Comparison between itraconazole and cotrimoxazole in the treatment of paracoccidiodomycosis.

Abstract:

BACKGROUND:There are no published reports on studies comparing itraconazole (ITC), sulfamethoxazole-trimethoprim (cotrimoxazole, CMX), and ITC followed by CMX (ITC/CMX) in the treatment of paracoccidiodomycosis. This study aimed to compare the efficacy, effectiveness, safety and time to clinical and serologic cure in paracoccidioidomycosis patients treated with ITC or CMX, the antifungal agents most widely used. METHODOLOGY:A quasi-experimental study was performed in 177 patients with a confirmed or probable diagnosis of paracoccidioidomycosis. Treatment was divided into two stages: 1) initial, which was continued until clinical cure was achieved and the erythrocyte sedimentation rate decreased to normal values; 2) complementary, which was continued until serologic cure was achieved. Medians were compared via the Mann-Whitney test, and frequencies were compared via the chi-squared test. The assessment of variables as a function of time was performed using Kaplan-Meier curves and Cox regression. The significance level was established as p≤0.05. PRINCIPAL FINDINGS:No difference was found in the efficacy and effectiveness of the initial treatment of 47 individuals given ITC and 130 individuals given CMX; however, the time to clinical cure was shorter in the former compared with the latter group (105 vs. 159 days; p = 0.001), specifically in patients with the chronic form. Efficacy and effectiveness of the three regimens were similar in the complementary treatment; however, the time to serologic cure was shorter when ITC (161 days) or CMX (495 days) was used compared with ITC/CMX (881 days) [p = 0.02]. The independent predictors of a shorter time to serologic cure were treatment with ITC [risk ratio = 6.61 (2.01-21.75)] or with CMX [risk ratio = 5.11 (1.91-13.67)]). The prevalence of side effects was lower with ITC (6.4%) than with CMX (20.0%; p = 0.03). CONCLUSIONS:Since ITC induced earlier clinical cure and was better tolerated than CMX, such triazole should be considered the first-choice for PCM treatment.

journal_name

PLoS Negl Trop Dis

authors

Cavalcante Rde S,Sylvestre TF,Levorato AD,de Carvalho LR,Mendes RP

doi

10.1371/journal.pntd.0002793

subject

Has Abstract

pub_date

2014-04-17 00:00:00

pages

e2793

issue

4

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-13-01588

journal_volume

8

pub_type

临床试验,杂志文章
  • Progress and impact of 13 years of the global programme to eliminate lymphatic filariasis on reducing the burden of filarial disease.

    abstract:BACKGROUND:A Global Programme to Eliminate Lymphatic Filariasis was launched in 2000, with mass drug administration (MDA) as the core strategy of the programme. After completing 13 years of operations through 2012 and with MDA in place in 55 of 73 endemic countries, the impact of the MDA programme on microfilaraemia, h...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0003319

    authors: Ramaiah KD,Ottesen EA

    更新日期:2014-11-20 00:00:00

  • Experimental and Natural Infections of Goats with Severe Fever with Thrombocytopenia Syndrome Virus: Evidence for Ticks as Viral Vector.

    abstract:BACKGROUND:Severe fever with thrombocytopenia syndrome virus (SFTSV), the causative agent for the fatal life-threatening infectious disease, severe fever with thrombocytopenia syndrome (SFTS), was first identified in the central and eastern regions of China. Although the viral RNA was detected in free-living and parasi...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0004092

    authors: Jiao Y,Qi X,Liu D,Zeng X,Han Y,Guo X,Shi Z,Wang H,Zhou M

    更新日期:2015-10-20 00:00:00

  • Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites.

    abstract:BACKGROUND:Schistosomiasis has been reported in 78 endemic countries and affects 240 million people worldwide. The digenetic parasite Schistosoma mansoni needs fresh water to compete its life cycle. There, it is susceptible to soluble compounds that can affect directly and/or indirectly the parasite's biology. The cerc...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0005789

    authors: Augusto RC,Tetreau G,Chan P,Walet-Balieu ML,Mello-Silva CC,Santos CP,Grunau C

    更新日期:2017-07-28 00:00:00

  • A household serosurvey to estimate the magnitude of a dengue outbreak in Mombasa, Kenya, 2013.

    abstract::Dengue appears to be endemic in Africa with a number of reported outbreaks. In February 2013, several individuals with dengue-like illnesses and negative malaria blood smears were identified in Mombasa, Kenya. Dengue was laboratory confirmed and an investigation was conducted to estimate the magnitude of local transmi...

    journal_title:PLoS neglected tropical diseases

    pub_type: 历史文章,杂志文章

    doi:10.1371/journal.pntd.0003733

    authors: Ellis EM,Neatherlin JC,Delorey M,Ochieng M,Mohamed AH,Mogeni DO,Hunsperger E,Patta S,Gikunju S,Waiboic L,Fields B,Ofula V,Konongoi SL,Torres-Velasquez B,Marano N,Sang R,Margolis HS,Montgomery JM,Tomashek KM

    更新日期:2015-04-29 00:00:00

  • Correction: Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis.

    abstract::[This corrects the article DOI: 10.1371/journal.pntd.0005370.]. ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 已发布勘误

    doi:10.1371/journal.pntd.0005474

    authors: Loos JA,Dávila VA,Rodriguez Rodrigues C,Petrigh R,Zoppi JA,Crocenzi FA,Cumino AC

    更新日期:2017-03-22 00:00:00

  • Correction: Brucellosis Seropositivity in Animals and Humans in Ethiopia: A Meta-analysis.

    abstract::[This corrects the article DOI: 10.1371/journal.pntd.0005006.]. ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 已发布勘误

    doi:10.1371/journal.pntd.0005236

    authors: Tadesse G

    更新日期:2016-12-20 00:00:00

  • Evaluation of nephroprotective and immunomodulatory activities of antioxidants in combination with cisplatin against murine visceral leishmaniasis.

    abstract:BACKGROUND:Most available drugs against visceral leishmaniasis are toxic, and growing limitations in available chemotherapeutic strategies due to emerging resistant strains and lack of an effective vaccine against visceral leishmaniasis deepens the crisis. Antineoplastic drugs like miltefosine have in the past been eff...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0001629

    authors: Sharma M,Sehgal R,Kaur S

    更新日期:2012-01-01 00:00:00

  • Pyrethroid resistance persists after ten years without usage against Aedes aegypti in governmental campaigns: Lessons from São Paulo State, Brazil.

    abstract:BACKGROUND:Aedes aegypti, vector of dengue, chikungunya and Zika viruses, is found at high densities in tropical urban areas. The dissemination of this vector is partially the consequence of failures in current vector control methods, still mainly relying upon insecticides. In the State of São Paulo (SP), Brazil, publi...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006390

    authors: Macoris ML,Martins AJ,Andrighetti MTM,Lima JBP,Valle D

    更新日期:2018-03-30 00:00:00

  • Contrasting the value of targeted versus area-wide mosquito control scenarios to limit arbovirus transmission with human mobility patterns based on different tropical urban population centers.

    abstract::Vector control is still our primary intervention for both prevention and mitigation of epidemics of many vector-borne diseases. Efficiently targeting control measures is important since control can involve substantial economic costs. Targeting is not always straightforward, as transmission of vector-borne diseases is ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0007479

    authors: Stone CM,Schwab SR,Fonseca DM,Fefferman NH

    更新日期:2019-07-03 00:00:00

  • Thalidomide in the treatment of erythema nodosum leprosum (ENL) in an outpatient setting: A five-year retrospective analysis from a leprosy referral centre in India.

    abstract::Erythema nodosum leprosum (ENL), or type 2 lepra reaction, is a multi-system immune-mediated complication in patients with multibacillary leprosy, frequently associated with chronicity and recurrences. Management of ENL requires high doses of oral corticosteroids, which may not be universally effective and pose seriou...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0008678

    authors: Upputuri B,Pallapati MS,Tarwater P,Srikantam A

    更新日期:2020-10-09 00:00:00

  • The Global Phylogeography of Lyssaviruses - Challenging the 'Out of Africa' Hypothesis.

    abstract::Rabies virus kills tens of thousands of people globally each year, especially in resource-limited countries. Yet, there are genetically- and antigenically-related lyssaviruses, all capable of causing the disease rabies, circulating globally among bats without causing conspicuous disease outbreaks. The species richness...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0005266

    authors: Hayman DT,Fooks AR,Marston DA,Garcia-R JC

    更新日期:2016-12-30 00:00:00

  • Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors.

    abstract::A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and twelve variations respectively at the P1, P2 and P3 positions. A Ki ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0003916

    authors: Avelar LA,Camilo CD,de Albuquerque S,Fernandes WB,Gonçalez C,Kenny PW,Leitão A,McKerrow JH,Montanari CA,Orozco EV,Ribeiro JF,Rocha JR,Rosini F,Saidel ME

    更新日期:2015-07-14 00:00:00

  • Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients.

    abstract:BACKGROUND:Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear. METHODOL...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0007312

    authors: Shaw T,Tellapragada C,Kamath A,Kalwaje Eshwara V,Mukhopadhyay C

    更新日期:2019-05-15 00:00:00

  • Systematic review and consensus guidelines for environmental sampling of Burkholderia pseudomallei.

    abstract:BACKGROUND:Burkholderia pseudomallei, a Tier 1 Select Agent and the cause of melioidosis, is a Gram-negative bacillus present in the environment in many tropical countries. Defining the global pattern of B. pseudomallei distribution underpins efforts to prevent infection, and is dependent upon robust environmental samp...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,评审

    doi:10.1371/journal.pntd.0002105

    authors: Limmathurotsakul D,Dance DA,Wuthiekanun V,Kaestli M,Mayo M,Warner J,Wagner DM,Tuanyok A,Wertheim H,Yoke Cheng T,Mukhopadhyay C,Puthucheary S,Day NP,Steinmetz I,Currie BJ,Peacock SJ

    更新日期:2013-01-01 00:00:00

  • Neglected tropical diseases in children: An assessment of gaps in research prioritization.

    abstract:BACKGROUND:Despite the known burden of neglected tropical diseases (NTDs) on child health, there is limited information on current efforts to increase pediatric therapeutic options. Our objective was to quantify and characterize research activity and treatment availability for NTDs in children in order to inform the pr...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0007111

    authors: Rees CA,Hotez PJ,Monuteaux MC,Niescierenko M,Bourgeois FT

    更新日期:2019-01-29 00:00:00

  • An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections.

    abstract:BACKGROUND:Efforts to control soil-transmitted helminth (STH) infections have intensified over the past decade. Field-survey data on STH prevalence, infection intensity and drug efficacy is necessary to guide the implementation of control programs and should be of the best possible quality. METHODOLOGY:During four cli...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0008625

    authors: Vlaminck J,Cools P,Albonico M,Ame S,Ayana M,Dana D,Keiser J,Matoso LF,Montresor A,Mekonnen Z,Corrêa-Oliveira R,Pinto SA,Sayasone S,Vercruysse J,Levecke B

    更新日期:2020-09-21 00:00:00

  • Updated global burden of cholera in endemic countries.

    abstract:BACKGROUND:The global burden of cholera is largely unknown because the majority of cases are not reported. The low reporting can be attributed to limited capacity of epidemiological surveillance and laboratories, as well as social, political, and economic disincentives for reporting. We previously estimated 2.8 million...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0003832

    authors: Ali M,Nelson AR,Lopez AL,Sack DA

    更新日期:2015-06-04 00:00:00

  • Distribution and Diversity of Pathogenic Leptospira Species in Peri-domestic Surface Waters from South Central Chile.

    abstract:BACKGROUND:Leptospirosis is a neglected zoonosis affecting animals and humans caused by infection with Leptospira. The bacteria can survive outside of hosts for long periods of time in soil and water. While identification of Leptospira species from human cases and animal reservoirs are increasingly reported, little is ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0004895

    authors: Mason MR,Encina C,Sreevatsan S,Muñoz-Zanzi C

    更新日期:2016-08-16 00:00:00

  • Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis.

    abstract:BACKGROUND:Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not yet available and the severe side-effects of the drugs in clinical use, linked to the parenteral administration route of most of them, are si...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0003666

    authors: Calvo-Álvarez E,Stamatakis K,Punzón C,Álvarez-Velilla R,Tejería A,Escudero-Martínez JM,Pérez-Pertejo Y,Fresno M,Balaña-Fouce R,Reguera RM

    更新日期:2015-03-31 00:00:00

  • The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection.

    abstract::Trypanosoma cruzi, the etiological agent of Chagas disease, consumes glucose and amino acids depending on the environmental availability of each nutrient during its complex life cycle. For example, amino acids are the major energy and carbon sources in the intracellular stages of the T. cruzi parasite, but their consu...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006170

    authors: Crispim M,Damasceno FS,Hernández A,Barisón MJ,Pretto Sauter I,Souza Pavani R,Santos Moura A,Pral EMF,Cortez M,Elias MC,Silber AM

    更新日期:2018-01-10 00:00:00

  • Field evaluation of DNA detection of human filarial and malaria parasites using mosquito excreta/feces.

    abstract::We recently developed a superhydrophobic cone-based method for the collection of mosquito excreta/feces (E/F) for the molecular xenomonitoring of vector-borne parasites showing higher throughput compared to the traditional approach. To test its field applicability, we used this platform to detect the presence of filar...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0008175

    authors: Minetti C,Pilotte N,Zulch M,Canelas T,Tettevi EJ,Veriegh FBD,Osei-Atweneboana MY,Williams SA,Reimer LJ

    更新日期:2020-04-08 00:00:00

  • Trypanosoma cruzi I and IV stocks from Brazilian Amazon are divergent in terms of biological and medical properties in mice.

    abstract:BACKGROUND:In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0002069

    authors: Monteiro WM,Margioto Teston AP,Gruendling AP,dos Reis D,Gomes ML,de Araújo SM,Bahia MT,Magalhães LK,de Oliveira Guerra JA,Silveira H,Toledo MJ,Vale Barbosa Md

    更新日期:2013-01-01 00:00:00

  • Flubendazole as a macrofilaricide: History and background.

    abstract::Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lea...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,评审

    doi:10.1371/journal.pntd.0006436

    authors: Geary TG,Mackenzie CD,Silber SA

    更新日期:2019-01-16 00:00:00

  • Dextran fractional clearance studies in acute dengue infection.

    abstract:BACKGROUND:Although increased capillary permeability is the major clinical feature associated with severe dengue infections the mechanisms underlying this phenomenon remain unclear. Dextran clearance methodology has been used to investigate the molecular sieving properties of the microvasculature in clinical situations...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0001282

    authors: Nguyen-Pouplin J,Pouplin T,Van TP,The TD,Thi DN,Farrar J,Tinh HT,Wills B

    更新日期:2011-08-01 00:00:00

  • Trend analysis of leprosy in Morocco between 2000 and 2017: Evidence on the single dose rifampicin chemoprophylaxis.

    abstract:BACKGROUND:Morocco has achieved the goal of leprosy elimination as a public health problem several years ago (less than 1 case/ 10 000 habitant). The aim of this study was to analyze trends of leprosy detection during the last 17 years taking into consideration the implementation of single dose rifampicin chemoprophyla...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006910

    authors: Khoudri I,Elyoussfi Z,Mourchid Y,Youbi M,Bennani Mechita N,Abouqal R,Maaroufi A

    更新日期:2018-12-20 00:00:00

  • SisLeish: A multi-country standardized information system to monitor the status of Leishmaniasis in the Americas.

    abstract:BACKGROUND:In the Americas, leishmaniasis is endemic in 18 countries, and from 2001 through 2015, 17 countries reported 843,931 cases of cutaneous and mucocutaneous leishmaniasis, and 12 countries reported 52,176 cases of visceral leishmaniasis. A Regional Information System (SisLeish) was created in order to provide k...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0005868

    authors: Maia-Elkhoury ANS,O B Valadas SY,Puppim-Buzanovsky L,Rocha F,Sanchez-Vazquez MJ

    更新日期:2017-09-05 00:00:00

  • A randomized trial of AmBisome monotherapy and AmBisome and miltefosine combination to treat visceral leishmaniasis in HIV co-infected patients in Ethiopia.

    abstract:BACKGROUND:Visceral leishmaniasis (VL) in human immunodeficiency virus (HIV) co-infected patients requires special case management. AmBisome monotherapy at 40 mg/kg is recommended by the World Health Organization. The objective of the study was to assess if a combination of a lower dose of AmBisome with miltefosine wou...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1371/journal.pntd.0006988

    authors: Diro E,Blesson S,Edwards T,Ritmeijer K,Fikre H,Admassu H,Kibret A,Ellis SJ,Bardonneau C,Zijlstra EE,Soipei P,Mutinda B,Omollo R,Kimutai R,Omwalo G,Wasunna M,Tadesse F,Alves F,Strub-Wourgaft N,Hailu A,Alexander N,

    更新日期:2019-01-17 00:00:00

  • Imported endemic mycoses in Spain: Evolution of hospitalized cases, clinical characteristics and correlation with migratory movements, 1997-2014.

    abstract::Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to mi...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0006245

    authors: Molina-Morant D,Sánchez-Montalvá A,Salvador F,Sao-Avilés A,Molina I

    更新日期:2018-02-15 00:00:00

  • Rapid identification of paragonimiasis foci by lay informants in Lao People's Democratic Republic.

    abstract:BACKGROUND:Paragonimiasis is a food-borne trematodiasis leading to lung disease. Worldwide, an estimated 21 million people are infected. Foci of ongoing transmission remain often unnoticed. We evaluated a simple questionnaire approach using lay-informants at the village level to identify paragonimiasis foci and suspect...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章

    doi:10.1371/journal.pntd.0000521

    authors: Odermatt P,Veasna D,Zhang W,Vannavong N,Phrommala S,Habe S,Barennes H,Strobel M

    更新日期:2009-09-22 00:00:00

  • Phylogeographic reconstruction of African yellow fever virus isolates indicates recent simultaneous dispersal into east and west Africa.

    abstract::Yellow fever virus (YFV) is a mosquito-borne flavivirus that is a major public health problem in tropical areas of Africa and South America. There have been detailed studies on YFV ecology in West Africa and South America, but current understanding of YFV circulation on the African continent is incomplete. This inadeq...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,评审

    doi:10.1371/journal.pntd.0001910

    authors: Beck A,Guzman H,Li L,Ellis B,Tesh RB,Barrett AD

    更新日期:2013-01-01 00:00:00