In vitro studies of Rickettsia-host cell interactions: Confocal laser scanning microscopy of Rickettsia helvetica-infected eukaryotic cell lines.

abstract：BACKGROUND:Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identi...

journal_title：PLoS neglected tropical diseases

authors： Li XK,Yang ZD,Du J,Xing B,Cui N,Zhang PH,Li H,Zhang XA,Lu QB,Liu W

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:Treponema pallidum infection evokes vigorous immune responses, resulting in tissue damage. Several studies have demonstrated that IL-17 may be involved in the pathogenesis of syphilis. However, the role of Th17 response in neurosyphilis remains unclear. METHODOLOGY/PRINCIPAL FINDINGS:In this study, Th17 in ...

journal_title：PLoS neglected tropical diseases

authors： Wang C,Zhu L,Gao Z,Guan Z,Lu H,Shi M,Gao Y,Xu H,Yang XF,Zhou P

更新日期：2014-07-31 00:00:00

abstract：BACKGROUND:Rhinoentomophthoromycosis, or rhino-facial conidiobolomycosis, is a rare, grossly disfiguring disease due to an infection with entomophthoralean fungi. We report a case of rhinoentomophthoromycosis from Gabon and suggest a staging system, which provides information on the prognosis and duration of antifungal...

journal_title：PLoS neglected tropical diseases

authors： Blumentrath CG,Grobusch MP,Matsiégui PB,Pahlke F,Zoleko-Manego R,Nzenze-Aféne S,Mabicka B,Sanguinetti M,Kremsner PG,Schaumburg F

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Trichinellosis is a serious zoonositc parasitosis worldwide. Because its clinical manifestations aren't specific, the diagnosis of trichinellosis is not easy to be made. Trichinella spiralis muscle larva (ML) excretory-secretory (ES) antigens are the most widely applied diagnostic antigens for human trichine...

journal_title：PLoS neglected tropical diseases

authors： Sun GG,Song YY,Jiang P,Ren HN,Yan SW,Han Y,Liu RD,Zhang X,Wang ZQ,Cui J

更新日期：2018-05-14 00:00:00

abstract：BACKGROUND:Dengue is a mosquito-borne viral disease caused by the four dengue viruses (DENV-1 to 4) that can also be transmitted by blood transfusion and organ transplantation. The distribution of DENV in the components of blood from infected donors is poorly understood. METHODS:We used an in-house TaqMan qRT-PCR assa...

journal_title：PLoS neglected tropical diseases

authors： Añez G,Heisey DA,Chancey C,Fares RC,Espina LM,Souza KP,Teixeira-Carvalho A,Krysztof DE,Foster GA,Stramer SL,Rios M

更新日期：2016-02-12 00:00:00

abstract：:Soil-transmitted helminthiases (STHs) constitute a public health problem that requires immediate action to resolve the morbidity of those harboring the parasites in their guts, to prevent infection in all those at risk, and to interrupt the vicious circle of poverty and disease in the affected communities, structural ...

journal_title：PLoS neglected tropical diseases

authors： Krolewiecki AJ

更新日期：2018-09-13 00:00:00

abstract：BACKGROUND:African trypanosomosis, primarily transmitted by tsetse flies, remains a serious public health and economic challenge in sub-Saharan Africa. Interventions employing natural repellents from non-preferred hosts of tsetse flies represent a promising management approach. Although zebras have been identified as n...

journal_title：PLoS neglected tropical diseases

authors： Olaide OY,Tchouassi DP,Yusuf AA,Pirk CWW,Masiga DK,Saini RK,Torto B

更新日期：2019-06-10 00:00:00

abstract：:The toxicity of available drugs for treatment of leishmaniasis, coupled with emerging drug resistance, make it urgent to find new therapies. Antimicrobial peptides (AMPs) have a strong broad-spectrum antimicrobial activity with distinctive modes of action and are considered as promising therapeutic agents. The defensi...

journal_title：PLoS neglected tropical diseases

authors： Dabirian S,Taslimi Y,Zahedifard F,Gholami E,Doustdari F,Motamedirad M,Khatami S,Azadmanesh K,Nylen S,Rafati S

更新日期：2013-10-17 00:00:00

abstract：BACKGROUND:Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antive...

journal_title：PLoS neglected tropical diseases

authors： Silva A,Johnston C,Kuruppu S,Kneisz D,Maduwage K,Kleifeld O,Smith AI,Siribaddana S,Buckley NA,Hodgson WC,Isbister GK

更新日期：2016-12-02 00:00:00

abstract：:Revealing the dispersal of dengue viruses (DENV) in time and space is central to understanding their epidemiology. However, the processes that shape DENV transmission patterns at the scale of local populations are not well understood, particularly the impact of such factors as human population movement and urbanizatio...

journal_title：PLoS neglected tropical diseases

authors： Rabaa MA,Ty Hang VT,Wills B,Farrar J,Simmons CP,Holmes EC

更新日期：2010-07-27 00:00:00

abstract：:Morbidity burden of lymphatic filariasis (LF) relies on the information from the Mass Drug Administration (MDA) programme where Community Health Volunteers (CHVs) passively report cases identified. Consequently, the exact prevalence of morbidity cases is not always accurate. The use of mobile phone technology to repor...

journal_title：PLoS neglected tropical diseases

authors： Debrah LB,Mohammed A,Osei-Mensah J,Mubarik Y,Agbenyega O,Ayisi-Boateng NK,Pfarr K,Kuehlwein JM,Klarmann-Schulz U,Hoerauf A,Debrah AY

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Canine rabies causes many thousands of human deaths every year in Africa, and continues to increase throughout much of the continent. METHODOLOGY/PRINCIPAL FINDINGS:This paper identifies four common reasons given for the lack of effective canine rabies control in Africa: (a) a low priority given for disease...

journal_title：PLoS neglected tropical diseases

authors： Lembo T,Hampson K,Kaare MT,Ernest E,Knobel D,Kazwala RR,Haydon DT,Cleaveland S

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Control and prevention of Chagas disease rely mostly on residual spraying of insecticides. In Argentina, vector control shifted from a vertical to a fully horizontal strategy based on community participation between 1992 and 2004. The effects of such strategy on Triatoma infestans, the main domestic vector, ...

journal_title：PLoS neglected tropical diseases

authors： Vazquez-Prokopec GM,Spillmann C,Zaidenberg M,Kitron U,Gürtler RE

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Chagas disease is one of the most important neglected tropical diseases in the Americas. Vectorborne transmission of Chagas disease has been historically rare in urban settings. However, in marginal communities near the city of Arequipa, Peru, urban transmission cycles have become established. We examined th...

journal_title：PLoS neglected tropical diseases

authors： Bayer AM,Hunter GC,Gilman RH,Cornejo Del Carpio JG,Naquira C,Bern C,Levy MZ

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:The genus Trichuris includes parasites of major relevance in veterinary and human medicine. Despite serious economic losses and enormous impact on public health, treatment options against whipworms are very limited. Additionally, there is an obvious lack of appropriately characterized experimental infection ...

journal_title：PLoS neglected tropical diseases

authors： Kulke D,Krücken J,Harder A,von Samson-Himmelstjerna G

更新日期：2014-02-20 00:00:00

abstract：:Insecticide resistance poses a significant threat to the control of arthropods that transmit disease agents. Nanoparticle carriers offer exciting opportunities to expand the armamentarium of insecticides available for public health and other pests. Most chemical insecticides are delivered by contact or feeding, and fr...

journal_title：PLoS neglected tropical diseases

authors： Norris EJ,Mullis AS,Phanse Y,Narasimhan B,Coats JR,Bartholomay LC

更新日期：2020-09-08 00:00:00

abstract：BACKGROUND:Praziquantel-based mass treatment is the main approach to controlling schistosomiasis mansoni in endemic areas. Interventions such as provision and use of safe water, minimising contact with infested water, disposal of stool in latrines and snail control provide key avenues to break the transmission cycle an...

journal_title：PLoS neglected tropical diseases

authors： Sanya RE,Tumwesige E,Elliott AM,Seeley J

更新日期：2017-10-02 00:00:00

abstract：BACKGROUND:Dengue is a mosquito-borne viral disease caused by four closely related serotypes of Dengue viruses (DENVs). This disease whose symptoms range from mild fever to potentially fatal haemorrhagic fever and hypovolemic shock, threatens nearly half the global population. There is neither a preventive vaccine nor ...

journal_title：PLoS neglected tropical diseases

authors： Korrapati AB,Swaminathan G,Singh A,Khanna N,Swaminathan S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Animal tungiasis is believed to increase the prevalence and parasite burden in humans. Animal reservoirs of Tunga penetrans differ among endemic areas and their role in the epidemiology of tungiasis had never been investigated in Uganda. METHODS AND FINDINGS:To identify the major animal reservoirs of Tunga ...

journal_title：PLoS neglected tropical diseases

authors： Mutebi F,Krücken J,Feldmeier H,Waiswa C,Mencke N,Sentongo E,von Samson-Himmelstjerna G

更新日期：2015-10-16 00:00:00

abstract：:To obtain further insight into geographic distribution of Leishmania species in Peru, a countrywide survey, including central to southern rainforest areas where information on causative parasite species is limited, was performed based on cytochrome b (cyt b) and mannose phosphate isomerase (mpi) gene analyses. A total...

journal_title：PLoS neglected tropical diseases

authors： Kato H,Cáceres AG,Seki C,Silupu García CR,Holguín Mauricci C,Castro Martínez SC,Moreno Paico D,Castro Muniz JL,Troyes Rivera LD,Villegas Briones ZI,Guerrero Quincho S,Sulca Jayo GL,Tineo Villafuerte E,Manrique de Lara Estrada C

更新日期：2019-06-20 00:00:00

abstract：BACKGROUND:Despite the reported success in reducing morbidity, praziquantel alone is insufficient for the control and elimination of schistosomiasis, partly due to its poor efficacy against the juvenile worms. Artemisinin derivatives are effective against juvenile worms but are less effective against adult worms. We co...

journal_title：PLoS neglected tropical diseases

authors： Mnkugwe RH,Minzi O,Kinung'hi S,Kamuhabwa A,Aklillu E

更新日期：2020-09-23 00:00:00

abstract：BACKGROUND:Dengue infection is endemic in many regions throughout the world. While insecticide fogging targeting the vector mosquito Aedes aegypti is a major control measure against dengue epidemics, the impact of this method remains controversial. A previous mathematical simulation study indicated that insecticide fog...

journal_title：PLoS neglected tropical diseases

authors： Oki M,Sunahara T,Hashizume M,Yamamoto T

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:A high proportion of grade 2 disability (visible deformity) is indicative of delay in detection of leprosy and leprosy is one of the major causes of preventable disability. We conducted this study to determine the risk factors associated with disability (G2D and G1D) among adult new leprosy cases and to me...

journal_title：PLoS neglected tropical diseases

authors： Srinivas G,Muthuvel T,Lal V,Vaikundanathan K,Schwienhorst-Stich EM,Kasang C

更新日期：2019-06-27 00:00:00

abstract：BACKGROUND:Leptospirosis, a spirochaetal zoonotic disease, is the cause of epidemics associated with high mortality in urban slum communities. Infection with pathogenic Leptospira occurs during environmental exposures and is traditionally associated with occupational risk activities. However, slum inhabitants reside in...

journal_title：PLoS neglected tropical diseases

authors： Maciel EA,de Carvalho AL,Nascimento SF,de Matos RB,Gouveia EL,Reis MG,Ko AI

更新日期：2008-01-30 00:00:00

abstract：OBJECTIVE:In some Pacific Island countries, such as Solomon Islands and Fiji, active trachoma is common, but ocular Chlamydia trachomatis (Ct) infection and trachomatous trichiasis (TT) are rare. On Tarawa, the most populous Kiribati island, both the active trachoma sign "trachomatous inflammation-follicular" (TF) and ...

journal_title：PLoS neglected tropical diseases

authors： Cama A,Müller A,Taoaba R,Butcher RMR,Itibita I,Migchelsen SJ,Kiauea T,Pickering H,Willis R,Roberts CH,Bakhtiari A,Le Mesurier RT,Alexander NDE,Martin DL,Tekeraoi R,Solomon AW,Global Trachoma Mapping Project.

更新日期：2017-09-12 00:00:00

abstract：INTRODUCTION:Chikungunya is an emerging public health problem in tropical and subtropical regions, due to ongoing transmission and its incapacitating acute disease phase, and chronic sequelae. The disease is responsible for a major impact on Health Related Quality of Life (HRQoL), which may last several years. To our k...

journal_title：PLoS neglected tropical diseases

authors： Elsinga J,Grobusch MP,Tami A,Gerstenbluth I,Bailey A

更新日期：2017-10-09 00:00:00

abstract：BACKGROUND:Intestinal parasitic infections remain among the most common infectious diseases worldwide. This study aimed to estimate their prevalence and provide a detailed analysis of geographical distribution of intestinal parasites in the metropolitan region of Rio de Janeiro, considering demographic, socio-economic,...

journal_title：PLoS neglected tropical diseases

authors： Faria CP,Zanini GM,Dias GS,da Silva S,de Freitas MB,Almendra R,Santana P,Sousa MD

更新日期：2017-03-08 00:00:00

abstract：BACKGROUND:The physiopathology of dengue hemorrhagic fever (DHF), a severe form of Dengue Fever, is poorly understood. We are unable to identify patients likely to progress to DHF for closer monitoring and early intervention during epidemics, so most cases are sent home. This study explored whether patients with select...

journal_title：PLoS neglected tropical diseases

authors： Figueiredo MA,Rodrigues LC,Barreto ML,Lima JW,Costa MC,Morato V,Blanton R,Vasconcelos PF,Nunes MR,Teixeira MG

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Scrub typhus is a neglected tropical disease that causes acute febrile illness. Diagnosis is made based upon serology, or detection of the causative agent-Orientia tsutsugamushi-using PCR or in vitro isolation. The enzyme-linked immunosorbent assay (ELISA) is an objective and reproducible means of detecting ...

journal_title：PLoS neglected tropical diseases

authors： Saraswati K,Phanichkrivalkosil M,Day NPJ,Blacksell SD

更新日期：2019-02-04 00:00:00

abstract：BACKGROUND:Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic shock is the most serious ...

journal_title：PLoS neglected tropical diseases

authors： Lam PK,Ngoc TV,Thu Thuy TT,Hong Van NT,Nhu Thuy TT,Hoai Tam DT,Dung NM,Hanh Tien NT,Thanh Kieu NT,Simmons C,Wills B,Wolbers M

更新日期：2017-04-27 00:00:00