How community engagement strategies shape participation in mass drug administration programmes for lymphatic filariasis: The case of Luangwa District, Zambia.

abstract：:One of the stated goals of the London Declaration on Neglected Tropical Diseases is the interruption of domiciliary transmissions of Chagas disease in the region of the Americas. We used a game-theoretic approach to assess the voluntary use of insecticide treated nets (ITNs) in the prevention of the spread of infectio...

journal_title：PLoS neglected tropical diseases

authors： Han CY,Issa H,Rychtář J,Taylor D,Umana N

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Dengue is the most prevalent arboviral disease of humans. Virus neutralizing antibodies are likely to be critical for clinical immunity after vaccination or natural infection. A number of human monoclonal antibodies (mAbs) have previously been characterized as able to neutralize the infectivity of dengue vir...

journal_title：PLoS neglected tropical diseases

authors： Tuan Vu T,Clapham H,Huynh VTT,Vo Thi L,Le Thi D,Vu NT,Nguyen GT,Huynh TTX,Duong KTH,Tran VT,Huynh HLA,Le Huynh DT,Huynh TLP,Nguyen TTV,Nguyen NM,Luong TTH,Phong NT,Nguyen CVV,Gough G,Wills B,Carrington LB,Simmon

更新日期：2019-11-01 00:00:00

abstract：:Control of arbovirus transmission remains focused on vector control through application of insecticides directly to the environment. However, these insecticide applications are often reactive interventions that can be poorly-targeted, inadequate for localized control during outbreaks, and opposed due to environmental ...

journal_title：PLoS neglected tropical diseases

authors： Nguyen C,Gray M,Burton TA,Foy SL,Foster JR,Gendernalik AL,Rückert C,Alout H,Young MC,Boze B,Ebel GD,Clapsaddle B,Foy BD

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:Echinococcosis is a life-threatening parasitic disease caused by Echinococcus spp. tapeworms with over one million people affected globally at any time. The Echinococcus spp. tapeworms in the human body release DNA to the circulatory system, which can be a biomarker for echinococcosis. Cell-free DNA (cfDNA) ...

journal_title：PLoS neglected tropical diseases

authors： Ji J,Li B,Li J,Danzeng W,Li J,Zhao Y,Qiangba G,Zhang Q,Renzhen N,Basang Z,Jia C,Gongsang Q,Ma J,Wang Y,Chen F,Zhou H,Huasang,Yin J,Xie J,Pei N,Cai H,Jiang H,Yang H,Wang J,Asan,Han X,Li J,Chen W,Yan

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology has rapidly emerged as a very effective tool for gene editing. Although great advances on gene editing in the medical entomology field have arisen, no attempts of gene editing have been reported in sand flies, the vectors of L...

journal_title：PLoS neglected tropical diseases

authors： Martin-Martin I,Aryan A,Meneses C,Adelman ZN,Calvo E

更新日期：2018-09-04 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is an infectious disease caused by various species of Leishmania and transmitted by several species of sand flies. CL is among the most neglected tropical diseases, and it has represented a major health threat over the past 20 years in Morocco. The main objectives of this study w...

journal_title：PLoS neglected tropical diseases

authors： Mhaidi I,El Kacem S,Ait Kbaich M,El Hamouchi A,Sarih M,Akarid K,Lemrani M

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:The mosquito resistance to the insecticides threatens malaria control efforts, potentially becoming a major public health issue. Alternative methods like ivermectin (IVM) administration to humans has been suggested as a possible vector control to reduce Plasmodium transmission. Anopheles aquasalis and Anophe...

journal_title：PLoS neglected tropical diseases

authors： Pinilla YT,C P Lopes S,S Sampaio V,Andrade FS,Melo GC,Orfanó AS,Secundino NFC,Guerra MGVB,Lacerda MVG,Kobylinski KC,Escobedo-Vargas KS,López-Sifuentes VM,Stoops CA,Baldeviano GC,Tarning J,Vasquez GM,Pimenta PFP,Monteiro

更新日期：2018-02-14 00:00:00

abstract：BACKGROUND:Schistosome eggs must traverse tissues of the intestine or bladder to escape the human host and further the life cycle. Escape from host tissues is facilitated by secretion of immuno-reactive molecules by eggs and the formation of an intense strong granulomatous response by the host which acts to exclude the...

journal_title：PLoS neglected tropical diseases

authors： Jones MK,Bong SH,Green KM,Holmes P,Duke M,Loukas A,McManus DP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Access to health care is a major requirement in improving health and fostering socioeconomic development. In the People's Republic of China (P.R. China), considerable changes have occurred in the social, economic, and health systems with a shift from a centrally planned to a socialist market economy. This br...

journal_title：PLoS neglected tropical diseases

authors： Balen J,Liu ZC,McManus DP,Raso G,Utzinger J,Xiao SY,Yu DB,Zhao ZY,Li YS

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is a mosquito-borne flavivirus distributed throughout much of Africa and Asia. Infection with the virus may cause acute febrile illness that clinically resembles dengue fever. A recent study indicated the existence of three geographically distinct viral lineages; however this analysis utili...

journal_title：PLoS neglected tropical diseases

authors： Haddow AD,Schuh AJ,Yasuda CY,Kasper MR,Heang V,Huy R,Guzman H,Tesh RB,Weaver SC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hospitalization of patients during outbreaks of chikungunya virus has been reported to be uncommon (0.5-8.7%), but more frequent among infants and the elderly. CHIKV was first detected in Puerto Rico in May 2014. We enrolled patients with acute febrile illness (AFI) presenting to two hospital emergency depar...

journal_title：PLoS neglected tropical diseases

authors： Hsu CH,Cruz-Lopez F,Vargas Torres D,Perez-Padilla J,Lorenzi OD,Rivera A,Staples JE,Lugo E,Munoz-Jordan J,Fischer M,Garcia Gubern C,Rivera Garcia B,Alvarado L,Sharp TM

更新日期：2019-01-14 00:00:00

abstract：:Cutaneous leishmaniasis caused by Leishmania major is an emergent, uncontrolled public health problem and there is no vaccine. A promising prophylactic approach has been immunotherapy with Toll-like receptor (TLR) agonists to enhance parasite-specific immune responses. We have previously reported that vaccination of C...

journal_title：PLoS neglected tropical diseases

authors： Huang L,Hinchman M,Mendez S

更新日期：2015-03-04 00:00:00

abstract：:The East/Central/South African genotype of Chikungunya virus with the E1-A226V mutation emerged in 2011 in Cambodia and spread in 2012. An outbreak of 190 cases was documented in Trapeang Roka, a rural village. We surveyed 425 village residents within 3-4 weeks after the outbreak, and determined the sensitivity and sp...

journal_title：PLoS neglected tropical diseases

authors： Galatas B,Ly S,Duong V,Baisley K,Nguon K,Chan S,Huy R,Ly S,Sorn S,Som L,Buchy P,Tarantola A

更新日期：2016-01-11 00:00:00

abstract：BACKGROUND:Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic shock is the most serious ...

journal_title：PLoS neglected tropical diseases

authors： Lam PK,Ngoc TV,Thu Thuy TT,Hong Van NT,Nhu Thuy TT,Hoai Tam DT,Dung NM,Hanh Tien NT,Thanh Kieu NT,Simmons C,Wills B,Wolbers M

更新日期：2017-04-27 00:00:00

abstract：:Community drug distributors (CDDs) who are volunteers have the responsibility of awareness creation, household census, drug distribution and record-keeping and are thus key stakeholders in the campaign for Lymphatic Filariasis (LF) elimination. Taking into account their experiences and perceptions is important for a s...

journal_title：PLoS neglected tropical diseases

authors： Njomo DW,Kimani BW,Kibe LW,Okoyo C,Omondi WP,Sultani HM

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:Mapping of lymphatic filariasis (LF) caused by Wuchereria bancrofti largely relies on the detection of circulating antigen using ICT cards. Several studies have recently shown that this test can be cross-reactive with sera of subjects heavily infected with Loa loa and thus mapping results in loiasis endemic ...

journal_title：PLoS neglected tropical diseases

authors： Wanji S,Esum ME,Njouendou AJ,Mbeng AA,Chounna Ndongmo PW,Abong RA,Fru J,Fombad FF,Nchanji GT,Ngongeh G,Ngandjui NV,Enyong PI,Storey H,Curtis KC,Fischer K,Fauver JR,Lew D,Goss CW,Fischer PU

更新日期：2019-03-08 00:00:00

abstract：:We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse ...

journal_title：PLoS neglected tropical diseases

authors： Morizot G,Jouffroy R,Faye A,Chabert P,Belhouari K,Calin R,Charlier C,Miailhes P,Siriez JY,Mouri O,Yera H,Gilquin J,Tubiana R,Lanternier F,Mamzer MF,Legendre C,Peyramond D,Caumes E,Lortholary O,Buffet P

更新日期：2016-01-06 00:00:00

abstract：BACKGROUND:Real-Time PCR-High Resolution Melting (qPCR-HRM) analysis has been recently described for rapid drug susceptibility testing (DST) of Mycobacterium leprae. The purpose of the current study was to further evaluate the validity, reliability, and accuracy of this assay for M. leprae DST in clinical specimens. M...

journal_title：PLoS neglected tropical diseases

authors： Araujo S,Goulart LR,Truman RW,Goulart IMB,Vissa V,Li W,Matsuoka M,Suffys P,Fontes AB,Rosa PS,Scollard DM,Williams DL

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homolo...

journal_title：PLoS neglected tropical diseases

authors： Woo PC,Lau SK,Lau CC,Tung ET,Chong KT,Yang F,Zhang H,Lo RK,Cai JP,Au-Yeung RK,Ng WF,Tse H,Wong SS,Xu S,Lam WH,Tse MK,Sze KH,Kao RY,Reiner NE,Hao Q,Yuen KY

更新日期：2016-08-25 00:00:00

abstract：OBJECTIVE:We evaluated the profile of patients referred to the Fiocruz Outpatient Clinic, a reference center for the diagnosis and treatment of leprosy in Rio de Janeiro, RJ, and analyzed the origins and outcomes of these referrals. METHODS:This is an observational retrospective study based on information collected fr...

journal_title：PLoS neglected tropical diseases

authors： Barbieri RR,Sales AM,Hacker MA,Nery JA,Duppre NC,Machado AM,Moraes MO,Sarno EN

更新日期：2016-10-12 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF), a global public health problem affecting approximately 120 million people worldwide, is a leading cause of disability in the developing world including the South Pacific. Despite decades of ongoing mass drug administration (MDA) in the region, some island nations have not yet achie...

journal_title：PLoS neglected tropical diseases

authors： Chambers EW,Hapairai L,Peel BA,Bossin H,Dobson SL

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:For decades La Réunion has experienced a number of epidemics that have resulted in efforts to control the density of Aedes species on this Island. This study was conducted to assess household-level expenditure on protective measures against mosquito nuisance on the Island of La Réunion in 2012. METHODOLOGY/...

journal_title：PLoS neglected tropical diseases

authors： Thuilliez J,Bellia C,Dehecq JS,Reilhes O

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Chagas disease is a vector-borne disease of major importance in the Americas. Disease prevention is mostly limited to vector control. Integrated interventions targeting ecological, biological and social determinants of vector-borne diseases are increasingly used for improved control. METHODOLOGY/PRINCIPAL F...

journal_title：PLoS neglected tropical diseases

authors： Dumonteil E,Nouvellet P,Rosecrans K,Ramirez-Sierra MJ,Gamboa-León R,Cruz-Chan V,Rosado-Vallado M,Gourbière S

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:Morocco has achieved the goal of leprosy elimination as a public health problem several years ago (less than 1 case/ 10 000 habitant). The aim of this study was to analyze trends of leprosy detection during the last 17 years taking into consideration the implementation of single dose rifampicin chemoprophyla...

journal_title：PLoS neglected tropical diseases

authors： Khoudri I,Elyoussfi Z,Mourchid Y,Youbi M,Bennani Mechita N,Abouqal R,Maaroufi A

更新日期：2018-12-20 00:00:00

abstract：:Zika virus (ZIKV) is an arbovirus primarily transmitted by Aedes mosquitoes. Like most viral infections, ZIKV viremia varies over several orders of magnitude, with unknown consequences for transmission. To determine the effect of viral concentration on ZIKV transmission risk, we exposed field-derived Ae. aegypti mosqu...

journal_title：PLoS neglected tropical diseases

authors： Tesla B,Demakovsky LR,Packiam HS,Mordecai EA,Rodríguez AD,Bonds MH,Brindley MA,Murdock CC

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:Leprosy is a Neglected Tropical Diseases (NTDs) known to cause stigma and discrimination in low-and middle-income countries. It often results in visible impairments, thus pre-disposing to poor mental health. Aim of the study was to estimate the prevalence of depression and anxiety among people affected by Le...

journal_title：PLoS neglected tropical diseases

authors： Govindasamy K,Jacob I,Solomon RM,Darlong J

更新日期：2021-01-22 00:00:00

abstract：OBJECTIVES:Burkholderia pseudomallei, the causative agent for melioidosis, has become a public health problem in India and across the world. Melioidosis can be difficult to diagnose because of the inconsistent clinical presentations of the disease. This study aims to determine the genetic diversity among the clinical i...

journal_title：PLoS neglected tropical diseases

authors： Balaji V,Perumalla S,Perumal R,Inbanathan FY,Rajamani Sekar SK,Paul MM,Sahni RD,Prakash JAJ,Iyadurai R

更新日期：2018-06-27 00:00:00

abstract：:Schistosomiasis affects approximately 240 million people in the world. Schistosoma mansoni eggs in the liver induce periportal fibrosis and hepatic failure driven by monocyte recruitment and macrophage activation, resulting in robust Th2 response. Here, we suggested a possible involvement of Galectin-3 (Gal-3), histon...

journal_title：PLoS neglected tropical diseases

authors： de Oliveira FL,Carneiro K,Brito JM,Cabanel M,Pereira JX,Paiva LA,Syn W,Henderson NC,El-Cheikh MC

更新日期：2017-02-23 00:00:00

abstract：:Morbidity burden of lymphatic filariasis (LF) relies on the information from the Mass Drug Administration (MDA) programme where Community Health Volunteers (CHVs) passively report cases identified. Consequently, the exact prevalence of morbidity cases is not always accurate. The use of mobile phone technology to repor...

journal_title：PLoS neglected tropical diseases

authors： Debrah LB,Mohammed A,Osei-Mensah J,Mubarik Y,Agbenyega O,Ayisi-Boateng NK,Pfarr K,Kuehlwein JM,Klarmann-Schulz U,Hoerauf A,Debrah AY

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Imported strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported strongyloidiasis in Spain. METHODOLOGY:This is an observational retrospective study that included ...

journal_title：PLoS neglected tropical diseases

authors： Salvador F,Treviño B,Chamorro-Tojeiro S,Sánchez-Montalvá A,Herrero-Martínez JM,Rodríguez-Guardado A,Serre-Delcor N,Torrús D,Goikoetxea J,Zubero Z,Velasco M,Sulleiro E,Molina I,López-Vélez R,Pérez-Molina JA,on behalf the +RE

更新日期：2019-05-16 00:00:00