当前位置： SCI文献检索 > PLoS Neglected Tropical Diseases期刊下所有文献 > Transmission assessment surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation.

Transmission assessment surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation.

Abstract：

BACKGROUND:Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low enough that it cannot be sustained even in the absence of drug intervention. Guidelines advanced by WHO call for a transmission assessment survey (TAS) to determine if MDA can be stopped within an LF evaluation unit (EU) after at least five effective rounds of annual treatment. To test the value and practicality of these guidelines, a multicenter operational research trial was undertaken in 11 countries covering various geographic and epidemiological settings. METHODOLOGY:The TAS was conducted twice in each EU with TAS-1 and TAS-2 approximately 24 months apart. Lot quality assurance sampling (LQAS) formed the basis of the TAS survey design but specific EU characteristics defined the survey site (school or community), eligible population (6-7 year olds or 1(st)-2(nd) graders), survey type (systematic or cluster-sampling), target sample size, and critical cutoff (a statistically powered threshold below which transmission is expected to be no longer sustainable). The primary diagnostic tools were the immunochromatographic (ICT) test for W. bancrofti EUs and the BmR1 test (Brugia Rapid or PanLF) for Brugia spp. EUs. PRINCIPAL FINDINGS/CONCLUSIONS:In 10 of 11 EUs, the number of TAS-1 positive cases was below the critical cutoff, indicating that MDA could be stopped. The same results were found in the follow-up TAS-2, therefore, confirming the previous decision outcome. Sample sizes were highly sex and age-representative and closely matched the target value after factoring in estimates of non-participation. The TAS was determined to be a practical and effective evaluation tool for stopping MDA although its validity for longer-term post-MDA surveillance requires further investigation.

journal_name

PLoS Negl Trop Dis

journal_title

PLoS neglected tropical diseases

authors

Chu BK,Deming M,Biritwum NK,Bougma WR,Dorkenoo AM,El-Setouhy M,Fischer PU,Gass K,Gonzalez de Peña M,Mercado-Hernandez L,Kyelem D,Lammie PJ,Flueckiger RM,Mwingira UJ,Noordin R,Offei Owusu I,Ottesen EA,Pavluck A,Pilotte

doi

10.1371/journal.pntd.0002584

subject

Has Abstract

pub_date

2013-12-05 00:00:00

pages

e2584

issue

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-13-01064

journal_volume

pub_type

杂志文章,多中心研究

在线工具

Transmission assessment surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation.