Mild manifestations of COVID-19 in healthcare workers.

abstract：BACKGROUND:Although increased capillary permeability is the major clinical feature associated with severe dengue infections the mechanisms underlying this phenomenon remain unclear. Dextran clearance methodology has been used to investigate the molecular sieving properties of the microvasculature in clinical situations...

journal_title：PLoS neglected tropical diseases

authors： Nguyen-Pouplin J,Pouplin T,Van TP,The TD,Thi DN,Farrar J,Tinh HT,Wills B

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) is a major diarrheal pathogen in developing countries, where it accounts for millions of infections and hundreds of thousands of deaths annually. While vaccine development to prevent diarrheal illness due to ETEC is feasible, extensive effort is needed to identify cons...

journal_title：PLoS neglected tropical diseases

authors： Harris JA,Roy K,Woo-Rasberry V,Hamilton DJ,Kansal R,Qadri F,Fleckenstein JM

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. Pharmacological...

journal_title：PLoS neglected tropical diseases

authors： Tzertzinis G,Egaña AL,Palli SR,Robinson-Rechavi M,Gissendanner CR,Liu C,Unnasch TR,Maina CV

更新日期：2010-03-09 00:00:00

abstract：:Trypanosoma cruzi has been subdivided into seven Discrete Typing Units (DTUs), TcI-TcVI and Tcbat. Two major evolutionary models have been proposed to explain the origin of hybrid lineages, but while it is widely accepted that TcV and TcVI are the result of genetic exchange between TcII and TcIII strains, the origin o...

journal_title：PLoS neglected tropical diseases

authors： Ramírez JC,Torres C,Curto MLA,Schijman AG

更新日期：2017-12-18 00:00:00

abstract：BACKGROUND:Global deworming programs aim to reach 75% of at-risk preschool-age children (pre-SAC) by 2020. The 2013 global pre-SAC deworming coverage initially published by the World Health Organization (WHO) was 23.9%, but this estimate inadequately captured deworming delivered through Child Health Day (CHD) platforms...

journal_title：PLoS neglected tropical diseases

authors： Kumapley RS,Kupka R,Dalmiya N

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL or kala azar) is the most serious form of human leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal leishmaniasis (PKDL) is a stigmatizing skin condition that often occurs in patients after successful treatment for VL. Lack of effective or appropri...

journal_title：PLoS neglected tropical diseases

authors： Osman M,Mistry A,Keding A,Gabe R,Cook E,Forrester S,Wiggins R,Di Marco S,Colloca S,Siani L,Cortese R,Smith DF,Aebischer T,Kaye PM,Lacey CJ

更新日期：2017-05-12 00:00:00

abstract：INTRODUCTION:Chikungunya virus (CHIKV) is a re-emerging pathogen responsible for causing outbreaks of febrile disease accompanied with debilitating joint pain. Symptoms typically persist for two weeks, but more severe and chronic chikungunya illnesses have been reported, especially in the elderly. Currently, there are ...

journal_title：PLoS neglected tropical diseases

authors： Arévalo MT,Huang Y,Jones CA,Ross TM

更新日期：2019-04-26 00:00:00

abstract：:Hansen's disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70-75% worldwide. About 10-50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5%...

journal_title：PLoS neglected tropical diseases

authors： Pavezzi PD,do Prado RB,Boin Filho PÂ,Gon ADS,Tuma B,Fornazieri MA,Scalone FM,Alves LRM,Montero RH,Casella AMB

更新日期：2020-09-21 00:00:00

abstract：BACKGROUND:Appropriate health and nutrition interventions to prevent long-term adverse effects in children are necessary before two years of age. One such intervention may include population-based deworming, recommended as of 12 months of age by the World Health Organization in soil-transmitted helminth (STH)-endemic a...

journal_title：PLoS neglected tropical diseases

authors： Joseph SA,Casapía M,Montresor A,Rahme E,Ward BJ,Marquis GS,Pezo L,Blouin B,Maheu-Giroux M,Gyorkos TW

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:In endemic areas, leptospirosis is more common and more severe in adults compared with children. Reasons to explain this discrepancy remain unclear and limited data focusing on adolescents are available. The objective of the study was to describe disease spectrum and outcome differences in children and adole...

journal_title：PLoS neglected tropical diseases

authors： Guerrier G,Hie P,Gourinat AC,Huguon E,Polfrit Y,Goarant C,D'Ortenzio E,Missotte I

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:Soil-transmitted helminths (STH) have acute and chronic manifestations, and can result in lifetime morbidity. Disease burden is difficult to quantify, yet quantitative evidence is required to justify large-scale deworming programmes. A recent Cochrane systematic review, which influences Global Burden of Dise...

journal_title：PLoS neglected tropical diseases

authors： Campbell SJ,Nery SV,Doi SA,Gray DJ,Soares Magalhães RJ,McCarthy JS,Traub RJ,Andrews RM,Clements AC

更新日期：2016-05-19 00:00:00

abstract：:Snakebites are a major Collective Health problem worldwide. In Brazil, Bothrops jararaca snake venom (BjV) evokes hemostatic disturbances, bleeding manifestations, and redox status imbalance. Specific antivenom therapy, although efficacious to revert most snakebite-induced manifestations, is incapable of treating seco...

journal_title：PLoS neglected tropical diseases

authors： Sachetto ATA,Rosa JG,Santoro ML

更新日期：2018-10-11 00:00:00

abstract：BACKGROUND:Hookworms infect millions of people worldwide and can cause severe clinical symptoms in their hosts. Prospective cohort studies in Brazil show high rates of hookworm reinfection in malnourished children compared to well-nourished children, despite previous treatment. Additionally, soil-transmitted helminth (...

journal_title：PLoS neglected tropical diseases

authors： Pacanaro CP,Dias SR,Serafim LR,Costa MP,Aguilar E,Paes PR,Alvarez-Leite JI,Rabelo EM

更新日期：2014-09-25 00:00:00

abstract：:Soil-transmitted helminths (STH) are a major cause of morbidity in tropical developing countries with a global infection prevalence of more than one billion people and disease burden of around 3.4 million disability adjusted life years. Infection prevalence directly correlates to inadequate sanitation, impoverished co...

journal_title：PLoS neglected tropical diseases

authors： Stracke K,Clarke N,Awburn CV,Vaz Nery S,Khieu V,Traub RJ,Jex AR

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:The impact of large scale Mass Drug Adminstration (MDA) of ivermectin on active onchocerciasis transmission by Simulium damnosum, which transmits the parasite O. volvulus is of great importance for onchocerciasis control programmes. We investigated in the Mbam river system area, the impact of MDA of ivermect...

journal_title：PLoS neglected tropical diseases

authors： Abong RA,Amambo GN,Hamid AA,Enow BA,Beng AA,Nietcho FN,Nji TM,Njouendou AJ,Ritter M,Esum ME,Deribe K,Cho JF,Fombad FF,Enyong PI,Poole C,Pfarr K,Hoerauf A,Carlow C,Wanji S

更新日期：2021-01-19 00:00:00

abstract：:Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed vaccines or antiviral therapies for CHIKV, the development of vaccine...

journal_title：PLoS neglected tropical diseases

authors： Gardner CL,Hritz J,Sun C,Vanlandingham DL,Song TY,Ghedin E,Higgs S,Klimstra WB,Ryman KD

更新日期：2014-02-20 00:00:00

abstract：BACKGROUND:After many years of neglect, schistosomiasis control is going to scale. The strategy of choice is preventive chemotherapy, that is the repeated large-scale administration of praziquantel (a safe and highly efficacious drug) to at-risk populations. The frequency of praziquantel administration is based on ende...

journal_title：PLoS neglected tropical diseases

authors： Schur N,Vounatsou P,Utzinger J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS:A seroepid...

journal_title：PLoS neglected tropical diseases

authors： Coral-Almeida M,Rodríguez-Hidalgo R,Celi-Erazo M,García HH,Rodríguez S,Devleesschauwer B,Benítez-Ortiz W,Dorny P,Praet N

更新日期：2014-05-22 00:00:00

abstract：BACKGROUND:In 2010 and 2011, Haiti was heavily affected by a large cholera outbreak that spread throughout the country. Although national health structure-based cholera surveillance was rapidly initiated, a substantial number of community cases might have been missed, particularly in remote areas. We conducted a commun...

journal_title：PLoS neglected tropical diseases

authors： Page AL,Ciglenecki I,Jasmin ER,Desvignes L,Grandesso F,Polonsky J,Nicholas S,Alberti KP,Porten K,Luquero FJ

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:South Sudan is one of the most endemic countries for visceral leishmaniasis (VL), and is frequently affected by large epidemics. In resource-limited settings, clinicians require a simple clinical tool to identify VL patients who are at increased risk of dying, and who need specialised treatment with liposoma...

journal_title：PLoS neglected tropical diseases

authors： Kämink SS,Collin SM,Harrison T,Gatluak F,Mullahzada AW,Ritmeijer K

更新日期：2017-10-02 00:00:00

abstract：:Leishmaniasis is a major health problem in some endemic areas and yet, no vaccine is available against any form of the disease. Historically, leishmanization (LZ) which is an inoculation of individual with live Leishmania, is the most effective control measure at least against cutaneous leishmaniasis (CL). Due to vari...

journal_title：PLoS neglected tropical diseases

authors： Davoudi N,Khamesipour A,Mahboudi F,McMaster WR

更新日期：2014-05-29 00:00:00

abstract：INTRODUCTION:A high proportion of grade 2 disability (visible deformity) is indicative of delay in detection of leprosy and leprosy is one of the major causes of preventable disability. We conducted this study to determine the risk factors associated with disability (G2D and G1D) among adult new leprosy cases and to me...

journal_title：PLoS neglected tropical diseases

authors： Srinivas G,Muthuvel T,Lal V,Vaikundanathan K,Schwienhorst-Stich EM,Kasang C

更新日期：2019-06-27 00:00:00

abstract：BACKGROUND:Since leprosy is both treated and controlled by multidrug therapy (MDT) it is important to monitor recurrent cases for drug resistance and to distinguish between relapse and reinfection as a means of assessing therapeutic efficacy. All three objectives can be reached with single nucleotide resolution using n...

journal_title：PLoS neglected tropical diseases

authors： Stefani MMA,Avanzi C,Bührer-Sékula S,Benjak A,Loiseau C,Singh P,Pontes MAA,Gonçalves HS,Hungria EM,Busso P,Piton J,Silveira MIS,Cruz R,Schetinni A,Costa MB,Virmond MCL,Diorio SM,Dias-Baptista IMF,Rosa PS,Matsuoka M

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management. Here, we quantify heterogeneities in Leishmania infantum parasite numbers in reservoir and non-reservoir host populations, and relate this ...

journal_title：PLoS neglected tropical diseases

authors： Courtenay O,Carson C,Calvo-Bado L,Garcez LM,Quinnell RJ

更新日期：2014-01-09 00:00:00

abstract：:Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After ...

journal_title：PLoS neglected tropical diseases

authors： El Baidouri F,Diancourt L,Berry V,Chevenet F,Pratlong F,Marty P,Ravel C

更新日期：2013-06-13 00:00:00

abstract：:Most treatments of leishmaniasis require hospitalization and present side effects or parasite resistance; innovations in drug formulation/reposition can overcome these barriers and must be pursued to increase therapeutic alternatives. Therefore, we tested polymyxin B (polB) potential to kill Leishmania amazonensis, ad...

journal_title：PLoS neglected tropical diseases

authors： Souza Ribeiro Costa J,Medeiros M,Yamashiro-Kanashiro EH,Rocha MC,Cotrim PC,Stephano MA,Lancellotti M,Tavares GD,Oliveira-Nascimento L

更新日期：2019-05-01 00:00:00

abstract：:Several medically important mosquito-borne flaviviruses have been detected in Argentina in recent years: Dengue (DENV), St. Louis encephalitis (SLEV), West Nile (WNV) and Yellow Fever (YFV) viruses. Evidence of Bussuquara virus (BSQV) and Ilheus virus (ILHV) activity were found, but they have not been associated with ...

journal_title：PLoS neglected tropical diseases

authors： Morales MA,Fabbri CM,Zunino GE,Kowalewski MM,Luppo VC,Enría DA,Levis SC,Calderón GE

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:Individuals exposed to malaria infections for a long time develop immune responses capable of blocking Plasmodium transmission to mosquito vectors, potentially limiting parasite spreading in nature. Development of a malaria TB vaccine requires a better understanding of the mechanisms and main effectors res...

journal_title：PLoS neglected tropical diseases

authors： Vallejo AF,Rubiano K,Amado A,Krystosik AR,Herrera S,Arévalo-Herrera M

更新日期：2016-06-29 00:00:00

abstract：BACKGROUND:Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distribution remains highly uncertain. Challenges in diagnosis and diagnostic methods as well as highly variable national health systems mean no single data source can reliably estimate the distribution o...

journal_title：PLoS neglected tropical diseases

authors： Brady OJ,Gething PW,Bhatt S,Messina JP,Brownstein JS,Hoen AG,Moyes CL,Farlow AW,Scott TW,Hay SI

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Dog rabies annually causes 24,000-70,000 deaths globally. We built a spreadsheet tool, RabiesEcon, to aid public health officials to estimate the cost-effectiveness of dog rabies vaccination programs in East Africa. METHODS:RabiesEcon uses a mathematical model of dog-dog and dog-human rabies transmission to...

journal_title：PLoS neglected tropical diseases

authors： Borse RH,Atkins CY,Gambhir M,Undurraga EA,Blanton JD,Kahn EB,Dyer JL,Rupprecht CE,Meltzer MI

更新日期：2018-05-23 00:00:00