Abstract:
:The burden of leptospirosis in humans and animals in Africa is higher than that reported from other parts of the world. However, the disease is not routinely diagnosed in the continent. One of major factors limiting diagnosis is the poor availability of live isolates of locally circulating Leptospira serovars for inclusion in the antigen panel of the gold standard microscopic agglutination test (MAT) for detecting antibodies against leptospirosis. To gain insight in Leptospira serovars and their natural hosts occurring in Tanzania, concomitantly enabling the improvement of the MAT by inclusion of fresh local isolates, a total of 52 Leptospira isolates were obtained from fresh urine and kidney homogenates, collected between 1996 and 2006 from small mammals, cattle and pigs. Isolates were identified by serogrouping, cross agglutination absorption test (CAAT), and molecular typing. Common Leptospira serovars with their respective animal hosts were: Sokoine (cattle and rodents); Kenya (rodents and shrews); Mwogolo (rodents); Lora (rodents); Qunjian (rodent); serogroup Grippotyphosa (cattle); and an unknown serogroup from pigs. Inclusion of local serovars particularly serovar Sokoine in MAT revealed a 10-fold increase in leptospirosis prevalence in Tanzania from 1.9% to 16.9% in rodents and 0.26% to 10.75% in humans. This indicates that local serovars are useful for diagnosis of human and animal leptospirosis in Tanzania and other African countries.
journal_name
PLoS Negl Trop Disjournal_title
PLoS neglected tropical diseasesauthors
Mgode GF,Machang'u RS,Mhamphi GG,Katakweba A,Mulungu LS,Durnez L,Leirs H,Hartskeerl RA,Belmain SRdoi
10.1371/journal.pntd.0004251subject
Has Abstractpub_date
2015-12-01 00:00:00pages
e0004251issue
12eissn
1935-2727issn
1935-2735pii
PNTD-D-15-00882journal_volume
9pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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