North American Culex pipiens and Culex quinquefasciatus are competent vectors for Usutu virus.

abstract：:Leprosy is an infectious disease caused by Mycobacterium leprae and frequently resulting in irreversible deformities and disabilities. Ticks play an important role in infectious disease transmission due to their low host specificity, worldwide distribution, and the biological ability to support transovarial transmissi...

journal_title：PLoS neglected tropical diseases

authors： Ferreira JDS,Souza Oliveira DA,Santos JP,Ribeiro CCDU,Baêta BA,Teixeira RC,Neumann ADS,Rosa PS,Pessolani MCV,Moraes MO,Bechara GH,de Oliveira PL,Sorgine MHF,Suffys PN,Fontes ANB,Bell-Sakyi L,Fonseca AH,Lara FA

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:Diagnosis of Trypanosoma cruzi infection by direct pathogen detection is complicated by the low parasite burden in subjects persistently infected with this agent of human Chagas disease. Determination of infection status by serological analysis has also been faulty, largely due to the lack of well-characteri...

journal_title：PLoS neglected tropical diseases

authors： Cooley G,Etheridge RD,Boehlke C,Bundy B,Weatherly DB,Minning T,Haney M,Postan M,Laucella S,Tarleton RL

更新日期：2008-10-08 00:00:00

abstract：BACKGROUND:Dengue is the most important mosquito-borne viral disease affecting humans. The only prevention measure currently available is the control of its vectors, primarily Aedes aegypti. Recent advances in genetic engineering have opened the possibility for a new range of control strategies based on genetically mod...

journal_title：PLoS neglected tropical diseases

authors： Magori K,Legros M,Puente ME,Focks DA,Scott TW,Lloyd AL,Gould F

更新日期：2009-09-01 00:00:00

abstract：:Schistosomiasis is an important neglected tropical disease caused by digenean helminth parasites of the genus Schistosoma. Schistosomes are unusual in that they are dioecious and the adult worms live in the blood system. MicroRNAs play crucial roles during gene regulation and are likely to be important in sex differen...

journal_title：PLoS neglected tropical diseases

authors： Marco A,Kozomara A,Hui JH,Emery AM,Rollinson D,Griffiths-Jones S,Ronshaugen M

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:Schistosomiasis has been reported in 78 endemic countries and affects 240 million people worldwide. The digenetic parasite Schistosoma mansoni needs fresh water to compete its life cycle. There, it is susceptible to soluble compounds that can affect directly and/or indirectly the parasite's biology. The cerc...

journal_title：PLoS neglected tropical diseases

authors： Augusto RC,Tetreau G,Chan P,Walet-Balieu ML,Mello-Silva CC,Santos CP,Grunau C

更新日期：2017-07-28 00:00:00

abstract：BACKGROUND:Reduced susceptibility of mosquito vectors to currently used insecticides hampers control interventions. Recently pyriproxyfen, an insect growth regulator has been demonstrated to effectively reduce the reproductive potential in vector mosquitoes. METHODS:Pyriproxyfen (PPF), in different concentrations (0.7...

journal_title：PLoS neglected tropical diseases

authors： Yadav K,Dhiman S,Acharya BN,Ghorpade RR,Sukumaran D

更新日期：2019-11-18 00:00:00

abstract：:A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and twelve variations respectively at the P1, P2 and P3 positions. A Ki ...

journal_title：PLoS neglected tropical diseases

authors： Avelar LA,Camilo CD,de Albuquerque S,Fernandes WB,Gonçalez C,Kenny PW,Leitão A,McKerrow JH,Montanari CA,Orozco EV,Ribeiro JF,Rocha JR,Rosini F,Saidel ME

更新日期：2015-07-14 00:00:00

abstract：:Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) that recently caused outbreaks in the Americas. Over the past 60 years, this virus has been observed circulating among African, Asian, and Pacific Island populations, but little attention has been paid by the scientific community until the discovery that large-...

journal_title：PLoS neglected tropical diseases

authors： Epelboin Y,Talaga S,Epelboin L,Dusfour I

更新日期：2017-11-16 00:00:00

abstract：:Ebolaviruses pose a substantial threat to wildlife populations and to public health in Africa. Evolutionary analyses of virus genome sequences can contribute significantly to elucidate the origin of new outbreaks, which can help guide surveillance efforts. The reconstructed between-outbreak evolutionary history of Zai...

journal_title：PLoS neglected tropical diseases

authors： Vrancken B,Wawina-Bokalanga T,Vanmechelen B,Martí-Carreras J,Carroll MW,Nsio J,Kapetshi J,Makiala-Mandanda S,Muyembe-Tamfum JJ,Baele G,Vermeire K,Vergote V,Ahuka-Mundeke S,Maes P

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Worldwide, an estimated 30 to 100 million people are infected with Strongyloides stercoralis, a soil-transmitted helminth. Information on the parasite is scarce in most settings. In semi-rural Cambodia, we determined infection rates and risk factors; compared two diagnostic methods (Koga agar plate [KAP] cul...

journal_title：PLoS neglected tropical diseases

authors： Khieu V,Schär F,Marti H,Sayasone S,Duong S,Muth S,Odermatt P

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Area-wide integrated pest management strategies that include a sterile insect technique component have been successfully used to eradicate tsetse fly populations in the past. To ensure the success of the sterile insect technique, the released males must be adequately sterile and be able to compete with their...

journal_title：PLoS neglected tropical diseases

authors： de Beer CJ,Moyaba P,Boikanyo SN,Majatladi D,Yamada H,Venter GJ,Vreysen MJ

更新日期：2017-03-17 00:00:00

abstract：:Schistosomes are intravascular helminths that infect over 200 million people worldwide. Deposition of eggs by adult schistosomes stimulates Th2 responses to egg antigens and induces granulomatous pathology that is a hallmark of schistosome infection. Paradoxically, schistosomes require host immune function for their d...

journal_title：PLoS neglected tropical diseases

authors： Ferragine CE,Walls CD,Davies SJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Morbidity due to Schistosoma haematobium and hookworm infections is marked in those with intense co-infections by these parasites. The development of a spatial predictive decision-support tool is crucial for targeting the delivery of integrated mass drug administration (MDA) to those most in need. We investi...

journal_title：PLoS neglected tropical diseases

authors： Soares Magalhães RJ,Biritwum NK,Gyapong JO,Brooker S,Zhang Y,Blair L,Fenwick A,Clements AC

更新日期：2011-06-01 00:00:00

abstract：:Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance. The pathogenesis of several of the most prevalent infections, including cholera and enteroxigenic Escherichia coli, is dom...

journal_title：PLoS neglected tropical diseases

authors： Das S,Angsantikul P,Le C,Bao D,Miyamoto Y,Gao W,Zhang L,Eckmann L

更新日期：2018-02-22 00:00:00

abstract：:Cystic echinococcosis (CE) is distributed worldwide, extending from China to the Middle East and from Mediterranean countries to the sub-Saharan Africa and South America. According to WHO, one million people around the world are suffering from CE with an estimated burden of 183,573 DALYs. The annual monetary burden of...

journal_title：PLoS neglected tropical diseases

authors： Borhani M,Fathi S,Lahmar S,Ahmed H,Abdulhameed MF,Fasihi Harandi M

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Schistosomiasis remains a significant health burden in many areas of the world. Morbidity control, focused on limiting infection intensity through periodic delivery of anti-schistosomal medicines, is the thrust of current World Health Organization guidelines (2006) for reduction of Schistosoma-related diseas...

journal_title：PLoS neglected tropical diseases

authors： Wang X,Gurarie D,Mungai PL,Muchiri EM,Kitron U,King CH

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Contacts of leprosy patients are at increased risk of developing leprosy and need to be targeted for early diagnosis. Seropositivity to the phenolic glycolipid I (PGL-I) antigen of Mycobacterium leprae has been used to identify contacts who have an increased risk of developing leprosy. In the present study, ...

journal_title：PLoS neglected tropical diseases

authors： Düppre NC,Camacho LA,Sales AM,Illarramendi X,Nery JA,Sampaio EP,Sarno EN,Bührer-Sékula S

更新日期：2012-01-01 00:00:00

abstract：:To control and prevent rabies in Latin America, mass dog vaccination campaigns (MDVC) are implemented mainly through fixed-location vaccination points: owners have to bring their dogs to the vaccination points where they receive the vaccination free of charge. Dog rabies is still endemic in some Latin-American countri...

journal_title：PLoS neglected tropical diseases

authors： Castillo-Neyra R,Toledo AM,Arevalo-Nieto C,MacDonald H,De la Puente-León M,Naquira-Velarde C,Paz-Soldan VA,Buttenheim AM,Levy MZ

更新日期：2019-08-01 00:00:00

abstract：UNLABELLED:/ BACKGROUND:Dengue is the most important arthropod borne viral disease worldwide in terms of morbidity and mortality and is caused by any of the four serotypes of dengue virus (DENV-1 to 4). Brazil is responsible for approximately 80% of dengue cases in the Americas, and since the introduction of dengue in...

journal_title：PLoS neglected tropical diseases

authors： Lima Mda R,Nogueira RM,Schatzmayr HG,de Filippis AM,Limonta D,dos Santos FB

更新日期：2011-05-03 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is a deadly vector-borne disease. Approximately 90% of Indian VL cases occur in Bihar, where the sand fly, Phlebotomus argentipes, is the principal vector. Sand fly control in Bihar consists of indoor residual spraying (IRS), the practice of spraying the inner walls of village dwe...

journal_title：PLoS neglected tropical diseases

authors： Poché DM,Garlapati RB,Mukherjee S,Torres-Poché Z,Hasker E,Rahman T,Bharti A,Tripathi VP,Prakash S,Chaubey R,Poché RM

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:Envenoming by viper snakes constitutes an important public health problem in Brazil and other developing countries. Local hemorrhage is an important symptom of these accidents and is correlated with the action of snake venom metalloproteinases (SVMPs). The degradation of vascular basement membrane has been p...

journal_title：PLoS neglected tropical diseases

authors： Baldo C,Jamora C,Yamanouye N,Zorn TM,Moura-da-Silva AM

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Health promotion is essential to the SAFE strategy for trachoma elimination. Schools are a valuable venue for health promotion. However, there is little literature about the impact of health education and water infrastructure in schools on facial cleanliness and trachoma in the community. Our study aimed to ...

journal_title：PLoS neglected tropical diseases

authors： Chen X,Munoz B,Mkocha H,Wolle MA,K West S

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Increased vascular permeability is a hallmark feature in severe dengue virus (DV) infection, and dysfunction of endothelial cells has been speculated to contribute in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Rho-family GTPase Rac1 is a significant element of endothelial b...

journal_title：PLoS neglected tropical diseases

authors： Wang JL,Zhang JL,Chen W,Xu XF,Gao N,Fan DY,An J

更新日期：2010-08-31 00:00:00

abstract：:Successful and sustainable intervention against human helminthiases depends on optimal utilisation of available control measures and development of new tools and strategies, as well as an understanding of the evolutionary implications of prolonged intervention on parasite populations and those of their hosts and vecto...

journal_title：PLoS neglected tropical diseases

authors： Lustigman S,Geldhof P,Grant WN,Osei-Atweneboana MY,Sripa B,Basáñez MG

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Human African trypanosomiasis is a severely neglected vector-borne disease that is always fatal if untreated. In Tanzania it is highly focalised and of major socio-economic and public health importance in affected communities. OBJECTIVES:This study aimed to estimate the public health burden of rhodesiense H...

journal_title：PLoS neglected tropical diseases

authors： Matemba LE,Fèvre EM,Kibona SN,Picozzi K,Cleaveland S,Shaw AP,Welburn SC

更新日期：2010-11-02 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi, the etiologic agent of Chagas Disease, is a major vector borne health problem in Latin America and an emerging infectious disease in the United States. METHODS:We tested the efficacy of a multi-component DNA-prime/DNA-boost vaccine (TcVac1) against experimental T. cruzi infection in a can...

journal_title：PLoS neglected tropical diseases

authors： Aparicio-Burgos JE,Ochoa-García L,Zepeda-Escobar JA,Gupta S,Dhiman M,Martínez JS,de Oca-Jiménez RM,Val Arreola M,Barbabosa-Pliego A,Vázquez-Chagoyán JC,Garg NJ

更新日期：2011-01-01 00:00:00

abstract：:Disseminated disease from non-typhoidal Salmonella enterica strains results in >20% mortality globally. Barriers to effective treatment include emerging multidrug resistance, antibiotic treatment failure, and risk factors such as malnutrition and related micronutrient deficiencies. Individuals in sub-Saharan Africa ar...

journal_title：PLoS neglected tropical diseases

authors： Stull-Lane AR,Lokken-Toyli KL,Diaz-Ochoa VE,Walker GT,Cevallos SA,Winter ALN,Muñoz ADH,Yang GG,Velazquez EM,Wu CY,Tsolis RM

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Protozoan parasites of the genus Leishmania cause a large spectrum of clinical manifestations known as Leishmaniases. These diseases are increasingly important public health problems in many countries both within and outside endemic regions. Thus, an accurate differential diagnosis is extremely relevant for ...

journal_title：PLoS neglected tropical diseases

authors： Zampieri RA,Laranjeira-Silva MF,Muxel SM,Stocco de Lima AC,Shaw JJ,Floeter-Winter LM

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Dengue virus (DENV) is the most important arbovirus worldwide, causing infections in endemic countries and returning travellers from these areas. Rapid diagnostic tests are needed to improve patient management and monitor local transmission. The detection of DENV non-structural protein 1 (NS1) is a useful to...

journal_title：PLoS neglected tropical diseases

authors： Alejo-Cancho I,Navero-Castillejos J,Peiró-Mestres A,Albarracín R,Barrachina J,Navarro A,Gonzalo V,Pastor V,Muñoz J,Martínez MJ

更新日期：2020-02-18 00:00:00

abstract：:Bat rabies is an emerging disease of public health significance in the Americas. The Caribbean island of Trinidad experiences periodic outbreaks within the livestock population. We performed molecular characterisation of Trinidad rabies virus (RABV) and used a Bayesian phylogeographic approach to investigate the exten...

journal_title：PLoS neglected tropical diseases

authors： Seetahal JF,Velasco-Villa A,Allicock OM,Adesiyun AA,Bissessar J,Amour K,Phillip-Hosein A,Marston DA,McElhinney LM,Shi M,Wharwood CA,Fooks AR,Carrington CV

更新日期：2013-08-22 00:00:00