Prevalence and risk factors for echinococcal infection in a rural area of northern Chile: a household-based cross-sectional study.

abstract：BACKGROUND:Mosquito salivary proteins (MSPs) modulate the host immune response, leading to enhancement of arboviral infections. Identification of proteins in saliva responsible for immunomodulation and counteracting their effects on host immune response is a potential strategy to protect against arboviral disease. We s...

journal_title：PLoS neglected tropical diseases

authors： Reagan KL,Machain-Williams C,Wang T,Blair CD

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for the development of an O. volvulus vaccine. The B. malayi gerbil model was used to confirm the efficacy of these Ov vaccine candidates on adult worms an...

journal_title：PLoS neglected tropical diseases

authors： Arumugam S,Wei J,Liu Z,Abraham D,Bell A,Bottazzi ME,Hotez PJ,Zhan B,Lustigman S,Klei TR

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:A relatively simple life history allows us to derive an expression for the extinction probability of populations of tsetse, vectors of African sleeping sickness. We present the uncertainty and sensitivity analysis of the extinction probability, to offer key insights into factors affecting the control or erad...

journal_title：PLoS neglected tropical diseases

authors： Are EB,Hargrove JW

更新日期：2020-05-11 00:00:00

abstract：:Visceral leishmaniasis (VL) is caused by parasitic protozoa of the genus Leishmania and is characterized by clinical manifestations such as fever, hepatosplenomegaly and anemia. Hemophagocytosis, the phenomenon of phagocytosis of blood cells by macrophages, is found in VL patients. In a previous study we established a...

journal_title：PLoS neglected tropical diseases

authors： Morimoto A,Uchida K,Chambers JK,Sato K,Hong J,Sanjoba C,Matsumoto Y,Yamagishi J,Goto Y

更新日期：2019-11-18 00:00:00

abstract：:The niche conservatism hypothesis states that related species diverge in niche characteristics at lower rates than expected, given their lineage divergence. Here we analyze whether niche conservatism is a common pattern among vector species (Hemiptera: Reduviidae: Triatominae) of Trypanosoma cruzi that inhabit North a...

journal_title：PLoS neglected tropical diseases

authors： Ibarra-Cerdeña CN,Zaldívar-Riverón A,Peterson AT,Sánchez-Cordero V,Ramsey JM

更新日期：2014-10-30 00:00:00

abstract：BACKGROUND:After the elimination of leprosy in 1995, there were 10-30 newly detected leprosy cases every year in Zhejiang Province, and the epidemiological characteristics of the newly detected leprosy cases have changed. While most of the newly detected cases came from other provinces in China, not Zhejiang, it brough...

journal_title：PLoS neglected tropical diseases

authors： Wu L,Shen Y,Yao Q,Sang X,Fei L,Kong W,Huang Y,Wang Y,Zeng F,Du N

更新日期：2021-01-07 00:00:00

abstract：:The massive flood in Malaysia's east coast in December 2014 has placed Kelantan in a possible dengue outbreak risk. At this point, community awareness is essential in preventing disease spread. However, no data on knowledge, attitude, and practice (KAP) of dengue in Kelantan have existed in relevance to flood disaster...

journal_title：PLoS neglected tropical diseases

authors： AhbiRami R,Zuharah WF

更新日期：2020-03-27 00:00:00

abstract：IMPORTANCE:Trichiasis surgery programs globally have faced high rates of poor surgical outcomes. Identifying correctable risk factors for improving long-term outcomes is essential for countries targeting elimination of trachoma as a public health problem. OBJECTIVE:To determine whether the location of trichiatic eyela...

journal_title：PLoS neglected tropical diseases

authors： Gower EW,Munoz B,Rajak S,Habtamu E,West SK,Merbs SL,Harding JC,Alemayehu W,Callahan EK,Emerson PM,Gebre T,Burton MJ

更新日期：2019-10-07 00:00:00

abstract：:The application of the organophosphate larvicide temephos to water storage containers is one of the most commonly employed dengue vector control methods. This systematic literature review is to the knowledge of the authors the first that aims to assess the community-effectiveness of temephos in controlling both vector...

journal_title：PLoS neglected tropical diseases

authors： George L,Lenhart A,Toledo J,Lazaro A,Han WW,Velayudhan R,Runge Ranzinger S,Horstick O

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Contacts of leprosy patients are at increased risk of developing leprosy and need to be targeted for early diagnosis. Seropositivity to the phenolic glycolipid I (PGL-I) antigen of Mycobacterium leprae has been used to identify contacts who have an increased risk of developing leprosy. In the present study, ...

journal_title：PLoS neglected tropical diseases

authors： Düppre NC,Camacho LA,Sales AM,Illarramendi X,Nery JA,Sampaio EP,Sarno EN,Bührer-Sékula S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The protozoan parasite Giardia intestinalis and the pathogenic bacterium Helicobacter pylori are well known for their high prevalences in human hosts worldwide. The prevalence of both organisms is known to peak in densely populated, low resource settings and children are infected early in life. Different Gia...

journal_title：PLoS neglected tropical diseases

authors： Ankarklev J,Hestvik E,Lebbad M,Lindh J,Kaddu-Mulindwa DH,Andersson JO,Tylleskär T,Tumwine JK,Svärd SG

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Optimal management of eumycetoma, a severely debilitating chronic progressive fungal infection of skin, disseminating to bone and viscera, remains challenging. Especially, optimal antifungal treatment and duration are ill defined. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a monocentric retrospective study...

journal_title：PLoS neglected tropical diseases

authors： Crabol Y,Poiree S,Bougnoux ME,Maunoury C,Barete S,Zeller V,Arvieux C,Pineau S,Amazzough K,Lecuit M,Lanternier F,Lortholary O,French Mycosis Study Group.

更新日期：2014-10-09 00:00:00

abstract：BACKGROUND:Dengue has become a major concern for international public health. Frequent epidemic outbreaks are believed to be driven by a complex interplay of immunological interactions between its four co-circulating serotypes and large fluctuations in mosquito densities. Viral lineage replacement events, caused for ex...

journal_title：PLoS neglected tropical diseases

authors： Lourenço J,Recker M

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Dengue virus infection (DVI) among children is a leading cause of hospitalization in endemic areas. Hospitalized patients are at risk of receiving unnecessary antibiotics. METHODS:A retrospective medical review analysis study was conducted to evaluate the prevalence, indication, and choice of antibiotics gi...

journal_title：PLoS neglected tropical diseases

authors： Adrizain R,Setiabudi D,Chairulfatah A

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Mass drug administration (MDA) using praziquantel is the WHO-recommended approach for control of schistosomiasis. However, few studies have compared the impact of different schedules of MDA on the resultant infection levels. We wished to evaluate whether annual MDA was more effective than less frequent treat...

journal_title：PLoS neglected tropical diseases

authors： Karanja DMS,Awino EK,Wiegand RE,Okoth E,Abudho BO,Mwinzi PNM,Montgomery SP,Secor WE

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune res...

journal_title：PLoS neglected tropical diseases

authors： Menino JF,Saraiva M,Gomes-Alves AG,Lobo-Silva D,Sturme M,Gomes-Rezende J,Saraiva AL,Goldman GH,Cunha C,Carvalho A,Romani L,Pedrosa J,Castro AG,Rodrigues F

更新日期：2013-07-25 00:00:00

abstract：BACKGROUND:Junín virus (JUNV), the etiologic agent of Argentine hemorrhagic fever (AHF), is classified by the NIAID and CDC as a Category A priority pathogen. Presently, antiviral therapy for AHF is limited to immune plasma, which is readily available only in the endemic regions of Argentina. T-705 (favipiravir) is a b...

journal_title：PLoS neglected tropical diseases

authors： Gowen BB,Juelich TL,Sefing EJ,Brasel T,Smith JK,Zhang L,Tigabu B,Hill TE,Yun T,Pietzsch C,Furuta Y,Freiberg AN

更新日期：2013-12-26 00:00:00

abstract：BACKGROUND:Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi (T. cruzi) that affects more than 6 million people, mainly in Latin America. Benznidazole is still the drug of choice in many countries to treat it in spite of its dosage regimen and adverse side effects such as such ...

journal_title：PLoS neglected tropical diseases

authors： Rial MS,Scalise ML,Arrúa EC,Esteva MI,Salomon CJ,Fichera LE

更新日期：2017-12-21 00:00:00

abstract：BACKGROUND:Envenoming by viper snakes constitutes an important public health problem in Brazil and other developing countries. Local hemorrhage is an important symptom of these accidents and is correlated with the action of snake venom metalloproteinases (SVMPs). The degradation of vascular basement membrane has been p...

journal_title：PLoS neglected tropical diseases

authors： Baldo C,Jamora C,Yamanouye N,Zorn TM,Moura-da-Silva AM

更新日期：2010-06-29 00:00:00

abstract：:Yellow fever virus (YFV) is a mosquito-borne flavivirus that is a major public health problem in tropical areas of Africa and South America. There have been detailed studies on YFV ecology in West Africa and South America, but current understanding of YFV circulation on the African continent is incomplete. This inadeq...

journal_title：PLoS neglected tropical diseases

authors： Beck A,Guzman H,Li L,Ellis B,Tesh RB,Barrett AD

更新日期：2013-01-01 00:00:00

abstract：:We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysacchari...

journal_title：PLoS neglected tropical diseases

authors： Im J,Islam MT,Kim DR,Ahmmed F,Chon Y,Zaman K,Khan AI,Ali M,Sur D,Kanungo S,Dutta S,Bhattacharya SK,Dougan G,Holt KE,Marks F,Kim JH,Qadri F,Clemens JD

更新日期：2020-08-17 00:00:00

abstract：:Hand, foot and mouth disease (HFMD) continues to challenge Asia with pandemic potential. In Vietnam, there have been two major outbreaks occurring during 2011-2012 (>200,000 hospitalizations and >200 deaths) and more recently in 2018 (>130,000 hospitalizations and 17 deaths). Given the high burden and the complex epid...

journal_title：PLoS neglected tropical diseases

authors： Nhan LNT,Khanh TH,Hong NTT,Van HMT,Nhu LNT,Ny NTH,Nguyet LA,Thanh TT,Anh NT,Hang VTT,Qui PT,Viet HL,Tung TH,Ha DQ,Tuan HM,Thwaites G,Chau NVV,Thwaites L,Hung NT,van Doorn HR,Tan LV

更新日期：2020-08-17 00:00:00

abstract：:Quantifying human mobility has significant consequences for studying physical activity, exposure to pathogens, and generating more realistic infectious disease models. Location-aware technologies such as Global Positioning System (GPS)-enabled devices are used increasingly as a gold standard for mobility research. The...

journal_title：PLoS neglected tropical diseases

authors： Paz-Soldan VA,Reiner RC Jr,Morrison AC,Stoddard ST,Kitron U,Scott TW,Elder JP,Halsey ES,Kochel TJ,Astete H,Vazquez-Prokopec GM

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:Most of the Leishmania genome is reported to be constitutively expressed during the life cycle of the parasite, with a few regulated genes. Inter-species comparative transcriptomics evidenced a low number of species-specific differences related to differentially distributed genes or the differential regulati...

journal_title：PLoS neglected tropical diseases

authors： Adaui V,Castillo D,Zimic M,Gutierrez A,Decuypere S,Vanaerschot M,De Doncker S,Schnorbusch K,Maes I,Van der Auwera G,Maes L,Llanos-Cuentas A,Arevalo J,Dujardin JC

更新日期：2011-05-10 00:00:00

abstract：BACKGROUND:Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is a paucity of data on ILC2s in the context of human parasitic infections and in particula...

journal_title：PLoS neglected tropical diseases

authors： Nausch N,Appleby LJ,Sparks AM,Midzi N,Mduluza T,Mutapi F

更新日期：2015-03-23 00:00:00

abstract：INTRODUCTION:The mosquito Aedes aegypti is the principal vector of dengue and yellow fever flaviviruses. Temephos is an organophosphate insecticide used globally to suppress Ae. aegypti larval populations but resistance has evolved in many locations. METHODOLOGY/PRINCIPAL FINDINGS:Quantitative Trait Loci (QTL) control...

journal_title：PLoS neglected tropical diseases

authors： Reyes-Solis Gdel C,Saavedra-Rodriguez K,Suarez AF,Black WC 4th

更新日期：2014-10-16 00:00:00

abstract：:The N-linked glycosylation motif at amino acid position 154-156 of the envelope (E) protein of West Nile virus (WNV) is linked to enhanced murine neuroinvasiveness, avian pathogenicity and vector competence. Naturally occurring isolates with altered E protein glycosylation patterns have been observed in WNV isolates; ...

journal_title：PLoS neglected tropical diseases

authors： Maharaj PD,Langevin SA,Bolling BG,Andrade CC,Engle XA,Ramey WN,Bosco-Lauth A,Bowen RA,Sanders TA,Huang CY,Reisen WK,Brault AC

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antibodies, though initially protective, decline during the first year of life to levels thought to be disease enhancing, before reaching undetectable levels. Infants have long been studied to understand the interaction betwee...

journal_title：PLoS neglected tropical diseases

authors： Clapham H,Cummings DA,Nisalak A,Kalayanarooj S,Thaisomboonsuk B,Klungthong C,Fernandez S,Srikiatkhachorn A,Macareo LR,Lessler J,Reiser J,Yoon IK

更新日期：2015-12-11 00:00:00

abstract：BACKGROUND:Schistosomiasis in one of the most prevalent parasitic diseases, affecting millions of people and animals in developing countries. Amongst the human-infective species S. haematobium is one of the most widespread causing urogenital schistosomiasis, a major human health problem across Africa, however in terms ...

journal_title：PLoS neglected tropical diseases

authors： Webster BL,Emery AM,Webster JP,Gouvras A,Garba A,Diaw O,Seye MM,Tchuente LA,Simoonga C,Mwanga J,Lange C,Kariuki C,Mohammed KA,Stothard JR,Rollinson D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Although antibody responses to dengue virus (DENV) in naturally infected individuals have been extensively studied, the functionality of DENV specific memory T cell responses in relation to clinical disease severity is incompletely understood. METHODOLOGY/PRINCIPAL FINDINGS:Using ex vivo IFNγ ELISpot assays...

journal_title：PLoS neglected tropical diseases

authors： Jeewandara C,Adikari TN,Gomes L,Fernando S,Fernando RH,Perera MK,Ariyaratne D,Kamaladasa A,Salimi M,Prathapan S,Ogg GS,Malavige GN

更新日期：2015-04-13 00:00:00