Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species.

abstract：BACKGROUND:We identified the species of Leishmania isolated from traveling and migrant patients attended in a reference center from 2000 to 2015, we performed the georeferencing of these species in Rio de Janeiro (RJ) state and we had knowledge about the human flows between the likely location of infection (LLI) and pl...

journal_title：PLoS neglected tropical diseases

authors： Miranda LFC,Pacheco RDS,Pimentel MIF,Salgueiro MM,da Silva AF,de Mello CX,Barros JHDS,Valete-Rosalino CM,Madeira MF,Xavier SCDC,Schubach AO

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) encoding heat-stable enterotoxin (ST) alone or with heat-labile enterotoxin (LT) cause moderate-to-severe diarrhea (MSD) in developing country children. The Global Enteric Multicenter Study (GEMS) identified ETEC encoding ST among the top four enteropathogens. Since th...

journal_title：PLoS neglected tropical diseases

authors： Vidal RM,Muhsen K,Tennant SM,Svennerholm AM,Sow SO,Sur D,Zaidi AKM,Faruque ASG,Saha D,Adegbola R,Hossain MJ,Alonso PL,Breiman RF,Bassat Q,Tamboura B,Sanogo D,Onwuchekwa U,Manna B,Ramamurthy T,Kanungo S,Ahmed S,Q

更新日期：2019-01-04 00:00:00

abstract：BACKGROUND:Soil-transmitted helminth (STH) infections are among the most prevalent neglected tropical diseases (NTD) worldwide. Since the publication of the WHO road map to combat NTD in 2012, there has been a renewed commitment to control STH. In this study, we analysed the geographical distribution and effect of comm...

journal_title：PLoS neglected tropical diseases

authors： Silver ZA,Kaliappan SP,Samuel P,Venugopal S,Kang G,Sarkar R,Ajjampur SSR

更新日期：2018-01-18 00:00:00

abstract：:As the most widespread tick-borne arbovirus causing infections in numerous countries in Asia, Africa and Europe, Crimean-Congo Hemorrhagic Fever Virus (CCHFV, family Nairoviridae) was included in the WHO priority list of emerging pathogens needing urgent Research & Development attention. To ensure preparedness for pot...

journal_title：PLoS neglected tropical diseases

authors： Emmerich P,Mika A,von Possel R,Rackow A,Liu Y,Schmitz H,Günther S,Sherifi K,Halili B,Jakupi X,Berisha L,Ahmeti S,Deschermeier C

更新日期：2018-03-26 00:00:00

abstract：:In Tunisia, cases of zoonotic cutaneous leishmaniasis caused by Leishmania major are increasing and spreading from the south-west to new areas in the center. To improve the current knowledge on L. major evolution and population dynamics, we performed multi-locus microsatellite typing of human isolates from Tunisian go...

journal_title：PLoS neglected tropical diseases

authors： Harrabi M,Bettaieb J,Ghawar W,Toumi A,Zaâtour A,Yazidi R,Chaâbane S,Chalghaf B,Hide M,Bañuls AL,Ben Salah A

更新日期：2015-08-24 00:00:00

abstract：:Leishmaniasis is a major health problem in some endemic areas and yet, no vaccine is available against any form of the disease. Historically, leishmanization (LZ) which is an inoculation of individual with live Leishmania, is the most effective control measure at least against cutaneous leishmaniasis (CL). Due to vari...

journal_title：PLoS neglected tropical diseases

authors： Davoudi N,Khamesipour A,Mahboudi F,McMaster WR

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:The options for treating the fatal disease human African trypanosomiasis are limited to a few drugs that are toxic or facing increasing resistance. New drugs that kill the causative agents, subspecies of Trypanosoma brucei, are therefore urgently needed. Little is known about the cellular mechanisms that lea...

journal_title：PLoS neglected tropical diseases

authors： Worthen C,Jensen BC,Parsons M

更新日期：2010-05-04 00:00:00

abstract：INTRODUCTION:Chikungunya is an emerging public health problem in tropical and subtropical regions, due to ongoing transmission and its incapacitating acute disease phase, and chronic sequelae. The disease is responsible for a major impact on Health Related Quality of Life (HRQoL), which may last several years. To our k...

journal_title：PLoS neglected tropical diseases

authors： Elsinga J,Grobusch MP,Tami A,Gerstenbluth I,Bailey A

更新日期：2017-10-09 00:00:00

abstract：:The global spread of vector-borne diseases remains a worrying public health threat, raising the need for development of new combat strategies for vector control. Knowledge of vector ecology can be exploited in this regard, including plant feeding; a critical resource that mosquitoes of both sexes rely on for survival ...

journal_title：PLoS neglected tropical diseases

authors： Nyasembe VO,Tchouassi DP,Pirk CWW,Sole CL,Torto B

更新日期：2018-02-20 00:00:00

abstract：:We recently reported that larval stage Aedes aegypti and several other species of mosquitoes grow when living bacteria are present in the gut but do not grow when living bacteria are absent. We further reported that living bacteria induce a hypoxia signal in the gut, which activates hypoxia-induced transcription facto...

journal_title：PLoS neglected tropical diseases

authors： Valzania L,Martinson VG,Harrison RE,Boyd BM,Coon KL,Brown MR,Strand MR

更新日期：2018-07-06 00:00:00

abstract：:The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm. The identification of compounds that target adult worms has been a...

journal_title：PLoS neglected tropical diseases

authors： Taldone T,Gillan V,Sun W,Rodina A,Patel P,Maitland K,O'Neill K,Chiosis G,Devaney E

更新日期：2010-06-15 00:00:00

abstract：:Q fever is a widespread zoonosis that is caused by Coxiella burnetii (C. burnetii), and ruminants are identified as the main sources of human infections. Some human cases have been described, but very limited information was available about Q fever in ruminants on Reunion Island, a tropical island in the Indian Ocean....

journal_title：PLoS neglected tropical diseases

authors： Cardinale E,Esnault O,Beral M,Naze F,Michault A

更新日期：2014-08-07 00:00:00

abstract：:Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A. aegypti strain (SP) developed 1650-fold resistance to permethrin, which is one of the most widely used pyrethroid insecticides for mosquito control. SP larvae also developed 8790-fold resistance following sele...

journal_title：PLoS neglected tropical diseases

authors： Kasai S,Komagata O,Itokawa K,Shono T,Ng LC,Kobayashi M,Tomita T

更新日期：2014-06-19 00:00:00

abstract：:Intracerebral microhemorrhages (CMHs) are small foci of hemorrhages in the cerebrum. Acute infections induced by some intracellular pathogens, including rickettsia, can result in CMHs. Annexin a2 (ANXA2) has been documented to play a functional role during intracellular bacterial adhesion. Here we report that ANXA2-kn...

journal_title：PLoS neglected tropical diseases

authors： Su Z,Chang Q,Drelich A,Shelite T,Judy B,Liu Y,Xiao J,Zhou C,He X,Jin Y,Saito T,Tang S,Soong L,Wakamiya M,Fang X,Bukreyev A,Ksiazek T,Russell WK,Gong B

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND:Although infection with Trypanosoma cruzi is thought to be lifelong, less than half of those infected develop cardiomyopathy, suggesting greater parasite control or even clearance. Antibody levels appear to correlate with T. cruzi (antigen) load. We test the association between a downwards antibody trajector...

journal_title：PLoS neglected tropical diseases

authors： Buss LF,Campos de Oliveira-da Silva L,Moreira CHV,Manuli ER,Sales FC,Morales I,Di Germanio C,de Almeida-Neto C,Bakkour S,Constable P,Pinto-Filho MM,Ribeiro AL,Busch M,Sabino EC

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:The mainstay of toxoplasmosis treatment targets the folate biosynthetic pathways and has not changed for the last 50 years. The activity of these chemotherapeutic agents is restricted to one lifecycle stage of Toxoplasma gondii, they have significant toxicity, and the impending threat of emerging resistance ...

journal_title：PLoS neglected tropical diseases

authors： Andrade RM,Chaparro JD,Capparelli E,Reed SL

更新日期：2014-07-31 00:00:00

abstract：:Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance. The pathogenesis of several of the most prevalent infections, including cholera and enteroxigenic Escherichia coli, is dom...

journal_title：PLoS neglected tropical diseases

authors： Das S,Angsantikul P,Le C,Bao D,Miyamoto Y,Gao W,Zhang L,Eckmann L

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:Dengue viral infection is a global health threat without vaccine or specific treatment. The clinical outcome varies from asymptomatic, mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF). While adaptive immune responses were found to be detrimental in the dengue pathogenesis, the roles of earlier...

journal_title：PLoS neglected tropical diseases

authors： Matangkasombut P,Chan-In W,Opasawaschai A,Pongchaikul P,Tangthawornchaikul N,Vasanawathana S,Limpitikul W,Malasit P,Duangchinda T,Screaton G,Mongkolsapaya J

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Transmission of Yersinia pestis by flea bite can occur by two mechanisms. After taking a blood meal from a bacteremic mammal, fleas have the potential to transmit the very next time they feed. This early-phase transmission resembles mechanical transmission in some respects, but the mechanism is unknown. Ther...

journal_title：PLoS neglected tropical diseases

authors： Hinnebusch BJ,Bland DM,Bosio CF,Jarrett CO

更新日期：2017-01-12 00:00:00

abstract：BACKGROUND:Fascioliasis is an emerging zoonotic disease of considerable veterinary and public health importance. Triclabendazole is the only available drug for treatment. Laboratory studies have documented promising fasciocidal properties of the artemisinins (e.g., artemether). METHODOLOGY:We carried out two explorato...

journal_title：PLoS neglected tropical diseases

authors： Keiser J,Sayed H,el-Ghanam M,Sabry H,Anani S,el-Wakeel A,Hatz C,Utzinger J,el-Din SS,el-Maadawy W,Botros S

更新日期：2011-09-01 00:00:00

abstract：:Drug combinations for the treatment of leishmaniasis represent a promising and challenging chemotherapeutic strategy that has recently been implemented in different endemic areas. However, the vast majority of studies undertaken to date have ignored the potential risk that Leishmania parasites could develop resistance...

journal_title：PLoS neglected tropical diseases

authors： García-Hernández R,Manzano JI,Castanys S,Gamarro F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:While considerable genomic and transcriptomic data are available for Schistosoma mansoni, many of its genes lack significant annotation. A transcriptomic study of individual tissues and organs of schistosomes could play an important role in functional annotation of the unknown genes, particularly by providin...

journal_title：PLoS neglected tropical diseases

authors： Nawaratna SS,McManus DP,Moertel L,Gobert GN,Jones MK

更新日期：2011-04-26 00:00:00

abstract：BACKGROUND:Plasmodium vivax and Hepatitis B virus (HBV) are globally outspread in similar geographic regions. The concurrence of both infections and its association with some degree of protection against symptomatic and/or severe vivax malaria has been already described. Nevertheless, data on how host response to both ...

journal_title：PLoS neglected tropical diseases

authors： Cruz LAB,Moraes MOA,Queiroga-Barros MR,Fukutani KF,Barral-Netto M,Andrade BB

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Dog rabies annually causes 24,000-70,000 deaths globally. We built a spreadsheet tool, RabiesEcon, to aid public health officials to estimate the cost-effectiveness of dog rabies vaccination programs in East Africa. METHODS:RabiesEcon uses a mathematical model of dog-dog and dog-human rabies transmission to...

journal_title：PLoS neglected tropical diseases

authors： Borse RH,Atkins CY,Gambhir M,Undurraga EA,Blanton JD,Kahn EB,Dyer JL,Rupprecht CE,Meltzer MI

更新日期：2018-05-23 00:00:00

abstract：BACKGROUND:Until 2008, human rabies had never been reported in French Guiana. On 28 May 2008, the French National Reference Center for Rabies (Institut Pasteur, Paris) confirmed the rabies diagnosis, based on hemi-nested polymerase chain reaction on skin biopsy and saliva specimens from a Guianan, who had never travell...

journal_title：PLoS neglected tropical diseases

authors： Meynard JB,Flamand C,Dupuy C,Mahamat A,Eltges F,Queuche F,Renner J,Fontanella JM,Hommel D,Dussart P,Grangier C,Djossou F,Dacheux L,Goudal M,Berger F,Ardillon V,Krieger N,Bourhy H,Spiegel A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The protozoan parasite Giardia intestinalis and the pathogenic bacterium Helicobacter pylori are well known for their high prevalences in human hosts worldwide. The prevalence of both organisms is known to peak in densely populated, low resource settings and children are infected early in life. Different Gia...

journal_title：PLoS neglected tropical diseases

authors： Ankarklev J,Hestvik E,Lebbad M,Lindh J,Kaddu-Mulindwa DH,Andersson JO,Tylleskär T,Tumwine JK,Svärd SG

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Transmission of dengue virus (DENV) from humans to mosquitoes represents a critical component of dengue epidemiology. Examinations of this process have generally been hampered by a lack of methods that adequately represent natural acquisition of DENV by mosquitoes from humans. In this study, we assessed arti...

journal_title：PLoS neglected tropical diseases

authors： Long KC,Sulca J,Bazan I,Astete H,Jaba HL,Siles C,Kocher C,Vilcarromero S,Schwarz J,Escobedo-Vargas KS,Castro-Llanos F,Angulo L,Flores G,Ramal-Asayag C,Halsey ES,Hontz RD,Paz-Soldan VA,Scott TW,Lambrechts L,Morrison

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination in Sierra Leone. Epidemiological coverage of mass drug administration (MDA) with ivermectin and albendazole had been reported >65% in all 12 districts annually. Eight districts qualified to implement transmission assessment survey (TAS) in 2013 but were d...

journal_title：PLoS neglected tropical diseases

authors： Bah YM,Paye J,Bah MS,Conteh A,Redwood-Sawyerr V,Sonnie M,Veinoglou A,Koroma JB,Hodges MH,Zhang Y

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:Yersinia pestis, the agent of plague, is considered a potential bioweapon due to rapid lethality when delivered as an aerosol. Levofloxacin was tested for primary pneumonic plague treatment in a nonhuman primate model mimicking human disease. METHODS AND RESULTS:Twenty-four African Green monkeys (AGMs, Chlo...

journal_title：PLoS neglected tropical diseases

authors： Layton RC,Mega W,McDonald JD,Brasel TL,Barr EB,Gigliotti AP,Koster F

更新日期：2011-02-08 00:00:00

abstract：BACKGROUND:There is a worldwide upscale in mass drug administration (MDA) programs to control the morbidity caused by soil-transmitted helminths (STHs): Ascaris lumbricoides, Trichuris trichiura and hookworm. Although anthelminthic drugs which are used for MDA are supplied by two pharmaceutical companies through donati...

journal_title：PLoS neglected tropical diseases

authors： Belew S,Getachew M,Suleman S,Mohammed T,Deti H,D'Hondt M,Wynendaele E,Mekonnen Z,Vercruysse J,Duchateau L,De Spiegeleer B,Levecke B

更新日期：2015-09-25 00:00:00