Failure of fluconazole in treating cutaneous leishmaniasis caused by Leishmania guyanensis in the Brazilian Amazon: An open, nonrandomized phase 2 trial.

abstract：BACKGROUND:The control of neglected tropical diseases (NTDs) has primarily focused on preventive chemotherapy and case management. Less attention has been placed on the role of ensuring access to adequate water, sanitation, and hygiene and personal preventive measures in reducing exposure to infection. Our aim was to a...

journal_title：PLoS neglected tropical diseases

authors： Tomczyk S,Deribe K,Brooker SJ,Clark H,Rafique K,Knopp S,Utzinger J,Davey G

更新日期：2014-11-13 00:00:00

abstract：BACKGROUND:The physiopathology of dengue hemorrhagic fever (DHF), a severe form of Dengue Fever, is poorly understood. We are unable to identify patients likely to progress to DHF for closer monitoring and early intervention during epidemics, so most cases are sent home. This study explored whether patients with select...

journal_title：PLoS neglected tropical diseases

authors： Figueiredo MA,Rodrigues LC,Barreto ML,Lima JW,Costa MC,Morato V,Blanton R,Vasconcelos PF,Nunes MR,Teixeira MG

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:After the elimination of leprosy in 1995, there were 10-30 newly detected leprosy cases every year in Zhejiang Province, and the epidemiological characteristics of the newly detected leprosy cases have changed. While most of the newly detected cases came from other provinces in China, not Zhejiang, it brough...

journal_title：PLoS neglected tropical diseases

authors： Wu L,Shen Y,Yao Q,Sang X,Fei L,Kong W,Huang Y,Wang Y,Zeng F,Du N

更新日期：2021-01-07 00:00:00

abstract：:The area of Walikale in North Kivu, Democratic Republic of Congo, is intensely affected by conflict and population displacement. Médecins-Sans-Frontières (MSF) returned to provide primary healthcare in July 2012. To better understand the impact of the ongoing conflict and displacement on the population, a retrospectiv...

journal_title：PLoS neglected tropical diseases

authors： Carrión Martín AI,Bil K,Salumu P,Baabo D,Singh J,Kik C,Lenglet A

更新日期：2014-09-18 00:00:00

abstract：:Burkholderia pseudomallei, the bacterial agent of melioidosis, causes disease through inhalation of infectious particles, and is classified as a Tier 1 Select Agent. Optical diagnostic imaging has demonstrated that murine respiratory disease models are subject to significant upper respiratory tract (URT) colonization....

journal_title：PLoS neglected tropical diseases

authors： Gutierrez MG,Pfeffer TL,Warawa JM

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei, a Tier 1 Select Agent and the cause of melioidosis, is a Gram-negative bacillus present in the environment in many tropical countries. Defining the global pattern of B. pseudomallei distribution underpins efforts to prevent infection, and is dependent upon robust environmental samp...

journal_title：PLoS neglected tropical diseases

authors： Limmathurotsakul D,Dance DA,Wuthiekanun V,Kaestli M,Mayo M,Warner J,Wagner DM,Tuanyok A,Wertheim H,Yoke Cheng T,Mukhopadhyay C,Puthucheary S,Day NP,Steinmetz I,Currie BJ,Peacock SJ

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:While we lack a complete understanding of the molecular mechanisms by which parasites establish and achieve protection from host immune responses, it is accepted that many of these processes are mediated by products, primarily proteins, released from the parasite. Parasitic nematodes occur in different lif...

journal_title：PLoS neglected tropical diseases

authors： Moreno Y,Geary TG

更新日期：2008-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0008129.]. ...

journal_title：PLoS neglected tropical diseases

authors： Alzaylaee H,Collins RA,Rinaldi G,Shechonge A,Ngatunga B,Morgan ER,Genner MJ

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Marburg virus (MARV), a zoonotic pathogen causing severe hemorrhagic fever in man, has emerged in Angola resulting in the largest outbreak of Marburg hemorrhagic fever (MHF) with the highest case fatality rate to date. METHODOLOGY/PRINCIPAL FINDINGS:A mobile laboratory unit (MLU) was deployed as part of the...

journal_title：PLoS neglected tropical diseases

authors： Grolla A,Jones SM,Fernando L,Strong JE,Ströher U,Möller P,Paweska JT,Burt F,Pablo Palma P,Sprecher A,Formenty P,Roth C,Feldmann H

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Area-wide integrated pest management strategies that include a sterile insect technique component have been successfully used to eradicate tsetse fly populations in the past. To ensure the success of the sterile insect technique, the released males must be adequately sterile and be able to compete with their...

journal_title：PLoS neglected tropical diseases

authors： de Beer CJ,Moyaba P,Boikanyo SN,Majatladi D,Yamada H,Venter GJ,Vreysen MJ

更新日期：2017-03-17 00:00:00

abstract：BACKGROUND:Scabies is a disease of worldwide significance, causing considerable morbidity in both humans and other animals. The scabies mite Sarcoptes scabiei burrows into the skin of its host, obtaining nutrition from host skin and blood. Aspartic proteases mediate a range of diverse and essential physiological functi...

journal_title：PLoS neglected tropical diseases

authors： Mahmood W,Viberg LT,Fischer K,Walton SF,Holt DC

更新日期：2013-11-07 00:00:00

abstract：:Rabies virus kills tens of thousands of people globally each year, especially in resource-limited countries. Yet, there are genetically- and antigenically-related lyssaviruses, all capable of causing the disease rabies, circulating globally among bats without causing conspicuous disease outbreaks. The species richness...

journal_title：PLoS neglected tropical diseases

authors： Hayman DT,Fooks AR,Marston DA,Garcia-R JC

更新日期：2016-12-30 00:00:00

abstract：BACKGROUND:Epidemiological studies carried out using culture or microscopy in most of the amoebiasis endemic developing countries, yielded confusing results since none of these could differentiate the pathogenic Entamoeba histolytica from the non-pathogenic Entamoeba dispar and Entamoeba moshkovskii. The Northeastern p...

journal_title：PLoS neglected tropical diseases

authors： Nath J,Ghosh SK,Singha B,Paul J

更新日期：2015-12-03 00:00:00

abstract：BACKGROUND:The cestode Echinococcus granulosus--the agent of cystic echinococcosis, a zoonosis affecting humans and domestic animals worldwide--is an excellent model for the study of host-parasite cross-talk that interfaces with two mammalian hosts. To develop the molecular analysis of these interactions, we carried ou...

journal_title：PLoS neglected tropical diseases

authors： Parkinson J,Wasmuth JD,Salinas G,Bizarro CV,Sanford C,Berriman M,Ferreira HB,Zaha A,Blaxter ML,Maizels RM,Fernández C

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is a major public health concern in Turkey and Sanliurfa represents the most endemic city in Turkey. Although children are most commonly affected by CL, detailed studies of pediatric CL in Turkey are lacking. METHODOLOGY/PRINCIPAL FINDINGS:In this report we retrospectively evalu...

journal_title：PLoS neglected tropical diseases

authors： Aksoy M,Doni N,Ozkul HU,Yesilova Y,Ardic N,Yesilova A,Ahn-Jarvis J,Oghumu S,Terrazas C,Satoskar AR

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:Trichinellosis is a serious zoonositc parasitosis worldwide. Because its clinical manifestations aren't specific, the diagnosis of trichinellosis is not easy to be made. Trichinella spiralis muscle larva (ML) excretory-secretory (ES) antigens are the most widely applied diagnostic antigens for human trichine...

journal_title：PLoS neglected tropical diseases

authors： Sun GG,Song YY,Jiang P,Ren HN,Yan SW,Han Y,Liu RD,Zhang X,Wang ZQ,Cui J

更新日期：2018-05-14 00:00:00

abstract：BACKGROUND:Dengue is endemic in the Western Pacific and Oceania and the region reports more than 200,000 cases annually. Outbreaks of dengue and severe dengue occur regularly and movement of virus throughout the region has been reported. Disease surveillance systems, however, in many areas are not fully established and...

journal_title：PLoS neglected tropical diseases

authors： Luang-Suarkia D,Mitja O,Ernst T,Bennett S,Tay A,Hays R,Smith DW,Imrie A

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Trachoma programs rely on guidelines made in large part using expert opinion of what will happen with and without intervention. Large community-randomized trials offer an opportunity to actually compare forecasting methods in a masked fashion. METHODS:The Program for the Rapid Elimination of Trachoma trials...

journal_title：PLoS neglected tropical diseases

authors： Liu F,Porco TC,Amza A,Kadri B,Nassirou B,West SK,Bailey RL,Keenan JD,Solomon AW,Emerson PM,Gambhir M,Lietman TM

更新日期：2015-08-24 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease possess extensive genetic diversity. This has led to the development of a plethora of molecular typing methods for the identification of both the known major genetic lineages and for more fine scale characterization of different multilocus genotypes within th...

journal_title：PLoS neglected tropical diseases

authors： Diosque P,Tomasini N,Lauthier JJ,Messenger LA,Monje Rumi MM,Ragone PG,Alberti-D'Amato AM,Pérez Brandán C,Barnabé C,Tibayrenc M,Lewis MD,Llewellyn MS,Miles MA,Yeo M

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distribution remains highly uncertain. Challenges in diagnosis and diagnostic methods as well as highly variable national health systems mean no single data source can reliably estimate the distribution o...

journal_title：PLoS neglected tropical diseases

authors： Brady OJ,Gething PW,Bhatt S,Messina JP,Brownstein JS,Hoen AG,Moyes CL,Farlow AW,Scott TW,Hay SI

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Leptospirosis is a neglected zoonosis affecting animals and humans caused by infection with Leptospira. The bacteria can survive outside of hosts for long periods of time in soil and water. While identification of Leptospira species from human cases and animal reservoirs are increasingly reported, little is ...

journal_title：PLoS neglected tropical diseases

authors： Mason MR,Encina C,Sreevatsan S,Muñoz-Zanzi C

更新日期：2016-08-16 00:00:00

abstract：BACKGROUND:The success of the global strategy to eliminate lymphatic filariasis (LF) through mass drug administration (MDA) campaigns is dependent on meeting high coverage levels over long periods of time. Community engagement plays a critical role in driving coverage and involvement of local communities in MDA for LF....

journal_title：PLoS neglected tropical diseases

authors： Silumbwe A,Halwindi H,Zulu JM

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:A cluster of eleven patients, including eight family members and three healthcare workers with fever and thrombocytopenia occurred in Yixing County, Jiangsu Province, China, from October to November 1996. However, the initial investigation failed to identify its etiology. Severe fever with thrombocytopenia s...

journal_title：PLoS neglected tropical diseases

authors： Hu J,Shi C,Li Z,Guo X,Qian Y,Tan W,Li X,Qi X,Su X,Zhou M,Wang H,Jiao Y,Bao C

更新日期：2018-06-25 00:00:00

abstract：:Entamoeba histolytica, a microaerophilic enteric protozoan parasite, causes amebic colitis and extra intestinal abscesses in millions of inhabitants of endemic areas. Trophozoites of E. histolytica are exposed to a variety of reactive oxygen and nitrogen species during infection. Since E. histolytica lacks key compone...

journal_title：PLoS neglected tropical diseases

authors： Husain A,Sato D,Jeelani G,Soga T,Nozaki T

更新日期：2012-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0005370.]. ...

journal_title：PLoS neglected tropical diseases

authors： Loos JA,Dávila VA,Rodriguez Rodrigues C,Petrigh R,Zoppi JA,Crocenzi FA,Cumino AC

更新日期：2017-03-22 00:00:00

abstract：BACKGROUND:Mosquito-borne viral diseases cause significant burden in much of the developing world. Although host-virus interactions have been studied extensively in the vertebrate host, little is known about mosquito responses to viral infection. In contrast to mosquitoes of the Aedes and Culex genera, Anopheles gambia...

journal_title：PLoS neglected tropical diseases

authors： Waldock J,Olson KE,Christophides GK

更新日期：2012-01-01 00:00:00

abstract：:Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lea...

journal_title：PLoS neglected tropical diseases

authors： Geary TG,Mackenzie CD,Silber SA

更新日期：2019-01-16 00:00:00

abstract：:Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use. Our aim was to discover antigens for the detection of antibodies to Trypanosoma congo...

journal_title：PLoS neglected tropical diseases

authors： Fleming JR,Sastry L,Crozier TW,Napier GB,Sullivan L,Ferguson MA

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:While considerable genomic and transcriptomic data are available for Schistosoma mansoni, many of its genes lack significant annotation. A transcriptomic study of individual tissues and organs of schistosomes could play an important role in functional annotation of the unknown genes, particularly by providin...

journal_title：PLoS neglected tropical diseases

authors： Nawaratna SS,McManus DP,Moertel L,Gobert GN,Jones MK

更新日期：2011-04-26 00:00:00

abstract：:Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyanogen consumption fr...

journal_title：PLoS neglected tropical diseases

authors： Nzwalo H,Cliff J

更新日期：2011-06-01 00:00:00