Potential for sylvatic and urban Aedes mosquitoes from Senegal to transmit the new emerging dengue serotypes 1, 3 and 4 in West Africa.

abstract：BACKGROUND:Access to health care is a major requirement in improving health and fostering socioeconomic development. In the People's Republic of China (P.R. China), considerable changes have occurred in the social, economic, and health systems with a shift from a centrally planned to a socialist market economy. This br...

journal_title：PLoS neglected tropical diseases

authors： Balen J,Liu ZC,McManus DP,Raso G,Utzinger J,Xiao SY,Yu DB,Zhao ZY,Li YS

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Mycobacterium tuberculosis causes the majority of tuberculosis (TB) cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M. bovis is considered a zoonosis; transmission is mainly through consumption of unpasteurized dairy products, ...

journal_title：PLoS neglected tropical diseases

authors： Bobadilla-del Valle M,Torres-González P,Cervera-Hernández ME,Martínez-Gamboa A,Crabtree-Ramirez B,Chávez-Mazari B,Ortiz-Conchi N,Rodríguez-Cruz L,Cervantes-Sánchez A,Gudiño-Enríquez T,Cinta-Severo C,Sifuentes-Osornio J,Ponce de L

更新日期：2015-09-30 00:00:00

abstract：BACKGROUND:Hantavirus pulmonary syndrome (HPS) is a life threatening disease transmitted by the rodent Oligoryzomys longicaudatus in Chile. Hantavirus outbreaks are typically small and geographically confined. Several studies have estimated risk based on spatial and temporal distribution of cases in relation to climate...

journal_title：PLoS neglected tropical diseases

authors： Nsoesie EO,Mekaru SR,Ramakrishnan N,Marathe MV,Brownstein JS

更新日期：2014-04-24 00:00:00

abstract：:Schistosomes are parasitic platyhelminths that currently infect over 200 million people globally. The parasites can live for years in a putatively hostile environment - the blood of vertebrates. We have hypothesized that the unusual schistosome tegument (outer-covering) plays a role in protecting parasites in the bloo...

journal_title：PLoS neglected tropical diseases

authors： Bhardwaj R,Skelly PJ

更新日期：2011-04-05 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets is essential for the development of more efficient therapeutic alternatives. Inhibition of sirtuins ...

journal_title：PLoS neglected tropical diseases

authors： Ritagliati C,Alonso VL,Manarin R,Cribb P,Serra EC

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Chagas disease is caused by the parasite Trypanosoma cruzi and is transmitted through triatomines (Hemiptera: Reduviidae). In the last year, many studies of triatomine gut microbiota have outlined its potential role in modulating vector competence. However, little is known about the microbiota present in the...

journal_title：PLoS neglected tropical diseases

authors： Lima MS,Laport MS,Lorosa ES,Jurberg J,Dos Santos KRN,da Silva Neto MAC,Rachid CTCDC,Atella GC

更新日期：2018-09-13 00:00:00

abstract：:Schistosomes are amongst the most important and neglected pathogens in the world, and schistosomiasis control relies almost exclusively on a single drug. The neuromuscular system of schistosomes is fertile ground for therapeutic intervention, yet the details of physiological events involved in neuromuscular function r...

journal_title：PLoS neglected tropical diseases

authors： Novozhilova E,Kimber MJ,Qian H,McVeigh P,Robertson AP,Zamanian M,Maule AG,Day TA

更新日期：2010-08-10 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis has now emerged as an important opportunistic disease in patients coinfected with human immunodeficiency virus type-1 (HIV-1). Although the effectiveness of HIV-1 protease inhibitors, such as nelfinavir, in antiretroviral therapies is well documented, little is known of the impact of t...

journal_title：PLoS neglected tropical diseases

authors： Kumar P,Lodge R,Trudel N,Ouellet M,Ouellette M,Tremblay MJ

更新日期：2010-03-30 00:00:00

abstract：:In Tunisia, cases of zoonotic cutaneous leishmaniasis caused by Leishmania major are increasing and spreading from the south-west to new areas in the center. To improve the current knowledge on L. major evolution and population dynamics, we performed multi-locus microsatellite typing of human isolates from Tunisian go...

journal_title：PLoS neglected tropical diseases

authors： Harrabi M,Bettaieb J,Ghawar W,Toumi A,Zaâtour A,Yazidi R,Chaâbane S,Chalghaf B,Hide M,Bañuls AL,Ben Salah A

更新日期：2015-08-24 00:00:00

abstract：BACKGROUND:Anti-leishmanial drug regimens that include a single dose AmBisome could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the appropriate single dose is unknown. METHODOLOGY:A multi-centre, open-label, non-inferiority, randomized controlled trial with an adaptive des...

journal_title：PLoS neglected tropical diseases

authors： Khalil EA,Weldegebreal T,Younis BM,Omollo R,Musa AM,Hailu W,Abuzaid AA,Dorlo TP,Hurissa Z,Yifru S,Haleke W,Smith PG,Ellis S,Balasegaram M,EL-Hassan AM,Schoone GJ,Wasunna M,Kimutai R,Edwards T,Hailu A

更新日期：2014-01-16 00:00:00

abstract：BACKGROUND:The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for the development of an O. volvulus vaccine. The B. malayi gerbil model was used to confirm the efficacy of these Ov vaccine candidates on adult worms an...

journal_title：PLoS neglected tropical diseases

authors： Arumugam S,Wei J,Liu Z,Abraham D,Bell A,Bottazzi ME,Hotez PJ,Zhan B,Lustigman S,Klei TR

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:Optimal management of eumycetoma, a severely debilitating chronic progressive fungal infection of skin, disseminating to bone and viscera, remains challenging. Especially, optimal antifungal treatment and duration are ill defined. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a monocentric retrospective study...

journal_title：PLoS neglected tropical diseases

authors： Crabol Y,Poiree S,Bougnoux ME,Maunoury C,Barete S,Zeller V,Arvieux C,Pineau S,Amazzough K,Lecuit M,Lanternier F,Lortholary O,French Mycosis Study Group.

更新日期：2014-10-09 00:00:00

abstract：BACKGROUND:Vector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and vector control, however, much less is known about the burden of ...

journal_title：PLoS neglected tropical diseases

authors： Alroy KA,Huang C,Gilman RH,Quispe-Machaca VR,Marks MA,Ancca-Juarez J,Hillyard M,Verastegui M,Sanchez G,Cabrera L,Vidal E,Billig EM,Cama VA,Náquira C,Bern C,Levy MZ,Working Group on Chagas Disease in Peru.

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Nifurtimox eflornithine combination therapy (NECT) to treat human African trypanosomiasis (HAT), commonly called sleeping sickness, was added to the World Health Organisation's (WHO) Essential Medicines List in 2009 and to the Paediatric List in 2012. NECT was further tested and documented in a phase IIIb cl...

journal_title：PLoS neglected tropical diseases

authors： Kuemmerle A,Schmid C,Kande V,Mutombo W,Ilunga M,Lumpungu I,Mutanda S,Nganzobo P,Ngolo D,Kisala M,Valverde Mordt O

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is a paucity of data on ILC2s in the context of human parasitic infections and in particula...

journal_title：PLoS neglected tropical diseases

authors： Nausch N,Appleby LJ,Sparks AM,Midzi N,Mduluza T,Mutapi F

更新日期：2015-03-23 00:00:00

abstract：BACKGROUND:Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antive...

journal_title：PLoS neglected tropical diseases

authors： Silva A,Johnston C,Kuruppu S,Kneisz D,Maduwage K,Kleifeld O,Smith AI,Siribaddana S,Buckley NA,Hodgson WC,Isbister GK

更新日期：2016-12-02 00:00:00

abstract：:Rabies is a fatal neurologic disease caused by lyssavirus infection. Bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. The epidemiology and pathogenesis of rabies in bats are poorly understood, making it difficult to prevent zoonotic transmission. To further our unde...

journal_title：PLoS neglected tropical diseases

authors： Begeman L,Suu-Ire R,Banyard AC,Drosten C,Eggerbauer E,Freuling CM,Gibson L,Goharriz H,Horton DL,Jennings D,Marston DA,Ntiamoa-Baidu Y,Riesle Sbarbaro S,Selden D,Wise EL,Kuiken T,Fooks AR,Müller T,Wood JLN,Cunningham

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Of the three diseases targeted for eradication by WHO, two are so-called Neglected Tropical Diseases (NTDs)-guinea worm disease (GWD) and yaws. The Guinea Worm Eradication Programme (GWEP) is in its final stages, with only 25 reported in 2016. However, global eradication still requires certification by WHO o...

journal_title：PLoS neglected tropical diseases

authors： Fitzpatrick C,Sankara DP,Agua JF,Jonnalagedda L,Rumi F,Weiss A,Braden M,Ruiz-Tiben E,Kruse N,Braband K,Biswas G

更新日期：2017-10-05 00:00:00

abstract：BACKGROUND:Travelers who acquire dengue infection are often routes for virus transmission to other regions. Nevertheless, the interplay between infected travelers, climate, vectors, and indigenous dengue incidence remains unclear. The role of foreign-origin cases on local dengue epidemics thus has been largely neglecte...

journal_title：PLoS neglected tropical diseases

authors： Shang CS,Fang CT,Liu CM,Wen TH,Tsai KH,King CC

更新日期：2010-08-03 00:00:00

abstract：BACKGROUND:In India, dengue disease is emerging as the most important vector borne public health problem due to rapid and unplanned urbanization, high human density and week management of the disease. Clinical cases are grossly underreported and not much information is available on prevalence and incidence of the disea...

journal_title：PLoS neglected tropical diseases

authors： Mishra AC,Arankalle VA,Gadhave SA,Mahadik PH,Shrivastava S,Bhutkar M,Vaidya VM

更新日期：2018-08-06 00:00:00

abstract：:Global distribution patterns of Cladophialophora carrionii, agent of human chromoblastomycosis in arid climates of Africa, Asia, Australia, Central-and South-America, were compared with similar data of the vicarious Fonsecaea spp., agents of the disease in tropical rain forests. Population diversities among 73 C. carr...

journal_title：PLoS neglected tropical diseases

authors： Deng S,Tsui CK,Gerrits van den Ende AH,Yang L,Najafzadeh MJ,Badali H,Li R,Hagen F,Meis JF,Sun J,Dolatabadi S,Papierok B,Pan W,de Hoog GS,Liao W

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Dog-bites and rabies are under-reported in developing countries such as Pakistan and there is a poor understanding of the disease burden. We prospectively collected data utilizing mobile phones for dog-bite and rabies surveillance across nine emergency rooms (ER) in Pakistan, recording patient health-seeking...

journal_title：PLoS neglected tropical diseases

authors： Zaidi SM,Labrique AB,Khowaja S,Lotia-Farrukh I,Irani J,Salahuddin N,Khan AJ

更新日期：2013-12-12 00:00:00

abstract：:A comprehensive analysis was done to evaluate the potential use of anti-parasitic macrocyclic lactones (including avermectins and milbemycins) for Buruli ulcer (BU) therapy. A panel containing nearly all macrocyclic lactones used in human or in veterinary medicine was analyzed for activity in vitro against clinical is...

journal_title：PLoS neglected tropical diseases

authors： Scherr N,Pluschke G,Thompson CJ,Ramón-García S

更新日期：2015-08-13 00:00:00

abstract：BACKGROUND:Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active protein kinase complex with Leishmania cyclins CYCA and C...

journal_title：PLoS neglected tropical diseases

authors： Walker RG,Thomson G,Malone K,Nowicki MW,Brown E,Blake DG,Turner NJ,Walkinshaw MD,Grant KM,Mottram JC

更新日期：2011-04-05 00:00:00

abstract：BACKGROUND:The high rate of leprosy cases among children under 15 years of age in Brazil indicates ongoing transmission within the community. The identification of the new leprosy cases among contacts can help identify the source of infection and interrupt the transmission chain. This study aims to determine the detect...

journal_title：PLoS neglected tropical diseases

authors： Pedrosa VL,Dias LC,Galban E,Leturiondo A,Palheta J Jr,Santos M,Moraes MO,Talhari C

更新日期：2018-02-26 00:00:00

abstract：:Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in patients with leproma...

journal_title：PLoS neglected tropical diseases

authors： Jin SH,An SK,Lee SB

更新日期：2017-06-21 00:00:00

abstract：BACKGROUND:With approximately 3 billion people at risk of acquiring the infection, dengue fever is now considered the most important mosquito-borne viral disease in the world, with 390 million dengue infections occurring every year, of which 96 million manifest symptoms with any level of disease severity. Treatment of ...

journal_title：PLoS neglected tropical diseases

authors： Aguiar M,Stollenwerk N,Halstead SB

更新日期：2016-12-21 00:00:00

abstract：:Phlebotomine sand flies are insects that are highly relevant in medicine, particularly as the sole proven vectors of leishmaniasis. Accurate identification of sand fly species is an essential prerequisite for eco-epidemiological studies aiming to better understand the disease. Traditional morphological identification ...

journal_title：PLoS neglected tropical diseases

authors： Chavy A,Nabet C,Normand AC,Kocher A,Ginouves M,Prévot G,Vasconcelos Dos Santos T,Demar M,Piarroux R,de Thoisy B

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Canine rabies causes many thousands of human deaths every year in Africa, and continues to increase throughout much of the continent. METHODOLOGY/PRINCIPAL FINDINGS:This paper identifies four common reasons given for the lack of effective canine rabies control in Africa: (a) a low priority given for disease...

journal_title：PLoS neglected tropical diseases

authors： Lembo T,Hampson K,Kaare MT,Ernest E,Knobel D,Kazwala RR,Haydon DT,Cleaveland S

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Hydatidosis is a zoonotic disease of worldwide distribution caused by Echinococcus granulosus. Our study aimed to determine the prevalence of human and canine echinococcosis as well as the associated risk factors in a rural area of the Limarí province in northern Chile. METHODOLOGY/PRINCIPAL FINDINGS:A cros...

journal_title：PLoS neglected tropical diseases

authors： Acosta-Jamett G,Weitzel T,Boufana B,Adones C,Bahamonde A,Abarca K,Craig PS,Reiter-Owona I

更新日期：2014-08-28 00:00:00