Zika virus infection in the Veterans Health Administration (VHA), 2015-2016.


BACKGROUND:Zika virus (ZIKV) is an important flavivirus infection. Although ZIKV infection is rarely fatal, risk for severe disease in adults is not well described. Our objective was to describe the spectrum of illness in U.S. Veterans with ZIKV infection. METHODOLOGY:Case series study including patients with laboratory-confirmed or presumed positive ZIKV infection in all Veterans Health Administration (VHA) medical centers. Adjusted odds ratios of clinical variables associated with hospitalization and neurologic complications was performed. PRINCIPAL FINDINGS:Of 1,538 patients tested between 12/2015-10/2016 and observed through 3/2017, 736 (48%) were RT-PCR or confirmed IgM positive; 655 (89%) were male, and 683 (93%) from VA Caribbean Healthcare System (VACHCS). Ninety-four (13%) were hospitalized, 91 (12%) in the VACHCS. Nineteen (3%) died after ZIKV infection. Hospitalization was associated with increased Charlson co-morbidity index (adjusted odds ratio [OR] 1.2; 95% confidence interval [CI], 1.1-1.3), underlying connective tissue disease (OR, 29.5; CI, 3.6-244.7), congestive heart failure (OR, 6; CI, 2-18.5), dementia (OR, 3.6; CI, 1.1-11.2), neurologic symptom presentation (OR, 3.9; CI, 1.7-9.2), leukocytosis (OR, 11.8; CI, 4.5-31), thrombocytopenia (OR, 7.8; CI, 3.3-18.6), acute kidney injury (OR, 28.9; CI, 5.8-145.1), or using glucocorticoids within 30 days of testing (OR, 13.3; CI 1.3-133). Patients presenting with rash were less likely to be hospitalized (OR, 0.29; CI, 0.13-0.66). Risk for neurologic complications increased with hospitalization (OR, 5.9; CI 2.9-12.2), cerebrovascular disease (OR 4.9; CI 1.7-14.4), and dementia (OR 2.8; CI 1.2-6.6). CONCLUSION:Older Veterans with multiple comorbidities or presenting with neurologic symptoms were at increased risk for hospitalization and neurological complications after ZIKV infection.


PLoS Negl Trop Dis


Schirmer PL,Wendelboe A,Lucero-Obusan CA,Ryono RA,Winters MA,Oda G,Martinez M,Saavedra S,Holodniy M




Has Abstract


2018-05-24 00:00:00














  • Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil.

    abstract::Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Nunes MR,Palacios G,Faria NR,Sousa EC Jr,Pantoja JA,Rodrigues SG,Carvalho VL,Medeiros DB,Savji N,Baele G,Suchard MA,Lemey P,Vasconcelos PF,Lipkin WI

    更新日期:2014-04-17 00:00:00

  • Chagas cardiomyopathy in the context of the chronic disease transition.

    abstract:BACKGROUND:Patients with Chagas disease have migrated to cities, where obesity, hypertension and other cardiac risk factors are common. METHODOLOGY/PRINCIPAL FINDINGS:The study included adult patients evaluated by the cardiology service in a public hospital in Santa Cruz, Bolivia. Data included risk factors for T. cru...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Hidron AI,Gilman RH,Justiniano J,Blackstock AJ,Lafuente C,Selum W,Calderon M,Verastegui M,Ferrufino L,Valencia E,Tornheim JA,O'Neal S,Comer R,Galdos-Cardenas G,Bern C,Chagas Disease Working Group in Peru and Bolivia.

    更新日期:2010-05-18 00:00:00

  • A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital.

    abstract:BACKGROUND:Salmonella serovars Typhi (S. Typhi) and Paratyphi A (S. Paratyphi A), the causative agents of enteric fever, have been routinely isolated organisms from the blood of febrile patients in the Kathmandu Valley since the early 1990s. Susceptibility against commonly used antimicrobials for treating enteric fever...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Zellweger RM,Basnyat B,Shrestha P,Prajapati KG,Dongol S,Sharma PK,Koirala S,Darton TC,Dolecek C,Thompson CN,Thwaites GE,Baker SG,Karkey A

    更新日期:2017-11-27 00:00:00

  • Congenital toxoplasmosis in Austria: Prenatal screening for prevention is cost-saving.

    abstract:BACKGROUND:Primary infection of Toxoplasma gondii during pregnancy can be transmitted to the unborn child and may have serious consequences, including retinochoroiditis, hydrocephaly, cerebral calcifications, encephalitis, splenomegaly, hearing loss, blindness, and death. Austria, a country with moderate seroprevalence...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Prusa AR,Kasper DC,Sawers L,Walter E,Hayde M,Stillwaggon E

    更新日期:2017-07-10 00:00:00

  • Household transmission of leptospira infection in urban slum communities.

    abstract:BACKGROUND:Leptospirosis, a spirochaetal zoonotic disease, is the cause of epidemics associated with high mortality in urban slum communities. Infection with pathogenic Leptospira occurs during environmental exposures and is traditionally associated with occupational risk activities. However, slum inhabitants reside in...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Maciel EA,de Carvalho AL,Nascimento SF,de Matos RB,Gouveia EL,Reis MG,Ko AI

    更新日期:2008-01-30 00:00:00

  • Increased risk for Entamoeba histolytica infection and invasive amebiasis in HIV seropositive men who have sex with men in Taiwan.

    abstract:BACKGROUND:Incidence of Entamoeba histolytica infection and clinical manifestations and treatment response of invasive amebiasis (IA) in HIV-infected patients have rarely been investigated before. METHODOLOGY/PRINCIPAL FINDINGS:At the National Taiwan University Hospital, medical records of HIV-infected patients who re...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Hung CC,Ji DD,Sun HY,Lee YT,Hsu SY,Chang SY,Wu CH,Chan YH,Hsiao CF,Liu WC,Colebunders R

    更新日期:2008-02-27 00:00:00

  • Transcriptional changes in the hookworm, Ancylostoma caninum, during the transition from a free-living to a parasitic larva.

    abstract:BACKGROUND:Third-stage larvae (L3) of the canine hookworm, Ancylostoma caninum, undergo arrested development preceding transmission to a host. Many of the mRNAs up-regulated at this stage are likely to encode proteins that facilitate the transition from a free-living to a parasitic larva. The initial phase of mammalian...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Datu BJ,Gasser RB,Nagaraj SH,Ong EK,O'Donoghue P,McInnes R,Ranganathan S,Loukas A

    更新日期:2008-01-09 00:00:00

  • Tissue invasion by Entamoeba histolytica: evidence of genetic selection and/or DNA reorganization events in organ tropism.

    abstract::Entamoeba histolytica infection may have various clinical manifestations. Nine out of ten E. histolytica infections remain asymptomatic, while the remainder become invasive and cause disease. The most common form of invasive infection is amebic diarrhea and colitis, whereas the most common extra-intestinal disease is ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Ali IK,Solaymani-Mohammadi S,Akhter J,Roy S,Gorrini C,Calderaro A,Parker SK,Haque R,Petri WA Jr,Clark CG

    更新日期:2008-04-09 00:00:00

  • Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin.

    abstract::Leishmaniasis is a serious global health problem affecting many people worldwide. While patients with leishmaniasis can be treated with several agents, drug toxicicty and the emergence of resistant strains render available treatments ineffective in the long run. Inhibitors of the mammalian target of rapamycin (mTOR) h...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Khadir F,Shaler CR,Oryan A,Rudak PT,Mazzuca DM,Taheri T,Dikeakos JD,Haeryfar SMM,Rafati S

    更新日期:2018-08-22 00:00:00

  • The additional benefit of residual spraying and insecticide-treated curtains for dengue control over current best practice in Cuba: Evaluation of disease incidence in a cluster randomized trial in a low burden setting with intensive routine control.

    abstract:BACKGROUND:Aedes control interventions are considered the cornerstone of dengue control programmes, but there is scarce evidence on their effect on disease. We set-up a cluster randomized controlled trial in Santiago de Cuba to evaluate the entomological and epidemiological effectiveness of periodical intra- and peri-d...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,随机对照试验


    authors: Toledo ME,Vanlerberghe V,Rosales JP,Mirabal M,Cabrera P,Fonseca V,Gómez Padrón T,Pérez Menzies M,Montada D,Van der Stuyft P

    更新日期:2017-11-08 00:00:00

  • Evidence that lipopolisaccharide may contribute to the cytokine storm and cellular activation in patients with visceral leishmaniasis.

    abstract:BACKGROUND:Visceral leishmaniasis (VL) is characterized by parasite-specific immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide (LPS) has been implicated in the immune activation of T-cell deficient diseases such as HIV/AIDS and idiopathic lymphocytopenia. The source of LPS is gram-negat...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Santos-Oliveira JR,Regis EG,Leal CR,Cunha RV,Bozza PT,Da-Cruz AM

    更新日期:2011-07-01 00:00:00

  • Evaluation of the health-related quality of life of children in Schistosoma haematobium-endemic communities in Kenya: a cross-sectional study.

    abstract:BACKGROUND:Schistosomiasis remains a global public health challenge, with 93% of the ~237 million infections occurring in sub-Saharan Africa. Though rarely fatal, its recurring nature makes it a lifetime disorder with significant chronic health burdens. Much of its negative health impact is due to non-specific conditio...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Terer CC,Bustinduy AL,Magtanong RV,Muhoho N,Mungai PL,Muchiri EM,Kitron U,King CH,Mutuku FM

    更新日期:2013-01-01 00:00:00

  • Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening.

    abstract::The potential use of clinically approved beta-lactams for Buruli ulcer (BU) treatment was investigated with representative classes analyzed in vitro for activity against Mycobacterium ulcerans. Beta-lactams tested were effective alone and displayed a strong synergistic profile in combination with antibiotics currently...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Arenaz-Callao MP,González Del Río R,Lucía Quintana A,Thompson CJ,Mendoza-Losana A,Ramón-García S

    更新日期:2019-01-28 00:00:00

  • Neutropenic Mice Provide Insight into the Role of Skin-Infiltrating Neutrophils in the Host Protective Immunity against Filarial Infective Larvae.

    abstract::Our knowledge and control of the pathogenesis induced by the filariae remain limited due to experimental obstacles presented by parasitic nematode biology and the lack of selective prophylactic or curative drugs. Here we thought to investigate the role of neutrophils in the host innate immune response to the infection...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Pionnier N,Brotin E,Karadjian G,Hemon P,Gaudin-Nomé F,Vallarino-Lhermitte N,Nieguitsila A,Fercoq F,Aknin ML,Marin-Esteban V,Chollet-Martin S,Schlecht-Louf G,Bachelerie F,Martin C

    更新日期:2016-04-25 00:00:00

  • An integrated linkage, chromosome, and genome map for the yellow fever mosquito Aedes aegypti.

    abstract:BACKGROUND:Aedes aegypti, the yellow fever mosquito, is an efficient vector of arboviruses and a convenient model system for laboratory research. Extensive linkage mapping of morphological and molecular markers localized a number of quantitative trait loci (QTLs) related to the mosquito's ability to transmit various pa...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Timoshevskiy VA,Severson DW,Debruyn BS,Black WC,Sharakhov IV,Sharakhova MV

    更新日期:2013-01-01 00:00:00

  • Response of extensively drug resistant Salmonella Typhi to treatment with meropenem and azithromycin, in Pakistan.

    abstract:INTRODUCTION:Salmonella Typhi is one of the leading health problems in Pakistan. With the emergence of extensively drug resistant (XDR) Salmonella Typhi, treatment options are limited. Here we report the clinical manifestations and the response to treatment of patients with XDR Typhoid fever. The patients were treated ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Qureshi S,Naveed AB,Yousafzai MT,Ahmad K,Ansari S,Lohana H,Mukhtar A,Qamar FN

    更新日期:2020-10-15 00:00:00

  • Cluster randomized trial comparing school-based mass drug administration schedules in areas of western Kenya with moderate initial prevalence of Schistosoma mansoni infections.

    abstract:BACKGROUND:Mass drug administration (MDA) using praziquantel is the WHO-recommended approach for control of schistosomiasis. However, few studies have compared the impact of different schedules of MDA on the resultant infection levels. We wished to evaluate whether annual MDA was more effective than less frequent treat...

    journal_title:PLoS neglected tropical diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Karanja DMS,Awino EK,Wiegand RE,Okoth E,Abudho BO,Mwinzi PNM,Montgomery SP,Secor WE

    更新日期:2017-10-23 00:00:00

  • Molecular investigations of a locally acquired case of melioidosis in Southern AZ, USA.

    abstract::Melioidosis is caused by Burkholderia pseudomallei, a Gram-negative bacillus, primarily found in soils in Southeast Asia and northern Australia. A recent case of melioidosis in non-endemic Arizona was determined to be the result of locally acquired infection, as the patient had no travel history to endemic regions and...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Engelthaler DM,Bowers J,Schupp JA,Pearson T,Ginther J,Hornstra HM,Dale J,Stewart T,Sunenshine R,Waddell V,Levy C,Gillece J,Price LB,Contente T,Beckstrom-Sternberg SM,Blaney DD,Wagner DM,Mayo M,Currie BJ,Keim P,Tua

    更新日期:2011-10-01 00:00:00

  • Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

    abstract:BACKGROUND:The two front-line drugs for chronic Trypanosoma cruzi infections are limited by adverse side-effects and declining efficacy. One potential new target for Chagas' disease chemotherapy is sterol 14alpha-demethylase (CYP51), a cytochrome P450 enzyme involved in biosynthesis of membrane sterols. METHODOLOGY/PR...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Chen CK,Doyle PS,Yermalitskaya LV,Mackey ZB,Ang KK,McKerrow JH,Podust LM

    更新日期:2009-01-01 00:00:00

  • Identification of cell-binding adhesins of Leptospira interrogans.

    abstract::Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic members of the genus Leptospira. Infection can lead to illness ranging from mild and non-specific to severe, with jaundice, kidney and liver dysfunction, and widespread endothelial damage. The adhesion of pathogenic Leptospira sp...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Evangelista KV,Hahn B,Wunder EA Jr,Ko AI,Haake DA,Coburn J

    更新日期:2014-10-02 00:00:00

  • Insights into the trypanosome-host interactions revealed through transcriptomic analysis of parasitized tsetse fly salivary glands.

    abstract::The agents of sleeping sickness disease, Trypanosoma brucei complex parasites, are transmitted to mammalian hosts through the bite of an infected tsetse. Information on tsetse-trypanosome interactions in the salivary gland (SG) tissue, and on mammalian infective metacyclic (MC) parasites present in the SG, is sparse. ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Telleria EL,Benoit JB,Zhao X,Savage AF,Regmi S,Alves e Silva TL,O'Neill M,Aksoy S

    更新日期:2014-04-24 00:00:00

  • Immunogenicity and Serological Cross-Reactivity of Saliva Proteins among Different Tsetse Species.

    abstract::Tsetse are vectors of pathogenic trypanosomes, agents of human and animal trypanosomiasis in Africa. Components of tsetse saliva (sialome) are introduced into the mammalian host bite site during the blood feeding process and are important for tsetse's ability to feed efficiently, but can also influence disease transmi...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Zhao X,Alves e Silva TL,Cronin L,Savage AF,O'Neill M,Nerima B,Okedi LM,Aksoy S

    更新日期:2015-08-27 00:00:00

  • Potency and breadth of human primary ZIKV immune sera shows that Zika viruses cluster antigenically as a single serotype.

    abstract::Zika virus (ZIKV) emerged as a global public health threat throughout the Americas since 2014. Phylogenetically, the virus is composed of three main lineages, an African, Asian, and American lineage. The recent emergence and spread of ZIKV has raised questions regarding the breadth and potency of human primary ZIKV im...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Nix CD,Salberg J,Coulter FJ,Kareko BW,Lyski ZL,Booty BL,Messer WB

    更新日期:2020-04-13 00:00:00

  • PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages.

    abstract::Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Par...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: de Léséleuc L,Orlova M,Cobat A,Girard M,Huong NT,Ba NN,Thuc NV,Truman R,Spencer JS,Adams L,Thai VH,Alcais A,Schurr E

    更新日期:2013-01-01 00:00:00

  • Sporotrichosis in sub-himalayan India.

    abstract::Sporotrichosis is endemic in the Sub-Himalayan belt, which ranges from the northern to the north-eastern Indian subcontinent. Similar to many parts of the developing world, sporotrichosis is commonly recognized clinically in this region however consolidated epidemiological data is lacking. We report epidemiological, c...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Verma S,Verma GK,Singh G,Kanga A,Shanker V,Singh D,Gupta P,Mokta K,Sharma V

    更新日期:2012-01-01 00:00:00

  • Clinical, etiological and epidemiological investigations of hand, foot and mouth disease in southern Vietnam during 2015 - 2018.

    abstract::Hand, foot and mouth disease (HFMD) continues to challenge Asia with pandemic potential. In Vietnam, there have been two major outbreaks occurring during 2011-2012 (>200,000 hospitalizations and >200 deaths) and more recently in 2018 (>130,000 hospitalizations and 17 deaths). Given the high burden and the complex epid...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Nhan LNT,Khanh TH,Hong NTT,Van HMT,Nhu LNT,Ny NTH,Nguyet LA,Thanh TT,Anh NT,Hang VTT,Qui PT,Viet HL,Tung TH,Ha DQ,Tuan HM,Thwaites G,Chau NVV,Thwaites L,Hung NT,van Doorn HR,Tan LV

    更新日期:2020-08-17 00:00:00

  • Inferring the Spatio-temporal Patterns of Dengue Transmission from Surveillance Data in Guangzhou, China.

    abstract:BACKGROUND:Dengue is a serious vector-borne disease, and incidence rates have significantly increased during the past few years, particularly in 2014 in Guangzhou. The current situation is more complicated, due to various factors such as climate warming, urbanization, population increase, and human mobility. The purpos...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Zhu G,Liu J,Tan Q,Shi B

    更新日期:2016-04-22 00:00:00

  • Serological evidence of Ebola virus exposure in dogs from affected communities in Liberia: A preliminary report.

    abstract::Filoviruses such as Ebola virus (EBOV) cause outbreaks of viral hemorrhagic fevers for which no FDA-approved vaccines or drugs are available. The 2014-2016 EBOV outbreak in West Africa infected approximately 30,000 people, killing more than 11,000 and affecting thousands more in areas still suffering from the effects ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Haun BK,Kamara V,Dweh AS,Garalde-Machida K,Forkay SSE,Takaaze M,Namekar M,Wong TAS,Bell-Gam Woto AER,Humphreys P,Weeks OI,Fallah MP,Berestecky JM,Nerurkar VR,Lehrer AT

    更新日期:2019-07-22 00:00:00

  • Multi-disease data management system platform for vector-borne diseases.

    abstract:BACKGROUND:Emerging information technologies present new opportunities to reduce the burden of malaria, dengue and other infectious diseases. For example, use of a data management system software package can help disease control programs to better manage and analyze their data, and thus enhances their ability to carry ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Eisen L,Coleman M,Lozano-Fuentes S,McEachen N,Orlans M,Coleman M

    更新日期:2011-03-29 00:00:00

  • Invasive plants facilitated by socioeconomic change harbor vectors of scrub typhus and spotted fever.

    abstract:BACKGROUND:Ecological determinants of most emerging vector-borne diseases are understudied, particularly for neglected tropical disease. Moreover, although socioeconomic impacts can have significant downstream effects on human risks to vector-borne diseases via a change in land cover, particularly facilitating the inva...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Wei CY,Wang JK,Shih HC,Wang HC,Kuo CC

    更新日期:2020-01-21 00:00:00