Viral and epidemiological determinants of the invasion dynamics of novel dengue genotypes.


BACKGROUND:Dengue has become a major concern for international public health. Frequent epidemic outbreaks are believed to be driven by a complex interplay of immunological interactions between its four co-circulating serotypes and large fluctuations in mosquito densities. Viral lineage replacement events, caused for example by different levels of cross-protection or differences in viral fitness, have also been linked to a temporary change in dengue epidemiology. A major replacement event was recently described for South-East Asia where the Asian-1 genotype of dengue serotype 2 replaced the resident Asian/American type. Although this was proposed to be due to increased viral fitness in terms of enhanced human-to-mosquito transmission, no major change in dengue epidemiology could be observed. METHODS/RESULTS:Here we investigate the invasion dynamics of a novel, advantageous dengue genotype within a model system and determine the factors influencing the success and rate of fixation as well as their epidemiological consequences. We find that while viral fitness overall correlates with invasion success and competitive exclusion of the resident genotype, the epidemiological landscape plays a more significant role for successful emergence. Novel genotypes can thus face high risks of stochastic extinction despite their fitness advantage if they get introduced during episodes of high dengue prevalence, especially with respect to that particular serotype. CONCLUSION:The rarity of markers for positive selection has often been explained by strong purifying selection whereby the constraints imposed by dengue's two-host cycle are expected to result in a high rate of deleterious mutations. Our results demonstrate that even highly beneficial mutants are under severe threat of extinction, which would suggest that apart from purifying selection, stochastic effects and genetic drift beyond seasonal bottlenecks are equally important in shaping dengue's viral ecology and evolution.


PLoS Negl Trop Dis


Lourenço J,Recker M




Has Abstract


2010-11-23 00:00:00












  • A serologic study of dengue in northwest Ethiopia: Suggesting preventive and control measures.

    abstract:BACKGROUND:Dengue is one of the most serious and rapidly spreading arboviral diseases in the world. Despite many acute febrile illnesses in Ethiopia, the burden of illness due to dengue in the country is largely unknown. Thus, the present study aimed to provide the first baseline data on seroprevalence and associated r...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Ferede G,Tiruneh M,Abate E,Wondimeneh Y,Damtie D,Gadisa E,Howe R,Aseffa A,Tessema B

    更新日期:2018-05-31 00:00:00

  • Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis.

    abstract:BACKGROUND:Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not yet available and the severe side-effects of the drugs in clinical use, linked to the parenteral administration route of most of them, are si...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Calvo-Álvarez E,Stamatakis K,Punzón C,Álvarez-Velilla R,Tejería A,Escudero-Martínez JM,Pérez-Pertejo Y,Fresno M,Balaña-Fouce R,Reguera RM

    更新日期:2015-03-31 00:00:00

  • Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species.

    abstract::Global distribution patterns of Cladophialophora carrionii, agent of human chromoblastomycosis in arid climates of Africa, Asia, Australia, Central-and South-America, were compared with similar data of the vicarious Fonsecaea spp., agents of the disease in tropical rain forests. Population diversities among 73 C. carr...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Deng S,Tsui CK,Gerrits van den Ende AH,Yang L,Najafzadeh MJ,Badali H,Li R,Hagen F,Meis JF,Sun J,Dolatabadi S,Papierok B,Pan W,de Hoog GS,Liao W

    更新日期:2015-10-23 00:00:00

  • Detection of clinical and neurological signs in apparently asymptomatic HTLV-1 infected carriers: Association with high proviral load.

    abstract::Several studies suggest that HTLV-1 infection may be associated with a wider spectrum of neurologic manifestations that do not meet diagnostic criteria for HAM/TSP. These conditions may later progress to HAM/TSP or constitute an intermediate clinical form, between asymptomatic HTLV-1 carriers and those with full myelo...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Haziot ME,Gascon MR,Assone T,Fonseca LAM,Luiz ODC,Smid J,Paiva AM,Marcusso RMDN,de Oliveira ACP,Casseb J

    更新日期:2019-05-01 00:00:00

  • Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress.

    abstract:BACKGROUND:Miltefosine (MIL) is an oral antileishmanial drug used for treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Recent reports indicate a significant decline in its efficacy with a high rate of relapse in VL as well as post kala-azar dermal leishmaniasis (PKDL). We investigated the parasitic ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Deep DK,Singh R,Bhandari V,Verma A,Sharma V,Wajid S,Sundar S,Ramesh V,Dujardin JC,Salotra P

    更新日期:2017-06-02 00:00:00

  • Correction: Growing evidence of Plasmodium vivax across malaria-endemic Africa.

    abstract::[This corrects the article DOI: 10.1371/journal.pntd.0007140.]. ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 已发布勘误


    authors: PLOS Neglected Tropical Diseases Staff.

    更新日期:2019-06-28 00:00:00

  • Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.

    abstract::Chagas disease is a significant health problem in Latin America and the available treatments have significant issues in terms of toxicity and efficacy. There is thus an urgent need to develop new treatments either via a repurposing strategy or through the development of new chemical entities. A key first step is the i...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: De Rycker M,Thomas J,Riley J,Brough SJ,Miles TJ,Gray DW

    更新日期:2016-04-15 00:00:00

  • Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us.

    abstract::Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: El Baidouri F,Diancourt L,Berry V,Chevenet F,Pratlong F,Marty P,Ravel C

    更新日期:2013-06-13 00:00:00

  • Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming.

    abstract:BACKGROUND:Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antive...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Silva A,Johnston C,Kuruppu S,Kneisz D,Maduwage K,Kleifeld O,Smith AI,Siribaddana S,Buckley NA,Hodgson WC,Isbister GK

    更新日期:2016-12-02 00:00:00

  • Clinical manifestations of dengue in relation to dengue serotype and genotype in Malaysia: A retrospective observational study.

    abstract:BACKGROUND:Malaysia experienced an unprecedented dengue outbreak from the year 2014 to 2016 that resulted in an enormous increase in the number of cases and mortality as compared to previous years. The causes that attribute to a dengue outbreak can be multifactorial. Viral factors, such as dengue serotype and genotype,...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Suppiah J,Ching SM,Amin-Nordin S,Mat-Nor LA,Ahmad-Najimudin NA,Low GK,Abdul-Wahid MZ,Thayan R,Chee HY

    更新日期:2018-09-18 00:00:00

  • Prevalence of Chagas disease in Latin-American migrants living in Europe: a systematic review and meta-analysis.

    abstract:BACKGROUND:Few studies have assessed the burden of Chagas disease in non-endemic countries and most of them are based on prevalence estimates from Latin American (LA) countries that likely differ from the prevalence in migrants living in Europe. The aim of this study was to systematically review the existing data infor...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,meta分析,评审


    authors: Requena-Méndez A,Aldasoro E,de Lazzari E,Sicuri E,Brown M,Moore DA,Gascon J,Muñoz J

    更新日期:2015-02-13 00:00:00

  • Chlamydia trachomatis ompA variants in trachoma: what do they tell us?

    abstract:BACKGROUND:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious cause of blindness. Sequence-based analysis of the multiple strains typically present in endemic communities may be informative for epidemiology, transmission, response to treatment, and understanding the host response. METHODS:Conjun...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Andreasen AA,Burton MJ,Holland MJ,Polley S,Faal N,Mabey DC,Bailey RL

    更新日期:2008-09-24 00:00:00

  • Skeeter Buster: a stochastic, spatially explicit modeling tool for studying Aedes aegypti population replacement and population suppression strategies.

    abstract:BACKGROUND:Dengue is the most important mosquito-borne viral disease affecting humans. The only prevention measure currently available is the control of its vectors, primarily Aedes aegypti. Recent advances in genetic engineering have opened the possibility for a new range of control strategies based on genetically mod...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Magori K,Legros M,Puente ME,Focks DA,Scott TW,Lloyd AL,Gould F

    更新日期:2009-09-01 00:00:00

  • A polyvalent coral snake antivenom with broad neutralization capacity.

    abstract::Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, prod...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Castillo-Beltrán MC,Hurtado-Gómez JP,Corredor-Espinel V,Ruiz-Gómez FJ

    更新日期:2019-03-11 00:00:00

  • Evaluation of the health-related quality of life of children in Schistosoma haematobium-endemic communities in Kenya: a cross-sectional study.

    abstract:BACKGROUND:Schistosomiasis remains a global public health challenge, with 93% of the ~237 million infections occurring in sub-Saharan Africa. Though rarely fatal, its recurring nature makes it a lifetime disorder with significant chronic health burdens. Much of its negative health impact is due to non-specific conditio...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Terer CC,Bustinduy AL,Magtanong RV,Muhoho N,Mungai PL,Muchiri EM,Kitron U,King CH,Mutuku FM

    更新日期:2013-01-01 00:00:00

  • Declining antibody levels to Trypanosoma cruzi correlate with polymerase chain reaction positivity and electrocardiographic changes in a retrospective cohort of untreated Brazilian blood donors.

    abstract:BACKGROUND:Although infection with Trypanosoma cruzi is thought to be lifelong, less than half of those infected develop cardiomyopathy, suggesting greater parasite control or even clearance. Antibody levels appear to correlate with T. cruzi (antigen) load. We test the association between a downwards antibody trajector...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Buss LF,Campos de Oliveira-da Silva L,Moreira CHV,Manuli ER,Sales FC,Morales I,Di Germanio C,de Almeida-Neto C,Bakkour S,Constable P,Pinto-Filho MM,Ribeiro AL,Busch M,Sabino EC

    更新日期:2020-10-27 00:00:00

  • Flubendazole as a macrofilaricide: History and background.

    abstract::Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lea...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,评审


    authors: Geary TG,Mackenzie CD,Silber SA

    更新日期:2019-01-16 00:00:00

  • Sporotrichosis in sub-himalayan India.

    abstract::Sporotrichosis is endemic in the Sub-Himalayan belt, which ranges from the northern to the north-eastern Indian subcontinent. Similar to many parts of the developing world, sporotrichosis is commonly recognized clinically in this region however consolidated epidemiological data is lacking. We report epidemiological, c...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Verma S,Verma GK,Singh G,Kanga A,Shanker V,Singh D,Gupta P,Mokta K,Sharma V

    更新日期:2012-01-01 00:00:00

  • Sero-Molecular Epidemiology of Japanese Encephalitis in Zhejiang, an Eastern Province of China.

    abstract:BACKGROUND:Sporadic Japanese encephalitis (JE) cases still have been reported in Zhejiang Province in recent years, and concerns about vaccine cross-protection and population-level immunity have been raised off and on within the public health sphere. Genotype I (GI) has replaced GIII as the dominant genotype in Asian c...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Pan JR,Yan JY,Zhou JY,Tang XW,He HQ,Xie RH,Mao HY,Zhang YJ,Xie SY

    更新日期:2016-08-25 00:00:00

  • The role of human movement in the transmission of vector-borne pathogens.

    abstract:BACKGROUND:Human movement is a key behavioral factor in many vector-borne disease systems because it influences exposure to vectors and thus the transmission of pathogens. Human movement transcends spatial and temporal scales with different influences on disease dynamics. Here we develop a conceptual model to evaluate ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Stoddard ST,Morrison AC,Vazquez-Prokopec GM,Paz Soldan V,Kochel TJ,Kitron U,Elder JP,Scott TW

    更新日期:2009-07-21 00:00:00

  • Field evaluation of DNA detection of human filarial and malaria parasites using mosquito excreta/feces.

    abstract::We recently developed a superhydrophobic cone-based method for the collection of mosquito excreta/feces (E/F) for the molecular xenomonitoring of vector-borne parasites showing higher throughput compared to the traditional approach. To test its field applicability, we used this platform to detect the presence of filar...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Minetti C,Pilotte N,Zulch M,Canelas T,Tettevi EJ,Veriegh FBD,Osei-Atweneboana MY,Williams SA,Reimer LJ

    更新日期:2020-04-08 00:00:00

  • Suppression of chikungunya virus replication and differential innate responses of human peripheral blood mononuclear cells during co-infection with dengue virus.

    abstract::Dengue and chikungunya are viral diseases transmitted to humans by infected Aedes spp. mosquitoes. With an estimated 390 million infected people per year dengue virus (DENV) currently causes the most prevalent arboviral disease. During the last decade chikungunya virus (CHIKV) has caused large outbreaks and has expand...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Ruiz Silva M,Aguilar Briseño JA,Upasani V,van der Ende-Metselaar H,Smit JM,Rodenhuis-Zybert IA

    更新日期:2017-06-23 00:00:00

  • Epidemiology of Chikungunya Virus Outbreaks in Guadeloupe and Martinique, 2014: An Observational Study in Volunteer Blood Donors.

    abstract:BACKGROUND:During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Gallian P,Leparc-Goffart I,Richard P,Maire F,Flusin O,Djoudi R,Chiaroni J,Charrel R,Tiberghien P,de Lamballerie X

    更新日期:2017-01-12 00:00:00

  • Trends of Mycobacterium bovis Isolation and First-Line Anti-tuberculosis Drug Susceptibility Profile: A Fifteen-Year Laboratory-Based Surveillance.

    abstract:BACKGROUND:Mycobacterium tuberculosis causes the majority of tuberculosis (TB) cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M. bovis is considered a zoonosis; transmission is mainly through consumption of unpasteurized dairy products, ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Bobadilla-del Valle M,Torres-González P,Cervera-Hernández ME,Martínez-Gamboa A,Crabtree-Ramirez B,Chávez-Mazari B,Ortiz-Conchi N,Rodríguez-Cruz L,Cervantes-Sánchez A,Gudiño-Enríquez T,Cinta-Severo C,Sifuentes-Osornio J,Ponce de L

    更新日期:2015-09-30 00:00:00

  • Aberrant plasma MMP and TIMP dynamics in Schistosoma - Immune reconstitution inflammatory syndrome (IRIS).

    abstract:BACKGROUND:Among the different faces of immune reconstitution inflammatory syndrome (IRIS) developing in HIV-patients, no clinical definition has been reported for Schistosomiasis-IRIS (Schisto-IRIS). Although Schisto-IRIS remains largely uninvestigated, matrix metalloproteinases (MMP) and tissue inhibitors of metallop...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Goovaerts O,Mwinzi PNM,Muok EMO,Ceulemans A,Colebunders R,Kestens L

    更新日期:2018-08-08 00:00:00

  • Spatial distribution of Taenia solium porcine cysticercosis within a rural area of Mexico.

    abstract::Cysticercosis is caused by Taenia solium, a parasitic disease that affects humans and rurally bred pigs in developing countries. The cysticercus may localize in the central nervous system of the human, causing neurocysticercosis, the most severe and frequent form of the disease. There appears to be an association betw...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Morales J,Martínez JJ,Rosetti M,Fleury A,Maza V,Hernandez M,Villalobos N,Fragoso G,de Aluja AS,Larralde C,Sciutto E

    更新日期:2008-01-01 00:00:00

  • The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue.

    abstract:BACKGROUND:Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic shock is the most serious ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Lam PK,Ngoc TV,Thu Thuy TT,Hong Van NT,Nhu Thuy TT,Hoai Tam DT,Dung NM,Hanh Tien NT,Thanh Kieu NT,Simmons C,Wills B,Wolbers M

    更新日期:2017-04-27 00:00:00

  • Environmental methods for dengue vector control - A systematic review and meta-analysis.

    abstract:BACKGROUND:Vector control remains the primary method to prevent dengue infections. Environmental interventions represent sustainable and safe methods as there are limited risks of environmental contamination and toxicity. The objective of this study is to perform a systematic review and meta-analysis of the effectivene...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,meta分析


    authors: Buhler C,Winkler V,Runge-Ranzinger S,Boyce R,Horstick O

    更新日期:2019-07-11 00:00:00

  • Over-Expression of Cysteine Leucine Rich Protein Is Related to SAG Resistance in Clinical Isolates of Leishmania donovani.

    abstract:BACKGROUND:Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable. Cysteine leucine rich protein (CLrP), was recognized as one of the overexpressed...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Das S,Shah P,Tandon R,Yadav NK,Sahasrabuddhe AA,Sundar S,Siddiqi MI,Dube A

    更新日期:2015-08-21 00:00:00

  • Morbidity management and surveillance of lymphatic filariasis disease and acute dermatolymphangioadenitis attacks using a mobile phone-based tool by community health volunteers in Ghana.

    abstract::Morbidity burden of lymphatic filariasis (LF) relies on the information from the Mass Drug Administration (MDA) programme where Community Health Volunteers (CHVs) passively report cases identified. Consequently, the exact prevalence of morbidity cases is not always accurate. The use of mobile phone technology to repor...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Debrah LB,Mohammed A,Osei-Mensah J,Mubarik Y,Agbenyega O,Ayisi-Boateng NK,Pfarr K,Kuehlwein JM,Klarmann-Schulz U,Hoerauf A,Debrah AY

    更新日期:2020-11-12 00:00:00