Host immune responses induced by specific Mycobacterium leprae antigens in an overnight whole-blood assay correlate with the diagnosis of paucibacillary leprosy patients in China.

abstract：:Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of Asia, where periodic outbreaks take hundreds of lives. Despite the catastrophes it causes, JE has remained a tropical disease uncom...

journal_title：PLoS neglected tropical diseases

authors： Ghosh D,Basu A

更新日期：2009-09-29 00:00:00

abstract：:Our knowledge and control of the pathogenesis induced by the filariae remain limited due to experimental obstacles presented by parasitic nematode biology and the lack of selective prophylactic or curative drugs. Here we thought to investigate the role of neutrophils in the host innate immune response to the infection...

journal_title：PLoS neglected tropical diseases

authors： Pionnier N,Brotin E,Karadjian G,Hemon P,Gaudin-Nomé F,Vallarino-Lhermitte N,Nieguitsila A,Fercoq F,Aknin ML,Marin-Esteban V,Chollet-Martin S,Schlecht-Louf G,Bachelerie F,Martin C

更新日期：2016-04-25 00:00:00

abstract：BACKGROUND:Health promotion is essential to the SAFE strategy for trachoma elimination. Schools are a valuable venue for health promotion. However, there is little literature about the impact of health education and water infrastructure in schools on facial cleanliness and trachoma in the community. Our study aimed to ...

journal_title：PLoS neglected tropical diseases

authors： Chen X,Munoz B,Mkocha H,Wolle MA,K West S

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Early warning systems (EWS) are management tools to predict the occurrence of epidemics of infectious diseases. While climate-based EWS have been developed for malaria, no standard protocol to evaluate and compare EWS has been proposed. Additionally, there are several neglected tropical diseases whose transm...

journal_title：PLoS neglected tropical diseases

authors： Chaves LF,Pascual M

更新日期：2007-10-22 00:00:00

abstract：:We recently reported that larval stage Aedes aegypti and several other species of mosquitoes grow when living bacteria are present in the gut but do not grow when living bacteria are absent. We further reported that living bacteria induce a hypoxia signal in the gut, which activates hypoxia-induced transcription facto...

journal_title：PLoS neglected tropical diseases

authors： Valzania L,Martinson VG,Harrison RE,Boyd BM,Coon KL,Brown MR,Strand MR

更新日期：2018-07-06 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0004470.]. ...

journal_title：PLoS neglected tropical diseases

authors： Decuypere S,Meehan CJ,Van Puyvelde S,De Block T,Maltha J,Palpouguini L,Tahita M,Tinto H,Jacobs J,Deborggraeve S

更新日期：2017-07-28 00:00:00

abstract：BACKGROUND:Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is comp...

journal_title：PLoS neglected tropical diseases

authors： Lestinova T,Rohousova I,Sima M,de Oliveira CI,Volf P

更新日期：2017-07-13 00:00:00

abstract：:Cutaneous leishmaniasis caused by Leishmania major is an emergent, uncontrolled public health problem and there is no vaccine. A promising prophylactic approach has been immunotherapy with Toll-like receptor (TLR) agonists to enhance parasite-specific immune responses. We have previously reported that vaccination of C...

journal_title：PLoS neglected tropical diseases

authors： Huang L,Hinchman M,Mendez S

更新日期：2015-03-04 00:00:00

abstract：:The vast burden of cryptococcal meningitis occurs in immunosuppressed patients, driven by HIV, and is caused by Cryptococcus neoformans var. grubii. We previously reported cryptococcal meningitis in Vietnam arising atypically in HIV uninfected, apparently immunocompetent patients, caused by a single amplified fragment...

journal_title：PLoS neglected tropical diseases

authors： Day JN,Qihui S,Thanh LT,Trieu PH,Van AD,Thu NH,Chau TTH,Lan NPH,Chau NVV,Ashton PM,Thwaites GE,Boni MF,Wolbers M,Nagarajan N,Tan PBO,Baker S

更新日期：2017-06-14 00:00:00

abstract：BACKGROUND:Central nervous system (CNS) infections are important diseases in both children and adults worldwide. The spectrum of infections is broad, encompassing bacterial/aseptic meningitis and encephalitis. Viruses are regarded as the most common causes of encephalitis and aseptic meningitis. Better understanding of...

journal_title：PLoS neglected tropical diseases

authors： Tan le V,Thai le H,Phu NH,Nghia HD,Chuong LV,Sinh DX,Phong ND,Mai NT,Man DN,Hien VM,Vinh NT,Day J,Chau NV,Hien TT,Farrar J,de Jong MD,Thwaites G,van Doorn HR,Chau TT

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:The range of the Asian tiger mosquito Aedes albopictus is expanding globally, raising the threat of emerging and re-emerging arbovirus transmission risks including dengue and chikungunya. Its detection in Papua New Guinea's (PNG) southern Fly River coastal region in 1988 and 1992 placed it 150 km from mainla...

journal_title：PLoS neglected tropical diseases

authors： Beebe NW,Ambrose L,Hill LA,Davis JB,Hapgood G,Cooper RD,Russell RC,Ritchie SA,Reimer LJ,Lobo NF,Syafruddin D,van den Hurk AF

更新日期：2013-08-08 00:00:00

abstract：:Schistosomiasis control and elimination has priority in public health agendas in several sub-Saharan countries. However, achieving these goals remains a substantial challenge. In order to assess progress of interventions and treatment efficacy it is pertinent to have accurate, feasible and affordable diagnostic tools....

journal_title：PLoS neglected tropical diseases

authors： Kildemoes AO,Vennervald BJ,Tukahebwa EM,Kabatereine NB,Magnussen P,de Dood CJ,Deelder AM,Wilson S,van Dam GJ

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:Third-stage larvae (L3) of the canine hookworm, Ancylostoma caninum, undergo arrested development preceding transmission to a host. Many of the mRNAs up-regulated at this stage are likely to encode proteins that facilitate the transition from a free-living to a parasitic larva. The initial phase of mammalian...

journal_title：PLoS neglected tropical diseases

authors： Datu BJ,Gasser RB,Nagaraj SH,Ong EK,O'Donoghue P,McInnes R,Ranganathan S,Loukas A

更新日期：2008-01-09 00:00:00

abstract：:Burkholderia pseudomallei causes the tropical infection melioidosis. Pneumonia is a common manifestation of melioidosis and is associated with high mortality. Understanding the key elements of host defense is essential to developing new therapeutics for melioidosis. As a flagellated bacterium encoding type III secreti...

journal_title：PLoS neglected tropical diseases

authors： West TE,Myers ND,Chantratita N,Chierakul W,Limmathurotsakul D,Wuthiekanun V,Miao EA,Hajjar AM,Peacock SJ,Liggitt HD,Skerrett SJ

更新日期：2014-09-18 00:00:00

abstract：BACKGROUND:The control of neglected tropical diseases (NTDs) has primarily focused on preventive chemotherapy and case management. Less attention has been placed on the role of ensuring access to adequate water, sanitation, and hygiene and personal preventive measures in reducing exposure to infection. Our aim was to a...

journal_title：PLoS neglected tropical diseases

authors： Tomczyk S,Deribe K,Brooker SJ,Clark H,Rafique K,Knopp S,Utzinger J,Davey G

更新日期：2014-11-13 00:00:00

abstract：BACKGROUND:Patients with New World cutaneous leishmaniasis (NWCL) caused by Leishmania Viannia are treated with parenteral sodium stibogluconate (SbV) to reduce the risk of development of mucocutanous leishmaniasis. Our centre manages patients with NWCL on an outpatient-basis. This study was conducted to assess the saf...

journal_title：PLoS neglected tropical diseases

authors： Wise ES,Armstrong MS,Watson J,Lockwood DN

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Burkholderia cepacia complex (Bcc) is a group of serious pathogens in cystic fibrosis patients and causes life threatening infections in immunocompromised patients. Species within the Bcc are widely distributed within the environment, can survive in the presence of disinfectants and antiseptics, and are inhe...

journal_title：PLoS neglected tropical diseases

authors： Farzana R,Jones LS,Rahman MA,Sands K,Portal E,Boostrom I,Kalam MA,Hasan B,Khan A,Walsh TR

更新日期：2020-04-09 00:00:00

abstract：BACKGROUND:Noma is a spreading and fulminant disease believed to be native to Sub-Saharan Africa over the last decade and associated with low socioeconomic status of citizens of the region. Within this noma belt, most epidemiological reports regarding the disease have emanated from the north western region of Nigeria. ...

journal_title：PLoS neglected tropical diseases

authors： Bello SA,Adeoye JA,Oketade I,Akadiri OA

更新日期：2019-07-22 00:00:00

abstract：INTRODUCTION:While we lack a complete understanding of the molecular mechanisms by which parasites establish and achieve protection from host immune responses, it is accepted that many of these processes are mediated by products, primarily proteins, released from the parasite. Parasitic nematodes occur in different lif...

journal_title：PLoS neglected tropical diseases

authors： Moreno Y,Geary TG

更新日期：2008-01-01 00:00:00

abstract：:Medical staff treating Coronavirus Disease 2019 (COVID-19) patients are at high risk for exposure to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and many have been infected, which may cause panic among medical workers, their relatives, health professionals, and government leaders. We report the epide...

journal_title：PLoS neglected tropical diseases

authors： Li J,Long X,Zhang Q,Fang X,Li N,Lin Z,Li J,Xiong N

更新日期：2020-12-22 00:00:00

abstract：BACKGROUND:The World Health Organization now recommends semiannual mass drug administration (MDA) of albendazole with integrated vector management as an option for eliminating lymphatic filariasis (LF) in areas of loiasis-endemic countries where it may not be safe to use diethylcarbamazine or ivermectin in MDA programs...

journal_title：PLoS neglected tropical diseases

authors： Pion SDS,Chesnais CB,Awaca-Uvon NP,Vlaminck J,Abdou A,Kunyu-Shako B,Kuyangisa Simuna G,Tambwe JP,Weil GJ,Boussinesq M

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. METHODOLOGY/PRINCIPAL FINDINGS:The TEN 11q/j isolate was characteriz...

journal_title：PLoS neglected tropical diseases

authors： Mikalová L,Strouhal M,Oppelt J,Grange PA,Janier M,Benhaddou N,Dupin N,Šmajs D

更新日期：2017-03-06 00:00:00

abstract：BACKGROUND:The treatment of Leishmaniasis caused by Leishmania (Viannia) guyanensis is based on a weak strength of evidence from very few clinical trials and some case series reports. Current treatment guidelines recommend pentamidine isethionate or meglumine antimoniate (Glucantime) as the first-line choices. Both are...

journal_title：PLoS neglected tropical diseases

authors： Francesconi VA,Francesconi F,Ramasawmy R,Romero GAS,Alecrim MDGC

更新日期：2018-02-26 00:00:00

abstract：BACKGROUND:Care to patients with Chagas disease (CD) is still a challenge for health systems in endemic and non-endemic countries. In the Brazilian public health system, the expansion of Primary Health Care (PHC) services to remote and disadvantaged areas has facilitated the access of patients with CD to medical care, ...

journal_title：PLoS neglected tropical diseases

authors： Damasceno RF,Sabino EC,Ferreira AM,Ribeiro ALP,Moreira HF,Prates TEC,Sampaio CA,Haikal DSA

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Protozoan parasites of the genus Leishmania cause a large spectrum of clinical manifestations known as Leishmaniases. These diseases are increasingly important public health problems in many countries both within and outside endemic regions. Thus, an accurate differential diagnosis is extremely relevant for ...

journal_title：PLoS neglected tropical diseases

authors： Zampieri RA,Laranjeira-Silva MF,Muxel SM,Stocco de Lima AC,Shaw JJ,Floeter-Winter LM

更新日期：2016-02-29 00:00:00

abstract：:The burden of leptospirosis in humans and animals in Africa is higher than that reported from other parts of the world. However, the disease is not routinely diagnosed in the continent. One of major factors limiting diagnosis is the poor availability of live isolates of locally circulating Leptospira serovars for incl...

journal_title：PLoS neglected tropical diseases

authors： Mgode GF,Machang'u RS,Mhamphi GG,Katakweba A,Mulungu LS,Durnez L,Leirs H,Hartskeerl RA,Belmain SR

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Real-Time PCR-High Resolution Melting (qPCR-HRM) analysis has been recently described for rapid drug susceptibility testing (DST) of Mycobacterium leprae. The purpose of the current study was to further evaluate the validity, reliability, and accuracy of this assay for M. leprae DST in clinical specimens. M...

journal_title：PLoS neglected tropical diseases

authors： Araujo S,Goulart LR,Truman RW,Goulart IMB,Vissa V,Li W,Matsuoka M,Suffys P,Fontes AB,Rosa PS,Scollard DM,Williams DL

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Salmonella Typhi is one of the leading health problems in Pakistan. With the emergence of extensively drug resistant (XDR) Salmonella Typhi, treatment options are limited. Here we report the clinical manifestations and the response to treatment of patients with XDR Typhoid fever. The patients were treated ...

journal_title：PLoS neglected tropical diseases

authors： Qureshi S,Naveed AB,Yousafzai MT,Ahmad K,Ansari S,Lohana H,Mukhtar A,Qamar FN

更新日期：2020-10-15 00:00:00

abstract：:Eukaryotes, protozoan, and helminth parasites make extensive use of protein kinases to control cellular functions, suggesting that protein kinases may represent novel targets for the development of anti-parasitic drugs. Because of their central role in intracellular signaling pathways, cyclic nucleotide-dependent kina...

journal_title：PLoS neglected tropical diseases

authors： Swierczewski BE,Davies SJ

更新日期：2009-08-25 00:00:00

abstract：BACKGROUND:Dengue is a serious vector-borne disease, and incidence rates have significantly increased during the past few years, particularly in 2014 in Guangzhou. The current situation is more complicated, due to various factors such as climate warming, urbanization, population increase, and human mobility. The purpos...

journal_title：PLoS neglected tropical diseases

authors： Zhu G,Liu J,Tan Q,Shi B

更新日期：2016-04-22 00:00:00