Evaluation of a novel microfluidic immuno-magnetic agglutination assay method for detection of dengue virus NS1 antigen.

abstract：BACKGROUND:The genus Trichuris includes parasites of major relevance in veterinary and human medicine. Despite serious economic losses and enormous impact on public health, treatment options against whipworms are very limited. Additionally, there is an obvious lack of appropriately characterized experimental infection ...

journal_title：PLoS neglected tropical diseases

authors： Kulke D,Krücken J,Harder A,von Samson-Himmelstjerna G

更新日期：2014-02-20 00:00:00

abstract：BACKGROUND:Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. METHODOLOGY:Cross-sectional interview data and stool s...

journal_title：PLoS neglected tropical diseases

authors： Riess H,Clowes P,Kroidl I,Kowuor DO,Nsojo A,Mangu C,Schüle SA,Mansmann U,Geldmacher C,Mhina S,Maboko L,Hoelscher M,Saathoff E

更新日期：2013-09-05 00:00:00

abstract：BACKGROUND:The simian parasite Plasmodium knowlesi is a common cause of human malaria in Malaysian Borneo and threatens the prospect of malaria elimination. However, little is known about the emergence of P. knowlesi, particularly in Sabah. We reviewed Sabah Department of Health records to investigate the trend of each...

journal_title：PLoS neglected tropical diseases

authors： William T,Rahman HA,Jelip J,Ibrahim MY,Menon J,Grigg MJ,Yeo TW,Anstey NM,Barber BE

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is a life-threatening disease caused by protozoan parasites of the Leishmania donovani complex. Early case detection followed by adequate treatment is essential to the control of VL. However, the available diagnostic tests are either invasive and require considerable expertise (pa...

journal_title：PLoS neglected tropical diseases

authors： Gao CH,Yang YT,Shi F,Wang JY,Steverding D,Wang X

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:Praziquantel-based mass treatment is the main approach to controlling schistosomiasis mansoni in endemic areas. Interventions such as provision and use of safe water, minimising contact with infested water, disposal of stool in latrines and snail control provide key avenues to break the transmission cycle an...

journal_title：PLoS neglected tropical diseases

authors： Sanya RE,Tumwesige E,Elliott AM,Seeley J

更新日期：2017-10-02 00:00:00

abstract：BACKGROUND:The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for the development of an O. volvulus vaccine. The B. malayi gerbil model was used to confirm the efficacy of these Ov vaccine candidates on adult worms an...

journal_title：PLoS neglected tropical diseases

authors： Arumugam S,Wei J,Liu Z,Abraham D,Bell A,Bottazzi ME,Hotez PJ,Zhan B,Lustigman S,Klei TR

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:The IAEA colony is the only one available for mass rearing of Glossina pallidipes, a vector of human and animal African trypanosomiasis in eastern Africa. This colony is the source for Sterile Insect Technique (SIT) programs in East Africa. The source population of this colony is unclear and its genetic dive...

journal_title：PLoS neglected tropical diseases

authors： Ciosi M,Masiga DK,Turner CM

更新日期：2014-02-13 00:00:00

abstract：:Two recombinant Fasciola hepatica antigens, saposin-like protein-2 (recSAP2) and cathepsin L-1 (recCL1), were assessed individually and in combination in enzyme-linked immunosorbent assays (ELISA) for the specific serodiagnosis of human fasciolosis in areas of low endemicity as encountered in Central Europe. Antibody ...

journal_title：PLoS neglected tropical diseases

authors： Gottstein B,Schneeberger M,Boubaker G,Merkle B,Huber C,Spiliotis M,Müller N,Garate T,Doherr MG

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:Dengue infection is endemic in many regions throughout the world. While insecticide fogging targeting the vector mosquito Aedes aegypti is a major control measure against dengue epidemics, the impact of this method remains controversial. A previous mathematical simulation study indicated that insecticide fog...

journal_title：PLoS neglected tropical diseases

authors： Oki M,Sunahara T,Hashizume M,Yamamoto T

更新日期：2011-10-01 00:00:00

abstract：:Plasmodium vivax, one of the five species of Plasmodium parasites that cause human malaria, is responsible for 25-40% of malaria cases worldwide. Malaria global elimination efforts will benefit from accurate and effective genotyping tools that will provide insight into the population genetics and diversity of this par...

journal_title：PLoS neglected tropical diseases

authors： Baniecki ML,Faust AL,Schaffner SF,Park DJ,Galinsky K,Daniels RF,Hamilton E,Ferreira MU,Karunaweera ND,Serre D,Zimmerman PA,Sá JM,Wellems TE,Musset L,Legrand E,Melnikov A,Neafsey DE,Volkman SK,Wirth DF,Sabeti PC

更新日期：2015-03-17 00:00:00

abstract：:In mammals subverted as hosts by protozoan parasites, the latter and/or the agonists they release are detected and processed by sensors displayed by many distinct immune cell lineages, in a tissue(s)-dependent context. Focusing on the T lymphocyte lineage, we review our present understanding on its transient or durabl...

journal_title：PLoS neglected tropical diseases

authors： Rodrigues V,Cordeiro-da-Silva A,Laforge M,Ouaissi A,Akharid K,Silvestre R,Estaquier J

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:Sporadic Japanese encephalitis (JE) cases still have been reported in Zhejiang Province in recent years, and concerns about vaccine cross-protection and population-level immunity have been raised off and on within the public health sphere. Genotype I (GI) has replaced GIII as the dominant genotype in Asian c...

journal_title：PLoS neglected tropical diseases

authors： Pan JR,Yan JY,Zhou JY,Tang XW,He HQ,Xie RH,Mao HY,Zhang YJ,Xie SY

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:American visceral leishmaniasis (AVL) is an emerging disease in the state of São Paulo, Brazil. Its geographical expansion and the increase in the number of human cases has been linked to dispersion of Lutzomyia longipalpis into urban areas. To produce more accurate risk maps we investigated the geographic d...

journal_title：PLoS neglected tropical diseases

authors： Casanova C,Colla-Jacques FE,Hamilton JG,Brazil RP,Shaw JJ

更新日期：2015-03-17 00:00:00

abstract：:The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determined the minimum nu...

journal_title：PLoS neglected tropical diseases

authors： Coutinho ML,Choy HA,Kelley MM,Matsunaga J,Babbitt JT,Lewis MS,Aleixo JA,Haake DA

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is a paucity of data on ILC2s in the context of human parasitic infections and in particula...

journal_title：PLoS neglected tropical diseases

authors： Nausch N,Appleby LJ,Sparks AM,Midzi N,Mduluza T,Mutapi F

更新日期：2015-03-23 00:00:00

abstract：BACKGROUND:Third-stage larvae (L3) of the canine hookworm, Ancylostoma caninum, undergo arrested development preceding transmission to a host. Many of the mRNAs up-regulated at this stage are likely to encode proteins that facilitate the transition from a free-living to a parasitic larva. The initial phase of mammalian...

journal_title：PLoS neglected tropical diseases

authors： Datu BJ,Gasser RB,Nagaraj SH,Ong EK,O'Donoghue P,McInnes R,Ranganathan S,Loukas A

更新日期：2008-01-09 00:00:00

abstract：BACKGROUND:Close to 800 million people in the world are at risk of schistosomiasis, 85 per cent of whom live in Africa. Recent studies have indicated that female genital schistosomiasis might increase the risk of human immunodeficiency virus (HIV) infection. The aim of this study is to quantify and analyse the characte...

journal_title：PLoS neglected tropical diseases

authors： Jourdan PM,Roald B,Poggensee G,Gundersen SG,Kjetland EF

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:In the roadmap on the neglected tropical diseases (NTD) the World Health Organization (WHO) aims at attaining at least 75% coverage of preventive chemotherapy in pre-school and school-age children by 2020. A randomized controlled trial was used to compare the effectiveness of praziquantel in treating Schisto...

journal_title：PLoS neglected tropical diseases

authors： Wang XY,He J,Juma S,Kabole F,Guo JG,Dai JR,Li W,Yang K

更新日期：2019-04-10 00:00:00

abstract：:Buruli ulcer (BU), caused by Mycobacterium ulcerans, is currently treated with a daily combination of rifampin and either injectable streptomycin or oral clarithromycin. An intermittent oral regimen would facilitate treatment supervision. We first evaluated the bactericidal activity of newer antimicrobials against M. ...

journal_title：PLoS neglected tropical diseases

authors： Chauffour A,Robert J,Veziris N,Aubry A,Pethe K,Jarlier V

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Travelers who acquire dengue infection are often routes for virus transmission to other regions. Nevertheless, the interplay between infected travelers, climate, vectors, and indigenous dengue incidence remains unclear. The role of foreign-origin cases on local dengue epidemics thus has been largely neglecte...

journal_title：PLoS neglected tropical diseases

authors： Shang CS,Fang CT,Liu CM,Wen TH,Tsai KH,King CC

更新日期：2010-08-03 00:00:00

abstract：BACKGROUND:The long-term treatment outcome of visceral leishmaniasis (VL) patients with HIV co-infection is complicated by a high rate of relapse, especially when the CD4 count is low. Although use of secondary prophylaxis is recommended, it is not routinely practiced and data on its effectiveness and safety are limite...

journal_title：PLoS neglected tropical diseases

authors： Diro E,Edwards T,Ritmeijer K,Fikre H,Abongomera C,Kibret A,Bardonneau C,Soipei P,Mutinda B,Omollo R,van Griensven J,Zijlstra EE,Wasunna M,Alves F,Alvar J,Hailu A,Alexander N,Blesson S

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4, promoting lethal, en...

journal_title：PLoS neglected tropical diseases

authors： De Jong HK,Achouiti A,Koh GC,Parry CM,Baker S,Faiz MA,van Dissel JT,Vollaard AM,van Leeuwen EM,Roelofs JJ,de Vos AF,Roth J,van der Poll T,Vogl T,Wiersinga WJ

更新日期：2015-04-10 00:00:00

abstract：:Human head lice are blood-sucking insects causing an infestation in humans called pediculosis capitis. The infestation is more prevalent in the school-aged population. Scalp itching, a common presenting symptom, results in scratching and sleep disturbance. The condition can lead to social stigmatization which can lead...

journal_title：PLoS neglected tropical diseases

authors： Brownell N,Sunantaraporn S,Phadungsaksawasdi K,Seatamanoch N,Kongdachalert S,Phumee A,Siriyasatien P

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND:Epidemics of meningococcal meningitis (MM) recurrently strike the African Meningitis Belt. This study aimed at investigating factors, still poorly understood, that influence annual incidence of MM serogroup A, the main etiologic agent over 2004-2010, at a fine spatial scale in Niger. METHODOLOGY/PRINCIPAL F...

journal_title：PLoS neglected tropical diseases

authors： Paireau J,Maïnassara HB,Jusot JF,Collard JM,Idi I,Moulia-Pelat JP,Mueller JE,Fontanet A

更新日期：2014-05-22 00:00:00

abstract：:Diagnosis of a first-time visceral leishmaniasis (VL) infection in Ethiopia is established by use of a rapid diagnostic test (RDT) detecting antibodies against rK39, direct agglutination test (DAT) and microscopy according to the national algorithm. The performance of individual tests and algorithm is variable and dep...

journal_title：PLoS neglected tropical diseases

authors： Kassa M,Abdellati S,Cnops L,Bremer Hinckel BC,Yeshanew A,Hailemichael W,Vogt F,Adriaensen W,Mertens P,Diro E,van Griensven J,Van den Bossche D

更新日期：2020-12-31 00:00:00

abstract：INTRODUCTION:Plasmodium knowlesi is now recognised as a leading cause of malaria in Malaysia. As humans come into increasing contact with the reservoir host (long-tailed macaques) as a consequence of deforestation, assessing the potential for a shift from zoonotic to sustained P. knowlesi transmission between humans is...

journal_title：PLoS neglected tropical diseases

authors： Imai N,White MT,Ghani AC,Drakeley CJ

更新日期：2014-07-24 00:00:00

abstract：:Plague, a zoonosis caused by Yersinia pestis, is still found in Africa, Asia, and the Americas. Madagascar reports almost one third of the cases worldwide. Y. pestis can be encountered in three very different types of foci: urban, rural, and sylvatic. Flea vector and wild rodent host population dynamics are tightly co...

journal_title：PLoS neglected tropical diseases

authors： Andrianaivoarimanana V,Kreppel K,Elissa N,Duplantier JM,Carniel E,Rajerison M,Jambou R

更新日期：2013-11-07 00:00:00

abstract：:Dengue, a vector-borne disease spread by Aedes mosquitoes, is a global threat. In the absence of an efficacious dengue vaccine, vector control is the key intervention tool in Singapore. A good understanding of vector habitats is essential to formulate operational strategies. We examined the distribution, long-term tre...

journal_title：PLoS neglected tropical diseases

authors： Rajarethinam J,Ong J,Neo ZW,Ng LC,Aik J

更新日期：2020-04-20 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is a mosquito-borne flavivirus distributed throughout much of Africa and Asia. Infection with the virus may cause acute febrile illness that clinically resembles dengue fever. A recent study indicated the existence of three geographically distinct viral lineages; however this analysis utili...

journal_title：PLoS neglected tropical diseases

authors： Haddow AD,Schuh AJ,Yasuda CY,Kasper MR,Heang V,Huy R,Guzman H,Tesh RB,Weaver SC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Primary infection of Toxoplasma gondii during pregnancy can be transmitted to the unborn child and may have serious consequences, including retinochoroiditis, hydrocephaly, cerebral calcifications, encephalitis, splenomegaly, hearing loss, blindness, and death. Austria, a country with moderate seroprevalence...

journal_title：PLoS neglected tropical diseases

authors： Prusa AR,Kasper DC,Sawers L,Walter E,Hayde M,Stillwaggon E

更新日期：2017-07-10 00:00:00