggested as a significant risk factor for anisakiasis. We performed a monocenter, cross...

journal_title：PLoS neglected tropical diseases

authors： Mladineo I,Poljak V,Martínez-Sernández V,Ubeira FM

更新日期：2014-02-06 00:00:00

abstract：BACKGROUND:Mass azithromycin distribution reduces under-5 child mortality. Trachoma control programs currently treat infants aged 6 months and older. Here, we report findings from an infant adverse event survey in 1-5 month olds who received azithromycin as part of a large community-randomized trial in Niger. METHODS ...

journal_title：PLoS neglected tropical diseases

authors： Oldenburg CE,Arzika AM,Maliki R,Kane MS,Lebas E,Ray KJ,Cook C,Cotter SY,Zhou Z,West SK,Bailey R,Porco TC,Keenan JD,Lietman TM,MORDOR Study Group.

更新日期：2018-11-12 00:00:00

abstract：:The complement cascade in mammalian blood can damage the alimentary tract of haematophagous arthropods. As such, these animals have evolved their own repertoire of complement-inactivating factors, which are inadvertently exploited by blood-borne pathogens to escape complement lysis. Unlike the bloodstream stages, the ...

journal_title：PLoS neglected tropical diseases

authors： Ooi CP,Haines LR,Southern DM,Lehane MJ,Acosta-Serrano A

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Monitoring of insect vector populations with respect to their susceptibility to one or more insecticides is a crucial element of the strategies used for the control of arthropod-borne diseases. This management task can nowadays be achieved more efficiently when assisted by IT (Information Technology) tools, ...

journal_title：PLoS neglected tropical diseases

authors： Dialynas E,Topalis P,Vontas J,Louis C

更新日期：2009-06-23 00:00:00

abstract：BACKGROUND:New strategies for collecting post-mortem tissue are necessary, particularly in areas with emerging infections. Minimally invasive autopsy (MIA) has been proposed as an alternative to conventional autopsy (CA), with promising results. Previous studies using MIA addressed the cause of death in adults and chil...

journal_title：PLoS neglected tropical diseases

authors： Duarte-Neto AN,Monteiro RAA,Johnsson J,Cunha MDP,Pour SZ,Saraiva AC,Ho YL,da Silva LFF,Mauad T,Zanotto PMA,Saldiva PHN,de Oliveira IRS,Dolhnikoff M

更新日期：2019-07-22 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease possess extensive genetic diversity. This has led to the development of a plethora of molecular typing methods for the identification of both the known major genetic lineages and for more fine scale characterization of different multilocus genotypes within th...

journal_title：PLoS neglected tropical diseases

authors： Diosque P,Tomasini N,Lauthier JJ,Messenger LA,Monje Rumi MM,Ragone PG,Alberti-D'Amato AM,Pérez Brandán C,Barnabé C,Tibayrenc M,Lewis MD,Llewellyn MS,Miles MA,Yeo M

更新日期：2014-08-28 00:00:00

abstract：:Schistosomiasis is a chronic and debilitating disease caused by blood flukes (digenetic trematodes) of the genus Schistosoma. Schistosomes are sexually dimorphic and exhibit dramatic morphological changes during a complex lifecycle which requires subtle gene regulatory mechanisms to fulfil these complex biological pro...

journal_title：PLoS neglected tropical diseases

authors： Cai P,Liu S,Piao X,Hou N,Gobert GN,McManus DP,Chen Q

更新日期：2016-04-29 00:00:00

abstract：:The bacterium Burkholderia ubonensis is commonly co-isolated from environmental specimens harbouring the melioidosis pathogen, Burkholderia pseudomallei. B. ubonensis has been reported in northern Australia and Thailand but not North America, suggesting similar geographic distribution to B. pseudomallei. Unlike most o...

journal_title：PLoS neglected tropical diseases

authors： Price EP,Sarovich DS,Webb JR,Hall CM,Jaramillo SA,Sahl JW,Kaestli M,Mayo M,Harrington G,Baker AL,Sidak-Loftis LC,Settles EW,Lummis M,Schupp JM,Gillece JD,Tuanyok A,Warner J,Busch JD,Keim P,Currie BJ,Wagner DM

更新日期：2017-09-14 00:00:00

abstract：BACKGROUND:Aedes albopictus, the Asian tiger mosquito, is a vector of several arboviruses including dengue and chikungunya, and is also a significant nuisance mosquito. It is one of the most invasive of mosquitoes with a relentlessly increasing geographic distribution. Conventional control methods have so far failed to...

journal_title：PLoS neglected tropical diseases

authors： Labbé GM,Scaife S,Morgan SA,Curtis ZH,Alphey L

更新日期：2012-01-01 00:00:00

abstract：:Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Middle East, affecting both humans and ruminants. There are no licensed vaccines or antivirals available for humans, whereas research using RVF virus (RVFV) is strictly regulated in many countries with safety concerns. Nonpathogenic...

journal_title：PLoS neglected tropical diseases

authors： Hallam HJ,Lokugamage N,Ikegami T

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homolo...

journal_title：PLoS neglected tropical diseases

authors： Woo PC,Lau SK,Lau CC,Tung ET,Chong KT,Yang F,Zhang H,Lo RK,Cai JP,Au-Yeung RK,Ng WF,Tse H,Wong SS,Xu S,Lam WH,Tse MK,Sze KH,Kao RY,Reiner NE,Hao Q,Yuen KY

更新日期：2016-08-25 00:00:00

abstract：:Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A. aegypti strain (SP) developed 1650-fold resistance to permethrin, which is one of the most widely used pyrethroid insecticides for mosquito control. SP larvae also developed 8790-fold resistance following sele...

journal_title：PLoS neglected tropical diseases

authors： Kasai S,Komagata O,Itokawa K,Shono T,Ng LC,Kobayashi M,Tomita T

更新日期：2014-06-19 00:00:00

abstract：:As rabies in carnivores is increasingly controlled throughout much of the Americas, bats are emerging as a significant source of rabies virus infection of humans and domestic animals. Knowledge of the bat species that maintain rabies is a crucial first step in reducing this public health problem. In North America, sev...

journal_title：PLoS neglected tropical diseases

authors： Nadin-Davis S,Alnabelseya N,Knowles MK

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:Marburg virus (MARV), a zoonotic pathogen causing severe hemorrhagic fever in man, has emerged in Angola resulting in the largest outbreak of Marburg hemorrhagic fever (MHF) with the highest case fatality rate to date. METHODOLOGY/PRINCIPAL FINDINGS:A mobile laboratory unit (MLU) was deployed as part of the...

journal_title：PLoS neglected tropical diseases

authors： Grolla A,Jones SM,Fernando L,Strong JE,Ströher U,Möller P,Paweska JT,Burt F,Pablo Palma P,Sprecher A,Formenty P,Roth C,Feldmann H

更新日期：2011-05-01 00:00:00

abstract：:Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circu...

journal_title：PLoS neglected tropical diseases

authors： Angulo J,Martínez-Valdebenito C,Marco C,Galeno H,Villagra E,Vera L,Lagos N,Becerra N,Mora J,Bermúdez A,Díaz J,Ferrés M,López-Lastra M

更新日期：2017-07-14 00:00:00

abstract：:The spread of dengue (DEN) worldwide combined with an increased severity of the DEN-associated clinical outcomes have made this mosquito-borne virus of great global public health importance. Progress in understanding DEN pathogenesis and in developing effective treatments has been hampered by the lack of a suitable sm...

journal_title：PLoS neglected tropical diseases

authors： Tan GK,Ng JK,Trasti SL,Schul W,Yip G,Alonso S

更新日期：2010-04-27 00:00:00

abstract：:Response to Zika virus (ZIKV) invasion in Brazil lagged a year from its estimated February 2014 introduction, and was triggered by the occurrence of severe congenital malformations. Dengue (DENV) and chikungunya (CHIKV) invasions tend to show similar response lags. We analyzed geo-coded symptomatic case reports from t...

journal_title：PLoS neglected tropical diseases

authors： Bisanzio D,Dzul-Manzanilla F,Gomez-Dantés H,Pavia-Ruz N,Hladish TJ,Lenhart A,Palacio-Vargas J,González Roldan JF,Correa-Morales F,Sánchez-Tejeda G,Kuri Morales P,Manrique-Saide P,Longini IM,Halloran ME,Vazquez-Prokopec GM

更新日期：2018-03-15 00:00:00