Abstract:
:Schistosomiasis is an important neglected tropical disease caused by digenean helminth parasites of the genus Schistosoma. Schistosomes are unusual in that they are dioecious and the adult worms live in the blood system. MicroRNAs play crucial roles during gene regulation and are likely to be important in sex differentiation in dioecious species. Here we characterize 112 microRNAs from adult Schistosoma mansoni individuals, including 84 novel microRNA families, and investigate the expression pattern in different sexes. By deep sequencing, we measured the relative expression levels of conserved and newly identified microRNAs between male and female samples. We observed that 13 microRNAs exhibited sex-biased expression, 10 of which are more abundant in females than in males. Sex chromosomes showed a paucity of female-biased genes, as predicted by theoretical evolutionary models. We propose that the recent emergence of separate sexes in Schistosoma had an effect on the chromosomal distribution and evolution of microRNAs, and that microRNAs are likely to participate in the sex differentiation/maintenance process.
journal_name
PLoS Negl Trop Disjournal_title
PLoS neglected tropical diseasesauthors
Marco A,Kozomara A,Hui JH,Emery AM,Rollinson D,Griffiths-Jones S,Ronshaugen Mdoi
10.1371/journal.pntd.0002402subject
Has Abstractpub_date
2013-09-12 00:00:00pages
e2402issue
9eissn
1935-2727issn
1935-2735pii
PNTD-D-12-01334journal_volume
7pub_type
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