Multiple Crimean-Congo hemorrhagic fever virus strains are associated with disease outbreaks in Sudan, 2008-2009.

abstract：:Zika virus (ZIKV) is an arbovirus primarily transmitted by Aedes mosquitoes. Like most viral infections, ZIKV viremia varies over several orders of magnitude, with unknown consequences for transmission. To determine the effect of viral concentration on ZIKV transmission risk, we exposed field-derived Ae. aegypti mosqu...

journal_title：PLoS neglected tropical diseases

authors： Tesla B,Demakovsky LR,Packiam HS,Mordecai EA,Rodríguez AD,Bonds MH,Brindley MA,Murdock CC

更新日期：2018-08-22 00:00:00

abstract：:Delivery of various forms of recombinant Theileria parva sporozoite antigen (p67) has been shown to elicit antibody responses in cattle capable of providing protection against East Coast fever, the clinical disease caused by T. parva. Previous formulations of full-length and shorter recombinant versions of p67 derived...

journal_title：PLoS neglected tropical diseases

authors： Tebaldi G,Williams LB,Verna AE,Macchi F,Franceschi V,Fry LM,Knowles DP,Donofrio G

更新日期：2017-08-11 00:00:00

abstract：BACKGROUND:Phlebotomus tobbi is a vector of Leishmania infantum, and P. sergenti is a vector of Leishmania tropica. Le. infantum and Le. tropica typically cause visceral or cutaneous leishmaniasis, respectively, but Le. infantum strains transmitted by P. tobbi can cause cutaneous disease. To better understand the compo...

journal_title：PLoS neglected tropical diseases

authors： Rohoušová I,Subrahmanyam S,Volfová V,Mu J,Volf P,Valenzuela JG,Jochim RC

更新日期：2012-01-01 00:00:00

abstract：:Helminth parasites are an assemblage of two major phyla of nematodes (also known as roundworms) and platyhelminths (also called flatworms). These parasites are a major human health burden, and infections caused by helminths are considered under neglected tropical diseases (NTDs). These infections are typified by limit...

journal_title：PLoS neglected tropical diseases

authors： Sharma A,Sharma M,Yogavel M,Sharma A

更新日期：2016-11-02 00:00:00

abstract：:Tsetse flies (Glossina spp.) transmit parasitic African trypanosomes (Trypanosoma spp.), including Trypanosoma congolense, which causes animal African trypanosomiasis (AAT). AAT detrimentally affects agricultural activities in sub-Saharan Africa and has negative impacts on the livelihood and nutrient availability for ...

journal_title：PLoS neglected tropical diseases

authors： Awuoche EO,Weiss BL,Vigneron A,Mireji PO,Aksoy E,Nyambega B,Attardo GM,Wu Y,O'Neill M,Murilla G,Aksoy S

更新日期：2017-11-20 00:00:00

abstract：BACKGROUND:Schistosome eggs must traverse tissues of the intestine or bladder to escape the human host and further the life cycle. Escape from host tissues is facilitated by secretion of immuno-reactive molecules by eggs and the formation of an intense strong granulomatous response by the host which acts to exclude the...

journal_title：PLoS neglected tropical diseases

authors： Jones MK,Bong SH,Green KM,Holmes P,Duke M,Loukas A,McManus DP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not yet available and the severe side-effects of the drugs in clinical use, linked to the parenteral administration route of most of them, are si...

journal_title：PLoS neglected tropical diseases

authors： Calvo-Álvarez E,Stamatakis K,Punzón C,Álvarez-Velilla R,Tejería A,Escudero-Martínez JM,Pérez-Pertejo Y,Fresno M,Balaña-Fouce R,Reguera RM

更新日期：2015-03-31 00:00:00

abstract：:Plague, a zoonosis caused by Yersinia pestis, is still found in Africa, Asia, and the Americas. Madagascar reports almost one third of the cases worldwide. Y. pestis can be encountered in three very different types of foci: urban, rural, and sylvatic. Flea vector and wild rodent host population dynamics are tightly co...

journal_title：PLoS neglected tropical diseases

authors： Andrianaivoarimanana V,Kreppel K,Elissa N,Duplantier JM,Carniel E,Rajerison M,Jambou R

更新日期：2013-11-07 00:00:00

abstract：BACKGROUND:Melioidosis is a severe bacterial infection caused by Burkholderia pseudomallei with a high case-fatality rate. Epidemiological and animal studies show the possibility of inhalation transmission. However, no B. pseudomallei concentrations in ambient air have been researched. Here, we developed a method to qu...

journal_title：PLoS neglected tropical diseases

authors： Chen YL,Yen YC,Yang CY,Lee MS,Ho CK,Mena KD,Wang PY,Chen PS

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:The objectives of this study were to 1) evaluate the influence of treatment with praziquantel on the inflammatory milieu in maternal, placental, and cord blood, 2) assess the extent to which proinflammatory signatures in placental and cord blood impacts birth outcomes, and 3) evaluate the impact of other hel...

journal_title：PLoS neglected tropical diseases

authors： Abioye AI,McDonald EA,Park S,Joshi A,Kurtis JD,Wu H,Pond-Tor S,Sharma S,Ernerudh J,Baltazar P,Acosta LP,Olveda RM,Tallo V,Friedman JF

更新日期：2019-06-12 00:00:00

abstract：BACKGROUND:Large-scale deworming programs have, to date, mostly targeted preschool- and school-age children. As community-based deworming programs become more common, deworming will be offered to women of reproductive age. The World Health Organization recommends preventive chemotherapy be administered to pregnant wome...

journal_title：PLoS neglected tropical diseases

authors： St-Denis K,Blouin B,Rahme E,Casapia M,Montresor A,Mupfasoni D,Mbabazi PS,Gyorkos TW

更新日期：2020-01-30 00:00:00

abstract：:Rickettsia (R.) helvetica is the most prevalent rickettsia found in Ixodes ricinus ticks in Germany. Several studies reported antibodies against R. helvetica up to 12.5% in humans investigated, however, fulminant clinical cases are rare indicating a rather low pathogenicity compared to other rickettsiae. We investigat...

journal_title：PLoS neglected tropical diseases

authors： Speck S,Kern T,Aistleitner K,Dilcher M,Dobler G,Essbauer S

更新日期：2018-02-12 00:00:00

abstract：:Aedes aegypti is the primary vector of several medically relevant arboviruses including dengue virus (DENV) types 1-4. Ae. aegypti transmits DENV by inoculating virus-infected saliva into host skin during probing and feeding. Ae. aegypti saliva contains over one hundred unique proteins and these proteins have diverse ...

journal_title：PLoS neglected tropical diseases

authors： Conway MJ,Londono-Renteria B,Troupin A,Watson AM,Klimstra WB,Fikrig E,Colpitts TM

更新日期：2016-09-15 00:00:00

abstract：INTRODUCTION:Buruli Ulcer (BU) is caused by the environmental microbe Mycobacterium ulcerans. Despite unclear transmission, contact with a BU endemic region is the key known risk factor. In Victoria, Australia, where endemic areas have been carefully mapped, we aimed to estimate the Incubation Period (IP) of BU by inte...

journal_title：PLoS neglected tropical diseases

authors： Trubiano JA,Lavender CJ,Fyfe JA,Bittmann S,Johnson PD

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:Imported strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported strongyloidiasis in Spain. METHODOLOGY:This is an observational retrospective study that included ...

journal_title：PLoS neglected tropical diseases

authors： Salvador F,Treviño B,Chamorro-Tojeiro S,Sánchez-Montalvá A,Herrero-Martínez JM,Rodríguez-Guardado A,Serre-Delcor N,Torrús D,Goikoetxea J,Zubero Z,Velasco M,Sulleiro E,Molina I,López-Vélez R,Pérez-Molina JA,on behalf the +RE

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:Zika (ZIKV) and Chikungunya (CHIKV) viruses are emerging Aedes-borne viruses that are spreading outside their known geographic range and causing wide-scale epidemics. It has been reported that these viruses can be transmitted efficiently by Ae. aegypti. Recent studies have shown that Ae. aegypti when transin...

journal_title：PLoS neglected tropical diseases

authors： Tan CH,Wong PJ,Li MI,Yang H,Ng LC,O'Neill SL

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:The high rate of leprosy cases among children under 15 years of age in Brazil indicates ongoing transmission within the community. The identification of the new leprosy cases among contacts can help identify the source of infection and interrupt the transmission chain. This study aims to determine the detect...

journal_title：PLoS neglected tropical diseases

authors： Pedrosa VL,Dias LC,Galban E,Leturiondo A,Palheta J Jr,Santos M,Moraes MO,Talhari C

更新日期：2018-02-26 00:00:00

abstract：:Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators have demonstrated that Ots encodes five different autotransporter domain (ATD) proteins (ScaA-ScaE). ScaA functions as an adhesin and confers protective immunity in a lethal mouse model of Ots...

journal_title：PLoS neglected tropical diseases

authors： Koralur MC,Ramaiah A,Dasch GA

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are responsible for a substantial health and economic burden, particularly to low-income societies. Quan...

journal_title：PLoS neglected tropical diseases

authors： Otero-Abad B,Torgerson PR

更新日期：2013-06-06 00:00:00

abstract：BACKGROUND:treatment of Mycobacterium ulcerans disease, or Buruli ulcer (BU), has shifted from surgery to treatment with streptomycin(STR)+rifampin(RIF) since 2004 based on studies in a mouse model and clinical trials. We tested two entirely oral regimens for BU treatment, rifampin(RIF)+clarithromycin(CLR) and rifapent...

journal_title：PLoS neglected tropical diseases

authors： Almeida D,Converse PJ,Ahmad Z,Dooley KE,Nuermberger EL,Grosset JH

更新日期：2011-01-04 00:00:00

abstract：BACKGROUND:Intestinal schistosomiasis and soil-transmitted helminth (STH) infections constitute major public health problems in many parts of sub-Saharan Africa. In this study we examined the functional significance of such polyparasite infections in anemia and undernutrition in Rwandan individuals. METHODS:Three poly...

journal_title：PLoS neglected tropical diseases

authors： Mupfasoni D,Karibushi B,Koukounari A,Ruberanziza E,Kaberuka T,Kramer MH,Mukabayire O,Kabera M,Nizeyimana V,Deville MA,Ruxin J,Webster JP,Fenwick A

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:On the Zanzibar islands, United Republic of Tanzania, elimination of urogenital schistosomiasis is strived for in the coming years. This qualitative study aimed to better understand community knowledge, perceptions, and practices associated with schistosomiasis among school-aged children on Unguja and Pemba ...

journal_title：PLoS neglected tropical diseases

authors： Person B,Ali SM,A'Kadir FM,Ali JN,Mohammed UA,Mohammed KA,Rollinson D,Knopp S

更新日期：2016-07-11 00:00:00

abstract：BACKGROUND:The caterpillar of the moth Premolis semirufa (Lepidoptera: Arctiidae), commonly named Pararama, is endemic of the Amazon basin. Accidental contact with these caterpillar bristles causes local symptoms such as intense heat, pain, edema and itching which last for three to seven days; however, after multiples ...

journal_title：PLoS neglected tropical diseases

authors： Villas-Boas IM,Gonçalves-de-Andrade RM,Pidde-Queiroz G,Assaf SL,Portaro FC,Sant'Anna OA,van den Berg CW,Tambourgi DV

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. Pharmacological...

journal_title：PLoS neglected tropical diseases

authors： Tzertzinis G,Egaña AL,Palli SR,Robinson-Rechavi M,Gissendanner CR,Liu C,Unnasch TR,Maina CV

更新日期：2010-03-09 00:00:00

abstract：:To control and prevent rabies in Latin America, mass dog vaccination campaigns (MDVC) are implemented mainly through fixed-location vaccination points: owners have to bring their dogs to the vaccination points where they receive the vaccination free of charge. Dog rabies is still endemic in some Latin-American countri...

journal_title：PLoS neglected tropical diseases

authors： Castillo-Neyra R,Toledo AM,Arevalo-Nieto C,MacDonald H,De la Puente-León M,Naquira-Velarde C,Paz-Soldan VA,Buttenheim AM,Levy MZ

更新日期：2019-08-01 00:00:00

abstract：:Mycobacterium tuberculosis complex (MTBC) comprises closely related species responsible for human and animal tuberculosis (TB). Efficient species determination is useful for epidemiological purposes, especially for the elucidation of the zoonotic contribution. In Algeria, data on MTBC genotypes are largely unknown. In...

journal_title：PLoS neglected tropical diseases

authors： Damene H,Tahir D,Diels M,Berber A,Sahraoui N,Rigouts L

更新日期：2020-11-30 00:00:00

abstract：:The immunomodulatory properties of lipophosphoglycans (LPG) from New World species of Leishmania have been assessed in Leishmania infantum and Leishmania braziliensis, the causative agents of visceral and cutaneous leishmaniasis, respectively. This glycoconjugate is highly polymorphic among species with variation in s...

journal_title：PLoS neglected tropical diseases

authors： Nogueira PM,Assis RR,Torrecilhas AC,Saraiva EM,Pessoa NL,Campos MA,Marialva EF,Ríos-Velasquez CM,Pessoa FA,Secundino NF,Rugani JN,Nieves E,Turco SJ,Melo MN,Soares RP

更新日期：2016-08-10 00:00:00

abstract：:We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse ...

journal_title：PLoS neglected tropical diseases

authors： Morizot G,Jouffroy R,Faye A,Chabert P,Belhouari K,Calin R,Charlier C,Miailhes P,Siriez JY,Mouri O,Yera H,Gilquin J,Tubiana R,Lanternier F,Mamzer MF,Legendre C,Peyramond D,Caumes E,Lortholary O,Buffet P

更新日期：2016-01-06 00:00:00

abstract：BACKGROUND:Aminoacyl tRNA synthetases are central enzymes required for protein synthesis. These enzymes are the known drug targets in bacteria and fungi. Here, we for the first time report the functional characterization of threonyl tRNA synthetase (LdThrRS) of Leishmania donovani, a protozoan parasite, the primary cau...

journal_title：PLoS neglected tropical diseases

authors： Chadha S,Vijayan R,Gupta S,Munde M,Gourinath S,Madhubala R

更新日期：2018-06-13 00:00:00

abstract：BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) is a major diarrheal pathogen in developing countries, where it accounts for millions of infections and hundreds of thousands of deaths annually. While vaccine development to prevent diarrheal illness due to ETEC is feasible, extensive effort is needed to identify cons...

journal_title：PLoS neglected tropical diseases

authors： Harris JA,Roy K,Woo-Rasberry V,Hamilton DJ,Kansal R,Qadri F,Fleckenstein JM

更新日期：2011-12-01 00:00:00