Last generation triazoles for imported eumycetoma in eleven consecutive adults.

abstract：BACKGROUND:Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic shock is the most serious ...

journal_title：PLoS neglected tropical diseases

authors： Lam PK,Ngoc TV,Thu Thuy TT,Hong Van NT,Nhu Thuy TT,Hoai Tam DT,Dung NM,Hanh Tien NT,Thanh Kieu NT,Simmons C,Wills B,Wolbers M

更新日期：2017-04-27 00:00:00

abstract：BACKGROUND:American visceral leishmaniasis (AVL) is an emerging disease in the state of São Paulo, Brazil. Its geographical expansion and the increase in the number of human cases has been linked to dispersion of Lutzomyia longipalpis into urban areas. To produce more accurate risk maps we investigated the geographic d...

journal_title：PLoS neglected tropical diseases

authors： Casanova C,Colla-Jacques FE,Hamilton JG,Brazil RP,Shaw JJ

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:Continued exposure to malaria-causing parasites in endemic regions of malaria induces significant levels of acquired immunity in adult individuals. A better understanding of the transcriptional basis for this acquired immunological response may provide insight into how the immune system can be boosted during...

journal_title：PLoS neglected tropical diseases

authors： Rojas-Peña ML,Vallejo A,Herrera S,Gibson G,Arévalo-Herrera M

更新日期：2015-08-05 00:00:00

abstract：:The N-linked glycosylation motif at amino acid position 154-156 of the envelope (E) protein of West Nile virus (WNV) is linked to enhanced murine neuroinvasiveness, avian pathogenicity and vector competence. Naturally occurring isolates with altered E protein glycosylation patterns have been observed in WNV isolates; ...

journal_title：PLoS neglected tropical diseases

authors： Maharaj PD,Langevin SA,Bolling BG,Andrade CC,Engle XA,Ramey WN,Bosco-Lauth A,Bowen RA,Sanders TA,Huang CY,Reisen WK,Brault AC

更新日期：2019-07-15 00:00:00

abstract：INTRODUCTION:Post-kala-azar dermal leishmaniasis (PKDL) is a cutaneous complication appearing after treatment of visceral leishmaniasis, and PKDL patients are considered infectious to sand flies and may therefore play a role in the transmission of VL. We estimated the risk and risk factors of PKDL in patients with past...

journal_title：PLoS neglected tropical diseases

authors： Uranw S,Ostyn B,Rijal A,Devkota S,Khanal B,Menten J,Boelaert M,Rijal S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The impact of large scale Mass Drug Adminstration (MDA) of ivermectin on active onchocerciasis transmission by Simulium damnosum, which transmits the parasite O. volvulus is of great importance for onchocerciasis control programmes. We investigated in the Mbam river system area, the impact of MDA of ivermect...

journal_title：PLoS neglected tropical diseases

authors： Abong RA,Amambo GN,Hamid AA,Enow BA,Beng AA,Nietcho FN,Nji TM,Njouendou AJ,Ritter M,Esum ME,Deribe K,Cho JF,Fombad FF,Enyong PI,Poole C,Pfarr K,Hoerauf A,Carlow C,Wanji S

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Aedes control interventions are considered the cornerstone of dengue control programmes, but there is scarce evidence on their effect on disease. We set-up a cluster randomized controlled trial in Santiago de Cuba to evaluate the entomological and epidemiological effectiveness of periodical intra- and peri-d...

journal_title：PLoS neglected tropical diseases

authors： Toledo ME,Vanlerberghe V,Rosales JP,Mirabal M,Cabrera P,Fonseca V,Gómez Padrón T,Pérez Menzies M,Montada D,Van der Stuyft P

更新日期：2017-11-08 00:00:00

abstract：:Burkholderia pseudomallei causes the tropical infection melioidosis. Pneumonia is a common manifestation of melioidosis and is associated with high mortality. Understanding the key elements of host defense is essential to developing new therapeutics for melioidosis. As a flagellated bacterium encoding type III secreti...

journal_title：PLoS neglected tropical diseases

authors： West TE,Myers ND,Chantratita N,Chierakul W,Limmathurotsakul D,Wuthiekanun V,Miao EA,Hajjar AM,Peacock SJ,Liggitt HD,Skerrett SJ

更新日期：2014-09-18 00:00:00

abstract：BACKGROUND:Leishmaniasis is a complex disease in which clinical outcome depends on factors such as parasite species, host genetics and immunity and vector species. In Brazil, Leishmania (Viannia) braziliensis is a major etiological agent of cutaneous (CL) and mucosal leishmaniasis (MCL), a disfiguring form of the disea...

journal_title：PLoS neglected tropical diseases

authors： Alves-Ferreira EV,Toledo JS,De Oliveira AH,Ferreira TR,Ruy PC,Pinzan CF,Santos RF,Boaventura V,Rojo D,López-Gonzálvez Á,Rosa JC,Barbas C,Barral-Netto M,Barral A,Cruz AK

更新日期：2015-09-14 00:00:00

abstract：BACKGROUND:Food and water-borne illness caused by ingestion of (oo)cysts of Cryptosporidium and Giardia is one of the major health problems globally. Several methods are available to detect Giardia cyst and Cryptosporidium oocyst in food and water. Most of the available methods require a good laboratory facility and we...

journal_title：PLoS neglected tropical diseases

authors： Shrestha R,Duwal R,Wagle S,Pokhrel S,Giri B,Neupane BB

更新日期：2020-09-08 00:00:00

abstract：:Cystic echinococcosis (CE) is distributed worldwide, extending from China to the Middle East and from Mediterranean countries to the sub-Saharan Africa and South America. According to WHO, one million people around the world are suffering from CE with an estimated burden of 183,573 DALYs. The annual monetary burden of...

journal_title：PLoS neglected tropical diseases

authors： Borhani M,Fathi S,Lahmar S,Ahmed H,Abdulhameed MF,Fasihi Harandi M

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Zika (ZIKV) and Chikungunya (CHIKV) viruses are emerging Aedes-borne viruses that are spreading outside their known geographic range and causing wide-scale epidemics. It has been reported that these viruses can be transmitted efficiently by Ae. aegypti. Recent studies have shown that Ae. aegypti when transin...

journal_title：PLoS neglected tropical diseases

authors： Tan CH,Wong PJ,Li MI,Yang H,Ng LC,O'Neill SL

更新日期：2017-05-19 00:00:00

abstract：:The World Health Organization (WHO) defines an effective round of mass drug administration (MDA) for lymphatic filariasis (LF) as one that reaches at least 65% of the target population. In its first round of MDA in 2011-2012, the National Program to Eliminate LF in Haiti achieved a 79% epidemiological coverage in urba...

journal_title：PLoS neglected tropical diseases

authors： Wodnik BK,Louis DH,Joseph M,Wilkers LT,Landskroener SD,Desir L,Lemoine JF,Lavery JV

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:In endemic areas, leptospirosis is more common and more severe in adults compared with children. Reasons to explain this discrepancy remain unclear and limited data focusing on adolescents are available. The objective of the study was to describe disease spectrum and outcome differences in children and adole...

journal_title：PLoS neglected tropical diseases

authors： Guerrier G,Hie P,Gourinat AC,Huguon E,Polfrit Y,Goarant C,D'Ortenzio E,Missotte I

更新日期：2013-09-26 00:00:00

abstract：:The area of Walikale in North Kivu, Democratic Republic of Congo, is intensely affected by conflict and population displacement. Médecins-Sans-Frontières (MSF) returned to provide primary healthcare in July 2012. To better understand the impact of the ongoing conflict and displacement on the population, a retrospectiv...

journal_title：PLoS neglected tropical diseases

authors： Carrión Martín AI,Bil K,Salumu P,Baabo D,Singh J,Kik C,Lenglet A

更新日期：2014-09-18 00:00:00

abstract：:Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput RNA-sequencing. Biopsies were taken from 8 patients with early cutaneous leishmaniasis and 17 patients with late cutaneous leishmaniasis. Although parasite DNA was found ...

journal_title：PLoS neglected tropical diseases

authors： Christensen SM,Dillon LA,Carvalho LP,Passos S,Novais FO,Hughitt VK,Beiting DP,Carvalho EM,Scott P,El-Sayed NM,Mosser DM

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:The factors influencing variation in the clinical forms of Chagas disease have not been elucidated; however, it is likely that the genetics of both the host and the parasite are involved. Several studies have attempted to correlate the T. cruzi strains involved in infection with the clinical forms of the dis...

journal_title：PLoS neglected tropical diseases

authors： Mendes TA,Reis Cunha JL,de Almeida Lourdes R,Rodrigues Luiz GF,Lemos LD,dos Santos AR,da Câmara AC,Galvão LM,Bern C,Gilman RH,Fujiwara RT,Gazzinelli RT,Bartholomeu DC

更新日期：2013-10-31 00:00:00

abstract：BACKGROUND:Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is a paucity of data on ILC2s in the context of human parasitic infections and in particula...

journal_title：PLoS neglected tropical diseases

authors： Nausch N,Appleby LJ,Sparks AM,Midzi N,Mduluza T,Mutapi F

更新日期：2015-03-23 00:00:00

abstract：BACKGROUND:The role of the immune response in influencing leptospirosis clinical outcomes is not yet well understood. We hypothesized that acute-phase serum cytokine responses may play a role in disease progression, risk for death, and severe pulmonary hemorrhage syndrome (SPHS). METHODOLOGY/PRINCIPAL FINDINGS:We perf...

journal_title：PLoS neglected tropical diseases

authors： Reis EA,Hagan JE,Ribeiro GS,Teixeira-Carvalho A,Martins-Filho OA,Montgomery RR,Shaw AC,Ko AI,Reis MG

更新日期：2013-09-19 00:00:00

abstract：:Intracerebral microhemorrhages (CMHs) are small foci of hemorrhages in the cerebrum. Acute infections induced by some intracellular pathogens, including rickettsia, can result in CMHs. Annexin a2 (ANXA2) has been documented to play a functional role during intracellular bacterial adhesion. Here we report that ANXA2-kn...

journal_title：PLoS neglected tropical diseases

authors： Su Z,Chang Q,Drelich A,Shelite T,Judy B,Liu Y,Xiao J,Zhou C,He X,Jin Y,Saito T,Tang S,Soong L,Wakamiya M,Fang X,Bukreyev A,Ksiazek T,Russell WK,Gong B

更新日期：2020-07-20 00:00:00

abstract：:Global efforts to control morbidity associated with soil-transmitted helminth infections (STH) have focused largely on the targeted treatment of high-risk groups, including children and pregnant women. However, it is not clear when such programs can be discontinued and there are concerns about the sustainability of cu...

journal_title：PLoS neglected tropical diseases

authors： DeWorm3 Trials Team.

更新日期：2020-11-02 00:00:00

abstract：BACKGROUND:Despite the known burden of neglected tropical diseases (NTDs) on child health, there is limited information on current efforts to increase pediatric therapeutic options. Our objective was to quantify and characterize research activity and treatment availability for NTDs in children in order to inform the pr...

journal_title：PLoS neglected tropical diseases

authors： Rees CA,Hotez PJ,Monuteaux MC,Niescierenko M,Bourgeois FT

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Soil-transmitted helminth (STH) infection leads to malnutrition and anemia, and has been linked to impaired child development. Previous research on this topic is limited and mostly conducted in school-age children. The goal of this study was to determine the effect of the number of detected STH infections be...

journal_title：PLoS neglected tropical diseases

authors： Blouin B,Casapia M,Joseph L,Gyorkos TW

更新日期：2018-07-27 00:00:00

abstract：INTRODUCTION:In addition to the commonly accepted importance of the vampire bat in the maintenance and transmission of the rabies virus (RABV) in South America, RABV infection of other species is widely evidenced, challenging their role in the viral cycle. METHODOLOGY / PRINCIPLES FINDINGS:To identify the bioecologica...

journal_title：PLoS neglected tropical diseases

authors： de Thoisy B,Bourhy H,Delaval M,Pontier D,Dacheux L,Darcissac E,Donato D,Guidez A,Larrous F,Lavenir R,Salmier A,Lacoste V,Lavergne A

更新日期：2016-01-25 00:00:00

abstract：BACKGROUND:Echinococcosis is a life-threatening parasitic disease caused by Echinococcus spp. tapeworms with over one million people affected globally at any time. The Echinococcus spp. tapeworms in the human body release DNA to the circulatory system, which can be a biomarker for echinococcosis. Cell-free DNA (cfDNA) ...

journal_title：PLoS neglected tropical diseases

authors： Ji J,Li B,Li J,Danzeng W,Li J,Zhao Y,Qiangba G,Zhang Q,Renzhen N,Basang Z,Jia C,Gongsang Q,Ma J,Wang Y,Chen F,Zhou H,Huasang,Yin J,Xie J,Pei N,Cai H,Jiang H,Yang H,Wang J,Asan,Han X,Li J,Chen W,Yan

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:South Sudan is one of the most endemic countries for visceral leishmaniasis (VL), and is frequently affected by large epidemics. In resource-limited settings, clinicians require a simple clinical tool to identify VL patients who are at increased risk of dying, and who need specialised treatment with liposoma...

journal_title：PLoS neglected tropical diseases

authors： Kämink SS,Collin SM,Harrison T,Gatluak F,Mullahzada AW,Ritmeijer K

更新日期：2017-10-02 00:00:00

abstract：:Community drug distributors (CDDs) who are volunteers have the responsibility of awareness creation, household census, drug distribution and record-keeping and are thus key stakeholders in the campaign for Lymphatic Filariasis (LF) elimination. Taking into account their experiences and perceptions is important for a s...

journal_title：PLoS neglected tropical diseases

authors： Njomo DW,Kimani BW,Kibe LW,Okoyo C,Omondi WP,Sultani HM

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:The simian parasite Plasmodium knowlesi is a common cause of human malaria in Malaysian Borneo and threatens the prospect of malaria elimination. However, little is known about the emergence of P. knowlesi, particularly in Sabah. We reviewed Sabah Department of Health records to investigate the trend of each...

journal_title：PLoS neglected tropical diseases

authors： William T,Rahman HA,Jelip J,Ibrahim MY,Menon J,Grigg MJ,Yeo TW,Anstey NM,Barber BE

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Chagas disease is a vector-borne disease of major importance in the Americas. Disease prevention is mostly limited to vector control. Integrated interventions targeting ecological, biological and social determinants of vector-borne diseases are increasingly used for improved control. METHODOLOGY/PRINCIPAL F...

journal_title：PLoS neglected tropical diseases

authors： Dumonteil E,Nouvellet P,Rosecrans K,Ramirez-Sierra MJ,Gamboa-León R,Cruz-Chan V,Rosado-Vallado M,Gourbière S

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:There is conflicting evidence on the immunologic benefit of treating helminth co-infections ("deworming") in HIV-infected individuals. Several studies have documented reduced viral load and increased CD4 count in antiretroviral therapy (ART) naïve individuals after deworming. However, there are a lack of dat...

journal_title：PLoS neglected tropical diseases

authors： Lankowski AJ,Tsai AC,Kanyesigye M,Bwana M,Haberer JE,Wenger M,Martin JN,Bangsberg DR,Hunt PW,Siedner MJ

更新日期：2014-08-07 00:00:00