Neglected tropical diseases in children: An assessment of gaps in research prioritization.

abstract：:Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyanogen consumption fr...

journal_title：PLoS neglected tropical diseases

authors： Nzwalo H,Cliff J

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Melioidosis is a tropical infectious disease associated with significant mortality due to early onset of sepsis. OBJECTIVE:We sought to review case reports of melioidosis from Malaysia. METHODS:We conducted a computerized search of literature resources including PubMed, OVID, Scopus, MEDLINE and the COCHRA...

journal_title：PLoS neglected tropical diseases

authors： Kingsley PV,Leader M,Nagodawithana NS,Tipre M,Sathiakumar N

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:Melioidosis is a severe bacterial infection caused by Burkholderia pseudomallei with a high case-fatality rate. Epidemiological and animal studies show the possibility of inhalation transmission. However, no B. pseudomallei concentrations in ambient air have been researched. Here, we developed a method to qu...

journal_title：PLoS neglected tropical diseases

authors： Chen YL,Yen YC,Yang CY,Lee MS,Ho CK,Mena KD,Wang PY,Chen PS

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:To be transmitted to vertebrate hosts via the saliva of their vectors, arthropod-borne viruses have to cross several barriers in the mosquito body, including the midgut infection and escape barriers. Yellow fever virus (YFV) belongs to the genus Flavivirus, which includes human viruses transmitted by Aedes m...

journal_title：PLoS neglected tropical diseases

authors： Danet L,Beauclair G,Berthet M,Moratorio G,Gracias S,Tangy F,Choumet V,Jouvenet N

更新日期：2019-08-14 00:00:00

abstract：:Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria (kinetoplast), where specific protein complexes detect and eliminate damage to DNA. One group of these p...

journal_title：PLoS neglected tropical diseases

authors： Rojas DA,Urbina F,Moreira-Ramos S,Castillo C,Kemmerling U,Lapier M,Maya JD,Solari A,Maldonado E

更新日期：2018-02-12 00:00:00

abstract：BACKGROUND:Paracoccidioidomycosis, a primary fungal infection restricted to Latin America, is acquired by inhalation of fungal particles. The immunoregulatory mechanisms that control the severe and mild forms of paracoccidioidomycosis are still unclear. Indoleamine 2,3-dioxygenase (IDO), an IFN-γ induced enzyme that ca...

journal_title：PLoS neglected tropical diseases

authors： Araújo EF,Loures FV,Bazan SB,Feriotti C,Pina A,Schanoski AS,Costa TA,Calich VL

更新日期：2014-11-20 00:00:00

abstract：OBJECTIVE:We conducted a systematic literature review with indirect comparison of studies evaluating therapeutic efficacy and toxicity associated to visceral leishmaniasis (VL) therapy among HIV infected individuals. MAIN OUTCOME MEASUREMENTS:The outcomes of interest were clinical and parasitological cure, mortality, ...

journal_title：PLoS neglected tropical diseases

authors： Cota GF,de Sousa MR,Fereguetti TO,Rabello A

更新日期：2013-05-02 00:00:00

abstract：BACKGROUND:Health promotion is essential to the SAFE strategy for trachoma elimination. Schools are a valuable venue for health promotion. However, there is little literature about the impact of health education and water infrastructure in schools on facial cleanliness and trachoma in the community. Our study aimed to ...

journal_title：PLoS neglected tropical diseases

authors： Chen X,Munoz B,Mkocha H,Wolle MA,K West S

更新日期：2021-02-01 00:00:00

abstract：:Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use. Our aim was to discover antigens for the detection of antibodies to Trypanosoma congo...

journal_title：PLoS neglected tropical diseases

authors： Fleming JR,Sastry L,Crozier TW,Napier GB,Sullivan L,Ferguson MA

更新日期：2014-06-12 00:00:00

abstract：:Tick-borne rickettsioses are world-spreading infectious zoonoses. Ticks serve as reservoirs and vectors for Rickettsia and play a key role in transmission of rickettsioses. Most of the Chinese rickettsiosis patients are reported from Northeastern China but the distribution of tick and tick-borne Rickettsia species in ...

journal_title：PLoS neglected tropical diseases

authors： Shao JW,Zhang XL,Li WJ,Huang HL,Yan J

更新日期：2020-06-04 00:00:00

abstract：BACKGROUND:BALB/c mice are highly susceptible while C57BL/6 are relatively resistant to experimental Trypanosoma congolense infection. Although regulatory T cells (Tregs) have been shown to regulate the pathogenesis of experimental T. congolense infection, their exact role remains controversial. We wished to determine ...

journal_title：PLoS neglected tropical diseases

authors： Okwor I,Onyilagha C,Kuriakose S,Mou Z,Jia P,Uzonna JE

更新日期：2012-01-01 00:00:00

abstract：:The Leishmania genus comprises up to 35 species, some with status still under discussion. The multilocus sequence typing (MLST)--extensively used for bacteria--has been proposed for pathogenic trypanosomatids. For Leishmania, however, a detailed analysis and revision on the taxonomy is still required. We have partiall...

journal_title：PLoS neglected tropical diseases

authors： Boité MC,Mauricio IL,Miles MA,Cupolillo E

更新日期：2012-01-01 00:00:00

abstract：:Rift Valley fever (RVF) is endemic in most parts of Africa and has also been reported to occur in the Arabian Peninsula. It is responsible for significant morbidity and mortality, particularly in livestock, but also in humans. During the last two decades several outbreaks of RVF have been reported in countries in Sout...

journal_title：PLoS neglected tropical diseases

authors： Fafetine J,Neves L,Thompson PN,Paweska JT,Rutten VP,Coetzer JA

更新日期：2013-01-01 00:00:00

abstract：:The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is well documented from laboratory-selected Trypanosoma brucei muta...

journal_title：PLoS neglected tropical diseases

authors： Graf FE,Ludin P,Wenzler T,Kaiser M,Brun R,Pyana PP,Büscher P,de Koning HP,Horn D,Mäser P

更新日期：2013-10-10 00:00:00

abstract：BACKGROUND:Rodents are reservoirs and hosts for several zoonotic diseases such as plague, leptospirosis, and leishmaniasis. Rapid development of industry and agriculture, as well as climate change throughout the globe, has led to change or increase in occurrence of rodent-borne diseases. Considering the distribution of...

journal_title：PLoS neglected tropical diseases

authors： Rabiee MH,Mahmoudi A,Siahsarvie R,Kryštufek B,Mostafavi E

更新日期：2018-04-19 00:00:00

abstract：BACKGROUND:Buruli ulcer is a chronic ulcerating skin condition, with the highest burden found in Central and West Africa where it disproportionately affects the most vulnerable populations. Treatment is demanding, comprising eight-weeks of daily antibiotics, regular wound care and possible surgical intervention. Treatm...

journal_title：PLoS neglected tropical diseases

authors： Collinson S,Frimpong VNB,Agbavor B,Montgomery B,Oppong M,Frimpong M,Amoako YA,Marks M,Phillips RO

更新日期：2020-05-26 00:00:00

abstract：BACKGROUND:In Latin America, there are 13 geographically isolated endemic foci distributed among Mexico, Guatemala, Colombia, Venezuela, Brazil and Ecuador. The communities of the three endemic foci found within Mexico have been receiving ivermectin treatment since 1989. In this study, we predicted the trend of occurre...

journal_title：PLoS neglected tropical diseases

authors： Lara-Ramírez EE,Rodríguez-Pérez MA,Pérez-Rodríguez MA,Adeleke MA,Orozco-Algarra ME,Arrendondo-Jiménez JI,Guo X

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4, promoting lethal, en...

journal_title：PLoS neglected tropical diseases

authors： De Jong HK,Achouiti A,Koh GC,Parry CM,Baker S,Faiz MA,van Dissel JT,Vollaard AM,van Leeuwen EM,Roelofs JJ,de Vos AF,Roth J,van der Poll T,Vogl T,Wiersinga WJ

更新日期：2015-04-10 00:00:00

abstract：:Mycobacterium tuberculosis complex (MTBC) comprises closely related species responsible for human and animal tuberculosis (TB). Efficient species determination is useful for epidemiological purposes, especially for the elucidation of the zoonotic contribution. In Algeria, data on MTBC genotypes are largely unknown. In...

journal_title：PLoS neglected tropical diseases

authors： Damene H,Tahir D,Diels M,Berber A,Sahraoui N,Rigouts L

更新日期：2020-11-30 00:00:00

abstract：:Enzootic strains of Venezuelan equine encephalitis virus (VEEV) have been isolated from febrile patients in the Peruvian Amazon Basin at low but consistent levels since the early 1990s. Through a clinic-based febrile surveillance program, we detected an outbreak of VEEV infections in Iquitos, Peru, in the first half o...

journal_title：PLoS neglected tropical diseases

authors： Morrison AC,Forshey BM,Notyce D,Astete H,Lopez V,Rocha C,Carrion R,Carey C,Eza D,Montgomery JM,Kochel TJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV), a reemerging pathogen causes a self limited illness characterized by fever, headache, myalgia and arthralgia. However, 10-20% affected individuals develop persistent arthralgia which contributes to considerable morbidity. The exact molecular mechanisms underlying these manifestatio...

journal_title：PLoS neglected tropical diseases

authors： Reddy V,Desai A,Krishna SS,Vasanthapuram R

更新日期：2017-01-26 00:00:00

abstract：BACKGROUND:Current chemotherapy for Chagas disease is unsatisfactory due to its limited efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment discontinuation. Combined therapy is envisioned as an ideal approach since it may improve treatment efficacy whilst decreasing toxici...

journal_title：PLoS neglected tropical diseases

authors： Diniz Lde F,Urbina JA,de Andrade IM,Mazzeti AL,Martins TA,Caldas IS,Talvani A,Ribeiro I,Bahia MT

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited. METHODOLOGY/PRINCIPAL FINDINGS:Four hundred and seventy nine acutely febrile...

journal_title：PLoS neglected tropical diseases

authors： Stubbs SCB,Johar E,Yudhaputri FA,Yohan B,Santoso MS,Hayati RF,Denis D,Blacklaws BA,Powers AM,Sasmono RT,Myint KSA,Frost SDW

更新日期：2020-12-21 00:00:00

abstract：:Our knowledge and control of the pathogenesis induced by the filariae remain limited due to experimental obstacles presented by parasitic nematode biology and the lack of selective prophylactic or curative drugs. Here we thought to investigate the role of neutrophils in the host innate immune response to the infection...

journal_title：PLoS neglected tropical diseases

authors： Pionnier N,Brotin E,Karadjian G,Hemon P,Gaudin-Nomé F,Vallarino-Lhermitte N,Nieguitsila A,Fercoq F,Aknin ML,Marin-Esteban V,Chollet-Martin S,Schlecht-Louf G,Bachelerie F,Martin C

更新日期：2016-04-25 00:00:00

abstract：BACKGROUND:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") st...

journal_title：PLoS neglected tropical diseases

authors： Bisoffi Z,Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Gobbo M,Bonafini S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:Dengue is the most prevalent arboviral disease transmitted by Aedes aegypti worldwide, whose chemical control is difficult, expensive, and of inconsistent efficacy. Releases of Metarhizium anisopliae--exposed Ae. aegypti males to disseminate conidia among female mosquitoes by mating represents a promising bi...

journal_title：PLoS neglected tropical diseases

authors： Garza-Hernández JA,Reyes-Villanueva F,Russell TL,Braks MA,Garcia-Munguia AM,Rodríguez-Pérez MA

更新日期：2015-10-16 00:00:00

abstract：:Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the...

journal_title：PLoS neglected tropical diseases

authors： de St Maurice A,Harmon J,Nyakarahuka L,Balinandi S,Tumusiime A,Kyondo J,Mulei S,Namutebi A,Knust B,Shoemaker T,Nichol ST,McElroy AK,Spiropoulou CF

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:Loiasis, a filarial infection caused by Loa loa usually thought to cause relatively minor morbidity, can cause serious and often fatal reactions in patients carrying very high levels of circulating Loa loa microfilariae (mf) following administration of microfilaricidal drugs. An experimental model of this co...

journal_title：PLoS neglected tropical diseases

authors： Wanji S,Eyong EE,Tendongfor N,Ngwa C,Esuka E,Kengne-Ouafo A,Datchoua-Poutcheu F,Enyong P,Hopkins A,Mackenzie CD

更新日期：2015-11-10 00:00:00

abstract：:Rabies is a fatal neurologic disease caused by lyssavirus infection. Bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. The epidemiology and pathogenesis of rabies in bats are poorly understood, making it difficult to prevent zoonotic transmission. To further our unde...

journal_title：PLoS neglected tropical diseases

authors： Begeman L,Suu-Ire R,Banyard AC,Drosten C,Eggerbauer E,Freuling CM,Gibson L,Goharriz H,Horton DL,Jennings D,Marston DA,Ntiamoa-Baidu Y,Riesle Sbarbaro S,Selden D,Wise EL,Kuiken T,Fooks AR,Müller T,Wood JLN,Cunningham

更新日期：2020-12-15 00:00:00

abstract：:The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characteristics make 8-oxoG a g...

journal_title：PLoS neglected tropical diseases

authors： Aguiar PH,Furtado C,Repolês BM,Ribeiro GA,Mendes IC,Peloso EF,Gadelha FR,Macedo AM,Franco GR,Pena SD,Teixeira SM,Vieira LQ,Guarneri AA,Andrade LO,Machado CR

更新日期：2013-06-13 00:00:00