Detection of Bartonella spp. in fleas by MALDI-TOF MS.

abstract：:Erythema nodosum leprosum (ENL), or type 2 lepra reaction, is a multi-system immune-mediated complication in patients with multibacillary leprosy, frequently associated with chronicity and recurrences. Management of ENL requires high doses of oral corticosteroids, which may not be universally effective and pose seriou...

journal_title：PLoS neglected tropical diseases

authors： Upputuri B,Pallapati MS,Tarwater P,Srikantam A

更新日期：2020-10-09 00:00:00

abstract：:Person-to-person transmission is a key feature of human Nipah virus outbreaks in Bangladesh. In contrast, in an outbreak of Nipah virus in Malaysia, people acquired infections from pigs. It is not known whether this important epidemiological difference is driven primarily by differences between NiV Bangladesh (NiV-BD)...

journal_title：PLoS neglected tropical diseases

authors： Clayton BA,Middleton D,Arkinstall R,Frazer L,Wang LF,Marsh GA

更新日期：2016-06-24 00:00:00

abstract：BACKGROUND:There is conflicting evidence on the immunologic benefit of treating helminth co-infections ("deworming") in HIV-infected individuals. Several studies have documented reduced viral load and increased CD4 count in antiretroviral therapy (ART) naïve individuals after deworming. However, there are a lack of dat...

journal_title：PLoS neglected tropical diseases

authors： Lankowski AJ,Tsai AC,Kanyesigye M,Bwana M,Haberer JE,Wenger M,Martin JN,Bangsberg DR,Hunt PW,Siedner MJ

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Many small studies have been done in Honduras estimating soil-transmitted helminthiasis (STH) prevalence but a country-wide study was last done in 2005. The country has the highest burden of malaria among all Central American countries. The present study was done to estimate country-wide STH prevalence and i...

journal_title：PLoS neglected tropical diseases

authors： Mejia Torres RE,Franco Garcia DN,Fontecha Sandoval GA,Hernandez Santana A,Singh P,Mancero Bucheli ST,Saboya M,Paz MY

更新日期：2014-10-16 00:00:00

abstract：:The burden of leptospirosis in humans and animals in Africa is higher than that reported from other parts of the world. However, the disease is not routinely diagnosed in the continent. One of major factors limiting diagnosis is the poor availability of live isolates of locally circulating Leptospira serovars for incl...

journal_title：PLoS neglected tropical diseases

authors： Mgode GF,Machang'u RS,Mhamphi GG,Katakweba A,Mulungu LS,Durnez L,Leirs H,Hartskeerl RA,Belmain SR

更新日期：2015-12-01 00:00:00

abstract：:Buruli ulcer (BU) is a subcutaneous necrotic infection of the skin caused by Mycobacterium ulcerans. It is the third most common human mycobacterial disease after tuberculosis (TB) and leprosy. The available methods for detection of the bacilli in lesions are microscopic detection, isolation and cultivation of the bac...

journal_title：PLoS neglected tropical diseases

authors： Avumegah MS,Waidyatillake NT,Michalski WP,O'Brien DP,Nelson TM,Athan E

更新日期：2020-04-06 00:00:00

abstract：:Chikungunya virus (CHIKV) infection is characterized by rash, acute high fever, chills, headache, nausea, photophobia, vomiting, and severe polyarthralgia. There is evidence that arthralgia can persist for years and result in long-term discomfort. Neurologic disease with fatal outcome has been documented, although at ...

journal_title：PLoS neglected tropical diseases

authors： van den Doel P,Volz A,Roose JM,Sewbalaksing VD,Pijlman GP,van Middelkoop I,Duiverman V,van de Wetering E,Sutter G,Osterhaus AD,Martina BE

更新日期：2014-09-04 00:00:00

abstract：BACKGROUND:During recent West Nile virus (WNV) outbreaks in the US, half of the reported cases were classified as neuroinvasive disease. WNV neuroinvasion is proposed to follow two major routes: hematogenous and/or axonal transport along the peripheral nerves. How virus spreads once within the central nervous system (C...

journal_title：PLoS neglected tropical diseases

authors： Maximova OA,Bernbaum JG,Pletnev AG

更新日期：2016-09-12 00:00:00

abstract：:In resource-limited settings, the scarcity of skilled personnel and adequate laboratory facilities makes the differential diagnosis of fevers complex [1-5]. Febrile illnesses are diagnosed clinically in most rural centers, and both Rapid Diagnostic Tests (RDTs) and clinical algorithms can be valuable aids to health wo...

journal_title：PLoS neglected tropical diseases

authors： Alirol E,Horie NS,Barbé B,Lejon V,Verdonck K,Gillet P,Jacobs J,Büscher P,Kanal B,Bhattarai NR,El Safi S,Phe T,Lim K,Leng L,Lutumba P,Mukendi D,Bottieau E,Boelaert M,Rijal S,Chappuis F

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:Rabies is a fatal encephalitis caused by viruses belonging to the genus Lyssavirus of the family Rhabdoviridae. It is a viral disease primarily affecting mammals, though all warm blooded animals are susceptible. Experimental rabies virus infection in birds has been reported, but naturally occurring infection...

journal_title：PLoS neglected tropical diseases

authors： Baby J,Mani RS,Abraham SS,Thankappan AT,Pillai PM,Anand AM,Madhusudana SN,Ramachandran J,Sreekumar S

更新日期：2015-07-22 00:00:00

abstract：:Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Par...

journal_title：PLoS neglected tropical diseases

authors： de Léséleuc L,Orlova M,Cobat A,Girard M,Huong NT,Ba NN,Thuc NV,Truman R,Spencer JS,Adams L,Thai VH,Alcais A,Schurr E

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are responsible for a substantial health and economic burden, particularly to low-income societies. Quan...

journal_title：PLoS neglected tropical diseases

authors： Otero-Abad B,Torgerson PR

更新日期：2013-06-06 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) and helminth infections elicit antagonistic immune effector functions and are co-endemic in several regions of the world. We therefore hypothesized that helminth infection may influence Mtb-specific T-cell immune responses. We evaluated the cytokine profile of Mtb-specific T cells in 7...

journal_title：PLoS neglected tropical diseases

authors： Amelio P,Portevin D,Reither K,Mhimbira F,Mpina M,Tumbo A,Nickel B,Marti H,Knopp S,Ding S,Penn-Nicholson A,Darboe F,Ohmiti K,Scriba TJ,Pantaleo G,Daubenberger C,Perreau M

更新日期：2017-07-31 00:00:00

abstract：BACKGROUND:Among the different faces of immune reconstitution inflammatory syndrome (IRIS) developing in HIV-patients, no clinical definition has been reported for Schistosomiasis-IRIS (Schisto-IRIS). Although Schisto-IRIS remains largely uninvestigated, matrix metalloproteinases (MMP) and tissue inhibitors of metallop...

journal_title：PLoS neglected tropical diseases

authors： Goovaerts O,Mwinzi PNM,Muok EMO,Ceulemans A,Colebunders R,Kestens L

更新日期：2018-08-08 00:00:00

abstract：:Fasciolosis caused by Fasciola gigantica is a neglected tropical disease but a constraint on the growth and productivity of cattle, buffaloes and sheep in the tropical countries of Asia and Africa. Resistance to commonly used anthelmintics in Fasciola has increased the need to search for alternative therapeutic target...

journal_title：PLoS neglected tropical diseases

authors： Anandanarayanan A,Raina OK,Lalrinkima H,Rialch A,Sankar M,Varghese A

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homolo...

journal_title：PLoS neglected tropical diseases

authors： Woo PC,Lau SK,Lau CC,Tung ET,Chong KT,Yang F,Zhang H,Lo RK,Cai JP,Au-Yeung RK,Ng WF,Tse H,Wong SS,Xu S,Lam WH,Tse MK,Sze KH,Kao RY,Reiner NE,Hao Q,Yuen KY

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:Scabies is a disease of worldwide significance, causing considerable morbidity in both humans and other animals. The scabies mite Sarcoptes scabiei burrows into the skin of its host, obtaining nutrition from host skin and blood. Aspartic proteases mediate a range of diverse and essential physiological functi...

journal_title：PLoS neglected tropical diseases

authors： Mahmood W,Viberg LT,Fischer K,Walton SF,Holt DC

更新日期：2013-11-07 00:00:00

abstract：:The spread of dengue (DEN) worldwide combined with an increased severity of the DEN-associated clinical outcomes have made this mosquito-borne virus of great global public health importance. Progress in understanding DEN pathogenesis and in developing effective treatments has been hampered by the lack of a suitable sm...

journal_title：PLoS neglected tropical diseases

authors： Tan GK,Ng JK,Trasti SL,Schul W,Yip G,Alonso S

更新日期：2010-04-27 00:00:00

abstract：BACKGROUND:Taenia solium cysticercosis affects millions of impoverished people worldwide and can cause neurocysticercosis, an infection of the central nervous system which is potentially fatal. Children may represent an especially vulnerable population to neurocysticercosis, due to the risk of cognitive impairment duri...

journal_title：PLoS neglected tropical diseases

authors： Openshaw JJ,Medina A,Felt SA,Li T,Huan Z,Rozelle S,Luby SP

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:We identified the species of Leishmania isolated from traveling and migrant patients attended in a reference center from 2000 to 2015, we performed the georeferencing of these species in Rio de Janeiro (RJ) state and we had knowledge about the human flows between the likely location of infection (LLI) and pl...

journal_title：PLoS neglected tropical diseases

authors： Miranda LFC,Pacheco RDS,Pimentel MIF,Salgueiro MM,da Silva AF,de Mello CX,Barros JHDS,Valete-Rosalino CM,Madeira MF,Xavier SCDC,Schubach AO

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune res...

journal_title：PLoS neglected tropical diseases

authors： Menino JF,Saraiva M,Gomes-Alves AG,Lobo-Silva D,Sturme M,Gomes-Rezende J,Saraiva AL,Goldman GH,Cunha C,Carvalho A,Romani L,Pedrosa J,Castro AG,Rodrigues F

更新日期：2013-07-25 00:00:00

abstract：:Community drug distributors (CDDs) who are volunteers have the responsibility of awareness creation, household census, drug distribution and record-keeping and are thus key stakeholders in the campaign for Lymphatic Filariasis (LF) elimination. Taking into account their experiences and perceptions is important for a s...

journal_title：PLoS neglected tropical diseases

authors： Njomo DW,Kimani BW,Kibe LW,Okoyo C,Omondi WP,Sultani HM

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:Bithynia siamensis goniomphalos is the snail intermediate host of the liver fluke, Opisthorchis viverrini, the leading cause of cholangiocarcinoma (CCA) in the Greater Mekong sub-region of Thailand. Despite the severe public health impact of Opisthorchis-induced CCA, knowledge of the molecular interactions o...

journal_title：PLoS neglected tropical diseases

authors： Prasopdee S,Sotillo J,Tesana S,Laha T,Kulsantiwong J,Nolan MJ,Loukas A,Cantacessi C

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection and treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed and treated and outcomes can be improved. METHODS:We tested 180 sera with the Toxoplasma ICT Ig...

journal_title：PLoS neglected tropical diseases

authors： Begeman IJ,Lykins J,Zhou Y,Lai BS,Levigne P,El Bissati K,Boyer K,Withers S,Clouser F,Noble AG,Rabiah P,Swisher CN,Heydemann PT,Contopoulos-Ioannidis DG,Montoya JG,Maldonado Y,Ramirez R,Press C,Stillwaggon E,Peyron F

更新日期：2017-06-26 00:00:00

abstract：BACKGROUND:The cestode Echinococcus granulosus--the agent of cystic echinococcosis, a zoonosis affecting humans and domestic animals worldwide--is an excellent model for the study of host-parasite cross-talk that interfaces with two mammalian hosts. To develop the molecular analysis of these interactions, we carried ou...

journal_title：PLoS neglected tropical diseases

authors： Parkinson J,Wasmuth JD,Salinas G,Bizarro CV,Sanford C,Berriman M,Ferreira HB,Zaha A,Blaxter ML,Maizels RM,Fernández C

更新日期：2012-01-01 00:00:00

abstract：:Crimean-Congo Hemorrhagic Fever Virus (CCHFV) and Hazara virus (HAZV) belong to the same viral serotype and family. HAZV has lately been used as a model system and surrogate to CCHFV. However, virus-host cell interaction and level of pathogenicity for these viruses are not well investigated nor compared. In this study...

journal_title：PLoS neglected tropical diseases

authors： Monteil V,Salata C,Appelberg S,Mirazimi A

更新日期：2020-11-24 00:00:00

abstract：:The global spread of vector-borne diseases remains a worrying public health threat, raising the need for development of new combat strategies for vector control. Knowledge of vector ecology can be exploited in this regard, including plant feeding; a critical resource that mosquitoes of both sexes rely on for survival ...

journal_title：PLoS neglected tropical diseases

authors： Nyasembe VO,Tchouassi DP,Pirk CWW,Sole CL,Torto B

更新日期：2018-02-20 00:00:00

abstract：AUTHOR SUMMARY:Designing and implementing effective programs for infectious disease control requires complex decision-making, informed by an understanding of the diseases, the types of disease interventions and control measures available, and the disease-relevant characteristics of the local community. Though disease m...

journal_title：PLoS neglected tropical diseases

authors： Standley CJ,Graeden E,Kerr J,Sorrell EM,Katz R

更新日期：2018-04-12 00:00:00

abstract：BACKGROUND:Leishmaniasis is a serious multifactorial parasitic disease with limited treatment options. Current chemotherapy is mainly consisted of drugs with serious drawbacks such as toxicity, variable efficacy and resistance. Alternative bioactive phytocompounds may provide a promising source for discovering new anti...

journal_title：PLoS neglected tropical diseases

authors： Karampetsou K,Koutsoni OS,Gogou G,Angelis A,Skaltsounis LA,Dotsika E

更新日期：2021-01-11 00:00:00

abstract：:Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated that bacterially-released mycolactone diffuses beyond infection foci, the spatiotemporal distribution of myco...

journal_title：PLoS neglected tropical diseases

authors： Colucci-Guyon E,Rifflet A,Saint-Auret S,da Costa A,Boucontet L,Laval T,Prehaud C,Blanchard N,Levraud JP,Boneca IG,Demangel C,Guenin-Macé L

更新日期：2020-12-02 00:00:00