Long-Lasting Immune Protection and Other Epidemiological Findings after Chikungunya Emergence in a Cambodian Rural Community, April 2012.

abstract：:The major arboviral diseases in mainland China include Japanese encephalitis, dengue fever, Crimean-Congo hemorrhagic fever (also known as Xinjiang hemorrhagic fever), and tick-borne encephalitis. These and other newly found arbovirus infections due to Banna virus and Tahyna virus contribute to a large and relatively ...

journal_title：PLoS neglected tropical diseases

authors： Gao X,Nasci R,Liang G

更新日期：2010-04-27 00:00:00

abstract：:Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi. It has high mortality as well as morbidity rates and usually affects the poorer sections of the population. The development of new, less harmful and more effective drugs is a promising research target, since current standard treatments are highly t...

journal_title：PLoS neglected tropical diseases

authors： Rea A,Tempone AG,Pinto EG,Mesquita JT,Rodrigues E,Silva LG,Sartorelli P,Lago JH

更新日期：2013-12-05 00:00:00

abstract：:Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed vaccines or antiviral therapies for CHIKV, the development of vaccine...

journal_title：PLoS neglected tropical diseases

authors： Gardner CL,Hritz J,Sun C,Vanlandingham DL,Song TY,Ghedin E,Higgs S,Klimstra WB,Ryman KD

更新日期：2014-02-20 00:00:00

abstract：:A 51-year-old man with 3-month unhealing cat bite wound was diagnosed with sporotrichosis, a subacute-to-chronic infection caused by the worldwide endemic, dimorphic fungus Sporothrix globosa. The case would help clinicians to raise awareness of human sporotrichosis due to cat bites, which remains rare and is likely t...

journal_title：PLoS neglected tropical diseases

authors： Liu Y,Liu L,Kang M,Zong Z

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are responsible for a substantial health and economic burden, particularly to low-income societies. Quan...

journal_title：PLoS neglected tropical diseases

authors： Otero-Abad B,Torgerson PR

更新日期：2013-06-06 00:00:00

abstract：:Tsetse are vectors of pathogenic trypanosomes, agents of human and animal trypanosomiasis in Africa. Components of tsetse saliva (sialome) are introduced into the mammalian host bite site during the blood feeding process and are important for tsetse's ability to feed efficiently, but can also influence disease transmi...

journal_title：PLoS neglected tropical diseases

authors： Zhao X,Alves e Silva TL,Cronin L,Savage AF,O'Neill M,Nerima B,Okedi LM,Aksoy S

更新日期：2015-08-27 00:00:00

abstract：BACKGROUND:Arboviruses have overlapping geographical distributions and can cause symptoms that coincide with more common infections. Therefore, arbovirus infections are often neglected by travel diagnostics. Here, we assessed the potential of syndrome-based approaches for diagnosis and surveillance of neglected arbovir...

journal_title：PLoS neglected tropical diseases

authors： Cleton NB,Reusken CB,Wagenaar JF,van der Vaart EE,Reimerink J,van der Eijk AA,Koopmans MP

更新日期：2015-09-15 00:00:00

abstract：INTRODUCTION:While we lack a complete understanding of the molecular mechanisms by which parasites establish and achieve protection from host immune responses, it is accepted that many of these processes are mediated by products, primarily proteins, released from the parasite. Parasitic nematodes occur in different lif...

journal_title：PLoS neglected tropical diseases

authors： Moreno Y,Geary TG

更新日期：2008-01-01 00:00:00

abstract：:Burkholderia pseudomallei causes the tropical infection melioidosis. Pneumonia is a common manifestation of melioidosis and is associated with high mortality. Understanding the key elements of host defense is essential to developing new therapeutics for melioidosis. As a flagellated bacterium encoding type III secreti...

journal_title：PLoS neglected tropical diseases

authors： West TE,Myers ND,Chantratita N,Chierakul W,Limmathurotsakul D,Wuthiekanun V,Miao EA,Hajjar AM,Peacock SJ,Liggitt HD,Skerrett SJ

更新日期：2014-09-18 00:00:00

abstract：BACKGROUND:Mass anthelmintic drug administration is recommended in developing countries to address infection by soil-transmitted helminthiases (STH). We quantified the public health benefit of treatment with mebendazole in eight million Vietnamese children aged 5-14 years from 2006 to 2011. This was compared to the env...

journal_title：PLoS neglected tropical diseases

authors： Debaveye S,Gonzalez Torres CV,De Smedt D,Heirman B,Kavanagh S,Dewulf J

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:The aetiological diagnostic of fevers in Laos remains difficult due to limited laboratory diagnostic facilities. However, it has recently become apparent that both scrub and murine typhus are common causes of previous undiagnosed fever. Epidemiological data suggests that scrub typhus would be more common in ...

journal_title：PLoS neglected tropical diseases

authors： Vallée J,Thaojaikong T,Moore CE,Phetsouvanh R,Richards AL,Souris M,Fournet F,Salem G,Gonzalez JP,Newton PN

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Usutu virus (USUV) is a member of the Japanese encephalitis virus (JEV) serocomplex in the Flaviviridae family. Emergence of USUV in Europe has led to disease burdens in birds and created increasing concern for the potential zoonotic transmission to humans. Whilst USUV has not been detected in the New World,...

journal_title：PLoS neglected tropical diseases

authors： Cook CL,Huang YS,Lyons AC,Alto BW,Unlu I,Higgs S,Vanlandingham DL

更新日期：2018-08-17 00:00:00

abstract：BACKGROUND:Since its beginning in 1999, the Schistosomiasis Control Program within the Unified Health System (PCE-SUS) has registered a cumulative coverage of just 20% of the population from the Rainforest Zone of Pernambuco (ZMP), northeast Brazil. This jeopardizes the accomplishment of the minimum goal of the Fifty-F...

journal_title：PLoS neglected tropical diseases

authors： Favre TC,Pereira AP,Galvão AF,Zani LC,Barbosa CS,Pieri OS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The global burden of cholera is largely unknown because the majority of cases are not reported. The low reporting can be attributed to limited capacity of epidemiological surveillance and laboratories, as well as social, political, and economic disincentives for reporting. We previously estimated 2.8 million...

journal_title：PLoS neglected tropical diseases

authors： Ali M,Nelson AR,Lopez AL,Sack DA

更新日期：2015-06-04 00:00:00

abstract：BACKGROUND:Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable. Cysteine leucine rich protein (CLrP), was recognized as one of the overexpressed...

journal_title：PLoS neglected tropical diseases

authors： Das S,Shah P,Tandon R,Yadav NK,Sahasrabuddhe AA,Sundar S,Siddiqi MI,Dube A

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND:During blood feeding, sand flies inject Leishmania parasites in the presence of saliva. The types and functions of cells present at the first host-parasite contact are critical to the outcome on infection and sand fly saliva has been shown to play an important role in this setting. Herein, we investigated th...

journal_title：PLoS neglected tropical diseases

authors： de Moura TR,Oliveira F,Rodrigues GC,Carneiro MW,Fukutani KF,Novais FO,Miranda JC,Barral-Netto M,Brodskyn C,Barral A,de Oliveira CI

更新日期：2010-06-15 00:00:00

abstract：:Mycetoma, one of the badly neglected tropical diseases, it is a localised chronic granulomatous inflammatory disease characterised by painless subcutaneous mass and formation of multiple sinuses that produce purulent discharge and grains. If untreated early and appropriately, it usually spread to affect the deep struc...

journal_title：PLoS neglected tropical diseases

authors： Bakhiet SM,Fahal AH,Musa AM,Mohamed ESW,Omer RF,Ahmed ES,El Nour M,Mustafa ERM,Sheikh A Rahman ME,Suliman SH,El Mamoun MAG,El Amin HM

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:We identified the species of Leishmania isolated from traveling and migrant patients attended in a reference center from 2000 to 2015, we performed the georeferencing of these species in Rio de Janeiro (RJ) state and we had knowledge about the human flows between the likely location of infection (LLI) and pl...

journal_title：PLoS neglected tropical diseases

authors： Miranda LFC,Pacheco RDS,Pimentel MIF,Salgueiro MM,da Silva AF,de Mello CX,Barros JHDS,Valete-Rosalino CM,Madeira MF,Xavier SCDC,Schubach AO

更新日期：2019-11-15 00:00:00

abstract：:Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manif...

journal_title：PLoS neglected tropical diseases

authors： Mitjà O,Šmajs D,Bassat Q

更新日期：2013-10-24 00:00:00

abstract：:Zika virus (ZIKV) is a Flavivirus (Flaviviridae) transmitted to humans mainly by the bite of an infected Aedes mosquitoes. Aedes aegypti is the primary epidemic vector of ZIKV and Ae. albopictus, the secondary one. However, the epidemiological role of both Aedes species in Central Africa where Ae. albopictus was recen...

journal_title：PLoS neglected tropical diseases

authors： Kamgang B,Vazeille M,Tedjou A,Yougang AP,Wilson-Bahun TA,Mousson L,Wondji CS,Failloux AB

更新日期：2020-03-23 00:00:00

abstract：:Rickettsia (R.) helvetica is the most prevalent rickettsia found in Ixodes ricinus ticks in Germany. Several studies reported antibodies against R. helvetica up to 12.5% in humans investigated, however, fulminant clinical cases are rare indicating a rather low pathogenicity compared to other rickettsiae. We investigat...

journal_title：PLoS neglected tropical diseases

authors： Speck S,Kern T,Aistleitner K,Dilcher M,Dobler G,Essbauer S

更新日期：2018-02-12 00:00:00

abstract：:Global efforts to control morbidity associated with soil-transmitted helminth infections (STH) have focused largely on the targeted treatment of high-risk groups, including children and pregnant women. However, it is not clear when such programs can be discontinued and there are concerns about the sustainability of cu...

journal_title：PLoS neglected tropical diseases

authors： DeWorm3 Trials Team.

更新日期：2020-11-02 00:00:00

abstract：BACKGROUND:Soil-transmitted helminth (STH) infections are among the most prevalent neglected tropical diseases (NTD) worldwide. Since the publication of the WHO road map to combat NTD in 2012, there has been a renewed commitment to control STH. In this study, we analysed the geographical distribution and effect of comm...

journal_title：PLoS neglected tropical diseases

authors： Silver ZA,Kaliappan SP,Samuel P,Venugopal S,Kang G,Sarkar R,Ajjampur SSR

更新日期：2018-01-18 00:00:00

abstract：:Trypanosoma cruzi, the etiological agent of Chagas disease, consumes glucose and amino acids depending on the environmental availability of each nutrient during its complex life cycle. For example, amino acids are the major energy and carbon sources in the intracellular stages of the T. cruzi parasite, but their consu...

journal_title：PLoS neglected tropical diseases

authors： Crispim M,Damasceno FS,Hernández A,Barisón MJ,Pretto Sauter I,Souza Pavani R,Santos Moura A,Pral EMF,Cortez M,Elias MC,Silber AM

更新日期：2018-01-10 00:00:00

abstract：BACKGROUND:Schistosomiasis has been reported in 78 endemic countries and affects 240 million people worldwide. The digenetic parasite Schistosoma mansoni needs fresh water to compete its life cycle. There, it is susceptible to soluble compounds that can affect directly and/or indirectly the parasite's biology. The cerc...

journal_title：PLoS neglected tropical diseases

authors： Augusto RC,Tetreau G,Chan P,Walet-Balieu ML,Mello-Silva CC,Santos CP,Grunau C

更新日期：2017-07-28 00:00:00

abstract：INTRODUCTION:This paper discusses the presence of Aedes aegypti pupae in different types of containers considering: volume, pH of the container, among other variables. METHODS:A nonlinear method for selection was applied, based on Mutual Information, by placing in order of importance the most appropriate variables for...

journal_title：PLoS neglected tropical diseases

authors： Medronho RA,Câmara VM,Macrini L

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:Dengue is a serious vector-borne disease, and incidence rates have significantly increased during the past few years, particularly in 2014 in Guangzhou. The current situation is more complicated, due to various factors such as climate warming, urbanization, population increase, and human mobility. The purpos...

journal_title：PLoS neglected tropical diseases

authors： Zhu G,Liu J,Tan Q,Shi B

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:Soil-transmitted helminths (STH) have acute and chronic manifestations, and can result in lifetime morbidity. Disease burden is difficult to quantify, yet quantitative evidence is required to justify large-scale deworming programmes. A recent Cochrane systematic review, which influences Global Burden of Dise...

journal_title：PLoS neglected tropical diseases

authors： Campbell SJ,Nery SV,Doi SA,Gray DJ,Soares Magalhães RJ,McCarthy JS,Traub RJ,Andrews RM,Clements AC

更新日期：2016-05-19 00:00:00

abstract：:Global distribution patterns of Cladophialophora carrionii, agent of human chromoblastomycosis in arid climates of Africa, Asia, Australia, Central-and South-America, were compared with similar data of the vicarious Fonsecaea spp., agents of the disease in tropical rain forests. Population diversities among 73 C. carr...

journal_title：PLoS neglected tropical diseases

authors： Deng S,Tsui CK,Gerrits van den Ende AH,Yang L,Najafzadeh MJ,Badali H,Li R,Hagen F,Meis JF,Sun J,Dolatabadi S,Papierok B,Pan W,de Hoog GS,Liao W

更新日期：2015-10-23 00:00:00

abstract：:Fasciolosis caused by Fasciola gigantica is a neglected tropical disease but a constraint on the growth and productivity of cattle, buffaloes and sheep in the tropical countries of Asia and Africa. Resistance to commonly used anthelmintics in Fasciola has increased the need to search for alternative therapeutic target...

journal_title：PLoS neglected tropical diseases

authors： Anandanarayanan A,Raina OK,Lalrinkima H,Rialch A,Sankar M,Varghese A

更新日期：2017-12-12 00:00:00