Characterization of schistosome tegumental alkaline phosphatase (SmAP).

abstract：BACKGROUND:Crimean-Congo hemorrhagic fever (CCHF) activity has recently been detected in the Kordufan region of Sudan. Since 2008, several sporadic cases and nosocomial outbreaks associated with high case-fatality have been reported in villages and rural hospitals in the region. PRINCIPAL FINDINGS:In the present study...

journal_title：PLoS neglected tropical diseases

authors： Aradaib IE,Erickson BR,Karsany MS,Khristova ML,Elageb RM,Mohamed ME,Nichol ST

更新日期：2011-01-01 00:00:00

abstract：:The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characteristics make 8-oxoG a g...

journal_title：PLoS neglected tropical diseases

authors： Aguiar PH,Furtado C,Repolês BM,Ribeiro GA,Mendes IC,Peloso EF,Gadelha FR,Macedo AM,Franco GR,Pena SD,Teixeira SM,Vieira LQ,Guarneri AA,Andrade LO,Machado CR

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Cryptosporidium is a leading cause of moderate-to-severe diarrhea (MSD) in young children in Africa. We examined factors associated with Cryptosporidium infection in MSD cases enrolled at the rural western Kenya Global Enteric Multicenter Study (GEMS) site from 2008-2012. METHODOLOGY/PRINCIPAL FINDINGS:At h...

journal_title：PLoS neglected tropical diseases

authors： Delahoy MJ,Omore R,Ayers TL,Schilling KA,Blackstock AJ,Ochieng JB,Moke F,Jaron P,Awuor A,Okonji C,Juma J,Farag TH,Nasrin D,Panchalingam S,Nataro JP,Kotloff KL,Levine MM,Oundo J,Roellig DM,Xiao L,Parsons MB,Laser

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:The clinical syndrome associated with secondary syphilis (SS) reflects the propensity of Treponema pallidum (Tp) to escape immune recognition while simultaneously inducing inflammation. METHODS:To better understand the duality of immune evasion and immune recognition in human syphilis, herein we used a comb...

journal_title：PLoS neglected tropical diseases

authors： Cruz AR,Ramirez LG,Zuluaga AV,Pillay A,Abreu C,Valencia CA,La Vake C,Cervantes JL,Dunham-Ems S,Cartun R,Mavilio D,Radolf JD,Salazar JC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Rodents are major reservoirs of pathogens responsible for numerous zoonotic diseases in humans and livestock. Assessing their microbial diversity at both the individual and population level is crucial for monitoring endemic infections and revealing microbial association patterns within reservoirs. Recently, ...

journal_title：PLoS neglected tropical diseases

authors： Razzauti M,Galan M,Bernard M,Maman S,Klopp C,Charbonnel N,Vayssier-Taussat M,Eloit M,Cosson JF

更新日期：2015-08-18 00:00:00

abstract：BACKGROUND:Mosquitoes feed on plant-derived fluids such as nectar and sap and are exposed to bioactive molecules found in this dietary source. However, the role of such molecules on mosquito vectorial capacity is unknown. Weather has been recognized as a major determinant of the spread of dengue, and plants under abiot...

journal_title：PLoS neglected tropical diseases

authors： Nunes RD,Ventura-Martins G,Moretti DM,Medeiros-Castro P,Rocha-Santos C,Daumas-Filho CR,Bittencourt-Cunha PR,Martins-Cardoso K,Cudischevitch CO,Menna-Barreto RF,Oliveira JH,Gusmão DS,Alves Lemos FJ,Alviano DS,Oliveira PL,Low

更新日期：2016-10-12 00:00:00

abstract：BACKGROUND:Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule (PRR) of the lectin ...

journal_title：PLoS neglected tropical diseases

authors： Antony JS,Ojurongbe O,Kremsner PG,Velavan TP

更新日期：2015-03-25 00:00:00

abstract：:We recently developed a superhydrophobic cone-based method for the collection of mosquito excreta/feces (E/F) for the molecular xenomonitoring of vector-borne parasites showing higher throughput compared to the traditional approach. To test its field applicability, we used this platform to detect the presence of filar...

journal_title：PLoS neglected tropical diseases

authors： Minetti C,Pilotte N,Zulch M,Canelas T,Tettevi EJ,Veriegh FBD,Osei-Atweneboana MY,Williams SA,Reimer LJ

更新日期：2020-04-08 00:00:00

abstract：:Apicomplexa tick-borne hemoparasites, including Babesia bovis, Babesia microti, and Theileria equi are responsible for bovine and human babesiosis and equine theileriosis, respectively. These parasites of vast medical, epidemiological, and economic impact have complex life cycles in their vertebrate and tick hosts. La...

journal_title：PLoS neglected tropical diseases

authors： Alzan HF,Knowles DP,Suarez CE

更新日期：2016-11-10 00:00:00

abstract：BACKGROUND:The diagnosis of canine echinococcosis can be a challenge in surveillance studies because there is no perfect gold standard that can be used routinely. However, unknown test specificities and sensitivities can be overcome using latent-class analysis with appropriate data. METHODOLOGY:We utilised a set of fa...

journal_title：PLoS neglected tropical diseases

authors： Hartnack S,Budke CM,Craig PS,Jiamin Q,Boufana B,Campos-Ponce M,Torgerson PR

更新日期：2013-01-01 00:00:00

abstract：:To eliminate schistosomiasis, appropriate diagnostic tests are required to monitor its prevalence and transmission, especially in the settings with low endemicity resulting from the consecutive mass drug administration. Antibodies that react with either crude soluble schistosome egg antigens or soluble worm antigen pr...

journal_title：PLoS neglected tropical diseases

authors： Mohammed ES,Nakamura R,Kalenda YD,Deloer S,Moriyasu T,Tanaka M,Fujii Y,Kaneko S,Hirayama K,Ibrahim AI,El-Seify MA,Metwally AM,Hamano S

更新日期：2020-09-11 00:00:00

abstract：:Cutaneous leishmaniasis caused by Leishmania major is an emergent, uncontrolled public health problem and there is no vaccine. A promising prophylactic approach has been immunotherapy with Toll-like receptor (TLR) agonists to enhance parasite-specific immune responses. We have previously reported that vaccination of C...

journal_title：PLoS neglected tropical diseases

authors： Huang L,Hinchman M,Mendez S

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:The IAEA colony is the only one available for mass rearing of Glossina pallidipes, a vector of human and animal African trypanosomiasis in eastern Africa. This colony is the source for Sterile Insect Technique (SIT) programs in East Africa. The source population of this colony is unclear and its genetic dive...

journal_title：PLoS neglected tropical diseases

authors： Ciosi M,Masiga DK,Turner CM

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:Aedes albopictus, the Asian tiger mosquito, is a vector of several arboviruses including dengue and chikungunya, and is also a significant nuisance mosquito. It is one of the most invasive of mosquitoes with a relentlessly increasing geographic distribution. Conventional control methods have so far failed to...

journal_title：PLoS neglected tropical diseases

authors： Labbé GM,Scaife S,Morgan SA,Curtis ZH,Alphey L

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hookworm infections are an important cause of (severe) anemia and iron deficiency in children in the tropics. Type of hookworm species (Ancylostoma duodenale or Necator americanus) and infection load are considered associated with disease burden, although these parameters are rarely assessed due to limitatio...

journal_title：PLoS neglected tropical diseases

authors： Jonker FA,Calis JC,Phiri K,Brienen EA,Khoffi H,Brabin BJ,Verweij JJ,van Hensbroek MB,van Lieshout L

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Schistosomiasis in one of the most prevalent parasitic diseases, affecting millions of people and animals in developing countries. Amongst the human-infective species S. haematobium is one of the most widespread causing urogenital schistosomiasis, a major human health problem across Africa, however in terms ...

journal_title：PLoS neglected tropical diseases

authors： Webster BL,Emery AM,Webster JP,Gouvras A,Garba A,Diaw O,Seye MM,Tchuente LA,Simoonga C,Mwanga J,Lange C,Kariuki C,Mohammed KA,Stothard JR,Rollinson D

更新日期：2012-01-01 00:00:00

abstract：:Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic members of the genus Leptospira. Infection can lead to illness ranging from mild and non-specific to severe, with jaundice, kidney and liver dysfunction, and widespread endothelial damage. The adhesion of pathogenic Leptospira sp...

journal_title：PLoS neglected tropical diseases

authors： Evangelista KV,Hahn B,Wunder EA Jr,Ko AI,Haake DA,Coburn J

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:Public health responses to outbreaks of dengue, chikungunya, and Zika virus have been stymied by the inability to control the primary vector, Aedes aegypti mosquitos. Consequently, the need for novel approaches to Aedes vector control is urgent. Placement of three autocidal gravid ovitraps (AGO traps) in ~85...

journal_title：PLoS neglected tropical diseases

authors： Sharp TM,Lorenzi O,Torres-Velásquez B,Acevedo V,Pérez-Padilla J,Rivera A,Muñoz-Jordán J,Margolis HS,Waterman SH,Biggerstaff BJ,Paz-Bailey G,Barrera R

更新日期：2019-07-25 00:00:00

abstract：:To control and prevent rabies in Latin America, mass dog vaccination campaigns (MDVC) are implemented mainly through fixed-location vaccination points: owners have to bring their dogs to the vaccination points where they receive the vaccination free of charge. Dog rabies is still endemic in some Latin-American countri...

journal_title：PLoS neglected tropical diseases

authors： Castillo-Neyra R,Toledo AM,Arevalo-Nieto C,MacDonald H,De la Puente-León M,Naquira-Velarde C,Paz-Soldan VA,Buttenheim AM,Levy MZ

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central role in dengue pathogenesis. Primary infections are typically associ...

journal_title：PLoS neglected tropical diseases

authors： Chaudhury S,Gromowski GD,Ripoll DR,Khavrutskii IV,Desai V,Wallqvist A

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Leprosy, caused by Mycobacterium leprae, affects over 200,000 people annually worldwide and remains endemic in the ethnically diverse, mountainous and underdeveloped southwestern provinces of China. Delayed diagnosis of leprosy persists in China, thus, additional knowledge to support early diagnosis, especia...

journal_title：PLoS neglected tropical diseases

authors： Chen X,You YG,Yuan YH,Yuan LC,Wen Y

更新日期：2019-04-24 00:00:00

abstract：BACKGROUND:Transmission of dengue virus (DENV) from humans to mosquitoes represents a critical component of dengue epidemiology. Examinations of this process have generally been hampered by a lack of methods that adequately represent natural acquisition of DENV by mosquitoes from humans. In this study, we assessed arti...

journal_title：PLoS neglected tropical diseases

authors： Long KC,Sulca J,Bazan I,Astete H,Jaba HL,Siles C,Kocher C,Vilcarromero S,Schwarz J,Escobedo-Vargas KS,Castro-Llanos F,Angulo L,Flores G,Ramal-Asayag C,Halsey ES,Hontz RD,Paz-Soldan VA,Scott TW,Lambrechts L,Morrison

更新日期：2019-02-12 00:00:00

abstract：:Trypanosoma cruzi has been subdivided into seven Discrete Typing Units (DTUs), TcI-TcVI and Tcbat. Two major evolutionary models have been proposed to explain the origin of hybrid lineages, but while it is widely accepted that TcV and TcVI are the result of genetic exchange between TcII and TcIII strains, the origin o...

journal_title：PLoS neglected tropical diseases

authors： Ramírez JC,Torres C,Curto MLA,Schijman AG

更新日期：2017-12-18 00:00:00

abstract：BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. Pharmacological...

journal_title：PLoS neglected tropical diseases

authors： Tzertzinis G,Egaña AL,Palli SR,Robinson-Rechavi M,Gissendanner CR,Liu C,Unnasch TR,Maina CV

更新日期：2010-03-09 00:00:00

abstract：:Cystic echinococcosis (CE) is distributed worldwide, extending from China to the Middle East and from Mediterranean countries to the sub-Saharan Africa and South America. According to WHO, one million people around the world are suffering from CE with an estimated burden of 183,573 DALYs. The annual monetary burden of...

journal_title：PLoS neglected tropical diseases

authors： Borhani M,Fathi S,Lahmar S,Ahmed H,Abdulhameed MF,Fasihi Harandi M

更新日期：2020-05-07 00:00:00

abstract：:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious blinding disease worldwide. Chronic conjunctival inflammation develops in childhood and leads to eyelid scarring and blindness in adulthood. The immune response to Ct provides only partial protection against re-infection, which can be frequent. ...

journal_title：PLoS neglected tropical diseases

authors： Hu VH,Holland MJ,Burton MJ

更新日期：2013-01-01 00:00:00

abstract：:The progression and variation of pathology during infections can be due to components from both host or pathogen, and/or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has been well studied in recent years, but the role of parasite genetic...

journal_title：PLoS neglected tropical diseases

authors： Morrison LJ,Tait A,McLellan S,Sweeney L,Turner CM,MacLeod A

更新日期：2009-12-01 00:00:00

abstract：:Novel strategies are required to control mosquitoes and the pathogens they transmit. One attractive approach involves maternally inherited endosymbiotic Wolbachia bacteria. After artificial infection with Wolbachia, many mosquitoes become refractory to infection and transmission of diverse pathogens. We evaluated the ...

journal_title：PLoS neglected tropical diseases

authors： Dodson BL,Hughes GL,Paul O,Matacchiero AC,Kramer LD,Rasgon JL

更新日期：2014-07-10 00:00:00

abstract：:Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput RNA-sequencing. Biopsies were taken from 8 patients with early cutaneous leishmaniasis and 17 patients with late cutaneous leishmaniasis. Although parasite DNA was found ...

journal_title：PLoS neglected tropical diseases

authors： Christensen SM,Dillon LA,Carvalho LP,Passos S,Novais FO,Hughitt VK,Beiting DP,Carvalho EM,Scott P,El-Sayed NM,Mosser DM

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is an important flavivirus infection. Although ZIKV infection is rarely fatal, risk for severe disease in adults is not well described. Our objective was to describe the spectrum of illness in U.S. Veterans with ZIKV infection. METHODOLOGY:Case series study including patients with laborato...

journal_title：PLoS neglected tropical diseases

authors： Schirmer PL,Wendelboe A,Lucero-Obusan CA,Ryono RA,Winters MA,Oda G,Martinez M,Saavedra S,Holodniy M

更新日期：2018-05-24 00:00:00