PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages.

abstract：BACKGROUND:The possible emergence of resistance to the only available drug for schistosomiasis spurs drug discovery that has been recently incentivized by the availability of improved transcriptome and genome sequence information. Transient RNAi has emerged as a straightforward and important technique to interrogate th...

journal_title：PLoS neglected tropical diseases

authors： Stefanić S,Dvořák J,Horn M,Braschi S,Sojka D,Ruelas DS,Suzuki B,Lim KC,Hopkins SD,McKerrow JH,Caffrey CR

更新日期：2010-10-19 00:00:00

abstract：BACKGROUND:Leptospirosis is a potentially fatal bacterial zoonosis that is endemic throughout the tropics and may be misdiagnosed as dengue. Delayed hospital admission of leptospirosis patients is associated with increased mortality. METHODOLOGY/PRINCIPAL FINDINGS:During a concurrent dengue/leptospirosis epidemic in P...

journal_title：PLoS neglected tropical diseases

authors： Sharp TM,Rivera García B,Pérez-Padilla J,Galloway RL,Guerra M,Ryff KR,Haberling D,Ramakrishnan S,Shadomy S,Blau D,Tomashek KM,Bower WA

更新日期：2016-02-25 00:00:00

abstract：BACKGROUND:The factors contributing to chronic Chagas' heart disease remain unknown. High nitric oxide (NO) levels have been shown to be associated with cardiomyopathy severity in patients. Further, NO produced via inducible nitric oxide synthase (iNOS/NOS2) is proposed to play a role in Trypanosoma cruzi control. Howe...

journal_title：PLoS neglected tropical diseases

authors： Carvalho CM,Silverio JC,da Silva AA,Pereira IR,Coelho JM,Britto CC,Moreira OC,Marchevsky RS,Xavier SS,Gazzinelli RT,da Glória Bonecini-Almeida M,Lannes-Vieira J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Mali has become increasingly interested in the evaluation of transmission of both Wuchereria bancrofti and Onchocerca volvulus as prevalences of both infections move toward their respective elimination targets. The SD Bioline Onchocerciasis/LF IgG4 Rapid Test was used in 2 evaluation units (EU) to assess its...

journal_title：PLoS neglected tropical diseases

authors： Dolo H,Coulibaly YI,Dembele B,Guindo B,Coulibaly SY,Dicko I,Doumbia SS,Dembele M,Traore MO,Goita S,Dolo M,Soumaoro L,Coulibaly ME,Diallo AA,Diarra D,Zhang Y,Colebunders R,Nutman TB

更新日期：2019-01-30 00:00:00

abstract：:Infection with the intracellular protozoan parasite Leishmania mexicana causes chronic disease in C57BL/6 mice, in which cutaneous lesions persist for many months with high parasite burdens (10(7)-10(8) parasites). This chronic disease process requires host IL-10 and FcγRIII. When Leishmania amastigotes are released f...

journal_title：PLoS neglected tropical diseases

authors： Buxbaum LU

更新日期：2013-05-09 00:00:00

abstract：:Rickettsia (R.) helvetica is the most prevalent rickettsia found in Ixodes ricinus ticks in Germany. Several studies reported antibodies against R. helvetica up to 12.5% in humans investigated, however, fulminant clinical cases are rare indicating a rather low pathogenicity compared to other rickettsiae. We investigat...

journal_title：PLoS neglected tropical diseases

authors： Speck S,Kern T,Aistleitner K,Dilcher M,Dobler G,Essbauer S

更新日期：2018-02-12 00:00:00

abstract：BACKGROUND:Careful monitoring for recrudescence of Wuchereria bancrofti infection is necessary in communities where mass drug administration (MDA) for the elimination of lymphatic filariasis (LF) as a public health problem has been stopped. During the post-MDA period, transmission assessment surveys (TAS) are recommend...

journal_title：PLoS neglected tropical diseases

authors： Irish SR,Al-Amin HM,Paulin HN,Mahmood ASMS,Khan RK,Muraduzzaman AKM,Worrell CM,Flora MS,Karim MJ,Shirin T,Shamsuzzaman AKM,Tahmina S,Lenhart A,Dubray C

更新日期：2018-07-26 00:00:00

abstract：:Trypanosomes rely on post-transcriptional mechanisms and mRNA-binding proteins for control of gene expression. Trypanosoma brucei ZC3H30 is an mRNA-binding protein that is expressed in both the bloodstream form (which grows in mammals) and the procyclic form (which grows in the tsetse fly midgut). Attachment of ZC3H30...

journal_title：PLoS neglected tropical diseases

authors： Chakraborty C,Clayton C

更新日期：2018-10-01 00:00:00

abstract：:The human mutilating disease chromoblastomycosis is caused by melanized members of the order Chaetothyriales. To assess population diversity among 123 clinical strains of agents of the disease in Brazil we applied sequencing of the rDNA internal transcribed spacer region, and partial cell division cycle and β-tubulin ...

journal_title：PLoS neglected tropical diseases

authors： Gomes RR,Vicente VA,Azevedo CM,Salgado CG,da Silva MB,Queiroz-Telles F,Marques SG,Santos DW,de Andrade TS,Takagi EH,Cruz KS,Fornari G,Hahn RC,Scroferneker ML,Caligine RB,Ramirez-Castrillon M,de Araújo DP,Heidrich D,Co

更新日期：2016-11-28 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is a re-emerging arbovirus associated with febrile illness often accompanied by rash and arthralgia that may persist for several years. Outbreaks are associated with high morbidity and create a public health challenge for countries affected. Recent outbreaks have occurred in both Eu...

journal_title：PLoS neglected tropical diseases

authors： Weger-Lucarelli J,Chu H,Aliota MT,Partidos CD,Osorio JE

更新日期：2014-07-24 00:00:00

abstract：:The proportion of Plasmodium vivax malaria among all malarias is increasing worldwide. Treatment with 8-aminoquinolines remain the only radical cure. However, 8-aminoquinolines can cause severe hemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. The population of the multi-ethnic Chittagong Hill ...

journal_title：PLoS neglected tropical diseases

authors： Ley B,Kibria MG,Khan WA,Auburn S,Phru CS,Jahan N,Johora FT,Thriemer K,Ami JQ,Hossain MS,Price RN,Koepfli C,Alam MS

更新日期：2020-09-14 00:00:00

abstract：INTRODUCTION:Post-kala-azar dermal leishmaniasis (PKDL) is a cutaneous complication appearing after treatment of visceral leishmaniasis, and PKDL patients are considered infectious to sand flies and may therefore play a role in the transmission of VL. We estimated the risk and risk factors of PKDL in patients with past...

journal_title：PLoS neglected tropical diseases

authors： Uranw S,Ostyn B,Rijal A,Devkota S,Khanal B,Menten J,Boelaert M,Rijal S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Rhinoentomophthoromycosis, or rhino-facial conidiobolomycosis, is a rare, grossly disfiguring disease due to an infection with entomophthoralean fungi. We report a case of rhinoentomophthoromycosis from Gabon and suggest a staging system, which provides information on the prognosis and duration of antifungal...

journal_title：PLoS neglected tropical diseases

authors： Blumentrath CG,Grobusch MP,Matsiégui PB,Pahlke F,Zoleko-Manego R,Nzenze-Aféne S,Mabicka B,Sanguinetti M,Kremsner PG,Schaumburg F

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Dengue is an important arboviral disease with about 100 million dengue cases per year, of which, ~5% result in severe disease. Clinical differentiation of dengue from other acute febrile illnesses (AFI) is difficult, and diagnostic blood tests are costly. We evaluated the utility of anti-DENV IgM in urine to...

journal_title：PLoS neglected tropical diseases

authors： Caraballo E,Poole-Smith BK,Tomashek KM,Torres-Velasquez B,Alvarado LI,Lorenzi OD,Ramos C,Carrión J,Hunsperger E

更新日期：2020-01-29 00:00:00

abstract：:Q fever is a widespread zoonosis that is caused by Coxiella burnetii (C. burnetii), and ruminants are identified as the main sources of human infections. Some human cases have been described, but very limited information was available about Q fever in ruminants on Reunion Island, a tropical island in the Indian Ocean....

journal_title：PLoS neglected tropical diseases

authors： Cardinale E,Esnault O,Beral M,Naze F,Michault A

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Cutaneous dirofilariosis is a canine mosquito-borne zoonosis that can cause larva migrans disease in humans. Dirofilaria repens is considered an emerging pathogen occurring with high prevalence in Mediterranean areas and many parts of tropical Asia. In Hong Kong, a second species, Candidatus Dirofilaria hong...

journal_title：PLoS neglected tropical diseases

authors： Yilmaz E,Fritzenwanker M,Pantchev N,Lendner M,Wongkamchai S,Otranto D,Kroidl I,Dennebaum M,Le TH,Anh Le T,Ramünke S,Schaper R,von Samson-Himmelstjerna G,Poppert S,Krücken J

更新日期：2016-10-11 00:00:00

abstract：BACKGROUND:Yellow fever is endemic in some countries in Africa, and Aedes aegpyti is one of the most important vectors implicated in the outbreak. The mapping of the nation-wide distribution and the detection of insecticide resistance of vector mosquitoes will provide the beneficial information for forecasting of dengu...

journal_title：PLoS neglected tropical diseases

authors： Kawada H,Higa Y,Futami K,Muranami Y,Kawashima E,Osei JH,Sakyi KY,Dadzie S,de Souza DK,Appawu M,Ohta N,Suzuki T,Minakawa N

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:Early warning systems (EWS) are management tools to predict the occurrence of epidemics of infectious diseases. While climate-based EWS have been developed for malaria, no standard protocol to evaluate and compare EWS has been proposed. Additionally, there are several neglected tropical diseases whose transm...

journal_title：PLoS neglected tropical diseases

authors： Chaves LF,Pascual M

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:The Norway rat (Rattus norvegicus) is the principal reservoir for leptospirosis in many urban settings. Few studies have identified markers for rat infestation in slum environments while none have evaluated the association between household rat infestation and Leptospira infection in humans or the use of inf...

journal_title：PLoS neglected tropical diseases

authors： Costa F,Ribeiro GS,Felzemburgh RD,Santos N,Reis RB,Santos AC,Fraga DB,Araujo WN,Santana C,Childs JE,Reis MG,Ko AI

更新日期：2014-12-04 00:00:00

abstract：:Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circu...

journal_title：PLoS neglected tropical diseases

authors： Angulo J,Martínez-Valdebenito C,Marco C,Galeno H,Villagra E,Vera L,Lagos N,Becerra N,Mora J,Bermúdez A,Díaz J,Ferrés M,López-Lastra M

更新日期：2017-07-14 00:00:00

abstract：:Several studies suggest that HTLV-1 infection may be associated with a wider spectrum of neurologic manifestations that do not meet diagnostic criteria for HAM/TSP. These conditions may later progress to HAM/TSP or constitute an intermediate clinical form, between asymptomatic HTLV-1 carriers and those with full myelo...

journal_title：PLoS neglected tropical diseases

authors： Haziot ME,Gascon MR,Assone T,Fonseca LAM,Luiz ODC,Smid J,Paiva AM,Marcusso RMDN,de Oliveira ACP,Casseb J

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi (T. cruzi) that affects more than 6 million people, mainly in Latin America. Benznidazole is still the drug of choice in many countries to treat it in spite of its dosage regimen and adverse side effects such as such ...

journal_title：PLoS neglected tropical diseases

authors： Rial MS,Scalise ML,Arrúa EC,Esteva MI,Salomon CJ,Fichera LE

更新日期：2017-12-21 00:00:00

abstract：BACKGROUND:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") st...

journal_title：PLoS neglected tropical diseases

authors： Bisoffi Z,Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Gobbo M,Bonafini S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB

更新日期：2014-01-09 00:00:00

abstract：:Cystic echinococcosis is still a major concern in South America. While some regions show advances in the control of the disease, others have among the highest incidence in the world. To reverse this situation the Pan American Health Organization (PAHO) has launched a regional project on cystic echinococcosis control a...

journal_title：PLoS neglected tropical diseases

authors： Morel N,Lassabe G,Elola S,Bondad M,Herrera S,Marí C,Last JA,Jensen O,Gonzalez-Sapienza G

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:In addition to the commonly accepted importance of the vampire bat in the maintenance and transmission of the rabies virus (RABV) in South America, RABV infection of other species is widely evidenced, challenging their role in the viral cycle. METHODOLOGY / PRINCIPLES FINDINGS:To identify the bioecologica...

journal_title：PLoS neglected tropical diseases

authors： de Thoisy B,Bourhy H,Delaval M,Pontier D,Dacheux L,Darcissac E,Donato D,Guidez A,Larrous F,Lavenir R,Salmier A,Lacoste V,Lavergne A

更新日期：2016-01-25 00:00:00

abstract：:Crimean-Congo Hemorrhagic Fever Virus (CCHFV) and Hazara virus (HAZV) belong to the same viral serotype and family. HAZV has lately been used as a model system and surrogate to CCHFV. However, virus-host cell interaction and level of pathogenicity for these viruses are not well investigated nor compared. In this study...

journal_title：PLoS neglected tropical diseases

authors： Monteil V,Salata C,Appelberg S,Mirazimi A

更新日期：2020-11-24 00:00:00

abstract：:Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput RNA-sequencing. Biopsies were taken from 8 patients with early cutaneous leishmaniasis and 17 patients with late cutaneous leishmaniasis. Although parasite DNA was found ...

journal_title：PLoS neglected tropical diseases

authors： Christensen SM,Dillon LA,Carvalho LP,Passos S,Novais FO,Hughitt VK,Beiting DP,Carvalho EM,Scott P,El-Sayed NM,Mosser DM

更新日期：2016-09-15 00:00:00

abstract：:Approximately 300,000 persons in the United States (US) are infected with Trypanosoma cruzi, the protozoan that causes Chagas disease, but less than 1% are estimated to have received antiparasitic treatment. Benznidazole was approved by the US Food and Drug Administration (FDA) for treatment of T. cruzi infection in 2...

journal_title：PLoS neglected tropical diseases

authors： Yoshioka K,Manne-Goehler J,Maguire JH,Reich MR

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:Protozoan parasites of the genus Leishmania cause a large spectrum of clinical manifestations known as Leishmaniases. These diseases are increasingly important public health problems in many countries both within and outside endemic regions. Thus, an accurate differential diagnosis is extremely relevant for ...

journal_title：PLoS neglected tropical diseases

authors： Zampieri RA,Laranjeira-Silva MF,Muxel SM,Stocco de Lima AC,Shaw JJ,Floeter-Winter LM

更新日期：2016-02-29 00:00:00

abstract：INTRODUCTION:The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species. This study aims to evaluate associations between Paracoccidioides phylogenetic species and corresponding clinical data. METHODS:Paracoccidioides strains from INI/Fioc...

journal_title：PLoS neglected tropical diseases

authors： de Macedo PM,Teixeira MM,Barker BM,Zancopé-Oliveira RM,Almeida-Paes R,Francesconi do Valle AC

更新日期：2019-04-15 00:00:00